| Project/Area Number |
20370026
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KUBOKAWA Kaoru 東京大学, 大学院・理学系研究科, 特任教授 (30240740)
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Hironori 新潟大学, 理学部, 准教授 (60221743)
NIIMURA Yoshihito 東京医科歯科大学, 難治疾患研究所, 准教授 (90396979)
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| Research Collaborator |
MIZUTA Takanobu 東京大学, 海洋研究所, 博士研究員
TANDO Yukiko 東京大学, 海洋研究所, 大学院生
INABA Mayumi 東京大学, 海洋研究所, 大学院生
IWATA Naoyuki 東京大学, 海洋研究所, 大学院生
SONALI Roy 東京大学, 海洋研究所, 外国人特別研究員
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 性ステロイド / ナメクジウオ / 進化 / 糖タンパク質ホルモン / 神経索 / 生体調節 / 甲状腺 / 下垂体 / ゲノム / 脊索動物 / 遺伝子発現 / EST / ホルモン |
|---|
| Research Abstract |
In order to consider the evolution of the endocrine mechanism to vertebrates, the endocrine mechanism of amphioxus belonging to the same phylum Chordata as vertebrates was investigated. There is a common sex steroidogenic pathway and 5α-reduced steroids is main in amphioxus. Furthermore, gene expressions of glycoprotein hormones, neurohypophyseal hormone, estrogen receptor and gonadotropin-releasing hormone receptors were shown in nerve cells of a nerve cord. These results suggest that many endocrine substances of amphioxus are homologous to those of vertebrates, but synthesized in a nerve cord as a neuroendocrine system.
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