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Feeding regulation in a novel Drosophila mutant showing unusual appetite.

Research Project

Project/Area Number 20370029
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionKobe University

Principal Investigator

OZAKI Mamiko  Kobe University, 大学院・理学研究科, 教授 (00314302)

Co-Investigator(Kenkyū-buntansha) TAKANO Toshiyuki  国立遺伝学研究所, 集団遺伝研究系, 准教授 (90202150)
伊藤 雅信  京都工芸繊維大学, 工芸科学研究科, 教授 (60221082)
Co-Investigator(Renkei-kenkyūsha) ITOH Masanobu  京都工芸繊維大学, 大学院・理工学研究科, 教授 (60221082)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywordsショウジョウバエ / 食欲 / 摂食異常 / 味覚 / 糖受容 / 電気生理 / DNAマイクロアレイ / 代謝異常 / ショウジョウバェ
Research Abstract

Increased and decreased appetites in flies would indicate low and high PER threshold to sucrose, respectively. A mutant TW1 showed hundredfold hyper feeding sensitivity to sucrose under starved condition, partially because of about tenfold increase in sensory sensitivity ; electrophysiological threshold of the sugar receptor cell of a tarsal sensillum decreased to 10% as starvation progressed. In vertebrates, appetite increase caused by starvation has mainly explained by central neuronal alteration via blood sugar and/or hormonal regulation. In Drosophila, however, the present study potentially suggested that increase in peripheral gustatory sensitivity significantly contributes to the appetite increase under starved condition.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (27 results)

All 2010 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (14 results) Book (5 results)

  • [Journal Article] クロキンバエにおける摂食行動の促進に関わる副嗅覚器情報受容部位の解析2010

    • Author(s)
      前田徹、平口鉄太郎、岩崎雅行、森岡律、尾崎まみこ
    • Journal Title

      日本味と匂学会誌 17巻

      Pages: 469-472

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] クロキンバエにおける摂食行動の促進に関わる副嗅覚器情報受容部位の解析2010

    • Author(s)
      前田徹, 平口鉄太郎, 岩崎雅行, 森岡律, 尾崎まみこ
    • Journal Title

      日本味と匂い学会誌

      Volume: 17 Pages: 469-472

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of genes up-regulated and down-regulated after 24 h starvation in the head of Drosophila2009

    • Author(s)
      藤川和世, 高橋文, 西村梓, 尾崎まみこ, 伊藤雅信, 高野敏行
    • Journal Title

      Gene

      Pages: 11-17

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ショウジョウバエ自然突然変異系統TW1の対飢餓略2009

    • Author(s)
      西村梓、石田裕幸、酒部真里奈岡本はるか、藤川和世、高橋文、伊藤雅信、高野敏行、尾崎まみこ
    • Journal Title

      16巻

      Pages: 315-316

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of genes up-regulated and down-regulated after 24h starvation in the head of Drosophila.2009

    • Author(s)
      藤川和世, 高橋文, 西村梓, 尾崎まみこ, 伊藤雅信, 高野敏行
    • Journal Title

      Gene 446

      Pages: 11-17

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ショウジョウバエ自然突然変異系統TW1の対飢餓戦略2009

    • Author(s)
      西村梓、石田裕幸、酒部真里奈、岡本はるか、藤川和世、高橋文、伊藤雅信、高野敏行、尾崎まみこ
    • Journal Title

      日本味と匂学会誌 16

      Pages: 315-316

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ショウジョウバエの新規変異体を用いた食欲調節の研究2008

    • Author(s)
      西村梓、石田裕幸、高橋文、高野敏行、伊藤雅信、藤川和世、尾崎まみこ
    • Journal Title

      日本味と匂学会誌 15巻

      Pages: 24-27

    • NAID

      110007369627

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ショウジョウバエの新規変異体を用いた食欲調節の研究2008

    • Author(s)
      西村梓, 石田裕幸, 高橋文, 高野敏行, 伊藤雅信, 藤川和世, 尾崎まみこ
    • Journal Title

      日本味と匂学会誌

      Pages: 313-316

    • NAID

      110007369627

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Chemosensory integration between taste and olfaction : Appetite regulation by lateralized olfactory systems in the blowfly, Phormiaregina.2010

    • Author(s)
      Hiraguchi, T., Maeda T., Ozaki M.
    • Organizer
      International Congress of Neuro-ethology
    • Place of Presentation
      Salamanca, Spain
    • Year and Date
      2010-08-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Chemosensory integration between taste and olfaction : Appetite regulation by lateralized olfactory systems in the blowfly, Phormia regina.2010

    • Author(s)
      Hiraguchi, T., Maeda, T., Ozaki, M
    • Organizer
      International Congress of Neuroethology
    • Place of Presentation
      Salamanca, Spain
    • Year and Date
      2010-08-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Survival strategies for starvation in a mutant of Drosophila melanogaster, TW12009

    • Author(s)
      Azusa Nishimura, Yuko Ishida, Marina Sakabe, Haruka Okamoto, Kazuyo Fujikawa,Yujiro Umesaki, Aya Takahashi, Toshiyuki Takano, Kenji Tomioka, Mamiko Ozaki
    • Organizer
      The 6th International Symposium on Molecular and Neural Mechanisms ofTaste and Olfactory Perception
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2009-11-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Survival strategies for starvation in a mutant of Drosophila melanogaster, TW1.2009

    • Author(s)
      Azusa Nishimura, Yuko Ishida, Marina Sakabe, Haruka Okamoto, Kazuyo Fujikawa, Yujiro Umesaki, Aya Takahashi, Toshiyuki Takano, Kenji Tomioka, Mamiko Ozaki
    • Organizer
      TW1. 7^<th> International symposium on molecular and neural mechanisms of taste and olfactory perception
    • Place of Presentation
      九州大学(福岡県)
    • Year and Date
      2009-11-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] ショウジョウバエ自然突然変異系統の多様な対飢餓戦略2009

    • Author(s)
      西村梓、石田裕幸、尾崎まみこ
    • Organizer
      日本動物学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-09-19
    • Related Report
      2010 Final Research Report
  • [Presentation] ショウジョウバエ自然突然変異系統の多様な対飢餓戦略2009

    • Author(s)
      西村梓、石田裕幸、尾崎まみこ
    • Organizer
      日本動物学会
    • Place of Presentation
      静岡グランシップ(静岡県)
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] ショウジョウバエ自然突然変異系統TW1の対飢餓戦略2009

    • Author(s)
      西村梓、石田裕幸、酒部真里奈岡本はるか、藤川和世、高橋文、伊藤雅信、高野敏行、尾崎まみこ
    • Organizer
      日本味と匂学会
    • Place of Presentation
      旭川
    • Year and Date
      2009-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] ショウジョウバエ自然突然変異系統TW1の対飢餓戦略2009

    • Author(s)
      西村梓、石田裕幸、酒部真里奈、岡本はるか、藤川和世、高橋文、伊藤雅信、高野敏行、尾崎まみこ
    • Organizer
      日本味と匂学会
    • Place of Presentation
      旭川市民文化会館(北海道)
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regulation of appetite and food intake by starvation in a novel Drosophila melanogaster mutant2008

    • Author(s)
      Azusa Nishimura, Yuko Ishida, Aya Takahashi, Toshiyuki Takano, Masanobu Itoh, Kazuyo Fjikawa, Mamiko Ozaki
    • Organizer
      The 6th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2008-12-07
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] ハエの食欲や食嗜好にかかわる神経・液性調節2008

    • Author(s)
      尾崎まみこ、西村梓、石田裕幸、前田徹
    • Organizer
      日本比較内分泌学会
    • Place of Presentation
      広島
    • Year and Date
      2008-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] ハエの食欲や食嗜好にかかわる神経・液性訓節2008

    • Author(s)
      尾崎まみこ, 西村梓, 石田裕幸, 前田徹
    • Organizer
      日本比較内分泌学会
    • Place of Presentation
      広島
    • Year and Date
      2008-12-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] ショウジョウバエの新規変異体を用いた食欲調節の研究2008

    • Author(s)
      西村梓、石田裕幸、高橋文、高野敏行、伊藤雅信、藤川和世、尾崎まみこ
    • Organizer
      日本味と匂学会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-18
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 絶食により甘味感受性の上昇するショウジョウバエ変異体の表現型解析2008

    • Author(s)
      藤川和世、高橋文、高野敏行、岡本はるか、伊藤雅信、西村梓、尾崎まみこ
    • Organizer
      日本遺伝学会、日本遺伝学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 絶食により甘味感受性の上昇するショウジョウバエ変異体の表現型解析2008

    • Author(s)
      藤川和世, 高橋文, 高野敏行, 岡本はるか, 伊藤雅信, 西村梓, 尾崎まみこ
    • Organizer
      日本遺伝学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-03
    • Related Report
      2008 Annual Research Report
  • [Book] In Frontiers in Sensin Biology and Engineering(Part II.Chemical communication, IV.Olfaction)2010

    • Author(s)
      Mamiko Ozaki, Midori Kidokoro-Kobayashi, Tetsutaro Hiraguchi
    • Total Pages
      300
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] Part II.Chemical communication, IV.Olfaction, In Frontiers in Sensing Biology and Engineering.2010

    • Author(s)
      Mamiko Ozaki, Midori Kidokoro-Kobayashi, Tetsutaro Hiraguchi
    • Publisher
      Springer(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] Insect Taste2009

    • Author(s)
      Mamiko Ozaki, Tadashi Nakamura, 他(共著)
    • Total Pages
      263
    • Publisher
      Taylor and Francis Group, Milton Park Abington, UK
    • Related Report
      2009 Annual Research Report
  • [Book] In insect Taste(Milton Park Abington, UK, Chemosensory regulation of feeding in the blowfly : Several studies after The Hungry Fly.)2008

    • Author(s)
      Mamiko Ozaki, Tadashi Nakamura
    • Total Pages
      263
    • Publisher
      Taylor and Francis Group
    • Related Report
      2010 Final Research Report
  • [Book] Chemosensory regulation of feeding in the blowfly : Several studies after The Hungry Fly. In insect Taste2008

    • Author(s)
      Mamiko Ozaki, Tadashi Nakamura
    • Total Pages
      266
    • Publisher
      Elsevier
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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