Physiological significance of phosphatidylinositol (PI) molecular species in PI signaling
| Project/Area Number |
20370045
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ARAI Hiroyuki The University of Tokyo, 大学院・薬学系研究科, 教授 (40167987)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Takao 東京大学, 大学院・薬学系研究科, 助教 (50361605)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 細胞情報伝達機構 / ホスファチジルイノシトール / アラキドン酸 / 脂肪酸転移酵素 / ボスファチジルイノシトール |
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| Research Abstract |
The fatty acid composition of phosphatidylinositol (PI) is unique in that most of PI fraction in mammalian tissues and cells constitutes the 1-stearoyl-2-arachidonoyl species. In this study, we identified acyltransferases, named LYCAT/ACL-10 and LPIAT1/MBOA-7,that incorporate stearic acid and arachidonic acid into lysoPI, respectively. Furthermore, we revealed the physiological significance of unique molecular species in PI by generating knockout worms and mice of these enzymes.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] C.elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol.2008
Author(s)
Lee H.C., Inoue T., Imae R., Kono N., Shirae S., Matsuda S., Gengyo-Ando K., Mitani S., Arai H.
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Journal Title
Mol.Biol.Cell 19
Pages: 1174-1184
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