| Project/Area Number |
20370076
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
NAKAYAMA Keiko Tohoku University, 大学院・医学系研究科, 教授 (60294972)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Noriko 東北大学, 大学院・医学系研究科, 助教 (10361073)
FUNAYAMA Ryo 東北大学, 大学院・医学系研究科, 助教 (20452295)
NAKANO Seiji 東北大学, 大学院・医学系研究科, 助手 (00529448)
DEL CARPIO Munoz Carlos Adriel 東北大学, 大学院・工学研究科, 准教授 (20231053)
NISHIDA Yuichiro 東北大学, 大学院・医学系研究科, 助教 (00551821)
山田 秀俊 東北大学, 大学院・医学系研究科, 助手 (70511955)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
|
|---|
| Keywords | ユビキチンリガーゼ / β-TrCP1 / Fbxw7 / ノックアウトマウス / ES細胞 / β-TcP2 |
|---|
| Research Abstract |
F-box protein functions as a ubiquitin ligase constructing SCF protein complex. In this preject, I focused my interest on typical F-box proteins, Fbxw7 and β-TrCP. I analyzed their gene targeting mice to elucidate the biological function of these proteins. Although Fbxw7 suppressed tumorigenesis in T lymphocytes and hematopoietic stem cell, it facilitated cell proliferation in primary embryonic fibroblasts and keratinocytes. b-TrCP promoted cell proliferation.
|
