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Analysis of the functional network governing cell division and cell differentiation

Research Project

Project/Area Number 20380055
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied microbiology
Research InstitutionTokyo University of Agriculture

Principal Investigator

YOSHIKAWA Hirofumi  Tokyo University of Agriculture, 応用生物科学部, 教授 (50175676)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords遺伝子発現 / 細胞分裂 / 脂質合成 / 細胞分化 / クエン酸回路 / 機能ネットワーク / 微生物 / 遺伝子 / 発現制御 / 胞子形成
Research Abstract

Analysis of the physiological significance of the stationary phase cells will contribute to the further understanding of cellular functions and genetic control systems in the viewpoint of functional network. We found an essential gene for lipid synthesis interacted with cell divisional machinery and involved in septum formation. While, a gene in the TCA cycle was found to be essential only for sporulationand was suggested to be a critical factor proceeding to the cell differentiation by sensing energy level of the cell.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (50 results)

All 2011 2010 2009 2008

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (36 results)

  • [Journal Article] Sequence-specific error profile of Illumina sequencers2011

    • Author(s)
      Nakamura K., Yoshikawa, H., Kanaya S., 他
    • Journal Title

      Nucleic Acids Research

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of Genome-wide DNA Polymorphisms by Whole-genome Sequencing of an Ancestral Japonica Rice Cultivar2011

    • Author(s)
      Y.Arai-Kichise, Y.Shiwa, H.Nagasaki, H.Yoshikawa, K.Wakasa
    • Journal Title

      Plant and Cell Physiology

      Volume: 52 Pages: 274-282

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole-genome resequencing shows numerous genes with nonsynonymous SNPs in the Japanese native cattle Kuchinoshima-Ushi2011

    • Author(s)
      R.Kawahara-Miki, Y.Shiwa, Y.Kichise, H.Yoshikawa, T.Kono
    • Journal Title

      BMC Genomics

      Volume: 12

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome of Bacillus subtilis phage SP 10 : comparative analysis with phage SPO1.2011

    • Author(s)
      L.M.Yee, T.Matsumoto, K.Yano, K.Asai, H.Yoshikawa, 他
    • Journal Title

      Biosci.Biotechnol.Biochem

      Volume: (in press)

    • NAID

      10028272756

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative Studies of Genome-Wide Maps of Nucleosomes between Deletion Mutants of elp3 and hos2 Genes of Saccharomyces cerevisiae.2011

    • Author(s)
      T.Matsumoto, C-S.Yun, H.Yoshikawa, H.Nishida
    • Journal Title

      PLoS ONE

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of nitrate assimilation in cyanobacteria2011

    • Author(s)
      Y.Ohashi, S.Watanabe, H.Yoshikawa, T.Omata, 他
    • Journal Title

      J.Exp.Botany

      Volume: 62(4) Pages: 1411-1424

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 枯草菌の環境ストレス応答機構2010

    • Author(s)
      吉川博文
    • Journal Title

      日本乳酸菌学会誌 21巻、No.1(総説)

      Pages: 16-26

    • NAID

      10029752187

    • Related Report
      2010 Final Research Report
  • [Journal Article] Novel antibacterial compounds specifically targeting the essential WalR response regulator.2010

    • Author(s)
      Yasuhiro G., Yoshikawa, H., Msadek T., Utsumi R.
    • Journal Title

      J.Antibiotics 63

      Pages: 127-134

    • NAID

      10030707938

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 枯草菌の環境ストレス応答機構2010

    • Author(s)
      吉川博文
    • Journal Title

      Japanese Journal of Lactic Acid Bacteria

      Volume: 21 Pages: 16-26

    • NAID

      10029752187

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Novel antibacterial compounds specifically targeting the essential WalR response regulator.2010

    • Author(s)
      Gotoh, Y., Furuta, E., Dubrac, S., YoshikaNa, H., Utsumi, R., 他
    • Journal Title

      J.Antibiotics 63

      Pages: 127-134

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesurements of transposition frequency of insertion sequence IS1 by GFP hop-on assay.2010

    • Author(s)
      Saito, T., Chibazakura, T., Tkahashi, K., Yoshikawa, H., Sekine, Y.
    • Journal Title

      J.Gen.Appl.Microbiol. 56

      Pages: 187-192

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of bacterial transformation efficiency using Plasmid Artificial Modification (PAM).2009

    • Author(s)
      Yasui K., Kano Y., Tanaka K., Watanabe K., Shimizu-Kadota M., Yoshikawa H., Suzuki T.
    • Journal Title

      Nucleic Acids Res. 37(1)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of bacterial transformation efficiencyusing Plasmid Artificial Modification (PAM).2009

    • Author(s)
      Yasu i, K., Kano, Y., Tanaka, k., Yoshikawa, H., Suzuki, T., 他
    • Journal Title

      Nucleic Acids Res. 37

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NbIR Is a Novel One-Component Response Regulator in the Cyanobacterium Synechococcus elongatus PCC 7942.2008

    • Author(s)
      Hiroaki Kato, Taku Chibazakura, Hirofumi Yoshikawa.
    • Journal Title

      Biosci. Biotechnol. Biochem. 72

      Pages: 1072-1079

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 枯草菌における脂質代謝と細胞分裂間の新規ネットワーク解析2011

    • Author(s)
      高田啓
    • Organizer
      日本農芸化学会2011年大会
    • Place of Presentation
      京都(発表は中止)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 脂質代謝と細胞分裂を共役させるネットワークの解析2011

    • Author(s)
      高田啓
    • Organizer
      第5回日本ゲノム微生物学会年会
    • Place of Presentation
      仙台(発表は中止)
    • Year and Date
      2011-03-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 次世代シーケンサーのための微生物ゲノム変異解析パイプラインの構築2010

    • Author(s)
      志波優、兼崎友、松本貴嗣、矢嶋俊介、吉川博文
    • Organizer
      日本分子生物学会第33回年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Geobacillus kaustophilus HTA426の3種のイノシトール脱水素酵素オルソログの発現と機能の解析2010

    • Author(s)
      三本木あずさ、森永哲郎、志波優、古川博文、吉田健一, 他
    • Organizer
      日本分子生物学会第33回年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of novel heat shock response mechanism mediated by the Initial nucleotide of transcription.2010

    • Author(s)
      Kobayashi, S.Ogawa, M., Matsumoto, M.Yoshikawa, H., 他
    • Organizer
      The 11^<th> Asian and Oceanian Conference on Transcription.
    • Place of Presentation
      Nakijin, Okinawa
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Fundamental heat shock response is generated by intrinsic mechanism of transcription initiation.2010

    • Author(s)
      吉川博文
    • Organizer
      The 11th Asian and Oceanian Conference on Transcription.
    • Place of Presentation
      Nakijin,(Okinawa)
    • Year and Date
      2010-07-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Fundamental heat shock response is generated by intrinsic mechanism of transcription intiation2010

    • Author(s)
      Kobayashi, S., Ogawa, M., Chibazakura, T.Yoshikawa, H., 他
    • Organizer
      The 11^<th> Asian and Oceanian Conference on Transcription.
    • Place of Presentation
      Nakijin, Okinawa
    • Year and Date
      2010-07-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genome resequencing and emerging issues in bacteria, rice and cattle.2010

    • Author(s)
      吉川博文
    • Organizer
      Illumina User symposium
    • Place of Presentation
      プーケット(タイ)(招待講演)
    • Year and Date
      2010-04-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Genome resequencing and emerging issues in bacteria, rice and cattle.2010

    • Author(s)
      Yoshikawa, H., Shiwa, Y., 他
    • Organizer
      Illumina User symposium
    • Place of Presentation
      Phuket, Thailand(招待講演)
    • Year and Date
      2010-04-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis workflows and experiences at NODAI genome research center2010

    • Author(s)
      Shiwa, Y.Yoshikawa, H., 他
    • Organizer
      Illumina User symposium, Asia Pacific & Japan
    • Place of Presentation
      Phuket, Thailand
    • Year and Date
      2010-04-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 枯草菌のRNAポリメラーゼに結合する小蛋白質(ω)の機能解析2010

    • Author(s)
      朝井計、松本貴嗣、佐久間萌里佳、矢野晃一、吉川博文
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 次世代シーケンサーによるSynechococcus elongatus PCC 7942のリシーケンス解析2010

    • Author(s)
      兼崎友、渡辺智、志波優、吉川博文
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Lactococcus lactis IO-1株におけるキシロース代謝関連遺伝子の転写解析2010

    • Author(s)
      鈴木成人、千葉櫻拓、園元謙二、門多真理子、吉川博文, 他
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 枯草菌ゲノムベクターシステムを利用したミニセルロソームの構築2010

    • Author(s)
      原裕一、中山薫、松岡聡、吉川博文
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞分裂から胞子形成開始への移行に関与する新規ネットワークの探索2010

    • Author(s)
      横川朋美
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 枯草菌に見出されたdksAオルソログ機能未知遺伝子群の解析2010

    • Author(s)
      吉田麻衣、渡辺智、吉川博文
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] シアノバクテリアSynechococcus elongatus PCC 7942株における複製開始点の同定2010

    • Author(s)
      渡辺智、兼崎友、大林龍胆、志波優、千葉櫻拓、吉川博文
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 曳糸性の安定化した納豆菌の育種2010

    • Author(s)
      加田茂樹、大河内悠貴、千葉櫻拓、関根靖彦、吉川博文, 他
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 次世代シーケンサーを用いたSynechococcus elongatus PCC 7942のリシーケンス解析2010

    • Author(s)
      兼崎友、渡辺智、志波優、吉川博文
    • Organizer
      第51回日本植物生理学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2010-03-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] シアノバクテリアSynechococcus elongatus PCC 7942における分子シャペロンDnaKとDnaJのパートナーシップ2010

    • Author(s)
      葉山綾乃、柴本理宏、小澤慎吾、渡辺智、荷村かおり、吉川博文
    • Organizer
      第51回日本植物生理学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2010-03-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] シアノバクテリアSynechococcus elongatus PCC 7942株における複製開始点の同定2010

    • Author(s)
      渡辺智、兼崎友、大林龍胆、志波優、千葉櫻拓、吉川博文
    • Organizer
      第51回日本植物生理学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 単細胞性紅藻Cyanidioschyzon merolaeにおけるGFPを用いた局在解析法2010

    • Author(s)
      佐藤淳、渡辺智、大沼みお、田中寛、吉川博文
    • Organizer
      第51回日本植物生理学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] バクテリアゲノムのリシーケンスによる変異解析とその問題点2010

    • Author(s)
      吉川博文
    • Organizer
      第4回日本ゲノム微生物学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-03-08
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] シアノバクテリアSynechococcus elongatus PCC 7942における分子シャペロンDnaKとDnaJのパートナーシップ2010

    • Author(s)
      葉山綾乃、渡辺智、荷村(松根)かおり、仲本準、吉川博文, 他
    • Organizer
      第4回日本ゲノム微生物学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-03-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of xylose metabolism in pentose phosphate pathway by Lactococcus lactis IO-1.2009

    • Author(s)
      棚町香織、花田克浩、中東憲治、吉川博文、園元謙二, 他
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 次世代シーケンサーによるラン藻Synechococcus elongatus PCC 7942のリシーケンス2009

    • Author(s)
      兼崎友、渡辺智、志波優、松本貴嗣、吉川博文, 他
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 酒米品種「雄町」のゲノム解読とSNPの検出2009

    • Author(s)
      吉瀬(新井)祐子、志波優、吉川博文、矢野昌裕、若狭暁
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日本在来野生牛(口之島牛)の全ゲノム配列解析2009

    • Author(s)
      津田薫、川原玲香、志波優、矢嶋俊介、吉川博文、河野友宏, 他
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 枯草菌の環境ストレス応答機構2009

    • Author(s)
      吉川博文
    • Organizer
      日本乳酸菌学会(招待講演)
    • Place of Presentation
      東京
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional analysis of the stress response mechanism in cyanobacteria----a new aspect of molecular chaperones----2009

    • Author(s)
      S.Watanabe, M.Sato, H.Yoshikawa
    • Organizer
      Fourth International Congress on Stress Responses in Biology and Medicine(招待講演)
    • Place of Presentation
      札幌
    • Year and Date
      2009-10-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 乳酸菌Lactococcus lactis IO-1におけるキシロース代謝の機構解明2009

    • Author(s)
      棚町香織、中東憲治、門多真理子、園元謙二、吉川博文, 他
    • Organizer
      日本生物工学会2009年大会
    • Place of Presentation
      宮崎
    • Year and Date
      2009-09-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Involvement of G3P acyltransferase, PlsX, in the cell division machinery.2009

    • Author(s)
      Takada H.
    • Organizer
      ASM Conference on Prokaryotic development.
    • Place of Presentation
      Cambridge, MA. USA
    • Year and Date
      2009-07-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of G3P acyltransferase, PlsX, in the cell division machinery2009

    • Author(s)
      Takada, H., Yoshikawa H.
    • Organizer
      ASM Conference on Prokaryotic development
    • Place of Presentation
      Cambridge, MA.USA
    • Year and Date
      2009-07-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Involvement of G3P acyltransferase, PlsX, in the cell division machinery.2009

    • Author(s)
      Yoshikawa H.
    • Organizer
      5th International Conference on gram-positive Microorganisms.
    • Place of Presentation
      San Diego, CA. USA
    • Year and Date
      2009-06-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of G3P acyltransferase, PlsX, in the cell division machinery2009

    • Author(s)
      Takada, H., Fukushima, S., Matsumoto, K., Yoshikawa H., 他
    • Organizer
      5th International Conference on gram-positive Microorganisms
    • Place of Presentation
      San Diego, CA.USA
    • Year and Date
      2009-06-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞分裂装置に関わる機能ネットワーク2009

    • Author(s)
      吉川博文
    • Organizer
      日本農芸化学会シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-29
    • Related Report
      2010 Final Research Report 2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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