Analysis of the signal transduction mechanism by ER stress sensor IRE1.
| Project/Area Number |
20380062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
KOHNO Kenji Nara Institute of Science and Technology, バイオサイエンス研究科, 教授 (50142005)
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| Co-Investigator(Renkei-kenkyūsha) |
SAITO Michiko 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (40379558)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | シグナル伝達 / ストレス / 動物 / 細胞・組織 / 蛋白質 / シグナル伝遠 |
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| Research Abstract |
Mammalian ER stress response pathway, IRE1α-XBP1, and the target molecule of IRE1β have been studied. As the result, the efficient splicing mechanism of precursor XBP1u mRNA, which encodes the precursor of a transcription factor XBP1s, has been precisely studied. Further IRE1β, specifically expressed in goblet cells of colon, plays an important role in the regulation of mRNA stability of secretory and membrane proteins.
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Report
(4 results)
Research Products
(119 results)
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[Journal Article] Reconstitution and characterization of the unconventional slicing of XBP1u mRNA in vitro.2011
Author(s)
Shinya, S., Kadokura, H., Imagawa, Y., Inoue, M., Yanagitani K., Kohno, K.
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Journal Title
Nuc. Acids Res. published online (Epub ahead of print)
Related Report
Peer Reviewed
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[Journal Article] Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.2009
Author(s)
Yanagitani K., Imagawa, Y., Iwawaki, T., Hosoda, A., Saito, M., Kimata, Y., Kohno, K.
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Journal Title
Mol.Cell 34
Pages: 191-200
Related Report
Peer Reviewed
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[Journal Article] Pioglitazone reduces ER stress in the liver : Direct monitoring of in vivo ER stress using ER stress-activated indicator transgenic mice.2009
Author(s)
Yoshiuchi, K., Kaneto, H., Matsuoka, TA, Kasami, R., Kohno, K., Iwawaki, T., Nakatani, Y., Yamasaki, Y., Shimomura, I., Matsuhisa, M.
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Journal Title
Endocr.J. 56
Pages: 1103-1111
Related Report
Peer Reviewed
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[Journal Article] ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-induced death by inducing aggregation of co-expressed wild-type VAPB.2009
Author(s)
Suzuki, H., Kanekura, K., Levine, T., Kohno, K., Olkkonen, V.M., Aiso, S., Matsuoka M.
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Journal Title
J.Neurochem. 108
Pages: 973-985
Related Report
Peer Reviewed
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