Studies on screening for bioactive compounds targeting gene repair, recombination and splicing systems.
| Project/Area Number |
20380070
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
SHINYA Kazuo National Institute of Advanced Industrial Science and Technology, バイオメディシナル情報研究センター, 主任研究員 (20251481)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 遺伝子修復 / 遺伝子組み換え / スプライシング / 抗がん剤 / 天然物 / スクリーニング / スプラシング阻害 / p27癌抑制遺伝子 / 抗腫瘍物質 / マクロライド系化合物 / 発がんプロモーター / 代謝拮抗剤 / マイトトキシン / スプライソソーム / 天然化合物 / 相同組み換え |
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| Research Abstract |
One of the significant problems about the cancer chemotherapy is the acquisition of resistance to antitumor agents against cancer cells, in which the gene repair mechanisms takes part in. Thus, gene repair system is considered to be the promising molecular target for the development of anti-tumor agents. In addition to repair system, transcription and modification such as splicing system is also shown to be attractive target for cancer chemotherapy.
In this research, we succeeded to construct the good assay systems to monitor gene repair and splicing activities, and also succeeded to discover inhibitors against these activities from natural products including microbial secondary metabolites as the results of wide drug screenings.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Anti-influenza virus compound from Streptomyces sp.RI18.2010
Author(s)
M.Takagi, K.Motohashi, A.Nagai, M.Izumikawa, M.Tanaka, S.Fuse, T.Doi, K.Iwase, A.Kawaguchi, K.Nagata, T.Takahashi, K.Shin-ya
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Journal Title
Org.Lett.
Volume: 12(20)
Pages: 4664-4666
Related Report
Peer Reviewed
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[Journal Article] New glycosylated derivatives of versipelostatin, the GRP78/Bipmolecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS6.2009
Author(s)
Ping Zhao, Jun-ya Ueda, Ikuko Kozone, Shuhei Chijiwa, Motoki Takagi,Fumitaka Kudo, Makoto Nishiyama, Kazuo Shin-ya, Tomohisa Kuzuyama.
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Journal Title
Org.Biomol.Chem. 7(7)
Pages: 144-1460
Related Report
Peer Reviewed
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[Journal Article] New glycosylated derivatives of versipelostatin, the GRP78/Bip molecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS62009
Author(s)
P. Zhao, J. Ueda, I. Kozone, S. Chijiwa, M. Takagi, F. Kudo, M. Nishiyama, K. Shin-ya, T. Kuzuyama
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Journal Title
Org. Biomol. Chem. 7
Pages: 1454-1460
Related Report
Peer Reviewed
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