| Project/Area Number |
20380153
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANAI Yoshiakira 東京大学, 大学院・農学生命科学研究科, 准教授 (30260326)
OHSAKO Seiichiro 東京大学, 大学院・医学(系)研究科, 准教授 (00274837)
MAEDA Seishi 兵庫医科大学, 医学部, 准教授 (10309445)
TSUNEKAWA Naoki 東京大学, 大学院・農学生命科学研究科, 助教 (50431838)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | Di(n-butyl) phthalate / Di-iso-butyl phthalate / 精細胞 / アポトーシス / テストステロン濃度 / ステロイドホルモン合成酵素 / エストロゲン / エストロゲンレセプター / di(n-butyl)phthalate / di-iso-butyl phthalate / ICI 182,780 / estradiol-3-benzoate / 精巣内テストステロン / エストロゲン受容体 / 精巣内テストステロン濃度 / セルトリ細胞 / ビメンチンフィラメント / Di-n-butyl phthalate / Estrogen / Estrogen receptor / TUNEL法 / ステロイド合成酵素遺伝子 / 一日精子産生量 |
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| Research Abstract |
Phthalate esters, widely used as a plasticizer in the manufacturing process of consumer products, are known to affect testes toxicologically. In the present study, di(n-butyl) phthalate(DBP) and di-iso-butyl phthalate(DiBP) which belong to phthalate esters, are used as materials, and the mechanism of their toxicological effects on testes are investigated by some different methods. As a result, DBP acts like an estrogen, and induces spermatogenic cell apoptosis, probably by activating estrogen receptors. On the other hand, DiBP induces spermatogenic cell apoptosis, probably independent of estrogen-mediated activity.
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