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Development of novel methods for diagnosis, prevention and treatment in inherited diseases(lysosomal storage diseases) in animals

Research Project

Project/Area Number 20380173
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical veterinary science
Research InstitutionKagoshima University

Principal Investigator

YAMATO Osamu  鹿児島大学, 農学部, 教授 (80261337)

Co-Investigator(Renkei-kenkyūsha) ENDOH Daiji  酪農学園大学, 獣医学部, 教授 (40168828)
KUNIEDA Tetsuo  岡山大学, 自然科学研究科, 教授 (80178011)
TAKEHANA Kazushige  酪農学園大学, 獣医学部, 教授 (80137413)
YAMANAKA Shoji  横浜市立大学, 大学病院, 准教授 (80264604)
OCHIAI Kenji  北海道大学, 獣医学研究科, 教授 (80214162)
UCHIDA Kazuyuki  東京大学, 農学生命科学研究科, 准教授 (10223554)
HASEGAWA Daisuke  日本獣医生命科学大学, 獣医学部, 講師 (20366793)
MATSUKI Naoaki  東京大学, 農学生命科学研究科, 教授 (40251417)
NAKAICHI Munekazu  山口大学, 農学部, 教授 (60243630)
ITAMOTO Kazuhiro  山口大学, 農学部, 准教授 (50379921)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywordsライソゾーム蓄積病 / 動物モデル / ガングリオシドーシス / サンドホフ病 / セロイドリポフスチン症 / 遺伝病 / スクリーニング
Research Abstract

Diagnostic and screening methods for a number of novel and known animal inherited diseases especially lysosomal storage disorders were developed in this study. For canine diseases such as GM1 gangliosidosis and neuronal ceroid lipofuscinosis, preventive strategies were planed and carried out. The preventive measures resulted in a decrease of carrier frequency without the occurrence of affected animals in Japan at the end of study period. Furthermore, anti-inflammatory therapy was carried out in a cat affected with GM2 gangliosidosis suggesting that this treatment might have a survival advantage. In addition, some novel inherited diseases were indentified in dogs and cats, which will be investigated in the next study.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report

Research Products

(97 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (52 results) (of which Peer Reviewed: 40 results) Presentation (22 results) Book (5 results) Remarks (18 results)

  • [Journal Article] A frameshift mutation in the canine HEXB gene in toy poodles with GM2 gangliosidosis variant 0(Sandhoff disease)2012

    • Author(s)
      Rahman MM, Chang HS, Mizukami K, Hossain MA, Yabuki A, Tamura S, Kitagawa M, Mitania S, Higo T, Uddin MM, Uchida K, Yamato O.
    • Journal Title

      Vet J

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal ceroid lipofuscinosis in Border Collie dogs in Japan : clinical and molecular epidemiological study(2000. 2011)2012

    • Author(s)
      Mizukami K, Kawamichi T, Koie H, Tamura S, Matsunaga S, Imamoto S, Saito M, Hasegawa D, Matsuki N, Tamahara S, Sato S, Yabuki A, Chang HS, Yamato O.
    • Journal Title

      Sci World J

      Volume: (in press) Pages: 383174-383174

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutational analysis of the feline CLN3 gene and an ultrastructural evaluation of lysosomal storage materials in a cat with neuronal ceroid lipofuscinosis : an investigation into the molecular basis of the disease2012

    • Author(s)
      Furusawa Y, Mizukami K, Yabuki A, Kuwamura M, Chang HS, Hossain MA, Rahman MM, Uddin MM, Mitani S, Yamato O.
    • Journal Title

      Vet J

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trapped neutrophil syndrome in a Border Collie dog : clinical, clinico-pathologic, and molecular findings2012

    • Author(s)
      Mizukami K, Shoubudani T, Nishimoto S, Kawamura R, Yabuki A, Yamato O.
    • Journal Title

      J Vet Med Sci

      Volume: 74(6) Pages: 797-800

    • NAID

      130002090076

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathological features of salivary gland cysts in a Shiba dog with GM1 gangliosidosis : a possible misdiagnosis as malignancy2012

    • Author(s)
      Rahman MM, Kawaguchi H, Miyoshi N, Yabuki A, Nakamoto Y, Ozawa T, Yamato O.
    • Journal Title

      J Vet Med Sci

      Volume: 74(4) Pages: 485-489

    • NAID

      130001410037

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dihydropyrimidinase deficiency : the first feline case of dihydropyrimidinuria with clinical and molecular findings2012

    • Author(s)
      Chang HS, Shibata T, Arai S, Zhang C, Yabuki A, Mitani S, Higo T, Sunagawa K, Mizukami K, Yamato O.
    • Journal Title

      JIMD Reports

      Volume: 6 Pages: 21-26

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serial MRI features of canine GM1 gangliosidosis : a possible imaging biomarker for diagnosis and progression of the disease2012

    • Author(s)
      Hasegawa D, Yamato O, Nakamoto Y, Ozawa T, Yabuki A, Itamoto K, Kuwabara T, Fujita M, Takahashi K, Mizoguchi S, Orima H.
    • Journal Title

      Sci World J

      Pages: 250197-250197

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Collie eye anomaly in Hokkaido dogs : case study2012

    • Author(s)
      Mizukami K, Chang HS, Ota M, Yabuki A, Hossain MA, Rahman MM, Uddin MM, Yamato O.
    • Journal Title

      Vet Ophthalmol

      Volume: 15(2) Pages: 128-132

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid genotyping assays for the 4-base pair deletion of canine MDR1/ABCB1 gene and low frequency of the mutant allele in Border Collie dogs2012

    • Author(s)
      Mizukami K, Chang HS, Yabuki A, Kawamichi T, Hossain MA, Rahman MM, Uddin MM, Yamato O.
    • Journal Title

      J Vet Diagn Invest

      Volume: 24(1) Pages: 127-134

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid genotyping assays for the 4-base pair deletion of canine MDR1/ABCB1 gene and low frequency of the mutant allele in Border Collie dogs2012

    • Author(s)
      Mtzukami K, et al
    • Journal Title

      J Vet Diagn Invest

      Volume: 24 Pages: 127-134

    • DOI

      10.1177/1040638711425591

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collie eye anomaly in Holdcaido dogs : case study2012

    • Author(s)
      Mizukami K, et al
    • Journal Title

      Vet Ophthalmol

      Volume: 15 Pages: 128-132

    • DOI

      10.1111/j.1463-5224.2011.00950.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serial MRI features of canine GM1 gangliosidosis : a possible imaging biomarker for diagnosis and progression of the disease2012

    • Author(s)
      Hasegawa D, et al
    • Journal Title

      Sci World J

      Volume: 2012

    • DOI

      10.1100/2012/250197

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid detection of GM1 ganglioside in cerebrospinal fluid in dogs with GM1 gangliosidosis using matrix-assisted laser desorption ionization time-of-flight mass spectrometry2011

    • Author(s)
      Satoh H, Yamauchi T, Yamasaki M, Maede Y, Yabuki A, Chang HS, Asanuma T, Yamato O.
    • Journal Title

      J Vet Diagn In

      Volume: 23(6) Pages: 1202-1207

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel rapid genotyping assays for neuronal ceroid lipofuscinosis in Border Collie dogs and high frequency of the mutant allele in Japan2011

    • Author(s)
      Mizukami K, Chang HS, Yabuki A, Kawamichi T, Kawahara N, Hayashi D, Hossain MA, Rahman MM, Uddin MM, Yamato O.
    • Journal Title

      J Vet Diagn Invest

      Volume: 23(6) Pages: 1131-1139

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical observation of canine degenerative myelopathy in two Pembroke Welsh Corgi dogs2011

    • Author(s)
      Ogawa M, Uchida K, Park E, Kamishina H, Sasaki J, Chang HS, Yamato O, Nakayama H.
    • Journal Title

      J Vet Med Sci

      Volume: 73(10) Pages: 1275-1279

    • NAID

      130000868053

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal ceroid-lipofuscinosis in longhaired Chihuahuas : clinical, pathological, and MRI findings2011

    • Author(s)
      Nakamoto Y, Yamato O, Uchida K, Nibe K, Tamura S, Ozawa T, Ueoka N, Nukaya A, Yabuki A, Nakaichi M.
    • Journal Title

      J Am Anim Hosp Assoc

      Volume: 47(4)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid and simple polymerase chain reaction-based diagnostic assays for GM2 gangliosidosis variant 0(Sandhoff-like disease) in Japanese domestic cats2011

    • Author(s)
      Rahman MM, Shoubudani T, Mizukami K, Chang HS, Hossain MA, Yabuki A, Mitani S, Higo T, Arai T, Yamato O.
    • Journal Title

      J Vet Diagn Invest

      Volume: 23(2) Pages: 338-342

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal ceroid-lipofuscinosis in longhaired Chihuahuas : clinical, pathological, and MRI findings2011

    • Author(s)
      Nakamoto Y, et al
    • Journal Title

      J. Am. Anim. Hosp. Assoc

      Volume: 47

    • DOI

      10.5326/jaaha-ms-5564

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical Observation of Canine Degenerative Myelopathy in Two Pembroke Welsh Corgi Dogs2011

    • Author(s)
      Ogawa M, et al
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 73 Issue: 10 Pages: 1275-1279

    • DOI

      10.1292/jvms.11-0097

    • NAID

      130000868053

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel rapid genotyping assays for neuronal ceroid lipofuscinosis in Border Collie dogs and high frequency of the mutant allele in Japan2011

    • Author(s)
      Mizukami K, et al
    • Journal Title

      J Vet Diagn Invest

      Volume: 23 Pages: 1131-1139

    • DOI

      10.1177/1040638711425590

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid detection of GM1 ganglioside in cerebro spinal fluid in dogs with GM1 gangliosidosis using matrix-assisted laser desorption ionization time-of-flight mass spectrometry2011

    • Author(s)
      Satoh H, et al
    • Journal Title

      J Vet Diagn Invest

      Volume: 23 Pages: 1202-1207

    • DOI

      10.1177/1040638711425592

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid and simple polymerase chain reaction-based diagnostic assays for GM2 gangliosidosis variant 0 (Sandhoff-like disease) in Japanese domestic cats.2011

    • Author(s)
      Rahman MM, Shoubudani T, Mizukami K, Chang HS, Hossain MA, Yabuki A, Mitani S, Higo T, Arai T, Yamato O*.
    • Journal Title

      J Vet Diagn Invest 23

      Pages: 338-342

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Rapid and simple polymerase chain reaction-based diagnostic assays for GM2 gangliosidosis variant 0 (Sandhoff-like disease) in Japanese domestic cats.2011

    • Author(s)
      Mohammad M.Rahman, et al.
    • Journal Title

      J.Vet.Diagn.Invest.

      Volume: 23 Pages: 338-342

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel rapid genotyping technique for Collie eye anomaly : SYBR Green. based real-time polymerase chain reaction method applicable to blood and saliva specimens on Flinders Technology Associates filter paper2010

    • Author(s)
      Chang HS, Mizukami K, Yabuki A, Hossain MA, Rahman MM, Uddin MM, Arai T, Yamato O.
    • Journal Title

      J Vet Diagn Invest

      Volume: 22(5) Pages: 708-715

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] GM2 gangliosidosis variant 0(Sandhoff-like disease) in a family of toy poodles2010

    • Author(s)
      Tamura S, Tamura Y, Uchida K, Nibe K, Nakaichi M, Hossain MA, Chang HS, Rahman MM, Yabuki A, Yamato O.
    • Journal Title

      J Vet Intern Med

      Volume: 24(5) Pages: 1013-1019

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid and reliable genotyping technique for GM1 gangliosidosis in Shiba dogs by real-time polymerase chain reaction with TaqMan-minor groove binder probes2010

    • Author(s)
      Chang HS, Arai T, Yabuki A, Hossain MA, Rahman MM, Mizukami K, Yamato O.
    • Journal Title

      J Vet Diagn Invest

      Volume: 22(2) Pages: 234-237

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel rapid genotyping technique for Collie eye anomaly : SYBR Green.based real-time polymerase chain reaction method applicable to blood and saliva specimens on Flinders Technology Associates filter paper.2010

    • Author(s)
      Chang HS, Mizukami K, Yabuki A, Hossain MA, Rahman MM, Uddin MM, Arai T, Yamato O*.
    • Journal Title

      J Vet Diagn Invest 22

      Pages: 708-715

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] GM2 gangliosidosis variant 0 (Sandhoff-like disease) in a family of toy poodles.2010

    • Author(s)
      Tamura S, Tamura Y, Uchida K, Nibe K, Nakaichi M, Hossain MA, Chang HS, Rahman MM, Yabuki A, Yamato O*.
    • Journal Title

      J Vet Intern Med 24

      Pages: 1013-1019

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Rapid and reliable genotyping technique for GM1 gangliosidosis in Shiba dogs by real-time polymerase chain reaction with TaqMan-minor groove binder probes.2010

    • Author(s)
      Chang HS, Arai T, Yabuki A, Hossain MA, Rahman MM, Mizukami K, Yamato O*.
    • Journal Title

      J Vet Diagn Invest 22

      Pages: 234-237

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] GM2 gangliosidosis variant 0 (Sandhoff-like disease) in a family of toy poodles.2010

    • Author(s)
      Shinji Tamura, et al.
    • Journal Title

      J.Vet.Intern.Med.

      Volume: 24 Pages: 1013-1019

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel rapid genotyping technique for Collie eye anomaly : SYBR Green-based real-time polymerase chain reaction method applicable to blood and saliva specimens on Flinders Technology Associates filter paper.2010

    • Author(s)
      Hye-Sook Chang, et al.
    • Journal Title

      J.Vet.Diagn.Invest.

      Volume: 22 Pages: 708-715

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid and reliable genotyping technique for GM1 gangliosidosis in Shiba dogs by real-time polymerise chain reaction with TaqMan-minor groove binder probes2010

    • Author(s)
      Hye-Sook Chang, et al.
    • Journal Title

      J.Vet.Diagn.Invest. 22

      Pages: 234-237

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation screening of canine GM1 gangliosidosis for preventive measures : absence of the mutant allele in breeding shiba dogs in the Czech Republic2009

    • Author(s)
      Yamato O, Funk H, Kawahara N, Funkova M, Entlerova Z, Petrusova H, Hayashi D, Satoh H, Yamasaki M, Maede Y, Yabuki A, Arai T.
    • Journal Title

      Jpn J Prophylactic Vet Med

      Volume: 1(2) Pages: 63-68

    • NAID

      40017342704

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exclusion of NEU1 and PPGB from candidate genes for a lysosomal storage disease in Japanese black cattle2009

    • Author(s)
      Masoudi AA, Yamato O, Yoneda K, Tsuji T, Mikami O, Kunieda T.
    • Journal Title

      Anim Sci J

      Volume: 80(5) Pages: 611-615

    • NAID

      10027887743

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal ceroid-lipofuscinosis in a Japanese domestic shorthair cat2009

    • Author(s)
      Kuwamura M, Nakagawa M, Nabe M, Yamate J, Inoue M, Satoh H, Yamato O.
    • Journal Title

      J Vet Med Sci

      Volume: 71(5) Pages: 665-667

    • NAID

      130000134382

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子検査によりGM1ガングリオシドーシスと確定診断された柴犬3症例の頭部MRI所見2009

    • Author(s)
      中本裕也, 大和修, 小澤剛, 長谷川大輔, 板本和仁, 方伯部健吾, 塚根美穂, 中市統三
    • Journal Title

      日獣誌

      Volume: 62(3) Pages: 219-224

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutation screening of canine GM1 gangliosidosis for preventive measures : absence of the mutant allele in breeding shiba dogs in the Czech Republic.2009

    • Author(s)
      Yamato O*., Funk H, Kawahara N, Funkova M, Entlerova Z, Petrusova H, Hayashi D, Satoh H, Yamasaki M, Maede Y, Yabuki A, Arai T.
    • Journal Title

      Jpn J Prophylactic Vet Med 1

      Pages: 63-68

    • NAID

      40017342704

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Exclusion of NEU1 and PPGB from candidate genes for a lysosomal storage disease in Japanese black cattle.2009

    • Author(s)
      Masoudi AA, Yamato O*., Yoneda K, Tsuji T, Mikami O, Kunieda T.
    • Journal Title

      Anim Sci J 80

      Pages: 611-615

    • NAID

      10027887743

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Neuronal ceroid-lipofuscinosis in a Japanese domestic shorthair cat.2009

    • Author(s)
      Kuwamura M, Nakagawa M, Nabe M, Yamate J, Inoue M, Satoh H, Yamato O*.
    • Journal Title

      J Vet Med Sci 71

      Pages: 665-667

    • NAID

      130000134382

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] 遺伝子検査によりGM1ガングリオシドーシスと確定診断された柴犬3 症例の頭部MRI所見2009

    • Author(s)
      中本裕也, 大和修, 小澤剛, 長谷川大輔, 板本和仁, 方伯部健吾, 塚根美穂, 中市統三
    • Journal Title

      日獣会誌 62

      Pages: 219-224

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Exclusion of NEU1 and PPGB from candidate genes for a lysosomal storage disease in Japanese black cattle2009

    • Author(s)
      Ali Akbar Masoudi, et al.
    • Journal Title

      Anim.Sci.J. 80

      Pages: 611-615

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation screening of canine GM1 gangliosidosis for preventive measures : absence of the mutant allele in breeding shiba dogs in the Czech Republic2009

    • Author(s)
      Osamu Yamato, et al.
    • Journal Title

      Jpn.J.Prophylactic Vet.Med. 1

      Pages: 63-68

    • NAID

      40017342704

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子検査によりGMlガングリオシドーシスと確定診断された柴犬3症例の頭部MRI所見2009

    • Author(s)
      中本裕也
    • Journal Title

      日本獣医師会雑誌 62

      Pages: 219-224

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal ceroid-lipofuscinosis in a Japanese domestic shorthair cat.2009

    • Author(s)
      Mitsuru Kuwamura
    • Journal Title

      J. Vet. Med. Sci. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological analysis of corneal opacity in Shiba dog in GM1 gangliosidosis2008

    • Author(s)
      Nagayasu A, Nakamura T, Yamato O, Tsuzuki K, Hosaka Y, Ueda H, Tangkawattana P, Takahana K.
    • Journal Title

      J Vet Med Sci

      Volume: 70(9) Pages: 881-886

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retrospective diagnosis of feline GM2 gangliosidosis variant 0(Sandhoff-like disease) in Japan : possible spread of the mutant allele in the Japanese domestic cat population2008

    • Author(s)
      Yamato O, Hayashi D, Satoh H, Shoda T, Uchida K, Nakayama H, Sakai H, Masegi T, Murai A, Iida T, Hisada H, Hisada A, Yamasaki M, Maede Y, Arai T.
    • Journal Title

      J Vet Med Sci

      Volume: 70(8) Pages: 813-818

    • NAID

      130000446910

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphological analysis of corneal opacity in Shiba dog in GM1 gangliosidosis.2008

    • Author(s)
      Nagayasu A, Nakamura T, Yamato O*., Tsuzuki K, Hosaka Y, Ueda H, Tangkawattana P, Takahana K.
    • Journal Title

      J Vet Med Sci 70

      Pages: 881-886

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Retrospective diagnosis of feline GM2 gangliosidosis variant 0 (Sandhoff-like disease) in Japan : possible spread of the mutant allele in the Japanese domestic cat population.2008

    • Author(s)
      Yamato O*., Hayashi D, Satoh H, Shoda T, Uchida K, Nakayama H, Sakai H, Masegi T, Murai A, Iida T, Hisada H, Hisada A, Yamasaki M, Maede Y, Arai T.
    • Journal Title

      J Vet Med Sci 70

      Pages: 813-818

    • NAID

      130000446910

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Molecular screening of canine GM1 gangliosidosis using blood smear specimens after prolonged storage : Detection of carriers among Shiba dogs in northern Japan.2008

    • Author(s)
      Yamato O*., Jo EO, Chang HS, Satoh H, Shoda T, Sato R, Uechi M, Kawasaki N, Naito Y, Yamasaki M, Maede Y, Arai T.
    • Journal Title

      J Vet Diagn Invest 20

      Pages: 68-71

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Molecular screening of canine GMl gangliosidosis using blood smear specimens after prolonged storage : Detection of carriers among Shiba dogs in northern Japan.2008

    • Author(s)
      Osamu Yamato
    • Journal Title

      J. Vet. Diagn. Invest. 20

      Pages: 68-71

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological analysis of corneal opacity in Shiba dog in GMI gangliosidosis.2008

    • Author(s)
      Aya Nagayasu
    • Journal Title

      J. Vet. Med. Soi. 70

      Pages: 881-886

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal ceroid-lipofuscinosis in long-haired Chihuahuas: clinical, pathological, and magnetic resonance imaging findings.

    • Author(s)
      Nakamoto Y, Yamato O*, Uchida K, Nibe K, Tamura S., Ozawa T, Ueoka N, Nukaya A, Yabuki A, Nakaichi M.
    • Journal Title

      J Am Anim Hosp Assoc in press

    • Related Report
      2010 Self-evaluation Report
  • [Presentation] ペットの遺伝病~どうして問題なのか、どうすれば減らせるか~. In : JSVCP市民公開講演(ペットの遺伝病とペットロス)2012

    • Author(s)
      大和修
    • Organizer
      日本獣医内科学アカデミー/日本獣医臨床病理学会2012年大会
    • Place of Presentation
      横浜
    • Year and Date
      2012-02-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 新興・再興の遺伝子疾患: TNS, CEA, MDR1など. In : JSVCPシンポジウム1(伴侶動物の遺伝子疾患update)2012

    • Author(s)
      大和修, 水上圭二郎
    • Organizer
      日本獣医内科学アカデミー/日本獣医臨床病理学会2012年大会
    • Place of Presentation
      横浜
    • Year and Date
      2012-02-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 伴侶動物の先天代謝異常症. In : JSVCPシンポジウム1(伴侶動物の遺伝子疾患update)2012

    • Author(s)
      大和修
    • Organizer
      日本獣医内科学アカデミー/日本獣医臨床病理学会2012年大会
    • Place of Presentation
      横浜
    • Year and Date
      2012-02-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 伴侶動物の先天代謝異常症.In : JSVCPシンポジウム1(伴侶動物の遺伝子疾患update)2012

    • Author(s)
      大和修
    • Organizer
      日本獣医内科学アカデミー/日本獣医臨床病理学会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2012-02-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新興・再興の遺伝子疾患:TNS, CEA, MDR1など.In : JSVCPシンポジウム1(伴侶動物の遺伝子疾患update)2012

    • Author(s)
      大和修, 水上圭二郎
    • Organizer
      日本獣医内科学アカデミー/日本獣医臨床病理学会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2012-02-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] ライソゾーム病Update2010

    • Author(s)
      大和修
    • Organizer
      第35回獣医神経病学会
    • Place of Presentation
      京都
    • Year and Date
      2010-12-12
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] ライソゾーム病Update.2010

    • Author(s)
      大和修
    • Organizer
      第35回獣医神経病学会
    • Place of Presentation
      京都
    • Year and Date
      2010-12-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Rapid detection of GM1 ganglioside in cerebrospinal fluid in dogs with GM1 gangliosidosis using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI TOF MS).2010

    • Author(s)
      Osamu Yamato, et al.
    • Organizer
      14th Congress of the International Society for Animal Clinical Biochemistry
    • Place of Presentation
      Corvallis, Oregon, USA
    • Year and Date
      2010-07-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ボーダーコリーの視覚異常を伴う遺伝病:セロイドリポフスチン症・コリー眼異常・X染色体性進行性網膜萎縮. In :比較眼科学会シンポジウム「ここまで来た眼・神経疾患の診断」2010

    • Author(s)
      大和修
    • Organizer
      日本獣医内科学アカデミー/日本獣医臨床病理学会2010年大会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-14
    • Related Report
      2011 Final Research Report
  • [Presentation] ボーダーコリーの視覚異常を伴う遺伝病:セロイドリポフスチン症・コリー眼異常・X染色体性進行性網膜萎縮. In:比較眼科学会シンポジウム「ここまで来た眼・神経疾患の診断」2010

    • Author(s)
      大和修
    • Organizer
      日本獣医内科学アカデミー/日本獣医臨床病理学会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] ボーダーコリーの視覚異常を伴う遺伝病:セロイドリポフスチン症・コリー眼異常・X染色体性進行性網膜萎縮2010

    • Author(s)
      大和修
    • Organizer
      比較眼科学会シンポジウム「ここまで来た眼・神経疾患の診断」. 日本獣医内科学アカデミー/日本獣医臨床病理学会2010 年大会
    • Place of Presentation
      東京
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 犬猫のライソゾーム病とその他関連疾患のスクリーニングについて. In :司祭機関・獣医臨床遺伝研究会共催シンポジウムポストシーケンス時代を迎えて~動物の遺伝性疾患をめぐる最近の話題~2009

    • Author(s)
      大和修
    • Organizer
      第147回日本獣医学会
    • Place of Presentation
      宇都宮
    • Year and Date
      2009-04-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 犬猫のライソゾーム病とその他関連疾患のスクリーニングについて. In:日本獣医学会・獣医臨床遺伝研究会共催シンポジウム ポストシーケンス時代を迎えて ~動物の遺伝性疾患をめぐる最近の話題~2009

    • Author(s)
      大和修
    • Organizer
      日本獣医学会
    • Place of Presentation
      宇都宮
    • Year and Date
      2009-04-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日本獣医臨床病理学会大会セミナー臨床徴候から診断へのアプローチ:運動失調(遺伝性)2009

    • Author(s)
      大和修
    • Organizer
      日本獣医内科学アカデミー/日本獣医臨床病理学会2009年大会
    • Place of Presentation
      東京
    • Year and Date
      2009-02-15
    • Related Report
      2011 Final Research Report
  • [Presentation] ボーダーコリーの神経セロイドリポフスチン症の国内発生状況2009

    • Author(s)
      大和 修
    • Organizer
      日本獣医師会三学会
    • Place of Presentation
      盛岡市
    • Year and Date
      2009-01-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 犬猫のライソゾーム病とその他関連疾患のスクリーニングについて2009

    • Author(s)
      大和修
    • Organizer
      司祭機関・獣医臨床遺伝研究会共催シンポジウム ポストシーケンス時代を迎えて~動物の遺伝性疾患をめぐる最近の話題~.第147回日本獣医学会
    • Place of Presentation
      宇都宮
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 日本獣医臨床病理学会大会セミナー 臨床徴候から診断へのアプローチ:運動失調(遺伝性)2009

    • Author(s)
      大和修
    • Organizer
      日本獣医内科学アカデミー/日本獣医臨床病理学会2009年大会
    • Place of Presentation
      東京
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 牛の先天的および後天的代謝異常症:ライソゾーム病と乳熱の話2008

    • Author(s)
      大和修
    • Organizer
      第75回鹿児島県家畜疾病診断研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2008-07-17
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 動物の遺伝病について:柴犬のGM1ガングリオシドーシス2008

    • Author(s)
      大和修
    • Organizer
      平成20年度日本犬保存会審査部研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 動物の遺伝病について:柴犬のGM1 ガングリオシドーシス2008

    • Author(s)
      大和修
    • Organizer
      平成20年度日本犬保存会審査部研究会
    • Place of Presentation
      東京
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 蓄積病の臨床・生化学2008

    • Author(s)
      大和修
    • Organizer
      日本獣医病理学会スライド・セミナー「蓄積病」.第145回日本獣医学会
    • Place of Presentation
      相模原
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 小動物の脳・脊髄疾患-診断と病理の最近の知見-犬猫のライソゾーム蓄積病:国内症例とその臨床を中心に2008

    • Author(s)
      大和修
    • Organizer
      第4回鹿児島大学小動物臨床フォーラム
    • Place of Presentation
      鹿児島
    • Related Report
      2010 Self-evaluation Report
  • [Book] 遺伝症(ガングリオシドーシス),遺伝病(コリー眼異常). In :予防動物医学研究会編集.新しいデーターで読む犬と猫の疾病早期診断マニュアル2011

    • Author(s)
      大和修
    • Publisher
      チクサン出版(緑書房)
    • Related Report
      2011 Final Research Report
  • [Book] よくみる犬と猫の品種好発性疾患(Breed predispositions to disease in popular dogs and cats)2011

    • Author(s)
      大和修
    • Publisher
      インターズー
    • Related Report
      2011 Final Research Report
  • [Book] 糸球体腎症,脳の疾患変性性疾患,脳の疾患先天性疾患,貧血と赤血球増加症2011

    • Author(s)
      大和修
    • Publisher
      文永堂出版
    • Related Report
      2011 Final Research Report
  • [Book] 遺伝症(ガングリオシドーシス),遺伝病(コリー眼異常).In:新しいデーターで読む犬と猫の疾病早期診断マニュアル(予防動物医学研究会編集)2011

    • Author(s)
      大和修(共著)
    • Total Pages
      14
    • Publisher
      チクサン出版・(緑書房),東京
    • Related Report
      2011 Annual Research Report
  • [Book] 新獣医学辞典( Na-K-ATPase赤血球,カタプレキシー,ガングリオシドーシス,吸収不良症候群,クラッペ病,好酸球性胃腸炎,自己免疫性溶血性貧血,シスチン尿症,失血性貧血,シトルリン血症,小脳形成不全症,セロイドリポフスチン症,先天性甲状腺腫,糖原病,ニーマンピック病,ハインツ小体溶血性貧血,ハエ咬み運動,ピルビン酸キナーゼ欠損症,フコシドーシス,プロトポルフィリン症,マンノシドーシス,ムコ多糖症,メープルシロップ尿症,メンケス病)(新獣医学辞典編集委員会編集)2008

    • Author(s)
      大和修
    • Publisher
      チクサン出版
    • Related Report
      2010 Self-evaluation Report
  • [Remarks] 田村慎司,大和修.犬の遺伝性神経変性性疾患における臨床獣医師の役割:ライソゾーム病症例の経験に基づいた考察.広島県獣医学雑誌26, 1-6, 2011 Aug.商業誌総説・解説

    • Related Report
      2011 Final Research Report
  • [Remarks] 大和修.犬の先天代謝異常症.ライソゾーム病・スフィンゴリピドーシス., J-VET No.289, 59-70, 2011.商業誌総説・解説

    • Related Report
      2011 Final Research Report
  • [Remarks] 大和修.治療シリーズ.私はこうしている.神経・筋肉・関節疾患ライソゾーム(蓄積)病. SA Medicine 12(6), 10-13, 2010.商業誌総説・解説

    • Related Report
      2011 Final Research Report
  • [Remarks] 中本裕也,小澤剛,矢吹映,大和修.柴犬のGM1ガングリオシドーシス.早期診断を導くために必要な知識., Clinic Note No.58, 71-82, 2010.商業誌総説・解説

    • Related Report
      2011 Final Research Report
  • [Remarks] 大和修.治療シリーズ.私はこうしている.血液疾患ホスホフルクトキナーゼ(PFK)欠損症. SA Medicine 12(1), 23-24, 2010.商業誌総説・解説

    • Related Report
      2011 Final Research Report
  • [Remarks] 大和修.治療シリーズ.私はこうしている.血液疾患ピルビン酸キナーゼ(PK)欠損症. SA Medicine 12(1), 22-23, 2010.商業誌総説・解説

    • Related Report
      2011 Final Research Report
  • [Remarks] 大和修.蓄積病の臨床・生化学.日本獣医病理学会および日本獣医病理専門家協会会報, 7月号, 6-10, 2008.商業誌総説・解説

    • Related Report
      2011 Final Research Report
  • [Remarks] 大和修. DAMNIT-Vで学ぶ神経病学各論第4回「ライソゾーム病」. CAP(Companion Animal Practice) No.229, 51-62, 2008.商業誌総説・解説

    • Related Report
      2011 Final Research Report
  • [Remarks] 大和修.動物の先天代謝異常症:ライソゾーム病および関連疾患について.鹿児島県獣医師会会報第41号, 20(1), 2-7, 2008.商業誌総説・解説

    • Related Report
      2011 Final Research Report
  • [Remarks] 田村慎司, 大和修. 犬の遺伝性神経変性性疾患における臨床獣医師の役割:ライソゾーム病症例の経験に基づいた考察.広島県獣医学雑誌 印刷中.

    • Related Report
      2010 Self-evaluation Report
  • [Remarks] 大和修. 犬の先天代謝異常症-ライソゾーム病・スフィンゴリピドーシス-.J-VET No.289, 59-70,2011.

    • Related Report
      2010 Self-evaluation Report
  • [Remarks] 大和修. 治療シリーズ.私はこうしている.神経・筋肉・関節疾患ライソゾーム蓄積)病. SAMedicine 12(6), 10-13, 2010.

    • Related Report
      2010 Self-evaluation Report
  • [Remarks] 中本裕也, 小澤 剛, 矢吹映,大和修. 柴犬のGM1 ガングリオシドーシス~早期診断を導くために必要な知識~. Clinic Note No.58, 71-82, 2010.

    • Related Report
      2010 Self-evaluation Report
  • [Remarks] 大和修. 治療シリーズ.私はこうしている.血液疾患 ホスホフルクトキナーゼ(PFK)欠損症. SAMedicine 12(1), 23-24, 2010.

    • Related Report
      2010 Self-evaluation Report
  • [Remarks] 大和修. 治療シリーズ.私はこうしている.血液疾患 ピルビン酸キナーゼ(PK)欠損症. SA Medicine12(1), 22-23, 2010.

    • Related Report
      2010 Self-evaluation Report
  • [Remarks] 大和修. 蓄積病の臨床・生化学. 日本獣医病理学会および日本獣医病理専門家協会会報,7月号, 6-10,2008.

    • Related Report
      2010 Self-evaluation Report
  • [Remarks] 大和修. DAMNIT-V で学ぶ神経病学各論第4回「ライソゾーム病」. CAP (Companion Animal Practice)No. 229, 51-62, 2008.

    • Related Report
      2010 Self-evaluation Report
  • [Remarks] 大和修. 動物の先天代謝異常症:ライソゾーム病および関連疾患について. 鹿児島県獣医師会会報第41号, 20(1), 2-7, 2008.

    • Related Report
      2010 Self-evaluation Report

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Published: 2008-03-31   Modified: 2016-04-21  

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