Preparation of new chiral building blocks and their practical use in the enantioselective total synthesis of bioactive polycyclic natural products
| Project/Area Number |
20390006
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Waseda University |
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Principal Investigator |
NAKADA Masahisa Waseda University, 理工学術院, 教授 (50198131)
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Naoyoshi 早稲田大学, 理工学術院, 助手 (70454048)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2008: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 合成化学 / 全合成 / 有機化学 |
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| Research Abstract |
Preparation of new chiral building blocks has advantage in the enantioselective total synthesis of naturally occurring important organic compounds (natural products) possessing diverse structures. In this research project, preparation methods of chiral building blocks via the catalysis with enzymes or chiral catalysts have been developed and they have been successfully applied to the enantioselective total synthesis of natural products including first syntheses. The chiral building blocks as well as their preparation methods will be used in the total synthesis of other natural products.
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Report
(4 results)
Research Products
(87 results)
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[Journal Article] Total Synthesis of(-)-FR182877 through the Tandem IMDA-IMHDA Reaction and the Stereoselective Transition Metal-Mediated Transformations2009
Author(s)
Tanaka, N., Suzuki, T., Matsumura, T., Hosoya, Y., Nakada, M.
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Journal Title
Angew.Chem., Int.Ed. 48
Pages: 2580-2583
Related Report
Peer Reviewed
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[Presentation] Synthetic Studies on Hyperforin2011
Author(s)
Uwamori, M; Saito, A.; Nakada, M.
Organizer
The 2th Symposium on Chiral Science & Technology Mesochemistry & Chemical Wisdom
Place of Presentation
早稲田大学西早稲田キャンパス
Year and Date
2011-03-02
Related Report
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[Presentation] Synthetic Studies on Hyperforin2011
Author(s)
Uwamori, M.; Saito, A.; Nakada, M.
Organizer
The 5th Global COE International Symposium on 'Practical Chemical Wisdom'
Place of Presentation
早稲田大学西早稲田キャンパス
Year and Date
2011-01-13
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