Ghrelin : its status as a pancreatic hormone, mechanisms by which it regulates insulin release and glucose metabolism, and its application for treating diabetes.
| Project/Area Number |
20390061
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General physiology
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
YADA Toshihiko Jichi Medical University, 医学部, 教授 (60166527)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
DEZAKI Katsuya 自治医科大学, 医学部, 准教授 (90337329)
NAKATA Masanori 自治医科大学, 医学部, 准教授 (10305120)
KAKEI Masafumi 自治医科大学, 医学部, 教授 (90214270)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
|
|---|
| Keywords | グレリン / cAMP / Kvチャネル / インスリン分泌 / 糖代謝 / 膵島G / HS-R / GKラット / 膵島 / Kチャネル / グルコース / グレリン受容体 / GHS-R / β細胞 / カルシウム |
|---|
| Research Abstract |
The effect of ghrelin on islet β-cells was mediated by GHSR, similarly to other organs. Ghrelin, via interacting with GHSR, attenuated glucose-induced cAMP production, which in turn activated Kv channels and attenuated glucose-induced increases in cytosolic Ca^<2+> and insulin secretion. In type 2 diabetic GK rats, ghrelin mRNA expression was elevated and infusion of GHSR receptor antagonist enhanced insulin release and decreased blood glucose levels, indicating an anti-diabetic effect.
|
Report
(4 results)
Research Products
(75 results)
-
-
-
-
-
-
-
[Journal Article] Reconstruction-dependent recovery from anorexia and time-related recovery of regulatory ghrelin system in gastrectomized rats2010
Author(s)
Koizumi M., Dezaki K., Hosoda H., Damdindorj B., Sone H., Ming L., Hosoya Y., Sata N., Kobayashi E., Kangawa K., Nagai H., Yasuda Y., Yada T.
-
Journal Title
International J. Peptides 2010
Pages: 10-10
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Regulation of voltage-gated K^+ channels by glucose metabolism in pancreatic β-cells2009
Author(s)
Yoshida M., Dezaki K., Yamato S., Aoki A., Sugawara H., Toyoshima H., Ishikawa S., Kawakami M., Nakata M., Yada T., Kakei M.
-
Journal Title
FEBS Lett 583
Pages: 2225-2230
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article]2009
Author(s)
矢田俊彦
-
Journal Title
日本肥満学会誌:肥満研究 中枢グルコース感知と全身代謝・摂食調節:開拓的研究とその継承(日本肥満学会)
Pages: 14-19
Related Report
-
-
-
-
-
-
-
-
-
-
[Presentation] Kv2.1-channel currents are mediated by phosphorylation of the channels during glucose stimulation2010
Author(s)
吉田昌史, 出崎克也, 青木厚, 豊島秀男, 石川三衛, 川上正舒, 中田正範, 矢田俊彦., 加計正文
Organizer
The American Diabetes Association 70th scientific sessions Abstracts: Diabetes:59(suppl. 1)A454, 2010
Place of Presentation
Orlando, USA
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
