| Project/Area Number |
20390125
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
|
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| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
KOIDE Yukio Hamamatsu University School of Medicine, 医学部, 理事 (30126809)
|
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| Co-Investigator(Kenkyū-buntansha) |
NAGATA Toshi 浜松医科大学, 医学部, 教授 (90275024)
TSUJIMURA Kunio 浜松医科大学, 医学部, 准教授 (10227407)
UCHIJIMA Masato 浜松医科大学, 医学部, 助教 (20252174)
SETO Shintaro 浜松医科大学, 医学部, 助教 (50383203)
CHIDA Kingo 浜松医科大学, 医学部, 准教授 (40197611)
SUDA Takafumi 浜松医科大学, 医学部, 助教 (30291397)
KATO Hideki 浜松医科大学, 医学部, 准教授 (30142053)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2008: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
|
|---|
| Keywords | ワクチン / 結核菌 / 潜伏期 / 再燃 / DNAワクチン / 潜伏感染 |
|---|
| Research Abstract |
Immunogenicity against latency-associated proteins of Mycobacterium tuberculosis (DosR and resuscitation promoting factor (Rpf) proteins) was investigated using C57BL/6 and BALB/c mice. Seven and three antigens were found to induce T cell responses and antibody production in both strains, respectively. Oligomannose-coated liposomes and chimeric-molecule vaccines utilizing fusion proteins of a tuberculosis antigen and heat shock protein 70 or a chemokine (MIP-1α) were established as new technologies to facilitate the antigen uptake by dendritic cells.
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