Identification and functional analysis of factors related to human herpesvirus pathogenesis
Project/Area Number |
20390138
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Virology
|
Research Institution | Kobe University |
Principal Investigator |
MORI Yasuko Kobe University, 大学院・医学研究科, 教授 (50343257)
|
Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Shigefumi 医薬基盤研究所, 創薬基盤研究部, プロジェクトリーダー (50311759)
TAKEMOTO Masaya 医薬基盤研究所, 基盤研究部, 研究員 (60379237)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
|
Keywords | 遺伝子発現 / 細胞向性 / ウイルス感染 / 病原性 |
Research Abstract |
HHV-6 is T lympho-tropic virus and causes several diseases by reactivation, but it is still unknown regarding the pathogenesis. Here we successfully established the construction system of HHV-6 recombinant virus that had not been established yet. We found that envelope glycoprotein gQ1 that is HHV-6 specific gene is essential for virus growth. Moreover, we found that HHV-6 is captured and transmitted to T cells by DC, and can replicate in T cells completely.
|
Report
(4 results)
Research Products
(41 results)