| Project/Area Number |
20390143
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
ARASE Hisashi 大阪大学, 微生物病研究所, 教授 (10261900)
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| Co-Investigator(Kenkyū-buntansha) |
SUENAGA Tadahiro 大阪大学, 微生物病研究所, 助教 (20396675)
UEHORI Junji 大阪大学, 微生物病研究所, 助教 (20432429)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2008: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | NK細胞 / 自然免疫 / 免疫制御 / 炎症 / 獲得免疫 / 好中球 / T細 / PILR / DCIR / ヘルペスウィルス / 宿主病原体相互作用 / ペア型レセプター / 抑制化レセプター |
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| Research Abstract |
In this study, we tried to elucidate host and pathogen ligands for paired receptors. By this analysis, we analyzed how immune response to self is regulated via inhibitory receptors and how pathogens evade immune response via inhibitory receptors. In addition, we analyzed how activating receptors is involved in host resistance to pathogens. We extensively analyzed function of PILR, one of paired receptors. We found that PILR associates with glycoprotein B of herpes simplex virus and is involved in entry of herpes simplex virus into cells. Furthermore, we found that specific O-glycans on CD99 and glycoprotein B are essential to associate with PILR. In addition, we identified PANP, a new molecules that is specifically expressed in nerve tissue, as a new ligand for PILR and suggested that PANP might be involved in the immune regulation in nerve tissues. These results suggested that paired receptors play an important role in immune regulation.
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