Diagnostic Performances and Cost-effectiveness of Screening Programs for Hepatitis C Virus-related Hepatocellular Carcinoma
| Project/Area Number |
20390152
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical sociology
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
INOUE Yuji Yamaguchi University, 大学院・医学系研究科, 教授 (80213180)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Haku 山口大学, 医学部・附属病院, 准教授 (50176195)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
|
|---|
| Keywords | 肝細胞癌 / スクリーニング / 診断特性 / 予後予測モデル / 費用対効果分析 / スクリーニング検査 / 腫瘍マーカ / 多変量モデル / マルコフモデル / 腫瘍増殖モデル / 費用対効果 / 超音波 |
|---|
| Research Abstract |
The significance of case-finding programs to detect hepatocellular carcinoma developed during the long-term follow-up of Hepatitis C Virus-related cirrhosis are controversial issues from the viewpoints of cost-effectiveness. Diagnostic characteristics of AFP and DCP had low performances to find the early stage of hepatocellular carcinoma. The surveillance programs for hepatocellular carcinoma should estimate to prolong life expectancy at a reasonable marginal cost-effectiveness ratio, however, structural sensitivity analysis should be performed to confirm the robustness of the results.
|
Report
(4 results)
Research Products
(25 results)
