Clinical application of a novel rapid gene analyzing method aiming at personalized medicine
| Project/Area Number |
20390164
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Gunma University |
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Principal Investigator |
MURAKAMI Masami Gunma University, 大学院・医学系研究科, 教授 (30241871)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Koujirou 群馬大学, 大学院・医学系研究科, 教授 (70174787)
NARA Makoto 群馬大学, 大学院・医学系研究科, 助教 (80420165)
OGIWARA Takayuki 群馬大学, 医学部, 助教 (80361377)
MORIMURA Tadashi 群馬大学, 医学部, 助教 (20436306)
TSUNEKAWA Katsuhiko 群馬大学, 大学院・医学系研究科, 助教 (30436307)
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| Co-Investigator(Renkei-kenkyūsha) |
LEZHAVA Alexander 独立行政法人理化学研究所, ゲノム科学総合研究センター, 専任研究員 (40443048)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 遺伝子 / 一塩基多型 / 糖尿病 / 肥満 / 薬剤反応性 / バイオテクノロジー |
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| Research Abstract |
In order to introduce personalized medicine, single nucleotide polymorphism of drug metabolizing enzymes in the warfarin treated patients and energy metabolism related proteins in the patients with diabetes and obesity using a novel rapid gene analyzing technique, the Smart Amplification Process.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Mechanism and role of high-density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells.2010
Author(s)
Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itch H, Kurose H, Murakami M, Okajima F
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Journal Title
J Biol Chem 285
Pages: 4387-4397
Related Report
Peer Reviewed
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[Journal Article] Effects of raloxifene on brachial arterial endothelial function, carotid wall thickness, and arterial stiffness in osteoporotic postmenopausal women.2010
Author(s)
Sumino H, Ichikawa S, Kasama S, Takahashi T, Sakamoto H, Koizumi A, Kanai H, Araki Y, Itch T, Iwasaki T, Sawada Y, Saito Y, Kumakura H, Takayama Y, Kanda T, Murakami M, Sakamaki T, Kurabayashi M
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Journal Title
Int Heart J 51
Pages: 60-67
NAID
Related Report
Peer Reviewed
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[Journal Article] Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism.2010
Author(s)
Bessho K, Etani Y, Ichimori H, Miyoshi Y, Namba N, Yoneda A, Ooue T, Chihara T, Morii E, Aoki T, Murakami M, Mushiake S, Ozono K
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Journal Title
Eur J Pediatr 169
Pages: 215-221
Related Report
Peer Reviewed
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[Journal Article] Rapid single-nucleotide polymorphism detection of cytochrome P450 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genes for the warfarin dose adjustment by the SMart-amplification process version 2.2009
Author(s)
Aomori T, Yamamoto K, Oguchi-Katayama A, Kawai Y, Ishidao T, Mitani Y, Kogo Y, Lezhava A, Fujita Y, Obayashi K, Nakamura K, Kohnke H, Wadelius M, Ekstrom L, Skogastierna C, Rane A, Kurabayashi M, Murakami M, Cizdziel PE, Hayashizaki Y, Horiuchi R
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Journal Title
Clin Chem 55
Pages: 804-812
Related Report
Peer Reviewed
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