Integrated cardiac stem cell therapy to treat heart failure
Project/Area Number |
20390223
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Okayama University |
Principal Investigator |
OH Hidemasa Okayama University, 病院, 教授 (50372579)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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Keywords | 心臓内幹細胞 / 再生医療 / 細胞移植 / 心不全 / 成長因子 / 塩基性線維芽細胞成長因子 / 組織工学 / 心筋再生医療 / 細胞治療 / Sca-1 / bFGF / MURC / 増殖因子 / Akt / 突然変異 / 心筋構造蛋白 / 遺伝子欠損マウス |
Research Abstract |
Current cell therapies for cardiac repair are limited by loss of the transplanted cells and poor differentiation. Controlled delivery of bFGF modulates the post-ischemic microenvironment to enhance human cardiosphere-derived cell engraftment and differentiation. This novel strategy demonstrates significant functional improvements after myocardial infarction and may potentially represent a therapeutic approach to be studied in a clinical trial in human heart failure.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Deficiency of nectin-2 leads to cardiac fibrosis and dysfunction under chronic pressure overload.2009
Author(s)
Satomi-Kobayashi S, Ueyama T, Mueller S, Toh R, Masano T, Sakoda T, Rikitake Y, Miyoshi J, Matsubara H, Oh H, Kawashima S, Hirata K, Takai Y.
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Journal Title
Hypertension 54
Pages: 825-831
Related Report
Peer Reviewed
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[Journal Article] Deficiency of nectin-2 leads to cardiac fibrosis and dysfunction under chronic pressure overload.2009
Author(s)
Satomi Kobayashi S, Ueyama T, Mueller S, Toh R, Masano T, Sakoda T, Rikitake Y, Miyoshi J, Matsubara H, Oh H, Kawashima S, Hirata K, Takai Y.
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Journal Title
Hypertension 54
Pages: 825-831
Related Report
Peer Reviewed
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[Journal Article] Controlled Delivery of Basic Fibroblast Growth Factor Promotes Human Cardiosphere-Derived Cell Engraftment to Enhance Cardiac Repair for Chronic Myocardial Infarction.2008
Author(s)
Takehara N, Tsutsumi Y, Tateishi K, Ogata T, Tanaka H, Ueyama T, Takahashi T, Takamatsu T, Fukushima M, Komeda M, Yamagishi M, Yaku H, Tabata Y, Matsubara H, Oh H.
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Journal Title
Journal of American College of Cardiology 52
Pages: 1858-1865
Related Report
Peer Reviewed
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[Journal Article] MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis.2008
Author(s)
Tagawa M, Ueyama T, Ogata T, Takehara N, Nakajima N, Isodono K, Asada S, Takahashi T, Matsubara H, Oh H.
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Journal Title
American Journal of Physiology Cell Physiology 295
Related Report
Peer Reviewed
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[Journal Article] MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance.2008
Author(s)
Ogata T, Ueyama T, Isodono K, Tagawa M, Takehara N, Kawashima T, Harada K, Takahashi T, Shioi T, Matsubara H, Oh H.
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Journal Title
Molecular and Cellular Biology 28
Pages: 3424-3436
Related Report
Peer Reviewed
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[Journal Article] MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance2008
Author(s)
Ogata T, Ueyama T, Isodono K, Tagawa M, Takehara N, Kawashima T, Harada K, Takahashi T, Shioi T, Matsubara H, Oh H.
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Journal Title
Mol Cell Biol. 28
Pages: 3424-3436
Related Report
Peer Reviewed
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[Journal Article] MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis2008
Author(s)
Tagawa M, Ueyama T, Ogata T, Takehara N, Nakajima N, Isodono K, Asada S, Takahashi T, Matsubara H, Oh H.
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Journal Title
Am J Physiol Cell Physiol. 295
Related Report
Peer Reviewed
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[Journal Article] Controlled delivery of basic fibroblast growth factor promotes human cardiosphere-derived cell engraftment to enhance cardiac repair for chronic myocardial infarction2008
Author(s)
Takahara N, Tsutsumi Y, Tateishi K, Ogata T, Tanaka H, Ueyama T, Takahashi T, Takamatau T, Fukushima M, Komeda M, Yamagishi M, Yaku H, Tabata Y, Matsubara H, Oh H.
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Journal Title
J Am Coll Cardiol. 52
Pages: 1858-1865
Related Report
Peer Reviewed
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[Book] 再生医療2009
Author(s)
中岡幹彦
Total Pages
7
Publisher
メディカルビュー社
Related Report
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