Optimal therapeutic approach on ischemic brain insult using bone marrow stromal cells cultured under simulated microgravity
| Project/Area Number |
20390246
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Hiroshima University |
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Principal Investigator |
MATSUMOTO Masayasu Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (20192346)
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| Co-Investigator(Kenkyū-buntansha) |
YUGE Rui 広島大学, 保健学研究科, 教授 (20263676)
OHTSUKI Toshiho 広島大学, 病院, 講師 (20418792)
TAKAHASHI Tetsuya 広島大学, 病院, 講師 (00435942)
YAMASHITA Hiroshi 広島大学, 病院, 講師 (20311813)
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| Co-Investigator(Renkei-kenkyūsha) |
TAHARA Hidetoshi 広島大学, 医歯薬学総合研究科, 教授 (00271065)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 脳神経疾患 / 移植・再生医療 / 虚血性脳損傷 / 動物モデル |
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| Research Abstract |
The culture methods of stem cells are a key factor for tissue engineering and several methods have been proposed. We have showed that simulated microgravity allows novel LIF-free and animal derived material-free culture methods for mouse embryonic stem cells. Our study indicates that culturing cells under simulated microgravity enhances their survival rate by maintaining an undifferentiated state of cells, making this a potentially attractive method for culturing donor cells to be used in grafting.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Trigeminal neuropathy from perineural spread of an amyloidoma detected by blink reflex and thin-slice magnetic resonance imaging.2010
Author(s)
Yamazaki Y, Ochi K, Nakata Y, Dohi E, Eguchi K, Yamaguchi S, Matsushige T, Ueda T, Amatya VJ, Takeshima Y, Nakamura T, Ohtsuki T, Kohriyama T, Matsumoto M.
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Journal Title
Muscle Nerve. 41
Pages: 875-878
Related Report
Peer Reviewed
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[Journal Article] Yuge L, Sasaki A, Kawahara Y, Wu SL, Matsumoto M, Manabe T, Kajiume T, Takeda M, Magaki T, Takahashi T, Kurisu K, Matsumoto M.2010
Author(s)
Yuge L, Sasaki A, Kawahara Y, Wu SL, Matsumoto M, Manabe T, Kajiume T, Takeda M, Magaki T, Takahashi T, Kurisu K, Matsumoto M.
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Related Report
Peer Reviewed
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[Journal Article] Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with (11) C-AC-5216.2009
Author(s)
Miyoshi M, Ito H, Arakawa R, Takahashi H, Takano H, Higuchi M, Okumura M, Otsuka T, Kodaka F, Sekine M, Sasaki T, Fujie S, Seki C, Maeda J, Nakao R, Zhang MR, Fukumura T, Matsumoto M, Suhara T.
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Journal Title
J Nucl Med 50
Pages: 1095-1101
Related Report
Peer Reviewed
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[Journal Article] A Randomized, Double-Blind Study Comparing the Safety and Efficacy of Clopidogrel versus Ticlopidine in Japanese Patients with Noncardioembolic Cerebral Infarction.2008
Author(s)
Fukuuchi Y, Tohgi H, Okudera T, Ikeda Y, Miyanaga Y, Uchiyama S, Hirano M, Shinohara Y, Matsumoto M, Yamaguchi T.
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Journal Title
Cerebrovasc Dis. 25
Pages: 40-49
Related Report
Peer Reviewed
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[Journal Article] Incidence of dementia, Alzheimer disease, and vascular dementia in a Japanese population : Radiation Effects ResearchFoundation adult health study.2008
Author(s)
Yamada M, Mimori Y, Kasagi F, Miyachi T, Ohshita T, Sudoh S, Ikeda J, Matsui K, Nakamura S, Matsumoto M, Fujiwara S, Sasaki H.
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Journal Title
Neuroepidemiology 30
Pages: 152-160
Related Report
Peer Reviewed
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