Understanding of pathogenesis of autism and development of its therapeutic way based on epigenomic information
| Project/Area Number |
20390295
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
KUBOTA Takeo University of Yamanashi, 大学院・医学工学総合研究部, 教授 (70293511)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAOKA Kenzo 山梨大学, クリーンエネルギー研究センター, 教授 (80107218)
TEZUKA Hideo 山梨大学, 総合分析実験センター, 准教授 (70155456)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Nobuhiko 地方独立法人大阪府立病院機構, 大阪府立母子保健総合医療センター, 企画調査部参事 (30416242)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 小児 / 自閉症 / エピゲノム / 病態 / 治療法 / 遺伝学 / 遺伝子 / ゲノム / 脳神経疾患 / 発現制御 / トランスレーショナルリサーチ |
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| Research Abstract |
Epigenetic abnormalities, as well as genetic mutations, are now considered to be causes of genetic diseases. One of those is an autistic disorder, Rett syndrome, which is caused byMECP2 gene mutations. In this study, we found new MECP2 target genes, which is involved in neuronal cell adhesion. Furthermore, we obtained some knowledge of the therapeutic methodology for epigenomic diseases with nutritional factors and gene-targeting epigenomic reagents.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Hematopoietic stem cell transplantation for X-linked thrombocytopenia from mild symptomatic carrier.2010
Author(s)
Okuya M, Kurosawa H, Kubota T, Endoh K, Ogiwara A, Nonoyama S, Hagisawa S, Sato Y, Matsushita T, Fukushima K, Sugita K, Sato T, Arisaka O.
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Journal Title
Bone Marrow Transplant 45
Pages: 607-609
Related Report
Peer Reviewed
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[Journal Article] Resistance of T-cell acute lymphoblastic leukemia (T-ALL) to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.2010
Author(s)
Akahane K, Inukai T, Zhang X, Hirose K, Kuroda I, Goi K, Honna H, Kagami K, Nakazawa S, Endoh K, Kubota T, Yagita H, Koyama-Okazaki T, Sugita K.
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Journal Title
Exp Hematol 38(10)
Pages: 885-895
Related Report
Peer Reviewed
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[Journal Article] JAK2V617F mutation-positive childhood essential thrombocythemia associated with cerebral venous sinus thrombosis.2009
Author(s)
Kurosawa H, Okuya M, Matsushita T, Kubota T, Endoh K, Kuwashima S, Hagisawa S, Sato Y, Fukushima K, Sugita K, Okada Y, Park MJ, Hayashi Y, Arisaka O.
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Journal Title
J.Pediatr Hematol Oncol 31
Pages: 678-680
Related Report
Peer Reviewed
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[Journal Article] Adult onset X-linked chronic granulomatous disease in a female patient caused by a de novo mutation in paternal-origin CYBB gene and skewed inactivation of normal maternal X chromosome.2008
Author(s)
Gono T, Yazaki M, Agematu K, Matuda M, Yasui K, Yamaura M, Hidaka F, Mizukami T, Nunoi H, Kubota T, Ikeda S.
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Journal Title
Intern Med 43
Pages: 1053-1056
Related Report
Peer Reviewed
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[Presentation] Idenfiticaiton of MeCP2-target synaptic molecules associated with pathogenesis of Rett syndrome.2010
Author(s)
Miyake K, Hirasawa T, Soutome M, Itoh M, Goto Y, Endoh K, Kudo S, Yokoi S, Taira T, Inazawa J, Kubota T
Organizer
第33回日本分子生物学会年年会・第83回日本生化学会大会
Place of Presentation
合同大会
Year and Date
2010-12-08
Related Report
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