• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The genetic analysis of calcineurin signaling pathway in schizophrenia.

Research Project

Project/Area Number 20390316
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

YAMADA Kazuo  The Institute of Physical and Chemical Research, 分子精神科学研究チーム, 副チームリーダー (10322695)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Takeo  独立行政法人理化学研究所, 分子精神科学研究チーム, チームリーダー (30249958)
OHNISHI Tetsuo  独立行政法人理化学研究所, 分子精神科学研究チーム, 研究員 (80373281)
HATTORI Eiji  独立行政法人理化学研究所, 分子精神科学研究チーム, 客員研究員 (80399443)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywords脳・神経疾患 / 遺伝子 / シグナル伝達 / ゲノム / マイクロアレイ
Research Abstract

The calcineurin cascade is central to neuronal signal transduction, and genes in this network are intriguing candidate schizophrenia susceptibility genes. In this study, we performed association studies of calcineurin-related candidate genes by using Japanese schizophrenic pedigrees and case-control samples. In addition, we conducted a genome-wide association study (GWAS), which is a potentially powerful tool for identifying the risk variants that underlie the disease. We found several novel candidate genes for the disease, and unveiled the accumulation of association signals from genes of GABAergic pathways in schizophrenia. Furthermore, we extended our study by using postmortem brains of schizophrenic patients and transgenic mice of candidate genes. These findings support the genetic association of altered calcineurin/GABA signaling with schizophrenia pathogenesis.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (77 results)

All 2011 2010 2009 2008 Other

All Journal Article (49 results) (of which Peer Reviewed: 49 results) Presentation (26 results) Remarks (2 results)

  • [Journal Article] Association study of Nogo-related genes with schizophrenia in a Japanese case-control sample.2011

    • Author(s)
      Jitoku D, Hattori E, Iwayama Y, Yamada K, Toyota T, Kikuchi M, Maekawa M, Nishikawa T, Yoshikawa T
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nominal association between a polymorphism in DGKH and bipolar disorder detected in a meta-analysis of East Asian case-control samples.2011

    • Author(s)
      Takata A, Kawasaki H, Iwayama Y, Yamada K, Gotoh L, Mitsuyasu H, Miura T, Kato T, Yoshikawa T, Kanba S
    • Journal Title

      Psychiatry Clin Neurosci. (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide Association Study of Schizophrenia in Japanese Population.2011

    • Author(s)
      Yamada K, Iwayama Y, Hattori E, Iwamoto K, Toyota T, Ohnishi T, Ohba H, Maekawa M, Kato T, Yoshikawa T
    • Journal Title

      PLoS ONE. (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility.2011

    • Author(s)
      Nakamura K, Iwata Y, Anitha A, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Suzuki K, Suda S, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 35(2)

      Pages: 454-458

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia.2010

    • Author(s)
      Maekawa M, Ohnishi T, Hashimoto K, Watanabe A, Iwayama Y, Ohba H, Hattori E, Yamada K, Yoshikawa T
    • Journal Title

      J Neurochem. 115(6)

      Pages: 1374-1385

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Further evidence for the role of MET in autism susceptibility.2010

    • Author(s)
      Thanseem I, Nakamura K, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, Anitha A, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Iwata Y, Suzuki K, Suda S, Kawai M, Sugihara G, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N
    • Journal Title

      Neurosci Res. 68(2)

      Pages: 137-141

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia : the Japanese population and meta-analysis.2010

    • Author(s)
      Iwata Y, Yamada K, Iwayama Y, Anitha A, Thanseem I, Toyota T, Hattori E, Ohnishi T, Maekawa M, Nakamura K, Suzuki K, Matsuzaki H, Tsuchiya KJ, Suda S, Sugihara G, Takebayashi K, Yamamoto S, Iwata K, Mori N, Yoshikawa T
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 153B(6)

      Pages: 1221-1227

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.2010

    • Author(s)
      Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, Kato N, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Noda M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H
    • Journal Title

      Neurosci Res. 67(2)

      Pages: 181-191

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder.2010

    • Author(s)
      Iwayama Y, Hattori E, Maekawa M, Yamada K, Toyota T, Ohnishi T, Iwata Y, Tsuchiya KJ, Sugihara G, Kikuchi M, Hashimoto K, Iyo M, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Iwamoto K, Okazaki Y, Kato T, Yoshikawa T
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 153B(2)

      Pages: 484-493

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain.2010

    • Author(s)
      Bundo M, Iwamoto K, Yamada K, Yoshikawa T, Kato T
    • Journal Title

      Psychiatry Clin Neurosci. 64(1)

      Pages: 57-61

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The chitinase 3-like 1 gene and schizophrenia : evidence from a multi-center case-control study and meta-analysis.2010

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S, Yoshikawa T, Ohmori T, Iwata N, Ozaki N, Takeda M
    • Journal Title

      Schizophr Res. 116(2-3)

      Pages: 126-132

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations.2010

    • Author(s)
      Yamada K, Matsuzaki S, Hattori T, Kuwahara R, Taniguchi M, Hashimoto H, Shintani N, Baba A, Kumamoto N, Yamada K, Yoshikawa T, Katayama T, Tohyama M
    • Journal Title

      PLoS One. Jan 6;5(1)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia.2010

    • Author(s)
      Maekawa M, et al.
    • Journal Title

      J Neurochem

      Volume: 115(6) Pages: 1374-1385

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Further evidence for the role of MET in autism susceptibility.2010

    • Author(s)
      Thanseem I, et al.
    • Journal Title

      Neurosci Res

      Volume: 68(2) Pages: 137-141

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia : the Japanese population and meta-analysis.2010

    • Author(s)
      Iwata Y, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet

      Volume: 153B(6) Pages: 1221-1227

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.2010

    • Author(s)
      Munesue T, et al.
    • Journal Title

      Neurosci Res

      Volume: 67(2) Pages: 181-191

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The chitinase 3-like 1 gene and schizophrenia : evidence from a multicenter case-control study and meta-analysis2010

    • Author(s)
      Ohi K, et al.
    • Journal Title

      Schizophr Res. 116(2-3)

      Pages: 126-132

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations2010

    • Author(s)
      Yamada K, et al.
    • Journal Title

      PLoS One 5(1)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain2010

    • Author(s)
      Bundo M, et al.
    • Journal Title

      Psychiatry Clin Neurosci. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population.2009

    • Author(s)
      Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano M, Nanko S, Akahane A, Ueno M, Kaneko N, Watanabe Y, Someya T, Hashimoto K, Iyo M, Itokawa M, Arai M, Nankai M, Inada T, Yoshida S, Kunugi H, Nakamura M, Iijima Y, Okazaki Y, Higuchi T, Yoshikawa T
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 150B(8)

      Pages: 1110-1117

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient.2009

    • Author(s)
      Maekawa M, Iwayama Y, Nakamura K, Sato M, Toyota T, Ohnishi T, Yamada K, Miyachi T, Tsujii M, Hattori E, Maekawa N, Osumi N, Mori N, Yoshikawa T
    • Journal Title

      Neurosci Lett. 462(3)

      Pages: 267-2671

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder.2009

    • Author(s)
      Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Thanseem I, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Kikuchi M, Tohyama M, Yoshikawa T, Mori N
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 150B(7)

      Pages: 967-976

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations.2009

    • Author(s)
      Yamada K, Hattori E, Iwayama Y, Toyota T, Ohnishi T, Iwata Y, Tsuchiya KJ, Sugihara G, Kikuchi M, Okazaki Y, Yoshikawa T
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 150B(4)

      Pages: 508-514

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Variable number of tandem repeat polymorphisms of DRD4 : re-evaluation of selection hypothesis and analysis of association with schizophrenia.2009

    • Author(s)
      Hattori E, Nakajima M, Yamada K, Iwayama Y, Toyota T, Saitou N, Yoshikawa T
    • Journal Title

      Eur J Hum Genet. 17(6)

      Pages: 793-801

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial DNA haplogroup analysis in patients with bipolar disorder.2009

    • Author(s)
      Kazuno AA, Munakata K, Mori K, Nanko S, Kunugi H, Nakamura K, Mori N, Yamada K, Yoshikawa T, Kato N, Kato T
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 150B(2)

      Pages: 243-247

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population2009

    • Author(s)
      Hattori E, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 150B(8)

      Pages: 1110-1117

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel missense mutation(Leu46Val)of PAX6 found in an autistic patient2009

    • Author(s)
      Maekawa M, et al.
    • Journal Title

      Neurosci Lett. 462(3)

      Pages: 267-271

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2(PCNT2)and DISC1-binding zinc finger protein(DBZ), with schizophrenia and with bipolar disorder2009

    • Author(s)
      Anitha A, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 150B(7)

      Pages: 967-976

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association analyses between brain-expressed fatty-acid binding protein(FABP)genes and schizophrenia and bipolar disorder2009

    • Author(s)
      Iwayama Y, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations2009

    • Author(s)
      Yamada K, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 150B(4)

      Pages: 508-514

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial DNA haplogroup analysis in patients with bipolar disorder2009

    • Author(s)
      Kazuno AA, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet 150B(2)

      Pages: 243-247

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding, zinc finger protein (DBZ), with schizophrenia and with bipolar disorder2009

    • Author(s)
      Anitha A, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variable number of tandem repeat polymorphisms of DRD4 : re-evaluation of selection hypothesis and analysis of association with schizophrenia2009

    • Author(s)
      Hattori E, et al.
    • Journal Title

      Eur J Hum Genet

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations2009

    • Author(s)
      Yamada K, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial DNA haplogroup analysis in patients with bipolar disorder2009

    • Author(s)
      Kazuno AA, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder2009

    • Author(s)
      Hayashi A, et al.
    • Journal Title

      Int J Neuropsychopharmacol 12

      Pages: 33-43

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and expression analyses reveal elevated expression of syntaxin 1A (STX1A) in high functioning autism.2008

    • Author(s)
      Nakamura K, Anitha A, Yamada K, Tsujii M, Iwayama Y, Hattori E, Toyota T, Suda S, Takei N, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya KJ, Sugihara G, Ouchi Y, Sugiyama T, Yoshikawa T, Mori N
    • Journal Title

      Int J Neuropsychopharmacol. 11(8)

      Pages: 1073-1084

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.2008

    • Author(s)
      Shi J, Wittke-Thompson JK, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 147B(7)

      Pages: 1047-1055

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurotransmission and bipolar disorder : a systematic family-based association study.2008

    • Author(s)
      Shi J, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 147B(7)

      Pages: 1270-1277

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analyses of roundabout (ROBO) axon guidance receptors in autism.2008

    • Author(s)
      Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Ouchi Y, Sugiyama T, Koizumi K, Higashida H, Takei N, Yoshikawa T, Mori N
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 147B(7)

      Pages: 1019-1027

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder.2008

    • Author(s)
      Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Tohyama M, Yoshikawa T, Mori N
    • Journal Title

      Biol Psychiatry. 63(7)

      Pages: 678-685

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and expression analyses reveal elevated expression of syntaxin 1A (STX1A) in high functioning autism2008

    • Author(s)
      Nakamura K, et al.
    • Journal Title

      Int J Neuropsychopharmacol 11

      Pages: 1073-1084

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analyses of roundabout (ROBO) axon guidance receptors in autism2008

    • Author(s)
      Anitha A, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet 147B

      Pages: 1019-1027

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low serum levels of brain-derived neurotrophic factor and epidermal growth factor in patients with chronic schizophrenia2008

    • Author(s)
      Ikeda Y, et al.
    • Journal Title

      Schizophr Res 101

      Pages: 58-66

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder2008

    • Author(s)
      Anitha A, et al.
    • Journal Title

      Biol Psychiatry 63

      Pages: 678-685

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] It is time to take a stand for medical research and against terrorism targeting medical scientists2008

    • Author(s)
      Krystal JH, et al.
    • Journal Title

      Biol Psychiatry 63

      Pages: 725-727

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurotransmission and bipolar disorder : a systematic family-based association study2008

    • Author(s)
      Shi J, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet 147B

      Pages: 1270-1277

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm2008

    • Author(s)
      Shi J, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet 147B

      Pages: 1047-1055

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility.

    • Author(s)
      Nakamura K, et al.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Genome wide association study identifies a potassium channel gene as a susceptibility gene for schizophrenia.2010

    • Author(s)
      山田和男, et al.
    • Organizer
      18th World Congress on Psychiatric Genetics
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2010-10-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Genome wide association study identifies a potassium channel gene as a susceptibility gene for schizophrenia.2010

    • Author(s)
      Yamada K, et al.
    • Organizer
      18th World Congress on Psychiatric Genetics
    • Place of Presentation
      Athens (Greece)
    • Year and Date
      2010-10-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症におけるゲノムワイド関連解析2010

    • Author(s)
      山田和男, 他
    • Organizer
      第18回日本精神行動遺伝医学会
    • Place of Presentation
      仙台、日本
    • Year and Date
      2010-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 統合失調症におけるゲノムワイド関連解析2010

    • Author(s)
      山田和男, 他
    • Organizer
      第18回日本精神行動遺伝医学会
    • Place of Presentation
      仙台(日本)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Association Analysis of Adenosine A1 receptor (ADORA1) and Dopamine D1 receptor (DRD1) genes with schizophrenia in the Japanese population.2009

    • Author(s)
      Gotoh L, et al.
    • Organizer
      59th Annual Meeting of the American Society of Human Genetics
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2009-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Association Analysis of Adenosine A1 receptor (ADORA1) and Dopamine D1 receptor (DRD1) genes with bipolar disorder in the Japanese population.2009

    • Author(s)
      Kawasaki H, et al.
    • Organizer
      59th Annual Meeting of the American Society of Human Genetics
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2009-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Association Analysis of Adenosine A1 receptor(ADORA1)and Dopamine D1 receptor(DRD1)genes with schizophrenia in the Japanese population2009

    • Author(s)
      Gotoh L, et al.
    • Organizer
      59th Annual Meeting of the American Society of Human Genetics
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Association Analysis of Adenosine A1 receptor(ADORA1)and Dopamine D1 receptor(DRD1)genes with bipolar disorder in the Japanese population2009

    • Author(s)
      Kawasaki H, et al.
    • Organizer
      59th Annual Meeting of the American Society of Human Genetics
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular targets for potentially disturbed lipid metabolism in functional psychoses.2009

    • Author(s)
      Yoshikawa T
    • Organizer
      The 1st Asian Workshop on Schizophrenia Research
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2009-02-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Molecular targets for potentially disturbed lipid metabolism in functional psychoses2009

    • Author(s)
      Takeo Yoshikawa
    • Organizer
      The 1^<st> Asian Workshop on Schizophrenia Research
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2009-02-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] A gene distributed by a chromosomal translocation in 4p15.2 was associated with schizophrenia.2008

    • Author(s)
      Haga S, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Testing genetic models and candidate genes for schizophrenia from an evolutionary viewpoint.2008

    • Author(s)
      Doi N, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Mitochondrial DNA hypothesis if schizophrenia : an integration of epidemiological and pathophysiological aspects.2008

    • Author(s)
      Doi N, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-14
    • Related Report
      2010 Final Research Report
  • [Presentation] A gene distributed by a chromosomal translocation in 4p15.2 was associated with schizophrenia2008

    • Author(s)
      Haga S, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Testing genetic models and candidate genes for schizophrenia from an evolutionary viewpoint2008

    • Author(s)
      Doi N, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mitochondrial DNA hypothesis if schizophrenia : an integration of epidemiological and pathophysiological aspects2008

    • Author(s)
      Doi N, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genetic roles of FABP7, 5 and 3 in functional psychoses.2008

    • Author(s)
      Iwayama Y, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Gene and expression analyses reveal elevated expression of syntaxin 1A in high functioning autism.2008

    • Author(s)
      Anitha A, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Genetic roles of FABP7, 5 and 3 in functional psychoses2008

    • Author(s)
      Iwayama Y, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gene and expression analyses reveal elevated expression of syntaxin 1A in high functioning autism2008

    • Author(s)
      Anitha A, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genetics of Bipolar disorder.2008

    • Author(s)
      Hattori E
    • Organizer
      2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      2008-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Genetics of Bipolar disorder2008

    • Author(s)
      Eiji Hattori
    • Organizer
      2^<nd> WFSBP Asia-Pacific Congress and 30^<th> Annual Meeting of JSBP
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      2008-09-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genetic architecture that defines endphenotypes in mice and its molecular relevance to mental disorders.2008

    • Author(s)
      Yoshikawa T
    • Organizer
      XXVI CINP Congress
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2008-07-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Genetic architecture that defines endphenotypes in mice and its molecular relevance to mental disorders2008

    • Author(s)
      Takeo Yoshikawa
    • Organizer
      XXVI CINP Congress
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2008-07-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Toward Genetics Dissection of Psychiatric Illnesses.2008

    • Author(s)
      Yoshikawa T
    • Organizer
      NIMH Lecture Series
    • Place of Presentation
      Bethesda, MD, USA
    • Year and Date
      2008-05-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Toward Genetics Dissection of Psychiatric Illnesses2008

    • Author(s)
      Takeo Yoshikawa
    • Organizer
      NIMH Lecture Series
    • Place of Presentation
      Bethesda, MD, USA
    • Year and Date
      2008-05-05
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://molpsych.brain.riken.jp/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://molpsych.brain.riken.jp/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi