Radionuclide imaging for tissue characterization and treatment effect of experimental atherosclerosis

• Project/Area Number: 20390321
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: TAMAKI Nagara Hokkaido University, 大学院・医学研究科, 教授 (30171888)
• Co-Investigator(Kenkyū-buntansha): KUGE Yuji 北海道大学, アイソトープ総合センター, 教授 (70321958)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2008: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: 動脈硬化 / 不安定プラーク / 核医学診断 / エミッショントモグラフィ / デオキシグルコース / アポトーシス / 核医学

Research Abstract

In order to assess atheroma vulnerability, we have selected two radiopharmaceuticals to probe atheroma imaging in vivo using apolipoprotein E knockout (apoE-/-) mice. The uptakes of FDG and Annexin A5 were quantitatively measured on autoradiography to compare with various parameters on histological and immunohistochemical staining. These uptakes were closely correlated with atheroma staging and macrophage infiltration. The current study indicated that the radionuclide imaging has a potential to identify atheroma vulnerability.

Research Products

• [Journal Article] Localization of deoxyglucose and annexin A5 in experimental atheroma correlates with macrophage infiltration but not lipid deposition in the lesion. (2011)
  • Author(s): Zhao Y, Zhao S, Kuge Y, Strauss WH, Blankenberg FG, Tamaki N.
  • Journal Title: Mol Imaging Biol. (印刷中)
  • Peer Reviewed
• [Journal Article] Localization of deoxyglucose and annexin A5 in experimental atheroma correlates with macrophage infiltration but not lipid deposition in the lesion. (2011)
  • Author(s): Zhao Y, et al.
  • Journal Title: Molecular Imaging and Biology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging. (2010)
  • Author(s): Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K, Ohkura K.
  • Journal Title: Nucl Med Biol. 37(4) Pages: 427-32
  • Peer Reviewed
• [Journal Article] Use of FDG PET to evaluate hyperbaric oxygen therapy for bisphosphonate-related osteonecrosis of the jaw. (2010)
  • Author(s): Yamazaki Y, Kitagawa Y, Hata H, Abe T, Murai C, Shiga T, Tamaki N.
  • Journal Title: Clin Nucl Med. 35(8) Pages: 590-1
  • NAID: 120003631379
  • Peer Reviewed
• [Journal Article] Quantitative analysis of coronary endothelial function with generator-produced ^<82>Rb PET : comparison with ^<15>O-labelled water PET. (2010)
  • Author(s): Yoshinaga K, Manabe O, Katoh C, Chen L, Klein R, Naya M, Dekemp RA, Williams K, Beanlands RS, Tamaki N.
  • Journal Title: Eur J Nucl Med Mol Imaging 37(12) Pages: 2233-2241
  • NAID: 120003537873
  • Peer Reviewed
• [Journal Article] In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging. (2010)
  • Author(s): Akizawa H, et al.
  • Journal Title: Nuclear Medicine and Biology Volume: 37 Pages: 427-432
  • Peer Reviewed
• [Journal Article] Use of FDG PET to evaluate hyperbaric oxygen therapy for bisphosphonate-related osteonecrosis of the jaw. (2010)
  • Author(s): Yamazaki Y, et al.
  • Journal Title: Clinical Nuclear Medicine Volume: 35 Pages: 590-591
  • Peer Reviewed
• [Journal Article] Molecular imaging of apoptosis with Radio-Labeled Annexin A5 focused on the evaluation of tumor response to chemotherapy. (2010)
  • Author(s): Kuge Y
  • Journal Title: Anti-Cancer Agents in Medicinal Chemistry (9) Pages: 1003-1011
  • Peer Reviewed
• [Journal Article] Synthesis and evaluation of a radioiodinated lumiracoxib derivative for the imaging of cyclooxygenase-2 expression. (2009)
  • Author(s): Kuge Y, Obokata N, Kimura H, Katada Y, Temma T, Suginoto Y, Aita K, Seki K, Tamaki N, Saji H
  • Journal Title: Nucl Med Biol 36(8) Pages: 869-876
  • Peer Reviewed
• [Journal Article] Therapeutic effects of acupuncture in patients with rheumatoid arthritis : a prospective study using 18F-FDG-PET. (2009)
  • Author(s): Sato M, Inubushi M, Shiga T, Hirata K, Okamoto S, Kamibayashi T, Tanimura K, Tamaki N
  • Journal Title: Ann Nucl Med 23(3) Pages: 311-316
  • NAID: 10025136226
  • Peer Reviewed
• [Journal Article] Myocardial imaging with ^<18>F-fluoro-2-deoxygluose positron emission tomography and magnetic resonance imaging in sarcoidosis. (2008)
  • Author(s): Ohira H, Tsujino I, Ishimura S, Oyama N, Takei T, Tsukamoto E, Miura M, Sakaue S, Tamaki N, Nishimura M
  • Journal Title: Eur J Nucl Med Mol Imaging 35(5) Pages: 933-941
  • Peer Reviewed
• [Journal Article] Usefulness of ^<11>C-methionine for differentiating tumors from granulomas in experimental rat models : a comparison with ^<18>F-FDG and ^<18>F-FLT. (2008)
  • Author(s): Zhao S, Kuge Y, Kohanawa M, Takahashi T, Zhao Y, Yi M, Kanegae K, Seki KI, Tamaki N
  • Journal Title: J Nucl Med 49(1) Pages: 135-141
  • NAID: 120003118186
  • Peer Reviewed
• [Journal Article] Prolonged high-fat feeding enhances aortic ^<18>F-FDG and ^<99m>Tc-annexin A5 uptake in apolipoprotein E-deficient and wild-type C57BL/6J mice. (2008)
  • Author(s): Zhao Y, Kuge Y, Zhao S, Strauss HW, Blankenberg FG, Tamaki N
  • Journal Title: J Nucl Med 49(10) Pages: 1707-14
  • NAID: 120003118185
  • Peer Reviewed
• [Journal Article] Prolonged high-fat feeding enhances aortic ^<18>F-FDG and ^<99m> Tc-annexin A5 uptake in apolipoprotein E-deficient and wild-type C57 BL / 6J mice (2008)
  • Author(s): Zhao Y
  • Journal Title: J Nucl Med 49(10) Pages: 1707-1714
  • Peer Reviewed
• [Journal Article] Usefulness of 11C-methionine for differentiating tumors from granulomas in experimental rat models : a comparison with 18F-FDG and 18F-FLT (2008)
  • Author(s): Zhao S
  • Journal Title: J Nucl Med 49(1) Pages: 135-141
  • Peer Reviewed
• [Presentation] Perspectives of cardiovascular molecular imaging. (Educational Session, Organizor). (2010)
  • Author(s): Tamaki N
  • Organizer: World Molecular Imaging Congress 2010
  • Place of Presentation: Kyoto. Japan
• [Presentation] Careful assessment of FDG uptake due to elevated FDG concentration in the blood and organs by high dose ARB administration: Experiment in mice given telmisartan (2010)
  • Author(s): Zhao Y, Zhao S, Kuge Y, Tamaki N
  • Organizer: 56 th Annual Meeting, Society of Nuclear Medicine
  • Place of Presentation: Salt Lake City
• [Presentation] Perspectives of PET in cardiovascular medicine (2010)
  • Author(s): Tamaki N
  • Organizer: 13th Asia-Oceanian Congress of Radiology
• [Presentation] Perspectives of cardiovascular molecular imaging. (2010)
  • Author(s): Tamaki N
  • Organizer: World Molecular Imaging Congress
  • Place of Presentation: 京都国際会議場(京都市) 招待講演
• [Presentation] Circulation to vessel walls ; 2009 SNM Hermann Blumgart Award Lecture. (2009)
  • Author(s): Tamaki N
  • Organizer: 56th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: Toronto(Invited lecture)
• [Presentation]
  • Author(s): Taipei, Taiwan(Invited lecture)
• [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development. State of the art and future perspectives. (2010)
  • Author(s): Tamaki N, Kuge Y (eds.)
  • Total Pages: 303
  • Publisher: Springer, Tokyo
• [Book] Molecular Imaging for Integrated Medical Therapy and Drug Development.State of the art and future perspectives. (2010)
  • Author(s): Talnaki N, Kuge Y編集
  • Total Pages: 303
  • Publisher: Springer
• [Book] In Molecular Imaging for Integrated Medical Therapy and Drug Development. (2010)
  • Author(s): Zhao Y
  • Total Pages: 9
  • Publisher: Springer