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Quantitative neuroreceptor imaging for mice using PET : development of micro litter ordered blood radioactivity counting system and the technique to omit arterial blood sampling

Research Project

Project/Area Number 20390333
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

KIMURA Yuichi  National Institute of Radiological Sciences, 分子イメージング研究センター, チームリーダ (60205002)

Co-Investigator(Kenkyū-buntansha) TOYAMA Hiroshi  藤田保健衛生大学, 医学部・放射線医学教室, 准教授 (90247643)
KITAMURA Keishi  (株)島津製作所, 基盤技術研究所, 課長 (30395941)
Co-Investigator(Renkei-kenkyūsha) HIGUCHI Makoto  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダ (10373359)
SHIDAHARA Miho  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (20443070)
HONTANI Hidekata  名古屋工業大学, 工学系研究科, 教授 (60282688)
SEKI Chie  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (40443080)
NISHIMOTO Takahiro  (株)島津製作所, 基盤技術研究所, 部長
WADA Yasuhiro  独立行政法人理化学研究所, 分子イメージング科学研究センター, 副チームリーダ
Research Collaborator NAGANAWA Mika  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員
SAKAGUCHI Kazuya  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Keywords分子イメージング / 核医学 / 脳 / トランスレーショナルリサーチ / マウス
Research Abstract

In this study, the methods for radioactivity counting system for micro-liter ordered blood were investigated. Also, the algorithm to omit arterial blood sampling was studied. For fully quantitative functional imaging using positron emission tomography (PET), the radioactivity concentration in arterial blood is required, and therefore, arterial blood sampling should be conducted. However, due to the small size in mice, the arterial blood sampling is an issue for PET quantitative measurement. This study aimed to realize quantitative PET functional imaging for mice, the system to measure radioactivity concentration in a few micro-liter arterial blood and the algorithm fo reduce the noise in PET data derived from mice based on MAP estimation were investigated.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (33 results)

All 2011 2010 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (19 results) Patent(Industrial Property Rights) (11 results) (of which Overseas: 5 results)

  • [Journal Article] パラメトリック固有空間を利用したPET動態データの雑音除去2011

    • Author(s)
      星野直輝, .本谷秀堅, 坂口和也, 坂田宗之, 石渡喜一, 木村裕一
    • Journal Title

      Medical Imaging Technology

      Volume: in press

    • NAID

      130000446944

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] パラメトリック固有空間を利用したPET動態データの雑音除去2010

    • Author(s)
      星野直輝,本谷秀堅,坂口和也,坂田宗之,石渡喜一,木村裕一
    • Journal Title

      Med Image Tech 28

      Pages: 362-370

    • NAID

      130000446944

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小動物における定量的画像解析2010

    • Author(s)
      外山宏,籏野健太郎,鈴木弘美,工藤元,野村昌彦,山田貴司,木村裕一,市瀬正則,澤田誠
    • Journal Title

      脳循環代謝 25

      Pages: 50-57

    • Related Report
      2010 Final Research Report
  • [Presentation] MAP-based denoising of dynamic PET data for quantitative receptor imaging2011

    • Author(s)
      Naoki Hoshino
    • Organizer
      SPIE Medical Imaging 2011
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-02-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] MAP-based Denoising of Dynamic PET Data for Quantitative Receptor Imaging2011

    • Author(s)
      Naoki Hoshino, Hidekata Hontani, Kazuya Sakaguchi, Muneyuki Sakata, Kiichi Ishiwata, Yuichi Kimura
    • Organizer
      Conference of Biomedical Applica-tions in Molecular, Structural, and Functional Imaging (Conference 7965), SPIE Medical Imag-ing 2011(7965-7943)
    • Place of Presentation
      Orland,FL,USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 小動物血液血漿分離・放射能濃度測定システム2010

    • Author(s)
      木村裕一, 他
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      さいたま市
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Micro-liter order blood sampling system for small animal molecular imaging using PET-Validation with animal study-2010

    • Author(s)
      N Hashidume, et.al.
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-09-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] パラメトリック固有空間を利用したPET動態データの雑音除去2010

    • Author(s)
      星野直輝
    • Organizer
      第29回日本医用画像工学会大会
    • Place of Presentation
      伊勢原市
    • Year and Date
      2010-07-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小動物PET用微少採血装置の開発-動物実験による全血及び血漿中放射能濃度測定系の評価-2010

    • Author(s)
      橋爪宣弥, 他
    • Organizer
      日本分子イメージング学会第5回総会
    • Place of Presentation
      大津
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小動物PET定量用微少採血装置の開発2010

    • Author(s)
      木村裕一
    • Organizer
      第3回小動物インビボイメージング研究会
    • Place of Presentation
      藤田保健衛生大学
    • Year and Date
      2010-01-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小動物血液血漿分離・放射能濃度測定システム2010

    • Author(s)
      木村裕一,橋爪宣弥,関千江,脇坂秀克,西本尚弘,北村圭司,菅野巖
    • Organizer
      第50回日本核医学会学術総会(核医学,47,)(JSNM-OSIX0103)
    • Place of Presentation
      さいたま市
    • Related Report
      2010 Final Research Report
  • [Presentation] Micro-liter Order Blood Sampling System for Small Animal Molecular Imaging Using PET?Validation with Animal Study2010

    • Author(s)
      N Hashidume,Y Kimura, C Seki, H Wakizaka, T Nishimoto, K Kitamura, I Kanno
    • Organizer
      Proceedings of 2010 World Molecular Imaging Congress (P0331B)
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] パラメトリック固有空間を利用したPET動態データの雑音除去2010

    • Author(s)
      星野直輝,本谷秀堅,坂口和也,坂田宗之,石渡喜一,木村裕一
    • Organizer
      第29回日本医用画像工学会大会(OP5-1)
    • Place of Presentation
      東海大学伊勢原キャンパス,伊勢原市,神奈川
    • Related Report
      2010 Final Research Report
  • [Presentation] 小動物PET用微少採血装置の開発動物実験による全血及び血漿中放射能濃度測定系の評価-2010

    • Author(s)
      橋爪宣弥,木村裕一,関千江,脇坂秀克,西本尚弘,北村圭司,菅野巖
    • Organizer
      日本分子イメージング学会機関誌3,P.44,日本分子イメージング学会第5回総会・学術集会
    • Place of Presentation
      大津市
    • Related Report
      2010 Final Research Report
  • [Presentation] PET受容体解析法MA1の計測データの誤差分布特性に基づく改善の試み(信学技報)(7-12,MI2009-76)2010

    • Author(s)
      星野直輝,本谷秀堅,長縄美香,坂口和也,坂田宗之,石渡喜一,木村裕一
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      那覇
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of microfluidic plasma counting system for small animal molecular imaging using PET-Measurement of small radioactivity concentration-2009

    • Author(s)
      木村裕一
    • Organizer
      2009 World Molecular Imaging Congress
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2009-09-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of microfluidic plasma counting system for small animal molecular imaging using PET-Principle validation for blood transportation system-2009

    • Author(s)
      Nobuya Hashidume
    • Organizer
      2009 World Molecular Imaging Congress
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2009-09-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小動物微少容量採血・血漿分離システムの開発-遠心分離システムへの血液の移行性の検討-2009

    • Author(s)
      木村裕一
    • Organizer
      第2回日本分子イメージング学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 小動物微少容量採血・血漿分離システムの開発-遠心分離システムへの血液移行性の検討-2009

    • Author(s)
      木村裕一
    • Organizer
      日本分子イメージング学会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of Mi-crofluidic Plasma Counting System for Small Animal Molecular Imaging Using PET - Measurement of Small Radioactivity Concentration2009

    • Author(s)
      Y Kimura, N Hashizume, T Nishimoto, K Kitamura, I Kanno
    • Organizer
      Proc 2009 World Molecular Imaging Congress(1172)
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of Microfluidic Plasma Counting System for Small Animal Molecular Imaging Using PET - Principle Validation for Blood Transportation System2009

    • Author(s)
      M Hashidume, Y Kimura, T Nishimoto, K Kitamura, I Kanno
    • Organizer
      Proc 2009 World Molecular Imaging Congress(1158)
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2010 Final Research Report
  • [Presentation] 小動物用微少容量採血・血漿分離システムの開発遠心分離システムへの血液の移行性の検討2009

    • Author(s)
      木村裕一,関千江,橋爪宣弥,西本尚弘,北村圭司,菅野巖
    • Organizer
      第2回日本分子イメージング学会総会・学術集会予稿集,日本分子イメージング学会
    • Place of Presentation
      千代田区,東京
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 測定システム2010

    • Inventor(s)
      木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
    • Industrial Property Rights Holder
      木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
    • Industrial Property Number
      2010-068152
    • Filing Date
      2010-12-28
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 測定システム2010

    • Inventor(s)
      木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
    • Industrial Property Rights Holder
      木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
    • Industrial Property Number
      2010-068151
    • Filing Date
      2010-10-28
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] Measuring Appratus, and Liquid Collecting and Measuring System Having the Same2010

    • Inventor(s)
      木村裕一, Keishi Kitamura, Takahiro Nishimoto, Chie Seki, Iwao Kanno
    • Industrial Property Rights Holder
      Yuichi Kimura, Keishi Kitamura, Takahiro Nishimoto, Chie Seki, Iwao Kanno
    • Filing Date
      2010-10-13
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Measureing apparatus, and liquid collecting and measuring system having the same2010

    • Inventor(s)
      Yuichi Kimiura, Keichi Kitamura, Takahiro Nishimoto, Chie Seki, Iwao Kanno
    • Industrial Property Rights Holder
      放射線医学総合研究所, 島津製作所
    • Filing Date
      2010-10-13
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 測定システム2010

    • Inventor(s)
      木村裕一, 橋爪宣弥, 北村圭司, 西本尚弘, 関千江, 菅野巖
    • Industrial Property Rights Holder
      放射線医学総合研究所,島津製作所
    • Filing Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 測定システム2010

    • Inventor(s)
      木村裕一, 橋爪宣弥, 北村圭司, 西本尚弘, 関千江, 菅野巖
    • Industrial Property Rights Holder
      放射線医学総合研究所,島津製作所
    • Filing Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 遠心分離装置2009

    • Inventor(s)
      木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
    • Industrial Property Rights Holder
      木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
    • Industrial Property Number
      2009-227513
    • Filing Date
      2009-09-30
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 液体採取装置、測定装置並びにそれらを備えた液体採取測定システム2009

    • Inventor(s)
      木村裕一, 関千江, 菅野巌, 北村圭司, 西本尚弘, 橋爪宣弥
    • Industrial Property Rights Holder
      (独)放射線医学総合研究所, (株)島津製作所
    • Filing Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 遠心分離装置2009

    • Inventor(s)
      木村裕一, 関千江, 菅野巌, 北村圭司, 西本尚弘, 橋爪宣弥
    • Industrial Property Rights Holder
      (独)放射線医学総合研究所, (株)島津製作所
    • Industrial Property Number
      2009-227513
    • Filing Date
      2009-09-30
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 液体採取装置における所定時刻の液体採取法2009

    • Inventor(s)
      木村裕一, 関千江, 菅野巌, 北村圭司, 西本尚弘, 橋爪宣弥
    • Industrial Property Rights Holder
      (独)放射線医学総合研究所, (株)島津製作所
    • Filing Date
      2009-03-19
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 液体採取装置、測定装置並びにそれらを備えた液体採取測定システム2008

    • Inventor(s)
      木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
    • Industrial Property Rights Holder
      木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
    • Filing Date
      2008
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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