Development of a rotating cerium-anode-equipped microangiographic system to visualize small arteries in major organs in clinical settings.

• Project/Area Number: 20390336
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tokai University
• Principal Investigator: MORI Hidezo Tokai University, 医学部, 教授 (90146598)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000); Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
• Keywords: 放射線 / X線・粒子線 / 循環器・高血圧 / 脳神経疾患 / 移植・再生医療 / 放射線・X線・粒子線 / 血管造影 / 微小血管 / 血管再生

Research Abstract

Conventional angiography can not visualize arterioles with a diameter range of 20-200μm. In other words the conventional system is not appropriate to evaluate pathophysiology of intramural small coronary arteries and/or cerebaral perforating arterie (diameter of 50-300μm) in clinical settings. In the present study, we developed a rotating cerium-anode- and a high-heat unit (5MHU) equipped-in-hospital microangiographic system and confirmed its performances in animal experiments.

Research Products

• [Journal Article] Magnification Embossed Radiography Utilizing Image-Shifting Subtraction Program (2010)
  • Author(s): Akihiro Osawa, Manabu Watanabe,Eiichi Sato, Hiroshi Matsukiyo, Toshiyuki Enomoto, Jiro Nagao, Purkhet Abderyim, Katsuo Aizawa, Etsuro Tanaka, Hidezo Mori, Toshiaki Kawai, Akira Ogawa, Kiyomi Takahashi, Shigehiro Sato, Jun Onagawa
  • Journal Title: Jpn J Appl Phys. 49 Pages: 37001-7
  • NAID: 40017033749
  • Peer Reviewed
• [Journal Article] Energy-Discriminating Gadolinium K-Edge X-ray Computed Tomography System (2010)
  • Author(s): Hiroshi Matsukiyo, Manabu Watanabe, Eiichi Sato, Akihiro Osawa, Toshiyuki Enomoto, Jiro Nagao, Purkhet Abderyim, Katsuo Alzawa, Keitaro Hitomi, Etsuro Tanaka, Hidezo Mori, Toshiaki Kawai, Akira Ogawa, Kiyomi Takahashi, Shigehiro Sato, Jun Onagawa
  • Journal Title: Jpn J Appl Phys. 49 Pages: 27001-6
  • NAID: 40016982545
  • Peer Reviewed
• [Journal Article] Year-long upregulation of connexin43 in rabbit hearts by heavy ion irradiation (2010)
  • Author(s): M.Amino, K.Yoshioka, D.Fujibayashi, T.Hashida, Y.Furusawa, W.Zareba, Y.Ikari, E.Tanaka, H.Mori, S.Inokuchi, I.Kodama, T.Tanabe
  • Journal Title: Am J Physiol Heart Circ Physiol. 298
  • Peer Reviewed
• [Journal Article] Year-long upregulation of connexin43 in rabbit hearts by heavy ionirradiation (2010)
  • Author(s): M.Amino, K.Yoshioka, D.Fujibayashi, T.Hashida, Y.Furusawa, W.Zareba, Y.Ikari, E.Tanaka, H.Mori, S.Inokuchi, I.Kodama, T.Tanabe
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 298 Pages: 1014-1021
  • Peer Reviewed
• [Journal Article] Energy-Discriminating Gadolinium K-Edge X-ray Computed Tomography System (2010)
  • Author(s): Hiroshi Matsukiyo, Manabu Watanabe, Eiichi Sato, Akihiro Osawa, Toshiyuki Enomoto, Jiro Nagao, Purkhet Abderyim, Katsuo AIzawa, Keitaro Hitomi, Etsuro Tanaka, Hidezo Mori, Toshiaki Kawai, Akira Ogawa, Kiyomi Takahashi, Shigehiro Sato, Jun Onagawa
  • Journal Title: Jpn J Appl Phys Volume: 49 Pages: 27001-6
  • NAID: 40016982545
  • Peer Reviewed
• [Journal Article] Magnification Embossed Radiography Utilizing Image-Shifting Subtraction Program (2010)
  • Author(s): Akihiro Osawa, Manabu Watanabe, Eiichi Sato, Hiroshi Matsukiyo, Toshiyuki Enomoto, Jiro Nagao, Purkhet Abderyim, Katsuo Aizawa, Etsuro Tanaka, Hidezo Mori, Toshiaki Kawai, Akira Ogawa, Kiyomi Takahashi, Shigehiro Sato, Jun Onagawa
  • Journal Title: Jpn J Appl Phys Volume: 49 Pages: 37001-7
  • NAID: 40017033749
  • Peer Reviewed
• [Journal Article] A trial for fine and low-dose imaging of biological specimens using quasi-monochromatic laser-Compton X-rays (2009)
  • Author(s): K.Yamada, R.Kuroda, H.Toyakawa, H.Ikeura-Sekiguchi, M.Yasumoto, M.Koike, F.Sakai, K.Mori, H.Mori, N.Fukuyama, E.Sato
  • Journal Title: Nuclear Instruments and Methods in Physics Research. A608
  • Peer Reviewed
• [Journal Article] Nitric Oxide Release in Human Aortic Endothelial Cells Mediated by Delivery of Amphiphilic Polysiloxane Nanoparticles to Caveolae (2009)
  • Author(s): T.Nishikawa, N.Iwakiri, Y.Kaneko, A.Taguchi, K.Fukushima, H.Mori, N.Morone, J.Kadokawa
  • Journal Title: Biomacromolecules. 10 Pages: 2074-2085
  • Peer Reviewed
• [Journal Article] Embossed radiography utilizing energy subtraction (2009)
  • Author(s): A.Osawa, M.Watanabe, E.Sato, H.Matsukiyo, T.Enomoto, J.Nagao, P.Abderyim, K.Aizawa, E.Tanaka, H.Mori, T.Kawai, S.Ehara, S.Sato, A.Ogawa, J.Onagawa
  • Journal Title: Radiol Phys Technol. 2 Pages: 77-86
  • Peer Reviewed
• [Journal Article] X-ray fluorescence camera for imaging of iodine media in vivo (2009)
  • Author(s): H.Matsukiyo, M.Watanabe, E.Sato, A.Osawa, T.Enomoto, J.Nagao, P. Abderyim, K.Aizawa, E.Tanaka, H.Mori, T.Kawai, S.Ehara, S.Sato, A.Ogawa, J.Onagawa
  • Journal Title: Radiol Phys Technol. 2 Pages: 46-53
  • Peer Reviewed
• [Journal Article] A trial for fine and low-dose imaging of biological specimens using quasi-monochromatic laser-Compton X-rays (2009)
  • Author(s): K.Yamada, R.Kuroda, H.Toyakawa, H.Ikeura-Sekiguchi, M.Yasumoto, M.Koike, F.Sakai, K.Mori, H.Mori, N.Fukuyama, E.Sato
  • Journal Title: Nuclear Instruments and Methods in Physics Research A608
  • Peer Reviewed
• [Journal Article] Nitric Oxide Release in Human Aortic Endothelial Cells Mediated by Delivery of Amphiphilic Polysiloxane Nanoparticles to Caveolae (2009)
  • Author(s): T.Nishikawa, N.Iwakiri, Y.Kaneko, A.Taguchi, K.Fukushima, H.Mori, N.Morone, J.Kadokawa
  • Journal Title: Biomacromolecules 10 Pages: 2074-2085
  • Peer Reviewed
• [Journal Article] Embossed radiography utilizing energy subtraction (2009)
  • Author(s): A. Osawa, M. Watanabe, E. Sato, H. Matsukiyo, T. Enomoto, J. Nagao, P. Abderyim, K. Aizawa, E. Tanaka, H. Mori, T. Kawai, S. Ehara, S. Sato, A. Ogawa, J. Onagawa
  • Journal Title: Radiol Phys Technol. 2009 ; 2 Pages: 77-86
  • Peer Reviewed
• [Journal Article] X-ray fluorescence camera for imaging of iodine media in vivo (2009)
  • Author(s): H. Matsukiyo, M. Watanabe, E. Sato, A. Osawa, T. Enomoto, J. Nagao, P. Abderyim, K. Aizawa, E. Tanaka, H. Mori, T. Kawai, S. Ehara, S. Sato, A. Ogawa, J, Onagawa
  • Journal Title: Radiol Phys Technol. 2009 ; 2 Pages: 46-53
  • Peer Reviewed
• [Journal Article] Adenosine triphosphate-sensitive potassium channels prevent extension of myocardial ischemia to subepicardium during hemorrhagic shock (2008)
  • Author(s): M.Nakagawa, S.Hori, T.Adachi, K.Miyazaki, S.Inoue, M.Suzuki, H.Mori, H.Nakazawa, N.Aikawa, S.Ogawa
  • Journal Title: Shock. Volume.30(2) Pages: 178-183
  • Peer Reviewed
• [Journal Article] Magnification K-Edge Angiography Utilizing 100-um-Focus Tungsten Tube and Gadolinium-Based Contrast Media (2008)
  • Author(s): Y.Sato, E.Sato, S.Ehara, T.Enomoto, E.Tanaka, H.Mori, T.Kawai, A.Ogawa, S.Sato, J.Onagawa
  • Journal Title: Jpn.J.Appl.Phys. 47(6) Pages: 4772-4776
  • Peer Reviewed
• [Journal Article] X-ray Spectra from a Brass-target Plasma Triode (2008)
  • Author(s): E.Sato, H.Obara, T.Enomoto, E.Tanaka, H.Mori, T.Kawai, T.Ichimaru, A.Ogawa, S.Sato, K.Takayama, J.Onagawa
  • Journal Title: Jpn.J.Med.Phys. Vol.27.No.4 Pages: 163-171
  • NAID: 10024347422
  • Peer Reviewed
• [Journal Article] Quantitative Assessment of Microcollateral Recruitment During Coronary Occlusion Using Real-time Intravenous Myocardial Contrast Echocardiography (2008)
  • Author(s): F.Ishikura, K.Otani, H.Kayano, T.Toshida, A.Iwata, T.Asanuma, M.Kitakaze, Y.Shinozaki, H.Mori, S.Beppu
  • Journal Title: J Am Soc Echocardiogr. 21(2) Pages: 139-45
  • Peer Reviewed
• [Journal Article] Role of Cu,Zn-SOD in the Synthesis of Endogenous Vasodilator Hydrogen Peroxide during Reactive Hyperemia in Mouse Mesenteric Microcirculation in Vivo. (2008)
  • Author(s): T.Yada, H.Shimokawa, K.Morikawa, A.Takaki, Y.Shinozaki, H.Mori, M.Goto, Y.Ogasawara, F.Kajiya
  • Journal Title: Am J Physiol Heart Circ Physiol. 294
  • Peer Reviewed
• [Journal Article] Single Injection of a Sustained-release Prostacyclin Analog Improves Pulmonary Hypertension in Rats. (2008)
  • Author(s): H.Obata, Y.Sakai, S.Ohnishi, S.Takeshita, H.Mori, M.Kodama K.Kangawa, Y.Aizawa, N.Nagaya
  • Journal Title: Am J Respir Crit Care Med. 177 Pages: 195-201
  • Peer Reviewed
• [Journal Article] Magnification K-Edge Angiography Utilizing 100-μm-Focus Tungsten Tube and Gadolinium-Based Contrast Media (2008)
  • Author(s): Y. Sato, E. Sato, S. Ehara, T. Enomoto, E. Tanaka, H. Mori, T. Kawai, A. Ogawa, S. Sato, J. Onagawa
  • Journal Title: Jpn. J. Appl. Phys. 2008 ; 47(6) Pages: 4772-4776
  • Peer Reviewed
• [Journal Article] Therapeutic effects of four molecular-weight fractions of Kurozu against dextran sulfate sodium-induced experimental colitis
  • Author(s): Shizuma T, Nagano M, Fujii A, Mori H, Fukuyama N.
  • Journal Title: Turk.J.Gastroenterol
  • Peer Reviewed
• [Journal Article] Protective effects of fermented rice vinegar sediment (Kurozu moromimatsu) in a diethylnitrosamine-induced hepatocellular carcinoma animal model
  • Author(s): Shizuma T, Ishiwata K, Nagano M, Mori H, Fukuyama N
  • Journal Title: J.Clin.Biochem.Nutr.
  • NAID: 130004879259
  • Peer Reviewed
• [Journal Article] Protective effects of Kurozu and Kurozu moromimatsu on dextran sulfate sodium-induced experimental colitis
  • Author(s): Toru Shizuma ; Kazuo Ishiwata ; Masanobu Nagano ; Hidezo Mori ; Naoto Fukuyama
  • Journal Title: Dig.Dis.Sci.
  • Peer Reviewed
• [Presentation] Visualization of perforating branches of cerebral arteries toward clinical evaluation of vascular disease and Alzheimer's-overlap syndrome (2011)
  • Author(s): H.Mori
  • Organizer: 26th International Conference of Alzheimer's Disease International
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2011-03-27
• [Presentation] Fingertip microangiography using synchrotron radiation toward prediction of diabetic angiopathy (2010)
  • Author(s): H.Mori, T.Fujii, N.Fukuyama, Y.Ikeya, Y.Shinozaki, K.Fukushima, K.Umetani, T.Tanabe
  • Organizer: European Congress of Radiology
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2010-03-04
• [Presentation] グループホームにおける介護法の効果に関する後ろ向き研究 (2010)
  • Author(s): 福山直人、盛英三
  • Organizer: 第52回日本老年医学会学術集会
• [Presentation] 訪問診療の有効性に関する研究 (2010)
  • Author(s): 福山直人、盛英三
  • Organizer: 第52回日本老年医学会学術集会
• [Presentation] 糖尿病早期微小血管障害の検出を目指した放射光指尖細動脈造影法 (2010)
  • Author(s): 福山直人、盛甚三
  • Organizer: 第52回日本老年医学会学術集会
• [Presentation] Acreative care approach to the elderly with cognitive impairment in a group home in Japan (2010)
  • Author(s): H.Mori, N.Fukuyama,Y.Ikeya, T.Fujii, T.Tanabe, K.Hanayama, K.Kimura, M.Hosoya
  • Organizer: 25th International Conference of Alzheimer's Disease International
  • Place of Presentation: Thessaloniki, Macedonia-Greece
• [Presentation] Fingertip microangiography using synchrotron radiation toward prediction of diabetic angiopathy (2010)
  • Author(s): H.Mori, T.Fujii, N.Fukuyama, Y.Ikeya, Y.Shinozaki, K.Fukushima, K.Umetani, T.Tanabe
  • Organizer: European Congress of Radiology
  • Place of Presentation: in Vienna, Austria
• [Presentation] Cardioprotective Effects of Hydrogen Peroxide and Erythropoietin during Acute Coronary Occlusionin Canine Coronary Native Collateral Microvessels in vivo (2010)
  • Author(s): T.Yada, H.Shimokawa, O.Hiramatsu, M.Satoh, N.Kashihara, Y.Shinozaki, H.Mori, A.Takaki, M.Goto, Y.Ogasawara, F.Kajiya
  • Organizer: 第74回日本循環器学会総会・学術集会
• [Presentation] Development of Microangiographic Systems for Visualization, Quantification and Therapeutic Evaluation of Angiogenic Vessels (2009)
  • Author(s): T. Fujii, N. Fukuyama, Y. Ikeya, E. Tanaka, T. Sekka, Y. Shinozaki, K. Yamada, K. Umetani, K. Hyodo, E. Sato, K. Fukushima, T. Tanabe, H. Mori
  • Organizer: 11th International Symposium on Anti-Angiogenic Agents.
  • Place of Presentation: San Diego(United states)
  • Year and Date: 2009-02-05
• [Presentation] Development of Fingertip Microangiography using Synchrotron Radiation to. Determine Fixed Combination in the Treatment of Metabolic Syndrome. (2009)
  • Author(s): H.Mori, T.Fujii, N.Fukuyama, Y.Ikeya, Y.Shinozaki, K.Umetani, T.Tanabe
  • Organizer: The 2 International Conference on Fixed Combination in the Treatment of Hypertension, Dyslipidemia and Diabetes Mellitues
  • Place of Presentation: Valencia, Spain.
• [Presentation] Role of H202 as an Endogenous EDHF during Coronary Occlusion and Injection of Erythropoietin in Canine Coronary Native Collateral Microvessels (2009)
  • Author(s): T.Yada, H.Shimokawa, O.Hiramatsu, Y.Shinozaki, H.Mori, M.Goto, Y.Ogasawara, F.Kajiya
  • Organizer: 第73回日本循環器学会総会・学術集会
• [Presentation] In-hospital Microangiography for Vascular Regeneration Therapy (2009)
  • Author(s): Y.Ikeya, N.Fukuyama, T.Fujii, S.Takeshita, K.Nishigami, Y.Tsutumi, H.Mori
  • Organizer: 第73回日本循環器学会総会・学術集会
• [Presentation] Adipose-Derived Stem Cell Sheet Transplantation Therapy for Failured Heart (2009)
  • Author(s): O.Ishida, I.Hagino, N.Nagaya, T.Shimizu, Y.Sawa, H.Mori, T.Yagihara
  • Organizer: 第73回日本循環器学会総会・学術集会
• [Presentation] 重症心不全に対する脂肪組織由来幹細胞シート移植治療法の開発 (2009)
  • Author(s): 石田治,宮原義典,永谷憲歳,盛英三
  • Organizer: 第8回日本再生医療学会
• [Presentation] Development of Microangiographic Systems for Visualization, Quantification and Therapeutic Evaluation of Angiogenic Vessels (2009)
  • Author(s): T.Fujii, N.Fukuyama, Y.Ikeya, E.Tanaka, T.Sekka, Y.Shinozaki, K.Yamada, K.Umetani, K.Hyodo, E.Sato, K.Fukushima, T.Tanabe, H.Mori
  • Organizer: 11th International Symposium on Anti-Angiogenic Agents.
  • Place of Presentation: San Diego (United States) February
• [Presentation] Adipose-Derived Stem Cell Sheet Transplantation Therapy on Swine Chronic Heart Failure Model (2008)
  • Author(s): O.Ishida, I.Hagino, N.Nagaya, T.Shimizu, Y.Sawa, H.Mori, T.Yagihara
  • Organizer: Scientific Sessions
  • Place of Presentation: American Heart Association
• [Presentation] Crucial Role of Hydrogen Peroxide as an Endogenous EDHF during Acute Coronary Occlusion and Injection of Erythropoietin in Canine Coronary Native Collateral Microcirculation in Vivo (2008)
  • Author(s): T.Yada, H.Shimokawa, O.Hiramatsu, Y.Shinozaki, H.Mori, M.Goto, Y.Ogasawara, F.Kajiya
  • Organizer: Scientific Sessions 2008
  • Place of Presentation: American Heart Association
• [Presentation] Development of advanced quantum-beam sources and their applications as sophisticated imaging tools (2008)
  • Author(s): K.Yamada, R.Kuroda, H.Toyokawa, H.Ikeura-Sekiguchi, M.Yasumoto, N.Sei, H.Ogawa, M.Koike, R.Suzuki, F.Sakai, K.Mori, H.Mori, N.Fukuyama, E.Sato
  • Organizer: Compton Sources for X/gamma Rays : Physics and Applications
  • Place of Presentation: in Italy
• [Presentation] CONTRIBUTIONS OF NANOTECHNOLOGY TO CARDIOVASCULAR REGENERATIVE MEDICINE (2008)
  • Author(s): H.Mori, N.Fukuyama, Y.Ikeya, T.Fujii, N.Nagaya, Y.Miyahara, O.Ishida, S.Takeda
  • Organizer: Fourth Annual Meeting of American Academy of Nanomedicine.
• [Presentation] Cardioprotective Effect of Hydrogen Peroxide and Erythropoietin During Acute Coronary Occlusion in Canine Coronary Native Collateral Microvessel ; in vivo
  • Author(s): T.Yada, H.Shimokawa, O.Hiramatsu, M.Satoh, N.Kashihara, Y.Shinozaki, H.Mori, A.Takaki, M.Goto, H.Nakamoto, Y.Ogasawara, F.Kajiya
  • Place of Presentation: American Heart Association (Orland, Florida)
• [Remarks] ホームページ等