| Project/Area Number |
20390348
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
HIROE Michiaki Research Institute, International Medical Center of Japan, 循環器科, 部長 (80101872)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Sosuke 国立国際医療研究センター(研究所), 戸山病院, 院長 (30118450)
SHIGEMATSU Hiroshi 東京医科大学, 医学部, 教授 (40134556)
OBITSU Yukio 東京医科大学, 医学部, 准教授 (10233610)
YOSHIDA Kyoko 三重大学, 大学院・医学系研究科, 准教授 (00242967)
AOKI Hiroki 久留米大学, 循環器病研究所, 准教授 (60322244)
YOSHIMURA Koichi 山口大学, 医学部, 准教授 (00322248)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2008: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Keywords | 大動脈瘤 / バイオマーカー / 病態生理 / 分子病態 / テネイシンC / C aC 12 / TN-Cノックアウトマウス / アンジオテンシンII / 炎症 / ノックアウトマウス |
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| Research Abstract |
Abdominal aortic aneurysm (AAA) is a fatal disease caused by the segmental weakening and dilation of aorta. In this project we found that tenascin-C (TNC), a matricellular protein, was expressed at the active lesion of AAA and may protect the aortic tissue. We also found that higher level of serum TNC was associated with the better outcome after the endovascular repair of AAA, suggesting that serum TNC level may be an useful biomarker in this context.
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