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脂肪肝グラフト部分肝移植における機能不全の解明と統合的治療法の開発

Research Project

Project/Area Number 20390359
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionThe University of Tokushima

Principal Investigator

SHIMADA Mitsuo  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (10216070)

Co-Investigator(Kenkyū-buntansha) YASUTOMO Koji  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (30333511)
TANAKA Shinji  東京医科歯科大学, 情報処理センター, 科学技術振興特別特認准教授 (30253420)
NAKAMURA Takanori  香川大学, 医学部, 教授 (70183887)
IMURA Satoru  徳島大学, 病院, 助教 (90380021)
MORINE Yuji  徳島大学, 病院, 助教 (60398021)
TAKEDA Eiji  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00144973)
UTSUNOMIYA Toru  徳島大学, 病院, 講師 (30304801)
IKEMOTO Tetsuya  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (20398019)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Keywords肝不全 / 肝移植 / 脂肪肝 / 肝虚血再灌流傷害 / 虚血再潅流傷害 / 大量肝切除術
Research Abstract

The majority of liver transplantation in Japan is living donor liver transplantation. As proportion of metabolic syndrome has recently been increasing, fatty liver of a candidate of donor has become a problem. We developed an animal model of non-alcoholic fatty liver (NAFL) disease, and gave similar surgical insults as liver transplantation, including ischemia-reperfusion injury and massive hepatectomy in the NAFL model. We obtained several novel findings regarding the mechanisms, by which NAFL induced liver functional insufficiency. We also found some possible therapeutic agents and strategies, which may improve the liver dysfunction and may support liver regeneration in these animal models.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (82 results)

All 2011 2010 2009 2008

All Journal Article (57 results) (of which Peer Reviewed: 52 results) Presentation (25 results)

  • [Journal Article] The Impact of Pegylated-Interferon alpha-2b on Partial and Massive Hepatectomy Model in Rats.2011

    • Author(s)
      Mori H, Shimada M
    • Journal Title

      Hepatogastroenterology. (in press).

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of a New Refrigerator for the Preservation of Whole Blood.2011

    • Author(s)
      Kanamoto M, Shimada M
    • Journal Title

      J Surg Res (in press).

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Pegylated Interferon α2b on Metastasis of Hepatocellular Carcinoma.2011

    • Author(s)
      Arakawa Y, Shimada M
    • Journal Title

      J Surg Res (in press).

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial Effects of Follistatin in Hepatic Ischemia-Reperfusion Injuries in Rats.2011

    • Author(s)
      Kanamoto M, Shimada M
    • Journal Title

      Dig Dis Sci 56(4)

      Pages: 1075-1081

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human adipose-derived stem cells : potential clinical applications in surgery.2011

    • Author(s)
      Utsunomiya T, Shimada M
    • Journal Title

      Surg Today 41

      Pages: 18-23

    • NAID

      10027818310

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of dihydropyrimidine dehydrogenase and thymidylate synthase expression in immunohistochemistry of intrahepatic cholangiocarcinoma.2011

    • Author(s)
      Nishi M, Shimada M
    • Journal Title

      Hepatol Res 41

      Pages: 64-70

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial Effects of Follistatin in Hepatic Ischemia-Reperfusion Injuries in Rats.2011

    • Author(s)
      Kanamoto M, et al.
    • Journal Title

      Dig Dis Sci

      Volume: 56

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human adipose-derived stem cells : potential clinical applications in surgery.2011

    • Author(s)
      Utsunomiya T, et al.
    • Journal Title

      Surg Today

      Volume: 41 Pages: 18-23

    • NAID

      10027818310

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD133 expression is a potential prognostic indicator in intrahepatic cholangio-carcinoma.2010

    • Author(s)
      島田光生
    • Journal Title

      J Gastroenterol 45

      Pages: 896-902

    • NAID

      10026611089

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular signatures of noncancerous liver tissue can predict the risk for late recurrence of hepatocellular carcinoma.2010

    • Author(s)
      Utsunomiya T, Shimada M
    • Journal Title

      J Gastroenterol 45

      Pages: 146-152

    • NAID

      10027214321

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch2 signaling is required for potent antitumor immunity in vivo.2010

    • Author(s)
      Sugimoto K, Shimada M
    • Journal Title

      J Immunol 184

      Pages: 4673-4678

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer.2010

    • Author(s)
      Wang EL, Shimada M
    • Journal Title

      Br J Cancer 102

      Pages: 908-915

    • NAID

      120006812023

    • Related Report
      2010 Final Research Report
  • [Journal Article] Impact of splenectomy in patients with liver cirrhosis : Results from 18 patients in a single center experience.2010

    • Author(s)
      Imura S, Shimada M
    • Journal Title

      Hepatol Res 40

      Pages: 894-900

    • NAID

      10026696793

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of long-term late-evening snack on health-related quality of life in cirrhotic patients.2010

    • Author(s)
      Yamanaka-Okumura H, Shimada M
    • Journal Title

      Hepatol Res 40

      Pages: 470-476

    • NAID

      10026391952

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Living donor liver transplantation using a left hepatic graft from a donor with a history of gastric cancer operation.2010

    • Author(s)
      Uchiyama H, Shimada M
    • Journal Title

      Transpl Int 23(2)

      Pages: 234-235

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] New stepwise cooling system for short-term porcine islet preservation.2010

    • Author(s)
      Ikemoto T, Shimada M
    • Journal Title

      Pancreas 39

      Pages: 960-963

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene-expression phenotypes for vascular invasiveness of hepatocellular carcinomas.2010

    • Author(s)
      Tanaka S, Shimada M
    • Journal Title

      Surgery 147

      Pages: 405-414

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor.2010

    • Author(s)
      Alam MS, Shimada M
    • Journal Title

      Proc Natl Acad Sci USA 107(13)

      Pages: 5943-5948

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 性差による肝胆膵疾患の臨床、病態、治療効果のDiscrepancy I.性差と各種肝疾患7)肝移植と性差2010

    • Author(s)
      島田光生, et al.
    • Journal Title

      肝胆膵 60

      Pages: 793-799

    • Related Report
      2010 Final Research Report
  • [Journal Article] 肝移植の画診断-生体ドナーの安全とレシピエントの予後向上をめざして-肝移植後の血栓、血管狭窄の診断と治療2010

    • Author(s)
      島田光生, et al.
    • Journal Title

      肝胆膵画 2(1)

      Pages: 69-78

    • Related Report
      2010 Final Research Report
  • [Journal Article] 肝疾患に対する脾摘・PSEの功罪肝切除と脾臓過小グラフト(Small-for-size-graft)に対する治療戦略門脈循環制御における脾摘の有用性2010

    • Author(s)
      島田光生, et al.
    • Journal Title

      肝胆膵 56

      Pages: 409-419

    • Related Report
      2010 Final Research Report
  • [Journal Article] Impact of splenectomy in patients with liver cirrhosis : Results from 18 patients in a single center experience.2010

    • Author(s)
      Imura S, et al.
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 894-900

    • NAID

      10026696793

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of long-term late-evening snack on health-related quality of life in cirrhotic patients.2010

    • Author(s)
      Yamanaka-Okumura H, et al.
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 470-476

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Living donor liver transplantation using a left hepatic graft from a donor with a history of gastric cancer operation.2010

    • Author(s)
      Uchiyama H, et al
    • Journal Title

      Transpl Int

      Volume: 23 Pages: 234-235

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular signatures of noncancerous liver tissue can predict the risk for late recurrence of hepatocellular carcinoma.2010

    • Author(s)
      Utsunomiya T,.
    • Journal Title

      J Gastroenterol (in press)

    • NAID

      10027214321

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高度進行肝癌に対する外科的アプローチミラノ基準外症例に対する肝移植2009

    • Author(s)
      島田光生, et al.
    • Journal Title

      肝胆膵 59

      Pages: 785-794

    • Related Report
      2010 Final Research Report
  • [Journal Article] Beneficial effects of splenectomy on massive hepatectomy model in rats.2009

    • Author(s)
      Arakawa Y, Shimada M
    • Journal Title

      Hepatol Res 39(4)

      Pages: 391-397

    • NAID

      10025325499

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A simple formula to calculate the liver drainage volume of the accessory right hepatic vein using its diameter alone.2009

    • Author(s)
      Hanaoka J, Shimada M
    • Journal Title

      Surgery 146(2)

      Pages: 264-268

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual hepatic artery reconstruction in living donor liver transplantation using a left hepatic graft with 2 hepatic arterial stumps.2009

    • Author(s)
      Uchiyama H, Shimada M
    • Journal Title

      Surgery 147

      Pages: 878-886

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Real time elastography for noninvasive diagnosis of liver fibrosis.2009

    • Author(s)
      Kanamoto M, Shimada M
    • Journal Title

      J Hepatobiliary Pancreat Surg 16(4)

      Pages: 463-467

    • NAID

      10025139730

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optimal administration of tacrolimus in reduced-size liver.2009

    • Author(s)
      Morine Y, Shimada M
    • Journal Title

      Dig Dis Sci 54(8)

      Pages: 1789-1793

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Geranylgeranylacetone prevents acute liver damage after massive hepatectomy in rats through suppression of a CXC chemokine GR01 and induction of heat shock proteins.2009

    • Author(s)
      Kanemura H, Shimada M
    • Journal Title

      J Gastrointest Surg 13(1)

      Pages: 66-73

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The changes of the medial right lobe, transplanted with left lobe liver graft from living donors.2009

    • Author(s)
      Ikegami T, Shimada M
    • Journal Title

      Transplantation 87(5)

      Pages: 698-703

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Argon gas embolism in the application of laparoscopic microwave coagulation therapy.2009

    • Author(s)
      Ikegami T, Shimada M
    • Journal Title

      J Hepatobiliary Pancreat Surg 16(3)

      Pages: 394-398

    • NAID

      10025139457

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expressions in hepatocellular carcinoma.2009

    • Author(s)
      Nii A, Shimada M
    • Journal Title

      Hepatol Res 39(3)

      Pages: 274-281

    • NAID

      10025324952

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surgical contribution to recurrence-free survival in patients with macrovascular-invasion- negative hepatocellular carcinoma.2009

    • Author(s)
      Tanaka S, Shimada M
    • Journal Title

      J Am Coll Surg 208

      Pages: 368-374

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypocaloric high-protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two pathways.2009

    • Author(s)
      Takeda E.
    • Journal Title

      Am J Physiol Endocrinol Metab 297(1)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The changes of the medial right lobe, transplanted with left lobe liver graft from living donors.2009

    • Author(s)
      Ikegami T.
    • Journal Title

      Transplantation 87(5)

      Pages: 698-703

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal administration of tacrolimus in reduced-size liver.2009

    • Author(s)
      Morine Y,.
    • Journal Title

      Dig Dis Sci 54(8)

      Pages: 1789-1793

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Geranylgeranylacetone Prevents Acute Liver Damage after Massive Hepatectomy in Rats through Suppression of a CXC Chemokine GROland Induction of Heat Shock Proteins2009

    • Author(s)
      Kanemura H.
    • Journal Title

      J Gastrointest Surg 13(1)

      Pages: 66-73

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of splenectomy on massive hepatectomy model inrats.2009

    • Author(s)
      Arakawa.
    • Journal Title

      Hepatol Res 39(4)

      Pages: 391-397

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A simple formula to calculate the liver drainage volume of the accessory right hepatic vein using its diameter alone.2009

    • Author(s)
      Hanaoka J.
    • Journal Title

      Surgery 146(2)

      Pages: 264-268

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-Time Elastography for noninvasive diagnosis of hepatic fibrosis.2009

    • Author(s)
      Kanamoto M, Shimada M, Ikegami T, Imura S, Morine Y, Kanemura H, Arakawa Y, Nii A.
    • Journal Title

      J Hepatobiliary Pancreat Surg 16(4)

      Pages: 463-467

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual hepatic artery reconstruction in living donor liver transplantation using a left lobe graft with two hepatic arteries2009

    • Author(s)
      Uchiyama H.
    • Journal Title

      Surgery (Epub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Living donor liver transplantation using a left hepatic graft from a donor with a history of gastric cancer operation.2009

    • Author(s)
      Uchiyama H
    • Journal Title

      Transpl Int (Epub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous retroperitoneal massive hematoma after living-donor liver transplantation : an unpredictable but critical complication.2008

    • Author(s)
      Imura S, Shimada M
    • Journal Title

      Hepatogastroenterology 55(86-87)

      Pages: 1778-1780

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial use of the round ligament as a patch graft for vena cava reconstruction.2008

    • Author(s)
      Ikegami T, Shimada M
    • Journal Title

      J Hepatobiliary Pancreat Surg 15(6)

      Pages: 581-584

    • NAID

      10023921169

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Current concept of small-for-size grafts in living donor liver transplantation.2008

    • Author(s)
      Ikegami T, Shimada M
    • Journal Title

      Surg Today 38(11)

      Pages: 971-982

    • NAID

      10024428912

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new technique to acquire additional liver volume for left lobe graft in living donor liver transplantation.2008

    • Author(s)
      Imura S, Shimada M
    • Journal Title

      Hepatogastroenterology 55(85)

      Pages: 1206-1210

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The timing of liver transplantation after primary hepatectomy for hepatocellular carcinoma : a special reference to recurrence pattern and Milan criteria.2008

    • Author(s)
      Ikegami T, Shimada M
    • Journal Title

      Transplantation 86(5)

      Pages: 641-646

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent role of splenectomy in chronic hepatic disorders.2008

    • Author(s)
      Ikegami T, Shimada M
    • Journal Title

      Hepatol Res 38(12)

      Pages: 1159-1171

    • NAID

      10023920406

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biliary reconstruction in right lobe living donor liver transplantation.2008

    • Author(s)
      Ikegami T, Shimada M
    • Journal Title

      Hepatol Res 38

      Pages: 1058-1059

    • NAID

      10024304933

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of Dai-kenchu-to (DKT) on human portal blood flow.2008

    • Author(s)
      Ogasawara T, Shimada M
    • Journal Title

      Hepatogastroenterology 55(82-83)

      Pages: 574-577

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of Kampo medicine Inchin-ko-to on liver function and regeneration after hepatectomy in rats.2008

    • Author(s)
      Ogasawara T, Shimada M
    • Journal Title

      Hepatol Res 38

      Pages: 818-824

    • NAID

      10021946043

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Strategies for improving the outcomes of small-for-size grafts in adult-to-adult living-donor liver transplantation.2008

    • Author(s)
      Imura S, Shimada M
    • Journal Title

      J Hepatobiliary Pancreat Surg 15(2)

      Pages: 102-110

    • NAID

      10024155924

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of fluvastatin on liver microcirculation and regeneration after massive hepatectomy in rats.2008

    • Author(s)
      Tokunaga T, Shimada M
    • Journal Title

      Dig Dis Sci 53(11)

      Pages: 2989-2994

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of fluvastatin on massive hepatectomy in rats.2008

    • Author(s)
      Tokunaga T, et al.
    • Journal Title

      Dig Dis Sci 53

      Pages: 2989-2994

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ABO-incompatible living donor liver transplantation for HCV-positive recipients.2010

    • Author(s)
      Shimada M.
    • Organizer
      20^<th> World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists.
    • Place of Presentation
      Cairo
    • Year and Date
      2010-10-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Timing of salvage transplantation after primary hepatectomy for hepatocellular carcinoma : a special reference to recurrence pattern and Up-to-7 criteria.2010

    • Author(s)
      Utsunomiya T, Shimada M, et al.
    • Organizer
      The 9th International Conference of The Asian Clinical Oncology Society.
    • Place of Presentation
      Gifu
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Small for size syndrome in liver transplantation.2010

    • Author(s)
      Shimada M.
    • Organizer
      9^<th> World Congress of the International Hepato-Pancreato-Biliary Association (IHPBA2010).
    • Place of Presentation
      Buenos Aires
    • Year and Date
      2010-04-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Advances in the Liver Cancer Surgery.2010

    • Author(s)
      Shimada M.
    • Organizer
      20^<th> Conference of the Asian Pacific Association for the Study of the Liver (APASL2010)
    • Place of Presentation
      China
    • Year and Date
      2010-03-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Small for size syndrome in liver transplantation.2010

    • Author(s)
      Shimada M
    • Organizer
      20^<th> Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Buenos Aires
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体肝移植レシピエント術後肝障害に対するMEINの有用性2010

    • Author(s)
      山田眞一郎
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      下関
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高圧酸素療法(HBO)の肝preconditioning効果(Microarray解析)2010

    • Author(s)
      齋藤裕
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      下関
    • Related Report
      2010 Annual Research Report
  • [Presentation] ABO-incompatible living donor liver transplantation for HCV-positive recipients.2010

    • Author(s)
      Shimada M
    • Organizer
      World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists.
    • Place of Presentation
      Cairo
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impact of left lobe graft on adult-to-adult living donor liver transplantation.2009

    • Author(s)
      Imura S, Shimada M, et al.
    • Organizer
      19th World Congress of the International Association of Surgeon's Gastroenterologists and Oncologists.
    • Place of Presentation
      Beijing
    • Year and Date
      2009-09-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Pathogenesis-oriented strategy for small-for-size graft in living donor adult liver transplantation.2009

    • Author(s)
      Shimada M.(招待)
    • Organizer
      19th World Congress of the International Association of Surgeon's Gastroenterologists and Oncologists (IASGO2009)
    • Place of Presentation
      中国
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pathogenesis-oriented strategy for small-for-size graft in living donor adult liver transplantation.2009

    • Author(s)
      Shimada M.
    • Organizer
      19th World Congress of the International Association of Surgeon's Gastroenterologists and Oncologists.
    • Place of Presentation
      Beijing
    • Year and Date
      2009-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Congestion of remnant liver after procurement of an extended left lobe graft in live donor.2009

    • Author(s)
      Shimada M.
    • Organizer
      14^<th> Congress of the European Society for Organ Transplantation.
    • Place of Presentation
      Paris
    • Year and Date
      2009-08-31
    • Related Report
      2010 Final Research Report
  • [Presentation] Impact of left lobe graft on adult-to-adult living donor liver transplantation.2009

    • Author(s)
      Imura S, Shimada M, et al.
    • Organizer
      14^<th> Congress of the European Society for Organ Transplantation.
    • Place of Presentation
      Paris
    • Year and Date
      2009-08-31
    • Related Report
      2010 Final Research Report
  • [Presentation] The usefulness of a new refrigerator for preservation of whole blood.2009

    • Author(s)
      Kanamoto M, Shimada M, et al.
    • Organizer
      14^<th> Congress of the European Society for Organ Transplantation.
    • Place of Presentation
      Paris
    • Year and Date
      2009-08-31
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of Kampo medicine 'Dai-kenchu-to' on portal blood flow in living donor liver transplant recipients.2009

    • Author(s)
      Kawata Y, Shimada M, et al.
    • Organizer
      14^<th> Congress of the European Society for Organ Transplantation.
    • Place of Presentation
      Paris
    • Year and Date
      2009-08-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Congestion of remnant liver after procurement of an extended left lobe graft in live donor.2009

    • Author(s)
      Shimada M.
    • Organizer
      14^<th> Congress of the European Society for Organ Transplantation (ESOT2009)
    • Place of Presentation
      パリ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Severe NAFL model ratにおける虚血再灌流障害に対するMHN-02の効果2009

    • Author(s)
      新居章
    • Organizer
      第109回 日本外科学会定期学術集会
    • Place of Presentation
      福岡国際会議場(福岡市東区馬出)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Our strategies for breaking the barrier of blood type incompatibility in living donor liver transplantation.2008

    • Author(s)
      Uchiyama H, Shimada M, et al.
    • Organizer
      18th World Congress of the IASGO.
    • Place of Presentation
      Istanbul
    • Year and Date
      2008-10-11
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット肝温虚血再潅流傷害モデルに対する濃厚流動食MHN-02の有用性2008

    • Author(s)
      花岡 潤, 他
    • Organizer
      第45回日本外科代謝栄養学会
    • Place of Presentation
      仙台
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Serial change of nutritional and metabolic status in Living donor liver transplant recipients.2008

    • Author(s)
      Shimada M.
    • Organizer
      International liver transplantation society.
    • Place of Presentation
      Paris
    • Year and Date
      2008-07-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of MHN-02 on ischemia-reperfusion injury in murine nonalcoholic fatty liver2008

    • Author(s)
      Nii A, et al.
    • Organizer
      International liver transplantation society 14^<th> Annual International Congress
    • Place of Presentation
      Paris, France
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肝虚血再潅流傷害に対するFollistatin/Activin systemに関する検討2008

    • Author(s)
      西 正暁, 他
    • Organizer
      第26回日本肝移植研究会
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] NASH model ratにおける虚血再潅流傷害に対するMHN-02の効果2008

    • Author(s)
      新居 章, 他
    • Organizer
      第44回日本肝癌研究会
    • Place of Presentation
      大阪
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of mhn-02 on ischemia-reperfusion injury in rat liver.2008

    • Author(s)
      Hanaoka J, Shimada M, et al.
    • Organizer
      Digestive Disease Week.
    • Place of Presentation
      San Diego
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 肝虚血再潅流傷害に対するfollistatinの保護効果に関する研究2008

    • Author(s)
      金本 真美, 他
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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