Identification of Risk Factors Related to Poor Angiogenic Potential of Bone Marrow Cells from Different Patients

• Project/Area Number: 20390370
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Yamaguchi University
• Principal Investigator: HAMANO Kimikazu Yamaguchi University, 大学院・医学系研究科, 教授 (60263787)
• Co-Investigator(Kenkyū-buntansha): HARADA Noriaki 山口大学, 大学院・医学系研究科, 教授 (70116747) ; MIKAMO Akihito 山口大学, 医学部・附属病院, 講師 (30372709)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: 骨髄細胞 / 血管再生 / 治療効果 / 細胞移植 / 再生医療 / 加齢 / 腎不全 / 貧血

Research Abstract

The implantation of autologous bone marrow cells has been used for the ischemic diseases. However, the outcomes of cell therapy obviously vary among patients. In this study, we have identified the risk factors related to poor angiogenic potential of bone marrow cells and developed a new scoring system to predict their angiogenic potential for the treatment of ischemic diseases.

Research Products

• [Journal Article] Impaired angiogenic potency of bone marrow cells from patients with advanced age, anemia, and renal failure. (2010)
  • Author(s): Li TS, Kubo M, Ueda K, Murakami M, Mikamo A, Hamano K.
  • Journal Title: J Thorac Cardiovasc Surg. 139(2) Pages: 459-465
  • Peer Reviewed
• [Journal Article] Impaired angiogenic potency of bone marrow cells from patients with advanced age, anemia, and renal failure (2010)
  • Author(s): Tao-Sheng Li
  • Journal Title: The Journal of Thoracic and Cardiovascular Surgery Volume: 139(2) Pages: 459-465
  • Peer Reviewed
• [Journal Article] Identification of risk factors related to poor angiogenic potency of bone marrow cells from different patients. (2009)
  • Author(s): Li TS, Kubo M, Ueda K, Murakami M, Ohshima M, Kobayashi T, Tanaka T, Shirasawa B, Mikamo A, Hamano K.
  • Journal Title: Circulation. 120(11 Suppl)
  • Peer Reviewed
• [Journal Article] Ischemic pre-conditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/reperfusion injury in the late phase. (2009)
  • Author(s): Kamota T, Li TS, Morikage N, Murakami M, Ohshima M, Kubo M, Kobayashi T, Mikamo A, Ikeda Y, Matsuzaki M, Hamano K.
  • Journal Title: J Am Coll Cardiol. 53(19) Pages: 1814-1822
  • Peer Reviewed
• [Journal Article] Identification of risk factors related to poor angiogenic prtency of bone marrow cells from different patients (2009)
  • Author(s): Tao-Sheng Li
  • Journal Title: Circulation 120
  • Peer Reviewed
• [Journal Article] Impaired angiogenic potency of bone marrow cells from patients with advanced age, anemia, and renal failure (2009)
  • Author(s): Tao-Sheng Li
  • Journal Title: The Journal of Thoracic and Cardiovascular Surgery 139 Pages: 459-465
  • Peer Reviewed
• [Journal Article] Ischemic pre-conditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/reperfusion injury in the late phase (2009)
  • Author(s): Takahiro Kamota
  • Journal Title: Journal of the American College of Cardiology 53 Pages: 1814-1822
  • Peer Reviewed
• [Journal Article] Transient increase of cytokines in the acute ischemic tissue is beneficial to cell-based therapeutic angiogenesis. (2008)
  • Author(s): Qin SL, Li TS, Kubo M, Ohshima M, Furutani A, Hamano K.
  • Journal Title: Circ J. 72(12) Pages: 2075-2080
  • NAID: 110006987367
  • Peer Reviewed
• [Journal Article] Myocardial repair achieved by the intramyocardial implantation of adult cardiomyocytes in combination with bone marrow cells. (2008)
  • Author(s): Li TS, Takahashi M, Ohshima M, Qin SL, Kubo M, Muramatsu K, Hamano K.
  • Journal Title: Cell Transplant. 17(6) Pages: 695-703
  • Peer Reviewed
• [Journal Article] Myocardial repair achieved by the intramyocardial implantation of adult cardiomyocytes in combination with bone marrow cells (2008)
  • Author(s): Tao-Sheng Li, et al
  • Journal Title: Cell Transplantation 17 Pages: 695-703
  • Peer Reviewed
• [Journal Article] Transient increase of cytokines in the acute ischemic tissue is beneficial to cell-based therapeutic angiogenesis (2008)
  • Author(s): Shu-Lan Qin, et al
  • Journal Title: Circulation Journal 72 Pages: 2075-2080
  • Peer Reviewed
• [Presentation] 心血管再生治療の現状と展望 (2009)
  • Author(s): 濱野公一
  • Organizer: 第21回北海道MMC研究会
  • Place of Presentation: 札幌、京王プラザホテル札幌
  • Year and Date: 2009-11-28
• [Presentation] 心血管再生治療の現状と展望 (2009)
  • Author(s): 濱野公一
  • Organizer: 第21回北海道MMC研究会
  • Place of Presentation: 札幌
  • Year and Date: 2009-11-28
• [Presentation] Identification of risk factors related to poor angiogenic potency of bone marrow cells from different patients. (2008)
  • Author(s): Li TS, Kubo M, Ueda K, Murakami M, Ohshima M, Kobayashi T, Tanaka T, Shirasawa B, Mikamo A, Hamano K
  • Organizer: American Heart Association 2008 Scientific Sessions
  • Place of Presentation: New Orleans, Ernest N.Morial Convention Center, USA
  • Year and Date: 2008-11-11
• [Presentation] Identification of risk factors related to poor angiogenic potency of bone marrow cells from different patients (2008)
  • Author(s): Tao-Sheng Li, et al
  • Organizer: American Heart Association Scientific Sessions 2008
  • Place of Presentation: New Orleans (U. S. A. )
  • Year and Date: 2008-11-11
• [Book] 虚血性心疾患に対する心血管再生治療の現状と未来(「びまん性冠動脈病変の臨床-基本的病態理解から治療の選択・実際」) (2010)
  • Author(s): 久保正幸, 李桃生, 濱野公一
  • Publisher: メジカルビュー社
• [Book] 虚血性心疾患に対する心血管再生治療の現状と未来「びまん性冠動脈病変の臨床-基本的病態理解から治療の選択・実際」 (2010)
  • Author(s): 久保正幸
  • Publisher: メジカルビュー社