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Elucidation of the immunological escape mechanisms and its application for cancer immunotherapy

Research Project

Project/Area Number 20390375
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

YASUMOTO Kosei  University of Occupational and Environmental Health, Japan, 医学部, 名誉教授 (30150452)

Co-Investigator(Kenkyū-buntansha) HANAGIRI Takeshi  産業医科大学, 医学部, 准教授 (30299614)
TAKENOYAMA Mitsuhiro  産業医科大学, 医学部, 非常勤医師 (10309966)
BABA Tetsuro  産業医科大学, 医学部, 助教 (10506348)
SHIGEMATSU Yoshiki  産業医科大学, 医学部, 助教 (10546469)
ICHIKI Yoshinobu  産業医科大学, 医学部, 助教 (80419837)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords肺癌 / 腫瘍抗原 / 免疫逃避 / 制御性T細胞 / HLA / TCR
Research Abstract

It is the important issue to resolve immunological escape mechanisms for the establishment of effective immunotherapies in cancer patients. Regulatory T cells accumulated in draining lymph nodes and the tumor tissue in lung cancer patients. Depletion of regulatory T cells resulted in the successful induction of CTL in vitro. By restoration of HLA class I expression on tumor cells, we could identify the antigen that may be associated with immunoediting. Finally, to solve the difficulties in the induction of CTL in immunosuppresive cancer patients, we succeeded in the generation of gd cells specific for tumor cell in vitro and in vivo by transducing the engineered T cell receptor specific for tumor antigen.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (118 results)

All 2011 2010 2009 2008

All Journal Article (42 results) (of which Peer Reviewed: 34 results) Presentation (76 results)

  • [Journal Article] Overexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrence2011

    • Author(s)
      Shimokawa H
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a lung cancer antigen evading CTL attack due to loss of human leukocyte antigen (HLA) class I expression.2010

    • Author(s)
      Baba T, Hanagiri T, Takenoyama M, Shiota H, Shigematsu Y, Ichiki Y, Uramoto H, So T, Yasumoto K
    • Journal Title

      Cancer Sci 101

      Pages: 2115-2120

    • NAID

      10027832080

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor antigens and serological biomarkers for the diagnosis of asbestos-related malignancies.2010

    • Author(s)
      Yasuda M, Hanagiri T, Takenoyama M, Yasumoto K
    • Journal Title

      Curr Res in Cancer 4

      Pages: 39-40

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 悪性胸膜中皮腫の治療経験2010

    • Author(s)
      浦本秀隆,下川秀彦,馬場哲郎,重松義紀,永田好香,小野憲司,竹之山光広,花桐武志
    • Journal Title

      J UOEH 32

      Pages: 257-264

    • NAID

      110007700771

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between HLA alleles and EGFR mutation in Japanese patients with adenocarcinoma of the lung.2010

    • Author(s)
      Uramoto H, So T, Nagata Y, Kuroda K, Shigematsu Y, Baba T, So T, Takenoyama M, Hanagiri T, Yasumoto K
    • Journal Title

      J Thorac Oncol 5

      Pages: 1136-1142

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a tumour associated antigen in lung cancer patients with asbestos exposure.2010

    • Author(s)
      Yasuda M, Hanagiri T, Shigematsu Y, Onitsuka T, Kuroda K, Baba T, Mizukami M, Ichiki Y, Uramoto H, Takenoyama M, Yasumoto K
    • Journal Title

      Anticancer Res 30

      Pages: 2631-2639

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of cancer/testis antigens expression in patients with non-small cell lung cancer.2010

    • Author(s)
      Shigematsu Y, Hanagiri T, Shiota H, Kuroda K, Baba T, Mizukami M, So T, Ichiki Y, Yasuda M, So T, Takenoyama M, Yasumoto K
    • Journal Title

      Lung Cancer 68

      Pages: 105-110

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma.2010

    • Author(s)
      Kuroda K, Takenoyama M, Baba T, Shigematsu Y, Shiota H, Ichiki Y, Yasuda M, Uramoto H, Hanagiri T, Yasumoto K
    • Journal Title

      Cancer Sci 101

      Pages: 46-53

    • NAID

      10027199379

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acquired resistance to gefitinib : the contribution of mechanisms other than the T790M, MET, and HGF status2010

    • Author(s)
      Onitsuka T
    • Journal Title

      Lung Cancer

      Volume: 68 Pages: 198-203

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive Molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte grctor status2010

    • Author(s)
      Onitsuka T
    • Journal Title

      J Thorac Oncol

      Volume: 5 Pages: 591-596

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Results of surgical resection for patients with large cell carcinoma of the lung2010

    • Author(s)
      Hanagiri T
    • Journal Title

      Int J Surg

      Volume: 8 Pages: 391-394

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a tumour associated antigen in lung cancer patients with asbestos exposure2010

    • Author(s)
      Yasuda M
    • Journal Title

      Anticancer Res

      Volume: 30 Pages: 2631-2639

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between HLA alleles and EGFR mutation in Japanese patients with adenocarcinoma of the lung2010

    • Author(s)
      Uramoto H
    • Journal Title

      J Thorac Oncol

      Volume: 5 Pages: 1136-1142

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 悪性胸膜中皮腫の治療経験2010

    • Author(s)
      浦本秀隆
    • Journal Title

      JUOEH

      Volume: 32 Pages: 257-264

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor antigens and serological biomarkers for the diagnosis of asbestos-related malignancies2010

    • Author(s)
      Yasuda M
    • Journal Title

      Curr Res in Cancer

      Volume: 4 Pages: 39-40

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a lung cancer antigen evading CTL attack due to loss of human leukocyte antigen (HLA) class I expression2010

    • Author(s)
      Baba T
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 2115-2120

    • NAID

      10027832080

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of PTEN expression by blocking nuclear translocation of EGR1 in Gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-acttivating mutations2010

    • Author(s)
      Yamamoto C
    • Journal Title

      Cancer Res

      Pages: 8715-8725

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between lymphangiogenesis-/micrometastasis- and adhesion-related molecules in resected stage I NSCLC2010

    • Author(s)
      Yamashita T
    • Journal Title

      Lung Cancer

      Volume: 70 Pages: 320-328

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquired resistance to gefitinib : The contribution of mechanisms other than the T790M, MET, and HGF status2010

    • Author(s)
      Onitsuka T.
    • Journal Title

      Lung Cancer (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma2010

    • Author(s)
      Kuroda K.
    • Journal Title

      Cancer Sci 101

      Pages: 46-53

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of cancer/testis antigens expression in patients with non-small cell lung cancer2010

    • Author(s)
      Shigematsu Y.
    • Journal Title

      Lung Cancer 68

      Pages: 105-110

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 癌免疫療法-最近の話題から-2009

    • Author(s)
      花桐武志,竹之山光広,安元公正
    • Journal Title

      Biotherapy 23

      Pages: 401-407

    • Related Report
      2010 Final Research Report
  • [Journal Article] Malignant mesothelioma-associated antigens recognized by tumor-infiltrating B cells and the clinical significance of the antibody titers.2009

    • Author(s)
      Shigematsu Y, Hanagiri T, Kuroda K, Baba T, Mizukami M, Ichiki Y, Yasuda M, Takenoyama M, Sugio K, Yasumoto K
    • Journal Title

      Cancer Sci 100

      Pages: 1326-1334

    • NAID

      10027192525

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of HLA class I alleles on postoperative prognosis of lung cancer patients in Japan.2009

    • Author(s)
      Nagata Y, Hanagiri T, Mizukami M, Kuroda K, Shigematsu Y, Baba T, Ichiki Y, Yasuda M, So T, Takenoyama M, Sugio K, Nagashima A, Yasumoto K
    • Journal Title

      Lung Cancer 65

      Pages: 91-97

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肺癌の免疫療法の現況と展望2009

    • Author(s)
      花桐武志,竹之山光広,安元公正
    • Journal Title

      呼吸器科 15

      Pages: 132-138

    • Related Report
      2010 Final Research Report
  • [Journal Article] 選択的ワクチン療法:非特異的免疫療法からの脱出?:現状と展望MAGE抗原を用いた免疫療法の可能性2009

    • Author(s)
      花桐武志,杉尾賢二,安元公正
    • Journal Title

      Oncology 6

      Pages: 72-80

    • Related Report
      2010 Final Research Report
  • [Journal Article] Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung.2009

    • Author(s)
      Nose N, Sugio K, Oyama T, Nozoe T, Uramoto H, Iwata T, Onitsuka T, Yasumoto K
    • Journal Title

      J Clin Oncol 27

      Pages: 411-417

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Current status and perspectives on immunotherapy for lung cancer.2009

    • Author(s)
      花桐武志, 竹之山光広, 安元公正
    • Journal Title

      Curr.Res.in Cancer 3

      Pages: 75-87

    • Related Report
      2010 Final Research Report
  • [Journal Article] Current status and perspectives on immunotherapy for lung cancer2009

    • Author(s)
      Hanagiri T.
    • Journal Title

      Curr Res in Cancer 3

      Pages: 75-87

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Expression of aromatase CYP19 and its relationship with parameters in NSCLC.2009

    • Author(s)
      Oyama T.
    • Journal Title

      Front Biosci 14

      Pages: 2285-2292

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung2009

    • Author(s)
      Nose N.
    • Journal Title

      J Clin Oncol 27

      Pages: 411-417

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 選択的ワクチン療法:非特異的免疫療法からの脱出?:現状と展望MAGE抗原を用いた免疫療法の可能性2009

    • Author(s)
      花桐武志
    • Journal Title

      Oncology 6

      Pages: 72-80

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 肺癌の免疫療法の現況と展望2009

    • Author(s)
      花桐武志
    • Journal Title

      呼吸器科 15

      Pages: 132-138

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Clinical significance of HLA class I alleles on postoperative prognosis of lung cancer patients in Japan2009

    • Author(s)
      Nagata Y.
    • Journal Title

      Lung Cancer 65

      Pages: 91-97

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Malignant mesothelioma-associated antigens recognized by tumor-infiltrating B cells and the clinical significance of the antibody titers2009

    • Author(s)
      Shigematsu Y.
    • Journal Title

      Cancer Sci 100

      Pages: 1326-1334

    • NAID

      10027192525

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discrimination of multiple primary lung cancers from intrapulmonary metastasis based on the expression of four cancer-related proteins2009

    • Author(s)
      Ono K.
    • Journal Title

      Cancer 115

      Pages: 3489-3500

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 癌免疫療法-最近の話題から-2009

    • Author(s)
      花桐武志
    • Journal Title

      Biotherapy 23

      Pages: 401-407

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Association Between Estrogen Receptor-{beta} Expression and Epidermal Growth Factor Receptor Mutation in the Postoperative Prognosis of Adenocarcinoma of the Lung2009

    • Author(s)
      Nose N
    • Journal Title

      J Clin Oncol 27(3)

      Pages: 411-417

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] clinical significance of HLA class I alleles on postoperative prognosis of lung cancer patients in Japan2009

    • Author(s)
      Nagata Y
    • Journal Title

      Lung Cancer (inpress)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospective phase II study of gefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations2009

    • Author(s)
      Sugio K
    • Journal Title

      Lung Cancer (inpress)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of Smoking as a Postoperative Prognostic Factor in Patients with Non-small Cell Lung Cancer.2008

    • Author(s)
      Hanagiri T, Sugio K, Mizukami M, Ichiki Y, Sugaya M, Yasuda M, Takenoyama M, Yasumoto K
    • Journal Title

      J Thorac Oncol 3

      Pages: 1127-1132

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of Smoking as a Postoperative Prognostic Factor in Patients with Non-small Cell Lung Cancer2008

    • Author(s)
      Hanagiri, T
    • Journal Title

      J Thorac Oncol 3(10)

      Pages: 1127-1132

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 悪性胸膜中皮腫に対する腫瘍特異的免疫応答の解析2010

    • Author(s)
      竹之山光広
    • Organizer
      第28回産業医科大学学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2010-10-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 悪性胸膜中皮腫に対する腫瘍特異的免疫応答の解析2010

    • Author(s)
      竹之山光広
    • Organizer
      第28回産業医科大学学会総会
    • Place of Presentation
      産業医科大学(北九州市)
    • Year and Date
      2010-10-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食道癌におけるHLA classI分子の発現に関する検討2010

    • Author(s)
      小野憲司,花桐武志,永田好香,下川秀彦,重松義紀,馬場哲郎,浦本秀隆,竹之山光広,安元公正
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] Diagnostic markers for malignatn pleural mesothelinoma : Serum antibody against antigens recognized by antibodies produced from tumor infiltraring B cells.2010

    • Author(s)
      Shigematsu Y, Kuroda K, Baba T, Ichiki Y, Ono K, Yasuda M, Uramoto H, So T, Takenoyama M, Hanagiri T, Yasumoto K
    • Organizer
      The 10th International Conferenceoftne International Mesothelinoma Interest Group
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] T細胞受容体移入γδT細胞による養子免疫療法への応用2010

    • Author(s)
      重松義紀,黒田耕志,馬場哲郎,永田好香,下川秀彦,小野憲司,浦本秀隆,竹之山光広,花桐武志,安元公正
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      熊本
    • Related Report
      2010 Final Research Report
  • [Presentation] T細胞受容体移入γδT細胞による治療効果の検討2010

    • Author(s)
      重松義紀,塩田広宣,黒田耕志,馬場哲郎,宗哲哉,小野憲司,浦本秀隆,宗知子,竹之山光広,花桐武志,安元公正
    • Organizer
      第31回癌免疫外科研究会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 局所進行期乳癌に対する術後補助療法としてのHER2蛋白ワクチンの検討2010

    • Author(s)
      黒田耕志,竹之山光広,馬場哲郎,重松義紀,宗哲哉,市来嘉伸,小野憲司,安田学,菅谷将一,浦本秀隆,宗知子,花桐武志,安元公正
    • Organizer
      第31回癌免疫外科研究会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 悪性胸膜中皮腫関連抗原の同定と機能解析2010

    • Author(s)
      重松義紀,黒田耕志,馬場哲郎,宗哲哉,安田学,小野憲司,浦本秀隆,宗知子,竹之山光広,花桐武志,安元公正
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台
    • Related Report
      2010 Final Research Report
  • [Presentation] 肺癌に高発現する新規腫瘍抗原ribosomal protein L19の機能解析2010

    • Author(s)
      黒田耕志,竹之山光広,塩田広宣,馬場哲郎,重松義紀,宗哲哉,水上真紀子,市来嘉伸,小野憲司,安田学,菅谷将一,浦本秀隆,宗知子,花桐武志,安元公正
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台
    • Related Report
      2010 Final Research Report
  • [Presentation] 癌精巣抗原KK-LC-1を認識するT細胞受容体移入γδT細胞を用いた養子免疫療法への応用2010

    • Author(s)
      重松義紀,塩田広宣,黒田耕志,馬場哲郎,宗哲哉,小野憲司,浦本秀隆,宗知子,竹之山光広,花桐武志,安元公正
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] 癌精巣抗原KK-LC-1を認識するT細胞受容体移入γδT細胞を用いた養子免疫療法への応用2010

    • Author(s)
      重松義紀
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺腺癌手術、及びEGFR-TKI投与症例における感受性、耐性に関する分子の包括的解析と臨床的意義2010

    • Author(s)
      浦本秀隆
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺腺癌におけるMACC1遺伝子増幅は術後再発を予測する2010

    • Author(s)
      下川秀彦
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺癌に高発現する新規腫瘍抗原ribosomal protein L19の機能解析2010

    • Author(s)
      黒田耕志
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 悪性胸膜中皮腫関連抗原の同定と機能解析2010

    • Author(s)
      重松義紀
    • Organizer
      第27回日本呼吸器外科学会総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 進行期乳癌に対する術後補助療法としてのHER2蛋白ワクチンの検討2010

    • Author(s)
      黒田耕志
    • Organizer
      第31回癌免疫外科研究会
    • Place of Presentation
      ホテルニューオータニ大阪(大阪市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] T細胞受容体移入vδT細胞による治療効果の検討2010

    • Author(s)
      重松義紀
    • Organizer
      第31回癌免疫外科研究会
    • Place of Presentation
      ホテルニューオータニ大阪(大阪市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] T細胞受容体移入vδT細胞による養子免疫療法への応用2010

    • Author(s)
      重松義紀
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      KKRホテル熊本(熊本市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Epithelial-mesenchymal transition status and EGFR mutation on EGFR-TKI-resistant lung adenocarcinoma2010

    • Author(s)
      Uramoto H
    • Organizer
      9th International Conference of The Asian Clinical Oncology Society
    • Place of Presentation
      岐阜グランドホテル(岐阜市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Diagnostic markers for malignant pleural mesothelioma : Serum antibody against antigens recognized by antibodies produced from tumor in filtraring B cells2010

    • Author(s)
      Shigematsu Y
    • Organizer
      The 10th International Conference of the International Mesothelioma Interest Group
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食道癌におけるToposomeraselの発現に関する検討2010

    • Author(s)
      小野憲司
    • Organizer
      第64回日本食道学会学術集会
    • Place of Presentation
      石橋文化ホール(久留米市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト非小細胞肺癌のゲフィチニブ耐性獲得におけるPTEN欠失とその制御メカニズム2010

    • Author(s)
      山本千鶴子
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      リーガロイヤルホテル大阪(大阪市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食道癌におけるHLA class I分子の発現に関する検討2010

    • Author(s)
      小野憲司
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      国立京都国際会議場(京都市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腫瘍抗原特異的T細胞受容体(TCR)遺伝子移入による抗腫瘍エフェクター細胞の誘導(第2報)2009

    • Author(s)
      竹之山光広,重松義紀,塩田広宣,黒田耕志,馬場哲郎,市来嘉伸,花桐武志,安元公正
    • Organizer
      第62回日本呼吸器学会・日本結核病学会九州支部春季学術講演会
    • Place of Presentation
      那覇
    • Year and Date
      2009-05-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 腫瘍抗原特異的T細胞受容体(TCR)遺伝子移入による抗腫瘍エフェクター細胞の誘導(第2報)2009

    • Author(s)
      竹之山光広
    • Organizer
      第62回 日本呼吸器学会・日本結核病学会九州支部春季学術講演会
    • Place of Presentation
      沖縄県男女共同参画センター(那覇市)
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] T細胞受容体移入γδT細胞を用いた特異的癌免疫療法の開発2009

    • Author(s)
      重松義紀,塩田広宣,黒田耕志,馬場哲郎,宗哲哉,小野憲司,浦本秀隆,宗知子,竹之山光広,花桐武志,安元公正
    • Organizer
      第63回日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規腫瘍抗原Ribosomal protein L19の発現と機能の解明2009

    • Author(s)
      黒田耕志,竹之山光広,宗知子,塩田広宣,馬場哲郎,重松義紀,永田好香,宗哲哉,市来嘉伸,安田学,小野憲司,浦本秀隆,花桐武志,安元公正
    • Organizer
      第63回日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] 腫瘍浸潤B細胞にて同定した悪性中皮腫関連抗原とその抗体価の臨床的意義2009

    • Author(s)
      重松義紀,黒田耕志,馬場哲郎,宗哲哉,小野憲司,浦本秀隆,宗知子,竹之山光広,花桐武志,安元公正
    • Organizer
      第63回日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] 肺癌における細胞障害性T細胞が認識する腫瘍抗原の同定2009

    • Author(s)
      竹之山光広,花桐武志,宗知子,安田学,市来嘉伸,宗哲哉,永田好香,馬場哲郎,重松義紀,黒田耕志,小野憲司,浦本秀隆,安元公正
    • Organizer
      第62回日本胸部外科学会定期学術集会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Immunotherapy for Lung Cancer.2009

    • Author(s)
      安元公正
    • Organizer
      11th Meeting of Chinese Lung Cancer
    • Place of Presentation
      Tianjin, China
    • Related Report
      2010 Final Research Report
  • [Presentation] Diagnostic Markers for Malignant Pleural Mesothelioma : Serum Antibody against Antigens Recognized by Antibodies Produced from Tumor Infiltrating B cells.2009

    • Author(s)
      重松義紀, 安元公正
    • Organizer
      2009 4th China Medicai Biotech Forum
    • Place of Presentation
      Dalian, China
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification of Tumor Associated Antigens Recognized by CTL in Patients with Lung Cancer.2009

    • Author(s)
      安元公正
    • Organizer
      2009 4thChina Medicai Biotech
    • Place of Presentation
      Forum Dailian, China
    • Related Report
      2010 Final Research Report
  • [Presentation] The identification of tumor antigens associated with asbestos-related lung cancer.2009

    • Author(s)
      Hanagiri T, Yasuda M, Kuroda K, Shigematsu Y, Baba T, So T, Ono K, Uramoto H, So T, Takenoyama M, Yasumoto K
    • Organizer
      13th World Conferenceon Lung Cancer
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 進行乳癌に対する術後アジュバンドとしてのCHP-HER2ワクチンと免疫学的モニタリング2009

    • Author(s)
      馬場哲郎,黒田耕志,重松義紀,永田好香,宗哲哉,市来嘉伸,宗知子,竹之山光広,花桐武志,安元公正
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] 石綿関連肺癌に対する液性免疫応答の解析2009

    • Author(s)
      安田学,花桐武志,黒田耕志,鬼塚貴光,重松義紀,馬場哲郎,永田好香,宗哲哉,小野憲司,浦本秀隆,宗知子,竹之山光広,安元公正
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] HLA発現異常を有する肺癌に対する腫瘍特異的Tリンパ球の解析2009

    • Author(s)
      黒田耕志,竹之山光広,馬場哲郎,重松義紀,宗哲哉,市来嘉伸,小野憲司,安田学,浦本秀隆,宗知子,花桐武志,安元公正
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] T細胞受容体移入γδT細胞を用いた特異的癌免疫療法の開発2009

    • Author(s)
      重松義紀,塩田広宣,黒田耕志,馬場哲郎,宗哲哉,市来嘉伸,小野憲司,浦本秀隆,宗知子,竹之山光広,花桐武志,安元公正
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] 肺癌における免疫標的の探索と治療への応用2009

    • Author(s)
      安元公正
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] HLA class I発現陰性肺癌細胞に対する腫瘍特異的細胞性免疫応答の解析2009

    • Author(s)
      黒田耕志,馬場哲郎,竹之山光広,重松義紀,宗哲哉,市来嘉伸,安田学,宗知子,花桐武志,杉尾賢二,安元公正
    • Organizer
      第30回癌免疫外科研究会
    • Place of Presentation
      久留米
    • Related Report
      2010 Final Research Report
  • [Presentation] 非小細胞肺癌におけるHLA発現と免疫応答の解析2009

    • Author(s)
      黒田耕志,塩田広宣,重松義紀,馬場哲郎,水上真紀子,市来嘉伸,安田学,大賀丈史,竹之山光広,花桐武志,杉尾賢二,安元公正
    • Organizer
      第26回日本呼吸器外科学会総会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] 肺癌患者の腫瘍特異的免疫応答の解析と免疫療法の構築2009

    • Author(s)
      竹之山光広
    • Organizer
      第26回日本呼吸器外科学会総会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] 悪性胸膜中皮腫における腫瘍抗原の同定と新規腫瘍マーカーとしての意義2009

    • Author(s)
      重松義紀,塩田広宣,黒田耕志,馬場哲郎,永田好香,水上真紀子,市来嘉伸,安田学,竹之山光広,花桐武志,杉尾賢二,安元公正
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report
  • [Presentation] 悪性胸膜中皮腫における腫瘍抗原の同定と新規腫瘍マーカーとしての意義2009

    • Author(s)
      重松義紀
    • Organizer
      第109回 日本外科学会定期学術集会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺癌患者の腫瘍特異的免疫応答の解析と免疫療法の構築2009

    • Author(s)
      竹之山光広
    • Organizer
      第26回 日本呼吸器外科学会総会
    • Place of Presentation
      西日本総合展示場,他(北九州市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 非小細胞肺癌におけるHLA発現と免疫応答の解析2009

    • Author(s)
      黒田耕志
    • Organizer
      第26回 日本呼吸器外科学会総会
    • Place of Presentation
      西日本総合展示場,他(北九州市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺癌に対する新規抗体療法の開発2009

    • Author(s)
      安田学
    • Organizer
      第26回 日本呼吸器外科学会総会
    • Place of Presentation
      西日本総合展示場,他(北九州市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] T細胞受容体移入γδT細胞を用いた特異的癌免疫療法の開発2009

    • Author(s)
      重松義紀
    • Organizer
      第30回 癌免疫外科研究会
    • Place of Presentation
      萃香園ホテル(久留米市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] HLA class I発現陰性肺癌細胞に対する腫瘍特異的細胞性免疫応答の解析2009

    • Author(s)
      黒田耕志
    • Organizer
      第30回 癌免疫外科研究会
    • Place of Presentation
      萃香園ホテル(久留米市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺癌における免疫標的の探索と治療への応用2009

    • Author(s)
      安元公正
    • Organizer
      第13回 日本がん免疫学会総会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] T細胞受容体移入γδT細胞を用いた特異的癌免疫療法の開発2009

    • Author(s)
      重松義紀
    • Organizer
      第13回 日本がん免疫学会総会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] HLA発現異常を有する肺癌に対する腫瘍特異的Tリンパ球の解析2009

    • Author(s)
      黒田耕志
    • Organizer
      第13回 日本がん免疫学会総会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 石綿関連肺癌に対する液性免疫応答の解析2009

    • Author(s)
      安田学
    • Organizer
      第13回 日本がん免疫学会総会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 進行乳癌に対する術後アジュバンドとしてのCHP-HER2ワクチンと免疫学的モニタリング2009

    • Author(s)
      馬場哲郎
    • Organizer
      第13回 日本がん免疫学会総会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 進行乳癌に対する術後アジュバントとしてのCHP-HER2ワクチン2009

    • Author(s)
      花桐武志
    • Organizer
      第17回 日本乳癌学会学術総会
    • Place of Presentation
      ホテル日航東京(東京都)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺腺癌患者におけるMET、EGFR、K-ras分子機構の解析2009

    • Author(s)
      鬼塚貴光
    • Organizer
      第42回 日本胸部外科学会九州地方会総会
    • Place of Presentation
      iichiko総合文化センター(大分市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] The identification of tumor antigens associated with asbestos-related lung cancer2009

    • Author(s)
      Hanagiri T.
    • Organizer
      13th World Conference on Lung Cancer
    • Place of Presentation
      The Moscone Center (San Francisco, USA)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of Tumor Associated Antigens Recognized by CTL in Patients with Lung Cancer2009

    • Author(s)
      Yasumoto K.
    • Organizer
      2009 4th China Medicai Biotech Forum
    • Place of Presentation
      Dalian World Expo Center (Dalian, China)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Diagnostic Markers for Malignant Pleural Mesothelioma : Serum Antibody against Antigens Recognized by Antibodies Produced from Tumor Infiltrating B cells2009

    • Author(s)
      Shigematsu Y.
    • Organizer
      2009 4th China Medicai Biotech Forum
    • Place of Presentation
      Dalian World Expo Center (Dalian, China)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Immunotherapy for Lung Cancer2009

    • Author(s)
      Yasumoto K.
    • Organizer
      11th Meeting of Chinese Lung Cancer
    • Place of Presentation
      Wanli Taida Hotel (Tianjin, China)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺癌における細胞障害性T細胞が認識する腫瘍抗原の同定2009

    • Author(s)
      竹之山光広
    • Organizer
      第62回日本胸部外科学会定期学術集会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腫瘍浸潤B細胞にて同定した悪性中皮腫関連抗原とその抗体価の臨床的意義2009

    • Author(s)
      重松義紀
    • Organizer
      第63回 日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺腺癌における増殖シグナル分子の解析:HGF, MET, EGFR, K-ras2009

    • Author(s)
      鬼塚貴光
    • Organizer
      第63回 日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規腫瘍抗原Ribosomal protein L19の発現と機能の解明2009

    • Author(s)
      黒田耕志
    • Organizer
      第63回 日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] T細胞受容体移入γδT細胞を用いた特異的癌免疫療法の開発2009

    • Author(s)
      重松義紀
    • Organizer
      第63回 日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 石綿関連肺癌に対する腫瘍抗原の探索と診断及び治療への応用(第2報)2008

    • Author(s)
      安田学
    • Organizer
      第26回産業医科大学学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肺癌におけるHLA class I分子の発現と細胞性免疫応答2008

    • Author(s)
      黒田耕志,竹之山光広,馬場哲郎,塩田広宣,重松義紀,水上真紀子,市来嘉伸,花桐武志,杉尾賢二,安元公正
    • Organizer
      第21回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 腫瘍の免疫逃避機構の解明とその克服2008

    • Author(s)
      花桐武志,重松義紀,黒田耕志,馬場哲郎,市来嘉伸,浦本秀隆,大賀丈史,竹之山光広,杉尾賢二,安元公正
    • Organizer
      第21回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] HLA class I発現を欠失した肺癌症例での新規癌関連抗原の同定2008

    • Author(s)
      馬場哲郎,塩田広宣,黒田耕志,重松義紀,水上真紀子,市来嘉伸,竹之山光広,花桐武志,杉尾賢二,安元公正
    • Organizer
      第49回日本肺癌学会総会
    • Place of Presentation
      北九州
    • Related Report
      2010 Final Research Report
  • [Presentation] 自己肺癌特異的CTL誘導における制御性T細胞の影響2008

    • Author(s)
      重松義紀,塩田広宣,黒田耕志,馬場哲郎,永田好香,水上真紀子,市来嘉伸,安田学,竹之山光広,花桐武志,杉尾賢二,安元公正
    • Organizer
      第12回基盤的癌免疫研究会総会
    • Place of Presentation
      さいたま
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 発現回復させたHLA class I分子に提示される新規肺癌抗原の同定2008

    • Author(s)
      馬場哲郎,塩田広宣,黒田耕志,重松義紀,水上真紀子,市来嘉伸,安田学,竹之山光広,花桐武志,杉尾賢二,安元公正
    • Organizer
      第48回日本呼吸器学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 肺癌所属リンパ節における制御性Tリンパ球の発現と機能解析2008

    • Author(s)
      重松義紀,塩田広宣,黒田耕志,馬場哲郎,水上真紀子,市来嘉伸,安田学,竹之山光広,花桐武志,杉尾賢二,安元公正
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Immune evasion of lung cancer cells by loss of expression of HLA class I.2008

    • Author(s)
      安元公正, 花桐武志, 竹之山光広, 馬場哲郎
    • Organizer
      1st European Lung Cancer Conference Geneva
    • Place of Presentation
      Switzerland
    • Related Report
      2010 Final Research Report
  • [Presentation] Immune evasion of lung cancer cells by loss of expression of HLA class I2008

    • Author(s)
      Yasumoto, K
    • Organizer
      Ist European Lung Cancer Conference
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肺癌所属リンパ節における制御性Tリンパ球のCTL誘導への影響2008

    • Author(s)
      重松義紀
    • Organizer
      第29回癌免疫外科研究会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] HLA classI発現を欠失した肺癌症例での新規癌関連抗原の同定2008

    • Author(s)
      馬場哲郎
    • Organizer
      第49回日本肺癌学会総会
    • Place of Presentation
      北九州
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肺癌におけるHLA class I 分子の発現と細胞性免疫応答2008

    • Author(s)
      黒田耕志
    • Organizer
      第21回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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