| Project/Area Number |
20390375
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
YASUMOTO Kosei University of Occupational and Environmental Health, Japan, 医学部, 名誉教授 (30150452)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HANAGIRI Takeshi 産業医科大学, 医学部, 准教授 (30299614)
TAKENOYAMA Mitsuhiro 産業医科大学, 医学部, 非常勤医師 (10309966)
BABA Tetsuro 産業医科大学, 医学部, 助教 (10506348)
SHIGEMATSU Yoshiki 産業医科大学, 医学部, 助教 (10546469)
ICHIKI Yoshinobu 産業医科大学, 医学部, 助教 (80419837)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
|
|---|
| Keywords | 肺癌 / 腫瘍抗原 / 免疫逃避 / 制御性T細胞 / HLA / TCR |
|---|
| Research Abstract |
It is the important issue to resolve immunological escape mechanisms for the establishment of effective immunotherapies in cancer patients. Regulatory T cells accumulated in draining lymph nodes and the tumor tissue in lung cancer patients. Depletion of regulatory T cells resulted in the successful induction of CTL in vitro. By restoration of HLA class I expression on tumor cells, we could identify the antigen that may be associated with immunoediting. Finally, to solve the difficulties in the induction of CTL in immunosuppresive cancer patients, we succeeded in the generation of gd cells specific for tumor cell in vitro and in vivo by transducing the engineered T cell receptor specific for tumor antigen.
|
