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Investigation of the immunotherapy targeting WT1 combined with chemotherapy against newly diagnosed malignant glioma.

Research Project

Project/Area Number 20390384
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionHyogo College of Medicine

Principal Investigator

IZUMOTO Shuichi  Hyogo College of Medicine, 医学部, 准教授 (40324769)

Co-Investigator(Kenkyū-buntansha) TSUBOI Akihiro  大阪大学, 医学系研究科, 寄附講座准教授 (10372608)
HASHIMOTO Naoya  大阪大学, 医学系研究科, 准教授 (90315945)
KINOSHITA Manabu  大阪大学, 医学系研究科, 助教 (40448064)
MORI Kanji  兵庫医科大学, 医学部, 講師 (50360269)
YUSUKE Tomogane  兵庫医科大学, 医学部, 助教 (10412008)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords悪性神経膠腫 / 膠芽腫 / WT1 / 免疫療法 / がんワクチン療法 / 悪性グリオーマ
Research Abstract

The safety and clinical responses of immunotherapy targeting the WT1 combined with chemotherapy against the patients with newly diagnosed malignant glioma were investigated. (1) The frequency of WT1-specific cytotoxic T lymphocytes in blood was increased from 0.196% to 0.256% during the combined treatment of TMZ/RT for 6 weeks. The frequency of Treg cells was increased from 4.8% to 7.5% during the combined treatment of TMZ/RT for 6 weeks, but the cell count was not changed. (2) "Phase I clinical trial of WT1 immunotherapy combined with temozolomide chemotherapy against the patients with newly diagnosed malignant glioma" was performed and was safe. (3) Expression of IFN-γand IL-10 from WT1-specific CD4+ helper T cells were investigated by RT-PCR. In patients who responded, a clear inverse correlation between IL-10-type and IFN-gamma-type WT1(332)-specific Th response was detected at pre- and 4 weeks post-vaccination. (4) Based on these results, WT1 immunotherapy combined with TMZ chemotherapy was safe and produced a immune-response.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (109 results)

All 2011 2010 2009 2008

All Journal Article (80 results) (of which Peer Reviewed: 77 results) Presentation (22 results) Book (7 results)

  • [Journal Article] Quantification of Cerebral Artery Motion during the Cardiac Cycle.2011

    • Author(s)
      Nishida T, Kinoshita M, Yoshimine T
    • Journal Title

      AJNR Am J Neuroradiol (Epub ahead of print)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of Tumor Volume Related to Peritumoral Edema in Intracranial Meningioma Treated with Extreme Hypofractionated Stereotactic Radiation Therapy in Three to Five Fractions.2011

    • Author(s)
      Morimoto M, Yoshioka Y, Hashimoto N
    • Journal Title

      Jpn J Clin Oncol 41

      Pages: 609-619

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of Tumor Volume Related to Peritumoral Edema in Intracranial Meningioma Treated with Extreme Hypofractionated Stereotactic Radiation Therapy in Three to Five Fractions.2011

    • Author(s)
      Morimoto M
    • Journal Title

      Jpn J Clin Oncol

      Volume: (Epub ahead)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A survey of disclosure of diagnosis to patients with glioma in Japan.2010

    • Author(s)
      Yamamoto F, Hashimoto N, Kinoshita M
    • Journal Title

      Int J Clin Oncol (Epub ahead of print)

    • NAID

      10029526965

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A clear correlation between WT1-specific Th response and clinical response in WT1 CTL epitope vaccination.2010

    • Author(s)
      Fujiki F, Tsuboi A, Izumoto S
    • Journal Title

      Anticancer Res 30

      Pages: 2247-2254

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] WT1 peptide vaccine induces reduction in minimal residual disease in an Imatinib-treated CML patient.2010

    • Author(s)
      Oji Y, Tsuboi A, Sugiyama H
    • Journal Title

      Eur J Haematol 85

      Pages: 358-360

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] High frequencies of less differentiated and more proliferative WT1-specific CD8+ T cells in bone marrow in tumor-bearing patients : an important role of bone marrow as a secondary lymphoid organ.2010

    • Author(s)
      Murao A, Oka Y, Tsuboi A
    • Journal Title

      Cancer Sci 101

      Pages: 848-854

    • NAID

      10026590478

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biased usage of BV gene families of T-cell receptors of WT1 (Wilms' tumor gene)-specific CD8+ T cells in patients with myeloid malignancies.2010

    • Author(s)
      Tanaka-Harada Y, Tsuboi A, Sugiyama H
    • Journal Title

      Cancer Sci 101

      Pages: 594-600

    • NAID

      10026589035

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Posttransplant lymphoproliferative disorders of the central nervous system after kidney transplantation : single center experience over 40 years. Two case reports.2010

    • Author(s)
      Arita H, Izumoto S, Kinoshita M, Hashimoto N
    • Journal Title

      Neurol Med Chir (Tokyo) 50

      Pages: 1079-1083

    • NAID

      10027123832

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A rare case of a simultaneously detected suprasellar and intramedullary spinal cord germinoma.2010

    • Author(s)
      Rabo CS, Hashimoto N, Kinoshita M
    • Journal Title

      Brain Tumor Pathol 27

      Pages: 117-120

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of WT1 protein expression level and MIB-1 staining index as predictor of response to WT1 immunotherapy in glioblastoma patients.2010

    • Author(s)
      Chiba Y, Hashimoto N, Tsuboi A
    • Journal Title

      Brain Tumor Pathol 27

      Pages: 29-34

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of concomitant temozolomide and radiation therapies on WT1-specific T-cells in malignant glioma.2010

    • Author(s)
      Chiba Y, Hashimoto N, Tsuboi A
    • Journal Title

      Jpn J Clin Oncol 40

      Pages: 395-403

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] MR molecular imaging of HER-2 in a murine tumor xenograft by SPIO labeling of anti-HER-2 affibody.2010

    • Author(s)
      Kinoshita M, Hashimoto N, Yoshimine T
    • Journal Title

      Contrast Media Mol Imaging 5

      Pages: 18-22

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistological profiling by B-cell differentiation status of primary central nervous system lymphoma treated by high-dose methotrexate chemotherapy.2010

    • Author(s)
      Kinoshita M, Hashimoto N, Izumoto S
    • Journal Title

      J Neurooncol 99

      Pages: 95-101

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] (11)C-methionine uptake correlates with tumor cell density rather than with microvessel density in glioma : A stereotactic image-histology comparison.2010

    • Author(s)
      Okita Y, Kinoshita M, Hashimoto N
    • Journal Title

      Neuroimage 49

      Pages: 2977-2982

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A surgically treated case of Lhermitte-Duclos disease with a precise natural history and high uptake of FDG on PET.2010

    • Author(s)
      Goto Y, Hashimoto N, Kinoshita M
    • Journal Title

      J Neurooncol 97

      Pages: 445-450

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion tensor-based tumor infiltration index cannot discriminate vasogenic edema from tumor-infiltrated edema.2010

    • Author(s)
      Kinoshita, Hashimoto N, Yoshimine T
    • Journal Title

      J Neurooncol 96

      Pages: 409-415

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sensitive immunohistochemical detection of WT1 protein in tumors with anti-WT1 antibody against WT1 235 peptide.2010

    • Author(s)
      Ichinohasama R, Tsuboi A, Sugiyama H
    • Journal Title

      Cancer Sci 10

      Pages: 1089-1092

    • NAID

      10026591723

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical study of multiple inflammatory pseudotumors with both brain and spinal cord involvement : A case report and review of literature.2010

    • Author(s)
      Ishihara M, Izumoto S, Yoshimine T
    • Journal Title

      Neurol Med Chir (Tokyo) 50

      Pages: 246-250

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳神経外科治療のスタンダード14.下垂体腺腫の治療:最近の話題2010

    • Author(s)
      泉本修一、有田憲生
    • Journal Title

      脳神経外科 38

      Pages: 79-89

    • Related Report
      2010 Final Research Report
  • [Journal Article] 悪性脳腫瘍治療におけるWT1免疫療法の可能性2010

    • Author(s)
      泉本修一
    • Journal Title

      兵医大医会誌 33

      Pages: 71-76

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A clear correlation between WT1-specific Th response and clinical response in WT1 CTL epitope vaccination.2010

    • Author(s)
      Fujiki F
    • Journal Title

      Anticancer Res

      Volume: 30(6) Pages: 2247-2254

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] WT1 peptide vaccine induces reduction in minimal residual disease in an Imatinib-treated CML patient2010

    • Author(s)
      Oji Y
    • Journal Title

      Eur J Haematol

      Volume: 85(4) Pages: 358-360

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High frequencies of less differentiated and more proliferative WT1-specific CD8+ T cells in bone marrow in tumor-bearing patients : an important role of bone marrow as a secondary lymphoid organ.2010

    • Author(s)
      Murao A
    • Journal Title

      Cancer Sci

      Volume: 101(4) Pages: 848-854

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biased usage of BV gene families of T-cell receptors of WT1 (Wilms' tumorgene)-specific CD8+ T cells in patients with myeloid malignancies.2010

    • Author(s)
      Tanaka-Harada Y
    • Journal Title

      Cancer Sci

      Volume: 101(3) Pages: 594-600

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Posttransplant lymphoproliferative disorders of the central nervous system after kidney transplantation : single center experience over 40 years. Two case reports.2010

    • Author(s)
      Arita H
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 50(12) Pages: 1079-83

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of WT1 protein expression level and MIB-1 staining indexas predictor of response to WT1 immunotherapy in glioblastoma patients.2010

    • Author(s)
      Chiba Y
    • Journal Title

      Brain Tumor Pathol

      Volume: 27(1) Pages: 29-34

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of concomitant temozolomide and radiation therapies on WT1-specific T-cells in malignant glioma.2010

    • Author(s)
      Chiba Y
    • Journal Title

      Jpn J Clin Oncol

      Volume: 40(5) Pages: 395-403

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MR molecular imaging of HER-2 in a murine tumor xenograft by SPIO labeling of anti-HER-2 affibody.2010

    • Author(s)
      Kinoshita M
    • Journal Title

      Contrast Media Mol Imaging

      Volume: 5(1) Pages: 18-22

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistological profiling by B-cell differentiation status of primarycentral nervous system lymphoma treated by high-dose methotrexate chemotherapy.2010

    • Author(s)
      Kinoshita M
    • Journal Title

      J Neurooncol

      Volume: 99(1) Pages: 95-101

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (11)C-methionine uptake correlates with tumor cell density rather than with microvessel density in glioma : A stereotactic image-histology comparison.2010

    • Author(s)
      Okita Y
    • Journal Title

      Neuroimage

      Volume: 49(4) Pages: 2977-2982

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion tensor-based tumor infiltration index cannot discriminate vasogenic edema from tumor-infiltrated edema.2010

    • Author(s)
      Kinoshita M
    • Journal Title

      J Neurooncol

      Volume: 96(3) Pages: 409-415

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical study of multiple inflammatory pseudotumors with both brain and spinal cord involvement : A case report and review of literature.2010

    • Author(s)
      Ishihara M
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 50(3) Pages: 246-250

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistological profiling of high-dose methotrexate chemotherapy treated primary centralnervous system lymphoma by B-cell differentiation status.2010

    • Author(s)
      Kinoshita M
    • Journal Title

      J Neurooncol

      Volume: 1 Pages: 95-101

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 悪性脳腫瘍治療におけるWT1免疫療法の可能性2010

    • Author(s)
      泉本修一
    • Journal Title

      兵医大医会誌(Acta Med.Hyogo.)

      Volume: 33(1) Pages: 71-76

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical study of multiple inflammatory pseudotumors with both brain and spinal cord involvement.2010

    • Author(s)
      Ishihara M
    • Journal Title

      Neurol Med Chir(Tokyo) 50

      Pages: 246-250

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MR molecular imaging of HER-2 in a murine tumor xenograft by SPIO labeling of anti-HER-2 affibody.2010

    • Author(s)
      Kinoshita M
    • Journal Title

      Contrast Media Mol Imaging 5

      Pages: 18-22

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-methionine uptake correlates with tumor cell density rather than with microvessel density in glioma : A stereotactic image-histology comparison.2010

    • Author(s)
      Okita Y
    • Journal Title

      Neuroimage 49

      Pages: 2977-2982

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffusion tensor-based tumor infiltration index cannot discriminate vasogenic edema from tumor-infiltrated edema.2010

    • Author(s)
      Kinoshita M
    • Journal Title

      J Neurooncol 96

      Pages: 409-415

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serial volumetric assessment of the natural history and growth pattern of incidentally discovered meningiomas.2009

    • Author(s)
      Hashiba T, Hashimoto N, Izumoto S
    • Journal Title

      J Neurosurgery 110

      Pages: 675-684

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wilms' tumor 1 (WT1) peptide immunotherapy for gynecological malignancy.2009

    • Author(s)
      Ohno S, Tsuboi A, Sugiyama H
    • Journal Title

      Anticancer Res 29

      Pages: 4779-4784

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] WT1 peptide vaccine as a paradigm for "cancer antigen-derived peptide"-based immunotherapy for malignancies : successful induction of anti-cancer effect by vaccination with a single kind of WT1 peptide.2009

    • Author(s)
      Oka Y, Tsuboi A, Sugiyama H
    • Journal Title

      Anticancer Agents Med Chem

      Pages: 787-97

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] WT1 peptide vaccination for the treatment of hematological malignancies : the present status and future direction.2009

    • Author(s)
      Oka Y, Tsuboi A, Sugiyama H
    • Journal Title

      Rinsho Ketsueki 50

      Pages: 352-7

    • NAID

      10024959811

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] WT1 IgG antibody for early detection of nonsmall cell lung cancer and as its prognostic factor.2009

    • Author(s)
      Oji Y, Tsuboi A, Sugiyama H
    • Journal Title

      Int J Cancer 125

      Pages: 381-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of eukaryotic elongation factor eEF2 in gastrointestinal cancers and its involvement in G2/M progression in the cell cycle.2009

    • Author(s)
      Nakamura J, Tsuboi A, Sugiyama H
    • Journal Title

      Int J Oncol 34

      Pages: 1181-1189

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] WT1 (Wilms tumor 1) peptide immunotherapy for childhood rhabdomyosarcoma : a case report.2009

    • Author(s)
      Ohta H, Tsuboi A, Murao A
    • Journal Title

      Pediatr Hematol Oncol 26

      Pages: 74-83

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of fractional anisotropy for determination of the cut-off value in 11C-methionine positron emission tomography for glioma.2009

    • Author(s)
      Kinoshita M, Hashimoto N, Goto T
    • Journal Title

      Neuroimage 45

      Pages: 312-318

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serial volumetric assessment of the natural history and growth pattern of incidentally discovered meningiomas.2009

    • Author(s)
      Hashiba T, Hashimoto N, Izumoto S
    • Journal Title

      J Neurosurg 110

      Pages: 675-84

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] WT1遺伝子産物を標的とする脳腫瘍の免疫療法:特集:脳腫瘍研究の最前線-遺伝子解析から治療までー2009

    • Author(s)
      橋本直哉、坪井昭博、泉本修一
    • Journal Title

      脳と神経 61

      Pages: 805-814

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gliomaの免疫療法-WT1ペプチドワクチン療法を中心に2009

    • Author(s)
      泉本修一
    • Journal Title

      脳神経外科速報 19

      Pages: 170-177

    • Related Report
      2010 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gliomaの免疫療法-WTIペプチドワクチン療法を中心に2009

    • Author(s)
      泉本修一
    • Journal Title

      脳神経外科速報 19

      Pages: 170-177

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 脳腫瘍研究の最前線-遺伝子解析から治療まで-WT1遺伝子産物を標的とする脳腫瘍の免疫療法2009

    • Author(s)
      橋本直哉
    • Journal Title

      61

      Pages: 805-814

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Serial volumetric assessment of the natural history and growth pattern of incidentally discovered meningiomas.2009

    • Author(s)
      Hashiba T
    • Journal Title

      J Neurosurgery 110

      Pages: 675-684

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wilms' tumor 1(WT1)peptide immunotherapy for gynecological malignancy.2009

    • Author(s)
      Ohno S
    • Journal Title

      Anticancer Res 29

      Pages: 4779-4784

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] WT1 peptide vaccine as a paradigm for "cancer antigen-derived peptide"-based immunotherapy for malignancies : successful induction of anti-cancer effect by vaccination with a single kind of WT1 peptide.2009

    • Author(s)
      Oka Y
    • Journal Title

      Anticancer Agents Med Chem 9

      Pages: 787-797

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] WT1 IgG antibody for early detection of nonsmall cell lung cancer and as its prognostic factor.2009

    • Author(s)
      Oji Y
    • Journal Title

      Int J Cancer 125

      Pages: 381-387

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of eukaryotic elongation factor eEF2 in gastrointestinal cancers and its involvement in G2/M progression in the cell cycle.2009

    • Author(s)
      Nakamura J
    • Journal Title

      Int J Oncol 34

      Pages: 1181-1189

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] WT1(Wilms tumor 1)peptide immunotherapy for childhood rhabdomyosarcoma : a case report.2009

    • Author(s)
      Ohta H
    • Journal Title

      Pediatr Hematol Oncol 26

      Pages: 74-83

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of fractional anisotropy for determination of the cut-off value in 11C-methionine positron emission tomography for glioma.2009

    • Author(s)
      Kinoshita M
    • Journal Title

      Neuroimage 45

      Pages: 312-318

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase II clinical trial of Wilms tumor 1 peptide vaccination for patients with recurrent glioblastoma multiforme.2008

    • Author(s)
      Izumoto S, Tsuboi A, Oka Y
    • Journal Title

      J Neurosurg. 108

      Pages: 963-71

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fractional anisotropy and tumor cell density of the tumor core show positive correlation in diffusion tensor magnetic resonance imaging of malignant brain tumors.2008

    • Author(s)
      Kinoshita M, Hashimoto N, Kishima H, Izumoto S
    • Journal Title

      Neuroimage 43

      Pages: 29-35

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical analysis of adhesion molecules and matrix metalloproteinases in malignant CNS lymphomas : a study comparing primary CNS malignant and CNS intravascular lymphomas.2008

    • Author(s)
      Kinoshita M, Izumoto S, Hashimoto N, Kishima H
    • Journal Title

      Brain Tumor Pathol 25

      Pages: 73-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A multicenter phase I trial of interfero-β and temozolomide combination therapy for high-grade gliomas (INTEGRA Study).2008

    • Author(s)
      Wakabayashi T, Kayama T, Hashimoto N
    • Journal Title

      Jpn J Clin Oncol 38

      Pages: 715-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A WT1 protein-derived, naturally processed 16-mer peptide, WT1(332), is a promiscuous helper peptide for induction of WT1-specific Th1-type CD4(+) T cells.2008

    • Author(s)
      Fujiki F, Oka Y, Kawakatsu M, Tsuboi A
    • Journal Title

      Microbiol Immunol 52

      Pages: 591-600

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a WT1 protein-derived peptide, WT1, as a HLA-A 0206-restricted, WT1-specific CTL epitope.2008

    • Author(s)
      Li Z, Oka Y, Tsuboi A
    • Journal Title

      Microbiol Immunol 52

      Pages: 551-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cancer antigen WT1 protein-derived peptide-based treatment of cancer-toward the further development.2008

    • Author(s)
      Oka Y, Tsuboi A, Fujiki F
    • Journal Title

      Curr Med Chem 15

      Pages: 3052-61

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] WT1 peptide vaccine for the treatment of cancer.2008

    • Author(s)
      Oka Y, Tsuboi A
    • Journal Title

      Curr Opin Immunol 20

      Pages: 211-20

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wilms' tumor gene WT1-shRNA as a potent apoptosis-inducing agent for solid tumors.2008

    • Author(s)
      Tatsumi N, Oji Y, Tsuboi A
    • Journal Title

      Int J Oncol 32

      Pages: 701-711

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] グリオーマに対する最新の免疫療法;Current orgqn topis:脳腫瘍-グリオーマ2008

    • Author(s)
      泉本修一
    • Journal Title

      癌と化学療法 35

      Pages: 926-930

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phase II clinical trial of Wilms tumor 1 peptide vaccination for patients with recurrent glioblastoma multiforme.2008

    • Author(s)
      Izumoto, S
    • Journal Title

      J Neurosurg 108

      Pages: 963-971

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fractional anisotropy and tumor cell density of the tumor core show positive correlation in diffusion tensor magnetic resonance imaging of malignant brain tumors.2008

    • Author(s)
      Kinoshita, M
    • Journal Title

      Neuroimage 43

      Pages: 29-35

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistocheraical analysis of adhesion molecules and matrix metalloproteinases in malignant CNS lymphomas : a study comparing primary CNS malignant and CNS intravascular lymphomas.2008

    • Author(s)
      Kinoshita, M
    • Journal Title

      Brain Tumor Pathol. 25

      Pages: 73-78

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serial volumetric assessment of the natural history and growth pattern of incidentally discovered meningiomas.2008

    • Author(s)
      Hashiba, T
    • Journal Title

      J Neurosurg 110

      Pages: 675-684

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A multicenter phase I trial of interferon-beta and temozolomide combination therapy for high-grade gliomas. (INTEGRA Study)2008

    • Author(s)
      Wakabayashi, T
    • Journal Title

      Jpn J Clin Oncol 383

      Pages: 715-718

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A WT1 protein-derived, naturally processed 16-mer peptide, WT1 (332), is a promiscuous hecper peptide for induction of wt1-specific Th1-type CD4 (+) T cells.2008

    • Author(s)
      Fujiki, F
    • Journal Title

      Microbiol Immunol 52

      Pages: 591-600

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a WT1 protein-derived peptide, WT1, as a HLA-A 0206-restricted, WT1-specific CTL epitope.2008

    • Author(s)
      Li, Z
    • Journal Title

      Microbiol Immunol 52

      Pages: 551-558

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer antigen WT1 protein-derived peptide"-based treatment of cancer-toward the further development2008

    • Author(s)
      Oka Y
    • Journal Title

      Curr Med Chem 15

      Pages: 3052-5061

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] WT1 peptide vaccine for the treatment of cancer.2008

    • Author(s)
      Oka Y
    • Journal Title

      Curr Opin Immunol 20

      Pages: 211-220

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wilms' tumor gene WT1-shRNA as a potent apoptosis-inducing agent for solid tumors2008

    • Author(s)
      Tatsumi N
    • Journal Title

      Int J Oncol 32

      Pages: 701-711

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] グリオーマに対する最新の免疫療法 ; Current organ topis : 脳腫瘍-グリオーマ2008

    • Author(s)
      泉本修一
    • Journal Title

      癌と化学療法 35

      Pages: 926-930

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 再発成人CNS PNETに対するWT1免疫療法の試み2010

    • Author(s)
      泉本修一
    • Organizer
      第28回日本脳腫瘍学会学術集会
    • Place of Presentation
      軽井沢
    • Year and Date
      2010-11-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 再発成人CNS PNETに対するWT1免疫療法の試み2010

    • Author(s)
      泉本修一
    • Organizer
      第28回日本脳腫瘍学会学術集会
    • Place of Presentation
      軽井沢、長野
    • Year and Date
      2010-11-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 髄膜腫における高次脳機能障害-とくに高齢者における特徴2010

    • Author(s)
      泉本修一
    • Organizer
      (シンポジウム)第69回日本脳神経外科学会総会シンポジウム19.
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 悪性脳腫瘍に対するWT1免疫療法の試み2010

    • Author(s)
      泉本修一
    • Organizer
      第37回岡山脳研究セミナー・第2回生態制御科学専攻セミナー合同シンポジウム
    • Place of Presentation
      岡山大学セミナー室岡山
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 悪性脳腫瘍に対するWT1免疫療法の試み2010

    • Author(s)
      泉本修一
    • Organizer
      第37回岡山脳研究セミナー・第2回生態制御科学専攻セミナー合同シンポジウム特別講演
    • Place of Presentation
      岡山大学セミナー室 岡山
    • Year and Date
      2010-10-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 髄膜腫における術前術後高次脳機能障害の検討2010

    • Author(s)
      泉本修一
    • Organizer
      第15回日本脳腫瘍の外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Clinical and immunological evaluation of WT1(Wilms tumor gene 1) peptide vaccination for patients with recurrent or refractory malignant brain tumors.2010

    • Author(s)
      泉本修一
    • Organizer
      18th International Conference on Brain Tumor Research and Therapy
    • Place of Presentation
      Travemunnde, Germany
    • Related Report
      2010 Final Research Report
  • [Presentation] Clinical and immunological evaluation of WT1 (Wilms tumor gene 1) peptide vaccination for patients with recurrent or refractory malignant brain tumors.2010

    • Author(s)
      Izumoto S
    • Organizer
      18^<th> International Conference on Brain Tumor Research and Therapy
    • Place of Presentation
      Travemunnde, Germany
    • Related Report
      2010 Annual Research Report
  • [Presentation] 成人CNS PNETと幼児期PNETとの臨床病理学的相違とIDH1遺伝子変異2009

    • Author(s)
      泉本修一
    • Organizer
      第27回日本脳腫瘍学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] グリオーマにおけるWT1遺伝子産物を標的とした免疫療法の新たな展開2009

    • Author(s)
      橋本直哉
    • Organizer
      第68回日本脳神経外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] WT1 immunotherapy for malignant gliomas.2009

    • Author(s)
      Hashimoto N
    • Organizer
      The 4th International Conference on WT1 in Human Neoplasia
    • Place of Presentation
      大阪・日本
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Phase II clinical trial of WTI vaccination against recurrent glioblastoma with analyses of WT1 specific cytotoxic T lymphocytes.2009

    • Author(s)
      Hashimoto N
    • Organizer
      The 3rd Quadrennial Meeting of the World Feduration of Neuro-Oncology Jointly
    • Place of Presentation
      横浜・日本
    • Year and Date
      2009-05-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 悪性リンパ腫に対するHD-MTX療法の長期治療成績と問題点-多施設共同臨床研究から2008

    • Author(s)
      泉本修一
    • Organizer
      第26回日本脳腫瘍学会
    • Place of Presentation
      松山
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 再発悪性神経膠腫に対するWT1ペプチドワクチン療法-臨床第2相試験2008

    • Author(s)
      橋本直哉
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 再発悪性神経膠腫に対するWT1ペプチドワクチン療法-臨床第2相試験-2008

    • Author(s)
      橋本直哉
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 前頭蓋窩巨大髄膜腫の摘出と前頭葉症候群の改善2008

    • Author(s)
      泉本修一
    • Organizer
      第67回日本脳神経外科学会学術総会
    • Place of Presentation
      盛岡
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 悪性神経膠腫に対するWT1ペプチドワクチン免疫療法の治療効果に影響を及ぼす因子2008

    • Author(s)
      千葉泰良
    • Organizer
      第9回日本分子脳神経外科学会
    • Place of Presentation
      京都
    • Year and Date
      2008-08-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Outcome and efficacy of reduced dose craniospinal irradiation and high-dose chemotherapy for high-risk medulloblastomas.2008

    • Author(s)
      Kagawa N
    • Organizer
      13th Internastional symposium on pediatricneuro-oncology
    • Place of Presentation
      シカゴ・米国
    • Year and Date
      2008-06-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 悪性グリオーマの免疫療法-れまでの流れと最新の治療-2008

    • Author(s)
      泉本修一
    • Organizer
      脳腫瘍レビュー
    • Place of Presentation
      東京
    • Year and Date
      2008-06-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 悪性グリオーマの免疫療法これまでの流れと最新の治療2008

    • Author(s)
      泉本修一
    • Organizer
      脳腫瘍レビュー'08
    • Place of Presentation
      東京
    • Year and Date
      2008-06-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] WT1 (Wilms tumor gene) peptide vaccination for patients with recurrent glioblastoma.2008

    • Author(s)
      泉本修一
    • Organizer
      17th Conference of Brain Tumor Research and Therapy.
    • Place of Presentation
      函館・日本
    • Year and Date
      2008-06-11
    • Related Report
      2010 Final Research Report
  • [Presentation] WT1 (Wilms tumor gene)peptide vaccination for patients with recurrent glioblastoma.2008

    • Author(s)
      Izumoto S
    • Organizer
      17th Conference of Brain Tumor Research and Therapy
    • Place of Presentation
      函館・日本
    • Year and Date
      2008-06-11
    • Related Report
      2008 Annual Research Report
  • [Book] Glioma : Immunotherapeutic Approaches(Yamanaka R (ed))(Peptide vaccine In)2010

    • Author(s)
      泉本修一
    • Publisher
      Landes Bioscience, Texas
    • Related Report
      2010 Final Research Report
  • [Book] 無症候性脳外科疾患の治療戦略(III無症候性脳腫瘍 6.頭蓋内嚢胞性疾患 NS NOW No.9)2010

    • Author(s)
      泉本修一、有田憲生
    • Publisher
      メディカルレビュー社
    • Related Report
      2010 Final Research Report
  • [Book] EBM脳神経外科疾患の治療2011-2012(II腫瘍9.中枢神経原発悪性リンパ腫に対する化学療法のエビデンスは?)2010

    • Author(s)
      森鑑二、泉本修一、有田憲生
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] 看護学テキストNICE(疾病と治療III 腎・泌尿器系/脳・神経系/精神/女性生殖器系/小児 脳神経系疾患F.小児に好発する脳腫瘍)2010

    • Author(s)
      泉本修一
    • Publisher
      南江堂
    • Related Report
      2010 Final Research Report
  • [Book] 看護学テキストNICE(疾病と治療III 腎・泌尿器系/脳・神経系/精神/女性生殖器系/小児 脳神経系疾患 J 一般的な開頭術)2010

    • Author(s)
      泉本修一
    • Publisher
      南江堂
    • Related Report
      2010 Final Research Report
  • [Book] 新時代の脳腫瘍学(-診断・治療の最前線-III.脳腫瘍の病理 各論 PNET 日本臨床68巻増刊号10)2010

    • Author(s)
      泉本修一、友金佑介、森鑑二、有田憲生
    • Related Report
      2010 Final Research Report
  • [Book] Peptide vaccine In : Yamanaka R (ed) Glioma : Immunotherapeutic Approaches.2010

    • Author(s)
      Izumoto S
    • Total Pages
      10
    • Publisher
      Landes Bioscience, Texas
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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