Bidirectional approach with neurotrophic factors for the acceleration of neuro-regeneration.

• Project/Area Number: 20390411
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Gunma University
• Principal Investigator: SAITO Shigeru Gunma University, 大学院・医学系研究科, 教授 (40251110)
• Co-Investigator(Kenkyū-buntansha): OGINO Yuichi 群馬大学, 医学部, 助教 (20420094) ; TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
• Keywords: 疼痛管理学 / 再生医学 / 栄養因子 / 痙痛管理学

Research Abstract

For the better recovery of damaged neurons, cellular environment seems to be crucial. In the present study, the authors assessed effects of neurotrophic factors in various settings. As the results, it was revealed that normo-glycemia is the best condition for the neuro-regeneration. Newly developed drug delivery system was identified as effective for gradual release of nerve activity controlling drugs.

Research Products

• [Journal Article] Activation of astrocytes in the spinal cord contributes to the development of bilateral allodynia after peripheral nerve injury in rats. (2010)
  • Author(s): Obata H, Sakurazawa S, Kimura M, Saito S
  • Journal Title: Brain Res. 1363 Pages: 72-80
  • Peer Reviewed
• [Journal Article] Technical communication : percutaneous radiofrequency mandibular nerve rhizotomy guided by high-speed real-time computed tomography fluoroscopy. (2010)
  • Author(s): Koizuka S, Saito S, Tobe M, Sekimoto K, Obata H, Koyama Y
  • Journal Title: Anesth Analg. 111(3) Pages: 763-7
  • Peer Reviewed
• [Journal Article] Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats. (2010)
  • Author(s): Obata H, Kimura M, Nakajima K, Tobe M, Nishikawa K, Saito S
  • Journal Title: J Pharmacol Exp Ther. 334(3) Pages: 1059-65
  • Peer Reviewed
• [Journal Article] Activation of astrocytes in the spinal cord contributes to the development of bilat eral allodynia after peripheral nerve injury in rats. (2010)
  • Author(s): Obata H
  • Journal Title: Brain Res. Volume: 1363 Pages: 72-80
  • Peer Reviewed
• [Journal Article] Technical communication : percutaneous radiofrequency mandibular nerve rhizotomy guided by high-speed real-time computed tomoaraphv fluorosconv. (2010)
  • Author(s): Koizuka S
  • Journal Title: Anesth Analg. Volume: 111 Pages: 763-767
  • Peer Reviewed
• [Journal Article] Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postonerative pain model in rats. (2010)
  • Author(s): Obata H
  • Journal Title: J Pharmacol Exp Ther. Volume: 334 Pages: 1059-1065
  • Peer Reviewed
• [Journal Article] Long-term effect of sciatic nerve block with slow-release lidocaine in a rat mode 1 of postoperative pain. (2010)
  • Author(s): Tobe M
  • Journal Title: Anesthesiology Volume: 112 Pages: 1473-1481
  • Peer Reviewed
• [Journal Article] Fibroblast growth factor and insulin-like growth factor rescue growth cones of sensory neurites from collapse after tetracaine-induced injury. (2010)
  • Author(s): Seki T
  • Journal Title: Anesth Analg. Volume: 110 Pages: 1468-1472
  • Peer Reviewed
• [Journal Article] Normal glucose enhances neuronal regeneration after lidocaine-induced injury. (2010)
  • Author(s): Abdel Nazeer A
  • Journal Title: Br J Anaesth. Volume: 104 Pages: 482-486
  • Peer Reviewed
• [Journal Article] Spinal microglial expression and mechanical hypersensitivity in a postoperative pain model : comparison with a neuropathic pain model. (2009)
  • Author(s): Ito N, Obata H, Saito S
  • Journal Title: Anesthesiology. 111(3) Pages: 640-8
  • Peer Reviewed
• [Journal Article] The radiobiological effectiveness of carbon-ion beams on growing neurons. (2009)
  • Author(s): Al-Jahdari WS, Suzuki Y, Yoshida Y, Hamada N, Shirai K, Noda SE, Funayama T, Sakashita T, Kobayashi Y, Saito S, Goto F, Nakano T
  • Journal Title: Int J Radiat Biol. 85(8) Pages: 700-9
  • Peer Reviewed
• [Journal Article] The nociceptive mechanism of 5-hydroxytryptamine released into the peripheral tissue in acute inflammatory pain in rats. (2009)
  • Author(s): Nakajima K, Obata H, Ito N, Goto F, Saito S
  • Journal Title: Eur J Pain. 13(5) Pages: 441-7
  • Peer Reviewed
• [Journal Article] Percutaneous radio-frequency thermocoagulation of the Gasserian ganglion guided by high-speed real-time CT fluoroscopy (2009)
  • Author(s): Koizuka S
  • Journal Title: Neuroradiology Vol.51(9) Pages: 563-6
  • Peer Reviewed
• [Journal Article] Thermal hyperalgeria via supraspinal mechanisms in mice lacking glutamate decarboxylase 65 (2009)
  • Author(s): Kubo K
  • Journal Title: J Pharmacol Exp Ther Vol.331(1) Pages: 162-9
  • Peer Reviewed
• [Journal Article] The radiobiological effectiveness of carbon-ion beams on growing neurons (2009)
  • Author(s): Al-Jahdari WS
  • Journal Title: Int J Radiat Biol Vol.85(8) Pages: 700-9
  • Peer Reviewed
• [Journal Article] Spinal microglial expression and mechanical hypersensitivity in a post operative pain model : comparison with a neuropathic pain model (2009)
  • Author(s): Ino N
  • Journal Title: Anesthesiology Vol.111(3) Pages: 640-8
  • Peer Reviewed
• [Journal Article] A novel bFGF-GH injection therapy for two patients with severe ischemic limb pain. (2008)
  • Author(s): Ito N, Saito S, Yamada MH, Koizuka S, Obata H, Nishikawa K, Tabata Y
  • Journal Title: J Anesth. 22(4) Pages: 449-52
  • NAID: 10024460980
  • Peer Reviewed
• [Journal Article] A novel bFGF-GH injection therapy for two patients with severe ischemic limb pain. (2008)
  • Author(s): Ito N. Saito S, Yamada MH, K oizuka S, Obata. H, Nishikawa K. Tabata Y
  • Journal Title: Journal of Anesthesia 22 Pages: 449-452
  • NAID: 10024460980
  • Peer Reviewed
• [Journal Article] Anatomic analysis of computed tomography images obtained during fluoroscopic computed tomography-guided percutaneous lumbar symnathectomy. (2008)
  • Author(s): Koizuka S, Saito S, Obata H, robe M, Koyama Y, Takahashi A.
  • Journal Title: Journal of Anesthesia 22 Pages: 373-377
  • Peer Reviewed
• [Journal Article] Growth cone collapse and neurite retractions: an approach to examine X-irradiation affects on neuron cells. (2008)
  • Author(s): A1-Jandari WS, Suzuki Y, Yoshida Y, Noda SE, Shirai K, Saito S, Goto F, Nakano T.
  • Journal Title: J Radiat. Res (Tokyo). 49 Pages: 481-489
  • NAID: 110006935554
  • Peer Reviewed
• [Journal Article] The nociceptive mechanism of 5-hydroxytryptamine released into the peripheral tissue in acute inflammatory pain in rats.
  • Author(s): Nakajima K, ObataH, Ito N, Goto R. Saito S.
  • Journal Title: European Journal of Pain (In press)
  • Peer Reviewed
• [Presentation] Antihypersensitivity effects of tramadol hydrochloride in a rat model of postoperative pain (2010)
  • Author(s): 木村雅文
  • Organizer: Society for Neuroscience Annual Meeting 2010
  • Year and Date: 2010-11-14
• [Presentation] Antihypersensitivity effects of tramadol hydrochloride in a rat model of postoperative pain (2010)
  • Author(s): Kimura M
  • Organizer: Society for Neuroscience Annual Meeting 2010
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-14
• [Presentation] 塩酸トラマドールの鎮痛作用機序-ラット術後痛モデルとマイクロダイアリシスでの検討- (2010)
  • Author(s): 木村雅文
  • Organizer: 第32回日本疼痛学会
  • Year and Date: 2010-07-03
• [Presentation] 塩酸トラマドールの鎮痛作用機序-ラット術後痛モデルとマイクロダイアリシスでの検討- (2010)
  • Author(s): 木村雅文
  • Organizer: 第32回日本痙痛学会
  • Place of Presentation: 京都市
  • Year and Date: 2010-07-03
• [Presentation] ミルナシプランおよびパロキセチンの鎮痛メカニズム (2010)
  • Author(s): 中島邦枝
  • Organizer: 日本麻酔科学会第57回学術集会
  • Year and Date: 2010-06-04
• [Book] CTガイド下神経ブロック (2011)
  • Author(s): 齋藤繁,他
  • Publisher: 真興交易(株)医書出版部
• [Book] CTガイド下神経ブロツク (2011)
  • Author(s): 齋藤繁
  • Publisher: 真興交易(株)医書出版部