Pathophysiology of unexplained recurrent pregnancy loss, preterm labor and preeclampsia from the viewpoint of reproductive immunology
Project/Area Number |
20390431
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | University of Toyama |
Principal Investigator |
SAITO Shigeru University of Toyama, 大学院・医学薬学研究部, 教授 (30175351)
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Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Akitoshi 富山大学, 大学院・医学薬学研究部, 助教 (00436792)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | 制御性T細胞 / 妊娠 / 着床不全 / 流産 / 早産 / 妊娠高血圧腎症 / IL-17 / 制御性NK細胞 / 妊娠高血圧症候群 / Granulysin |
Research Abstract |
T-helper (Th) cells play a central role in modulating immune responses. We discuss the pathophysiology of unexplained recurrent pregnancy loss, preterm labor and preeclampsia from the viewpoint of new Th1/Th2/Th17 and regulatory T (Treg) cell paradigm. We have reported that Treg cells play an essential role for maintenance of allogeneic pregnancy in early pregnancy, but not in late pregnancy. We also found that paternal antigen-specific Treg cells increase in uterine draining lymphonodes before the implantation and in uterus after implantation. We have found NKreg cells increase in the pregnant uterus and they express CD25 on their surface. They produce immunosuppressive cytokines such as IL-10 and TGFβ. Th17 cells increased in the uterus of preterm labor cases with severe chorioamnionitis and of spontaneous abortion cases in late stage, and there were significant positive correlation between Th17 cells number and neutrophil number. IL-17 also augment the TNF-α-induced IL-8 secretion by amniotic mesenchymal cells in a dose dependent manner. In preeclampsia, we found the production of VEGF and Galectin-1 by peripheral blood-T cells and -NK cells was decreased suggesting that angiogenesis and tolerance induction systems are dysregulated in preeclampsia.
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Report
(4 results)
Research Products
(172 results)
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[Journal Article] Peripheral blood galectin-1-expressing T and natural killer cells in normal pregnancy and preeclampsia.2011
Author(s)
Molvarec A, Blois M S, Stenczer B, Toldi G, Tirado-Gonzalez I, Ito M, Shima T, Yoneda S, Vasarhelyi B, Rigo J., Saito S.
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Journal Title
Clin.Immunol
Volume: 139
Pages: 48-56
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Peer Reviewed
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[Journal Article] A role for IL-17 in induction of an inflammation at fetomaternal interface in preterm labour.2010
Author(s)
Ito M., Nakashima A., Hidaka T., Okabe M., Bac N.D., Ina S., Yoneda S., Shiozaki A., Sumi S., Tsuneyama K., Nikaido T., Saito S.
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Journal Title
J.Reprod Immunol. 84
Pages: 75-85
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Peer Reviewed
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[Journal Article] A role for IL-17 in induction of an inflammation at fetomaternal interface in preterm labour.2010
Author(s)
Ito M, Nakashima A, Hidaka T, Okabe M, Bac ND, Ina S, Yoneda S, Shiozaki A, Sumi S, Tsuneyama K, Nikaido T, Saito S.
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Journal Title
J.Reprod Immunol. 84
Pages: 75-85
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Peer Reviewed
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[Journal Article] IFPA Meeting 2009 Workshops Report. Placenta 31, Supplement A2010
Author(s)
Lash G.E., Burton G.J., Chamley, L.W.Clifton V.L., Constancia M, Crocker I.P., Dantzer V., Desoye G., Drewlo S., Hemmings D.G., Hiendleder S., Kalionis B., Keelan J.A., Kudom Y., Lewis R.M., Manuelpillai U., Murthi P., Natale D., Pfarrer C., Robertson S., Saffery R., Saito S., Sferruzzi-Perri A., Sobrevia L., Waddell B.J., Roberts C.T.
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Peer Reviewed
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[Journal Article] ワークショップ12「不育症の新たな原因探索と治療」本邦における不育症のリスク因子とその予後に関する研究2009
Author(s)
齋藤滋, 杉浦真弓, 田中忠夫, 藤井知行, 杉俊隆, 丸山哲夫, 竹下俊行, 山田秀人, 小澤伸晃, 木村正, 山本樹生, 藤井俊策, 中塚幹也, 下屋浩一郎
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Journal Title
日本周産期・新生児医学会雑誌 45
Pages: 1144-1148
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[Journal Article] Gestational choriocarcinoma in one placenta of dichorionic diamniotic twins who showed severe anemia.2009
Author(s)
Shiozaki A, Yoneda N, Yoneda S, Soeda Y, Hamashima T, Ishizawa S, Tamura K, Horikawa S, Higashiyama H, Yoshida T, Miyawaki T, Saito S.
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Journal Title
Placenta 30
Pages: 821-821
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Peer Reviewed
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[Journal Article] ワークショップ12「不育症の新たな原因探索と治療」本邦における不育症のリスク因子とその予後に関する研究.2009
Author(s)
齋藤滋, 杉浦真弓, 田中忠夫, 藤井知行, 杉俊隆, 丸山哲夫, 竹下俊行, 山田秀人, 小澤伸晃, 木村正, 山本樹生, 藤井俊策, 中塚幹也, 下屋浩一郎
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Journal Title
日本周産期・新生児医学会雑誌 45
Pages: 1144-1148
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[Journal Article] Interleukin (IL)-17A Stimulates IL-8 Secretion, Cyclooxygensase-2 Expression, and Cell Proliferation of Endometriotic Stromal Cells2008
Author(s)
Hirata T., Osuga Y., Haiasaki K., Yoshino O., Ito M., Hasegawa A., Takemura Y., Hirota Y., Nose E., Morimoto C., Harada M., Koga K., Tajima T., Saito S., Yano T., Taketani Y.
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Journal Title
Endocrinology 149
Pages: 1260-1267
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Peer Reviewed
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[Journal Article] Peripheral blood galectin-1-expressing T and natural killer cells in normal pregnancy and preeclampsia.
Author(s)
Molvarec A, Blois M S, Stenczer B, Toldi G, Tirado-Gonzalez I, Ito M, Shima T, Yoneda S, Vasarhelyi B, Rigo J., Saito S.
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Peer Reviewed
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[Presentation] 不育症と免疫2010
Author(s)
齋藤滋
Organizer
大阪府産婦人科懇話会(特別講演)
Place of Presentation
大阪
Year and Date
2010-09-25
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[Presentation] 子宮内膜症におけるTh17の発現とその意義2008
Author(s)
平田哲也, 大須賀穣, 演崎かほり, 吉野 修, 原田美由紀, 長谷川亜希子, 田島敏樹, 児玉亜子, 伊藤実香, 齋藤滋, 矢野 哲, 武谷雄二
Organizer
第60回日本産科婦人科学会総会・学術講演会
Place of Presentation
横浜
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