| Co-Investigator(Kenkyū-buntansha) |
SONODA Koh-hei 山口大学, 医学系・研究科, 教授 (10294943)
MARUYAMA Ikuro 鹿児島大学, 医歯学総合研究科, 特任教授 (20082282)
TAKAO Sonshin 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 教授 (80171411)
KOSAI Ken-ichiro 鹿児島大学, 医歯学総合研究科, 教授 (90258418)
SUDA Yasuo 鹿児島大学, 理工学部・研究科, 教授 (70179282)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Research Abstract |
We performed the study of vitreoretinal diseases from the points of its pathogenesis, molecular mechanism, and treatment. First, the relationship between intravitreous damage-associated molecular pattern and retinal damage was analyzed. As a result, retinal pathology was strongly affected not only by bioactive molecules such as cytokines, but rather by damaged cells and its related proteins. The experimental treatment using KO animals was very effective. The present findings are quite beneficial for developing a new treatment with minimal tissue damage.
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