Study of vitreous body : Analysis of microenvironmental control and development of novel treatment.

• Project/Area Number: 20390450
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kagoshima University
• Principal Investigator: SAKAMOTO Taiji 鹿児島大学, 医歯学総合研究科, 教授 (10235179)
• Co-Investigator(Kenkyū-buntansha): SONODA Koh-hei 山口大学, 医学系・研究科, 教授 (10294943) ; MARUYAMA Ikuro 鹿児島大学, 医歯学総合研究科, 特任教授 (20082282) ; TAKAO Sonshin 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 教授 (80171411) ; KOSAI Ken-ichiro 鹿児島大学, 医歯学総合研究科, 教授 (90258418) ; SUDA Yasuo 鹿児島大学, 理工学部・研究科, 教授 (70179282)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
• Keywords: 硝子体細胞 / SDF-1 / 硝子体免疫 / 薬物治療 / 超音波 / 治療薬物

Research Abstract

We performed the study of vitreoretinal diseases from the points of its pathogenesis, molecular mechanism, and treatment. First, the relationship between intravitreous damage-associated molecular pattern and retinal damage was analyzed. As a result, retinal pathology was strongly affected not only by bioactive molecules such as cytokines, but rather by damaged cells and its related proteins. The experimental treatment using KO animals was very effective. The present findings are quite beneficial for developing a new treatment with minimal tissue damage.

Research Products

• [Journal Article] 急速に失明に至り,特異な対光反射を示した悪性腫瘍随伴網膜症 (2011)
  • Author(s): 尾辻太, 精松徳子, 中尾久美子, 坂本泰二
  • Journal Title: 日本眼科学会雑誌 Volume: 115(10) Pages: 924-929
  • NAID: 10029689411
  • Peer Reviewed
• [Journal Article] Targeting CD9 produces stimulus-independent antiangiogenic effects predominantly in activated endothelial cells during angiogenesis : A novel antiangiogenic therapy (2011)
  • Author(s): Kamisasanuki T, Tokushige S, Terasaki H, Khai NC, Wang Y, Sakamoto T, Kosai K.
  • Journal Title: Biochem Biophys Res Commun Volume: 413(1) Pages: 128-135
  • URL: http://dx.doi.org/10.1016/j.bbrc.2011.08.068
  • Peer Reviewed
• [Journal Article] NSAIDs inhibit neovascularization of choroid through HO-1-dependent pathway (2011)
  • Author(s): Yoshinaga N, Arimura N, Otsuka H, Kawahara K, Hashiguchi T, Maruyama I, Sakamoto T.
  • Journal Title: Lab Invest Volume: 91(9) Issue: 9 Pages: 1277-1290
  • DOI: 10.1038/labinvest.2011.101
  • Peer Reviewed
• [Journal Article] A case of intraocular lymphoma having retinal adverse events associated with intravitreal methotrexate (2011)
  • Author(s): Kuroiwa N, Abematsu N, Matsuo Y, Nakao K, Sakamoto T.
  • Journal Title: Nihon Ganka Gakkai Zasshi Volume: 115(7) Pages: 611-616
  • NAID: 10029368198
  • Peer Reviewed
• [Journal Article] Japanese Retina and Vitreous Society Triamcinolone Survey Group (2011)
  • Author(s): Sakamoto T, Ishibashi T, Ogura Y, Shiraga F, Takeuchi S, Yamashita H
  • Journal Title: Nihon Ganka Gakkai Zasshi Volume: 115(6) Pages: 523-8
  • Peer Reviewed
• [Journal Article] Visual outcome after intravitreal triamcinolone acetonide depends on optical coherence tomographic patterns in patients with diffuse diabetic macular edema (2011)
  • Author(s): Shimura M, Yasuda K, Nakazawa T, Hirano Y, Sakamoto T, Ogura Y, Shiono T.
  • Journal Title: Retin Volume: 31(4) Issue: 4 Pages: 748-754
  • DOI: 10.1097/iae.0b013e3181f04991
  • Peer Reviewed
• [Journal Article] Ocular surface molecule after transconjunctival vitrectomy (2011)
  • Author(s): Fujita A, Uchino E, Otsuka H, Arimura N, Noda N, Ishibashi T, Sakamoto T.
  • Journal Title: Br J Ophthalmol Volume: 95(3) Pages: 419-423
  • Peer Reviewed
• [Journal Article] Incidence of outer foveal defect after macular hole surgery (2011)
  • Author(s): Kawano H, Uemura A, Sakamoto T.
  • Journal Title: Am J Ophthalmol Volume: 151(2) Pages: 31-322
  • URL: http://dx.doi.org/10.1016/j.ajo.2010.08.034
  • Peer Reviewed
• [Journal Article] Hyalocytes : Essential cells of the vitreous cavity in vitreoretinal pathophysiology (2011)
  • Author(s): Sakamoto T. Ishibashi T.
  • Journal Title: Retina Volume: 31(2) Issue: 2 Pages: 222-228
  • DOI: 10.1097/iae.0b013e3181facfa9
  • Peer Reviewed
• [Journal Article] Survey of triamcinolone-related non-infectious endophthalmitis (2011)
  • Author(s): Sakamoto T, Ishibashi T, Ogura Y, Shiraga F, Takeuchi S, Yamashita H; Japanese Retina and Vitreous Society Triamcinolone Survey Group
  • Journal Title: Nihon Ganka Gakkai Zasshi Volume: 115(6) Pages: 523-528
  • NAID: 10029368022
  • Peer Reviewed
• [Journal Article] Ocular surface molecule after transconjunctival vitrectomy (2011)
  • Author(s): Fujita A, Uchino E, Otsuka H, Arimura N, Noda N, Ishibashi T, Sakamoto T.
  • Journal Title: Br J Ophthalmol. 95(3) Pages: 419-423
• [Journal Article] Incidence of outer foveal defect after macular hole surgery. (2011)
  • Author(s): Kawano H, Uemura A, Sakamoto T.
  • Journal Title: Am J Ophthalmol. 151(2) Pages: 318-322
• [Journal Article] Hyalocytes : Essential cells of the vitreous cavity in vitreoretinal pathophysiology? (2011)
  • Author(s): Sakamoto T. Ishibashi T.
  • Journal Title: Retina 31(2) Pages: 222-228
• [Journal Article] Ocular surface molecule after transconjunctival vitrectomy. (2011)
  • Author(s): Fujita A, Uchino E, Otsuka H, Arimura N, Noda Y, Ishibashi T, Sakamoto T.
  • Journal Title: Br J Ophthalmol. Volume: 95(3) Pages: 419-423
  • Peer Reviewed
• [Journal Article] Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment (2010)
  • Author(s): Otsuka H, Arimura N, Sonoda S, Nakamura M, Hashiguchi T, Maruyama I, Nakao S, Hafezi-Moghadam A, Sakamoto T.
  • Journal Title: Am J Pathol Volume: 177(5) Issue: 5 Pages: 2268-2277
  • DOI: 10.2353/ajpath.2010.100134
  • Peer Reviewed
• [Journal Article] Combination therapy for retinal vein occlusion (2010)
  • Author(s): Shimura M, Yasuda K, Nakazawa T, Takeshita T, Shiono T, Sakamoto T.
  • Journal Title: Ophthalmology Volume: 117(9)
  • URL: http://dx.doi.org/10.1016/j.ophtha.2010.03.077
  • Peer Reviewed
• [Journal Article] Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment. (2010)
  • Author(s): Otsuka H, Arimura N, Sonoda S, Nakamura M, Hashiguchi T, Maruyama I, Nakao S, Hafezi-Moghadam A, Sakamoto T.
  • Journal Title: Am J Pathol. 177(5) Pages: 2268-2277
• [Journal Article] Combination therapy for retinal vein occlusion (2010)
  • Author(s): Shimura M, Yasuda K, Nakazawa T, Takeshita T, Shiono T, Sakamoto T
  • Journal Title: Ophthalmology 117(9)
• [Journal Article] Predictable signs of benign course of polypoidal choroidal vasculopathy : based upon the long-term observation of non-treated eyes. (2010)
  • Author(s): Okubo A, Arimura N, Abematsu N, Sakamoto T.
  • Journal Title: Acta Ophthalmol. Volume: 88(4)
  • Peer Reviewed
• [Journal Article] Vitrectomy for exudative age-related macular degeneration with vitreous hemorrhage. (2010)
  • Author(s): Sakamoto T, Sheu SJ, Arimura N, Sameshima S, Shimura M, Uemura A, Kawano H, Wu TT, Kubota T, Sohma R, Noda Y.
  • Journal Title: Retina. Volume: 30(6) Pages: 856-864
  • Peer Reviewed
• [Journal Article] Bcell-derived vascular endothelial growth factor A promotes lymphangiogenesis and high endothelial venule expansion in lymph nodes. (2010)
  • Author(s): Shrestha B, Hashiguchi T, Ito T, Miura N, Takenouchi K, Oyama Y, Kawahara K, Tancharoen S, Ki-I Y, Arimura N, Yoshinaga N, Noma S, Shrestha C, Nitanda T, Kitajima S, Arimura K, Sato M, Sakamoto T, Maruyama I.
  • Journal Title: J Immunol. Volume: 184(9) Pages: 4819-4826
  • Peer Reviewed
• [Journal Article] 眼内炎症性疾患の新しい治療 (2010)
  • Author(s): 坂本泰二
  • Journal Title: 学術の動向(日本学術会議) Volume: 7月号 Pages: 14-17
  • NAID: 130000450881
  • Peer Reviewed
• [Journal Article] 眼内長期滞留ガス(SF6, C3F8)ガイドライン (2010)
  • Author(s): 大路正人, 小椋祐一郎, 坂本泰二, 白神史雄, 平形明人, 寺崎浩子, 東範行, 飯島裕幸, 飯田知弘, 池田恒彦, 石橋達朗, 岸章治, 竹内忍, 中澤満, 根木昭, 堀貞夫, 堀口正之, 松村美代, 山下英俊, 山本修一, 湯澤美都子, 吉田晃敏, 吉村長久
  • Journal Title: 日本眼科学会雑誌 Volume: 114 Pages: 110-115
  • Peer Reviewed
• [Journal Article] Aniridia associated with aphakia and secondary glaucoma. (2010)
  • Author(s): Terasaki H, Yamashita T, Tanaka M, Takahashi M, Sakamoto T.
  • Journal Title: Jpn J Ophthalmol. Volume: 54(5) Pages: 504-505
  • NAID: 10027666075
  • Peer Reviewed
• [Journal Article] Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment. (2010)
  • Author(s): Otsuka H, Arimura N, Sonoda S, Nakamura M, Hashiguchi T, Maruyama I, Nakao S, Hafbzi-Moghadam A, Sakamoto T.
  • Journal Title: Am J Pathol. Volume: 177(5) Pages: 2268-2277
  • Peer Reviewed
• [Journal Article] Combination therapy for retinal vein occlusion. (2010)
  • Author(s): Shimura M, Yasuda K, Nakazawa T, Takeshita T, Shiono T, Sakamoto T.
  • Journal Title: Ophthalmology. Volume: 117(9)
  • Peer Reviewed
• [Journal Article] Intraocular expression and release of high-mobility group box 1 protein in retinal detachment (2009)
  • Author(s): Arimura N, Ki-i Y, Hashiguchi T, Kawahara K, Biswas KK, Nakamura M, Sonoda Y, Yamakiri K, Okubo A, Sakamoto T, Maruyama I.
  • Journal Title: Lab Invest Volume: 89(3) Pages: 278-289
  • Peer Reviewed
• [Journal Article] Posturing time after macular hole surgery modified by optical coherence tomography images : a pilot study (2009)
  • Author(s): Masuyama K, Yamakiri K, Arimura N, Sonoda Y, Doi N, Sakamoto T.
  • Journal Title: Am J Ophthalmol Volume: 147(3) Pages: 481-488
  • URL: http://dx.doi.org/10.1016/j.ajo.2008.09.028
  • Peer Reviewed
• [Journal Article] Intraocular expression and release of high-mobility group box 1 protein in retinal detachment. (2009)
  • Author(s): Arimura N, Ki-i Y, Hashiguchi T, Kawahara K, Biswas KK, Nakamura M, Sonoda Y, Yamakiri K, Okubo A, Sakamoto T, Maruyama I
  • Journal Title: Lab Invest. 89(3) Pages: 278-289
• [Journal Article] Posturing time after macular hole surgery modified by optical coherence tomography images : a pilot study. (2009)
  • Author(s): Masuyama K, Yamakiri K, Arimura N, Sonoda Y, Doi N, Sakamoto T.
  • Journal Title: Am J Ophthalmol. 147(3) Pages: 481-488
• [Journal Article] Vitreous mediators after intravitreal bevacizumab or triamcinolone acetonide in eyes with proliferative diabetic retinopathy (2009)
  • Author(s): Arimura N, Ohtsuka H, Yamakiri K, Sonoda Y, Nakao S, Noda Y, Hashiguchi T, Maruyama I, Sakamoto T.
  • Journal Title: Ophthalmology 116(5) Pages: 921-926
  • Peer Reviewed
• [Journal Article] Drug reflux during posterior subtenon infusion of triamcinolone acetonide in diffuse diabetic macular edema not only brings insufficient reduction but also causes elevation of intraocular pressure (2009)
  • Author(s): Shimura M, Yasuda K, Nakazawa T, Shiono T, Sakamoto T, Nishida K.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 247(7) Pages: 907-912
  • Peer Reviewed
• [Journal Article] Intraocular expression and release of high-mobility group box 1 protein in retinal detachment (2009)
  • Author(s): Arimura N, Ki-i Y, Hashiguchi T, Kawahara K, Biswas KK, Nakamura M, Sonoda Y, Yamakiri K, Okubo A, Sakamoto T, Maruyama I.
  • Journal Title: Lab Invest 89(3) Pages: 278-289
  • Peer Reviewed
• [Journal Article] Posturing time after macular hole surgery modified by optical coherence tomography images : a pilot study (2009)
  • Author(s): Masuyama K, Yamakiri K, Arimura N, Sonoda Y, Doi N, Sakamoto T.
  • Journal Title: Am J Ophthalmol. 147(3) Pages: 481-488
  • Peer Reviewed
• [Journal Article] Anterior ischemic optic neuropathy associated with Vogt-Koyanagi-Harada disease (2009)
  • Author(s): Nakao K, Mizushima Y, Abematsu N, Goh N, Sakamoto T.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 247(10) Pages: 1417-1425
  • Peer Reviewed
• [Journal Article] Visualizing vitreous in vitrectomy by triamcinolone (2009)
  • Author(s): Sakamoto T, Ishibashi T.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 247(9) Pages: 1153-1163
  • Peer Reviewed
• [Journal Article] Posturing time after macular hole surgery modified by optical coherence tomography images : a pilot study. (2009)
  • Author(s): Masuyama K, Yamakiri K, Arimura N, Sonoda Y, Doi N, Sakamoto T.
  • Journal Title: Am J Ophthalmol 147(3) Pages: 481-488
  • Peer Reviewed
• [Journal Article] Intraocular expression and release of high-mobility group box 1 protein in retinal detachment. (2009)
  • Author(s): Arimura N, Ki-i Y, Hashiguchi T, Kawahara K, Biswas KK, Nakamura M, Sonoda Y, Yamakiri K, Okubo A, Sakamoto T, Maruyama I.
  • Journal Title: Lab Invest. 89(3) Pages: 278-289
  • Peer Reviewed
• [Journal Article] Intraoperative characteristics of the posterior vitreous cortex in patients with epiretinal membrane. (2008)
  • Author(s): Yamashita T, Uemura A, Sakamoto T.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 246(3) Pages: 333-337
  • Peer Reviewed
• [Journal Article] Age-related maculopathy and sunlight exposure evaluated by objective measurement. (2008)
  • Author(s): Hirakawa M, Tanaka M, Tanaka Y, Okubo A, Koriyama C, Tsuji M, Akiba S, Miyamoto K, Hillebr, G, Yamashita T, Sakamoto T.
  • Journal Title: Br J Ophthalmol 92(5) Pages: 630-634
  • Peer Reviewed
• [Journal Article] One-year results of a multicenter controlled clinical trial of triamcinolone in pars plana vitrectomy. (2008)
  • Author(s): Yamakiri K, Sakamoto T, Noda Y, Nakahara M, Ogino N, Kubota T, Yokoyama M, Furukawa M, Ishibashi T.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 246(7) Pages: 959-966
  • Peer Reviewed
• [Journal Article] Clinical features of early and late stage polypoidal choroidal vasculopathy characterized by lesion size and disease duration. (2008)
  • Author(s): Okubo A, Hirakawa M, Ito M, Sameshima M, Sakamoto T.
  • Journal Title: Graefe's Arch Clin Exp Ophthalmo 246(4) Pages: 491-499
  • Peer Reviewed
• [Journal Article] Comparative therapy evaluation of intravitreal bevacizumab and triamcinolone acetonide on persistent diffuse diabetic macular edema. (2008)
  • Author(s): Shimura M, Nakazawa T, Yasuda K, Shiono T, Iida T, Sakamoto T, Nishida K.
  • Journal Title: Am J Ophthalmol 145(5) Pages: 854-861
  • Peer Reviewed
• [Journal Article] Long-term outcomes of visual field defects after indocyanine green-assisted macular hole surgery.
  • Author(s): Yamashita T, Uemura A, Kita H, Sakamoto T.
  • Journal Title: Retina (in press)
  • Peer Reviewed
• [Journal Article] Vitreous Mediators after Intravitreal Bevacizumab or Triamcinolone Acetonide in Eyes with Proliferative Diabetic Retinopathy・
  • Author(s): Arimura N, Otsuka H, Yamakiri K, Sonoda Y, Nakao S, Noda Y, Hashiguchi T, Maruyama I, Sakamoto T.
  • Journal Title: Ophthalmology (in press)
  • Peer Reviewed
• [Presentation] ポリープ状脈絡膜血管症における動静脈交差部の血管拍動 (2011)
  • Author(s): 大久保明子, 鮫島宗文, 坂本泰二
  • Organizer: TEAM2011
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-12-02
• [Presentation] 小児の裂孔原性網膜剥離に対する強膜内陥術の術後屈折変化 (2011)
  • Author(s): 寺崎寛人, 山切啓太, 山下高明, 土居範仁, 上村昭典, 坂本泰二
  • Organizer: TEAM2011
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-12-02
• [Presentation] 硝子体出血における血管内皮細胞増殖因子についての検討 (2011)
  • Author(s): 白澤誠, 有村昇, 大塚寛樹, 園田祥三, 橋口照人, 坂本泰二
  • Organizer: TEAM2011
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-12-02
• [Presentation] 大型黄斑円孔へのinverted internal limiting membrane(ILM) flap technique手術 (2011)
  • Author(s): 山下敏史, 川野浩輝, 川野純廣, 園田恭志, 山切啓太, 坂本泰二
  • Organizer: TEAM2011
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-12-02
• [Presentation] 中心性漿液性脈絡網膜症に対する低照射容量PDTの検討 (2011)
  • Author(s): 園田祥三, 大塚寛樹, 白澤誠, 有村昇, 上笹貫太郎, 喜井裕哉, 大久保明子, 坂本泰二
  • Organizer: TEAM2011
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-12-02
• [Presentation] The subfoveal choroidal thickness in Japanese young normal eyes (2011)
  • Author(s): Takehiro Yamashita, Toshifumi Yamashita, Minoru Tanaka, Yuya Kii, Kumiko Nakao, Taiji Sakamoto
  • Organizer: The 4^<th> joint meeting of Korea-China-JapanOphthalmologists
  • Place of Presentation: Seoul Korea
  • Year and Date: 2011-11-04
• [Presentation] The subfoveal choroidal thickness in Japanese young normal eyes (2011)
  • Author(s): Takehiro Yamashita, Toshifumi Yamashita, Minoru Tanaka, Yuya Kii, Kumiko Nakao, Taiji Sakamoto
  • Organizer: The 4^<th> joint meeting of Korea-China-Japan Ophthalmologists
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-11-04
• [Presentation] 小児増殖硝子体網膜症の2症例に対するヘビーシリコーンオイルの使用経験 (2011)
  • Author(s): 藤原悠子, 山切啓太, 坂本泰二
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-10-09
• [Presentation] 新しい眼圧計(DCT)で測定した正常眼圧の分布 (2011)
  • Author(s): 伊東健, 田原昭彦, 渡部晃久, 久保田敏昭, 池田康博, 坂本泰二
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-10-08
• [Presentation] 翼状片手術における術中マイトマイシンC塗布の角膜内皮細胞への影響 (2011)
  • Author(s): 内野英輔, 藤田敦子, 精松泰子, 坂本泰二
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-10-08
• [Presentation] NSAIDs点眼による脈絡膜血管新生抑制 (2011)
  • Author(s): 吉永就正, 有村昇, 大塚寛樹, 竹之内和則, 貞村ゆかり, 野間聖, 川原幸一, 園田祥三, 橋口照人, 丸山征郎, 坂本泰二
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-10-08
• [Presentation] 外傷性角膜炎に続発した真菌性虹彩肉芽腫の1例 (2011)
  • Author(s): 藤田敦子, 田上純眞, 精松泰子, 内野英輔, 坂本泰二
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-10-07
• [Presentation] 鹿児島県の健康診査における網膜静脈閉塞症に関する調査 (2011)
  • Author(s): 水島崇, 前之原茂穂, 山下高明, 坂本泰二
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-10-07
• [Presentation] 乳頭黄斑角と視神経乳頭周囲網膜神経線維層最厚部の関連 (2011)
  • Author(s): 田中実, 山下高明, 喜井裕哉, 中尾久美子, 坂本泰二
  • Organizer: 第22回日本緑内障学会
  • Place of Presentation: 秋田ビューホテル・アトリオン(秋田市)
  • Year and Date: 2011-09-24
• [Presentation] 視神経乳頭周囲網膜神経線維層厚における最厚部の近視性変化 (2011)
  • Author(s): 山下高明, 田中実, 喜井裕哉, 中尾久美子, 坂本泰二
  • Organizer: 第22回日本緑内障学会
  • Place of Presentation: 秋田ビューホテル・アトリオン(秋田市)
  • Year and Date: 2011-09-23
• [Presentation] 抗VEGF薬網膜疾患治療の問題点 (2011)
  • Author(s): 坂本泰二
  • Organizer: 第50回日本白内障学会総会・第26回日本白内障屈折矯正手術学会総会
  • Place of Presentation: 福岡サンパレス(福岡市)(招待講演)
  • Year and Date: 2011-06-17
• [Presentation] Optic disc swelling in Vogt-Koyanagi-Harada disease (2011)
  • Author(s): Nakao K, Abematsu N, Mizushima Y, Sakamoto T.
  • Organizer: Joint Congress of SOE/AAO
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2011-06-04
• [Presentation] 黒色細胞腫に伴う網膜下新生血管に対しベバシズマブ硝子体注射が奏功した1例 (2011)
  • Author(s): 上笹貫太郎, 大塚寛樹, 喜井裕哉, 園田祥三, 坂本泰二
  • Organizer: 第81回九州眼科学会
  • Place of Presentation: 沖縄県市町村自治会館(那覇市)
  • Year and Date: 2011-05-28
• [Presentation] 強膜トンネル併用円蓋部基底線維柱帯切除術単独と白内障手術併用の術後成績の検討 (2011)
  • Author(s): 田中実, 喜井裕哉, 山下高明, 坂本泰二
  • Organizer: 第81回九州眼科学会
  • Place of Presentation: 沖縄県市町村自治会館(那覇市)
  • Year and Date: 2011-05-27
• [Presentation] 角膜内皮移植術後に発症したサイトメガロウィルス角膜内皮炎の一例 (2011)
  • Author(s): 内野英輔, 園田祥三, 藤田敦子, 精松泰子, 坂本泰二
  • Organizer: 第81回九州眼科学会
  • Place of Presentation: 沖縄県市町村自治会館(那覇市)
  • Year and Date: 2011-05-27
• [Presentation] Biology of hyalocytes, Special Invited Lecture, International Symposiu for New Inshight of Translational Research (2011)
  • Author(s): Sakamoto T.
  • Organizer: 2011 BOVRC and CRCID joint symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-05-21
• [Presentation] Biology of hyalocytes, Special Invited Lecture, International symposium for New Inshight of Translational Research (2011)
  • Author(s): Sakamoto T
  • Organizer: 2011 BOVRC and CRCID joint symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-05-21
• [Presentation] 黄斑円孔術後早期のうつ向き姿勢(Pr)解除時期決定の試み (2011)
  • Author(s): 山下敏史, 山切啓太, 坂本泰二
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-05-14
• [Presentation] 糖尿病網膜症と網膜静脈閉塞症における硝子体中VEGFとIL-6, IL-8の比率 (2011)
  • Author(s): 有村昇, 吉永就正, 大塚寛樹, 山切啓太, 園田恭志, 山下敏史, 園田祥三, 坂本泰二
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-05-13
• [Presentation] 糖尿病網膜症と網膜静脈閉塞症における硝子体中VEGFとIL-6,IL-8の比率 (2011)
  • Author(s): 有村昇, 吉永就正, 大塚寛樹, 山切啓太, 園田恭志, 山下敏史, 園田祥三, 坂本泰二
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-05-13
• [Presentation] Transwell^<TM>を用いた極性ブタ網膜色素上皮細胞の培養 (2011)
  • Author(s): 園田祥三, 大塚寛樹, 白澤誠, 有村昇, 園田恭志, 坂本泰二
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-05-12
• [Presentation] Non-infectious Endophthalmitis After Intravitreal Injection of Triamcinolone Acetonide (2011)
  • Author(s): Hiroki Otsuka, Noboru Arimura, Taro Kamisasanuki, Yukiko Matsuo, Futoshi Otsuji, Yasushi Sonoda, Keita Yamakiri, Taiji Sakamoto
  • Organizer: ARVO2011
  • Place of Presentation: Fort Lauderdale・U. S. A
  • Year and Date: 2011-05-05
• [Presentation] Non-infectious Endophthalmitis After Intravitreal Injection of Triamcinolone Acetonide (2011)
  • Author(s): Hiroki Otsuka, Noboru Arimura, Taro Kamisasanuki, Yukiko Matsuo, Futoshi Otsuji, Yasushi Sonoda, Keita Yamakiri, Taiji Sakamoto
  • Organizer: ARVO2011
  • Place of Presentation: Fort Lauderdale・U.S.A
  • Year and Date: 2011-05-05
• [Presentation] Nsaids Eye Drop As Anti-oxidant Treatment In Choroidal Neovascularization (2011)
  • Author(s): Narimasa Yoshinaga, Noboru Arimura, Shozo Sonoda, Kazunori Takenouchi, Yukari Sadamura, Satoshi Noma, Ko-ichi Kawahara, Teruto Hashiguchi, Ikuro Maruyama, Taiji Sakamoto
  • Organizer: ARVO2011
  • Place of Presentation: Fort Lauderdale・U. S. A
  • Year and Date: 2011-05-02
• [Presentation] Nsaids Eye Drop As Anti-oxidant Treatment In Choroidal Neovascularization (2011)
  • Author(s): Narimasa Yoshinaga, Noboru Arimura, Shozo Sonoda, Kazunori Takenouchi, Yukari Sadamura, Satoshi Noma, Ko-ichi Kawahara, Teruto Hashiguchi, Ikuro Maruyama, Taiji Sakamoto
  • Organizer: ARVO2011
  • Place of Presentation: Fort Lauderdale・U.S.A
  • Year and Date: 2011-05-02
• [Presentation] Inhibition Of Choroidal Neovascularization By Targeting To Membrane Protein Cd9 (2011)
  • Author(s): Hiroto Terasaki, Taro Kamisasanuki, Ken-ichiro Kosai, Taiji Sakamoto
  • Organizer: ARVO2011
  • Place of Presentation: Fort Lauderdale・U. S. A
  • Year and Date: 2011-05-01
• [Presentation] Long-term Intraocular Pressure After 20 Gauge Pars PlanaVitrectomy (2011)
  • Author(s): Takehiro Yamashita, Yuya Kii, Akinori Uemura, Taiji Sakamoto
  • Organizer: ARVO2011
  • Place of Presentation: Fort Lauderdale・U. S. A
  • Year and Date: 2011-05-01
• [Presentation] Long-term Intraocular Pressure After 20 Gauge Pars Plana Vitrectomy (2011)
  • Author(s): Takehiro Yamashita, Yuya Kii, Akinori Uemura, Taiji Sakamoto
  • Organizer: ARVO2011
  • Place of Presentation: Fort Lauderdale・U.S.A
  • Year and Date: 2011-05-01
• [Presentation] Inhibition Of Choroidal Neovascularization By Targeting To Membrane Protein Cd9 (2011)
  • Author(s): Hiroto Terasaki, Taro Kamisasanuki, Ken-ichiro Kosai, Taiji Sakamoto
  • Organizer: ARVO2011
  • Place of Presentation: Fort Lauderdale・U.S.A
  • Year and Date: 2011-05-01
• [Presentation] Chromovitrectomy (2010)
  • Author(s): Sakamoto T.
  • Organizer: Rebert Burns lecture of Mason Eye Institute(Part 2), University of Missouri
  • Place of Presentation: Colombia, Missouri, USA
  • Year and Date: 2010-10-23
• [Presentation] Chromovitrectomy.Rebert Burns lecture of Mason Eye Institute (Part 2) (2010)
  • Author(s): Sakamoto T
  • Organizer: University of Missouri
  • Place of Presentation: Colombia, Missouri, USA
  • Year and Date: 2010-10-23
• [Presentation] Chromovitrectomy. (2010)
  • Author(s): Taiji Sakamoto.
  • Organizer: Yale Eye Center Clinical Conference Series.
  • Place of Presentation: U.S.A(New Haven.)
  • Year and Date: 2010-10-22
• [Presentation] Biology of Vitreous Cavity : Roles of Hyalocytes. (2010)
  • Author(s): Taiji Sakamoto.
  • Organizer: Yale Eye Center Clinical Conference Series.
  • Place of Presentation: U.S.A(New Haven.)
  • Year and Date: 2010-10-21
• [Presentation] Intravitreous mediators in diabetic retinopathy (2010)
  • Author(s): Sakamoto T.
  • Organizer: Sympsium. ARVO summer conference. NIH
  • Place of Presentation: Bethesda, USA
  • Year and Date: 2010-08-01
• [Presentation] Non-steroidal anti-inflammatory drug(NSAID)in exudative AMD. (2010)
  • Author(s): 坂本泰二
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場 (名古屋市)
  • Year and Date: 2010-04-16
• [Presentation] Transwell を用いた極性ヒト網膜色素上皮細胞の培養の確立およにその利用について 極性ヒト網膜色素上皮細胞の培養 (2010)
  • Author(s): 園田祥三, Satoru Kase, Stephan J Ryan, Ram kannan, David R Hinton, 坂本泰二
  • Organizer: 厚生労働省難治性疾患克服研究事業 網膜脈絡膜・視神経萎縮症調査研究班 平成21年度会議
  • Place of Presentation: 名古屋市立大学(名古屋市)
  • Year and Date: 2010-01-16
• [Presentation] Intravitreous mediators in diabetic retinopathy. (2010)
  • Author(s): Sakamoto T.
  • Organizer: Sympsium. ARVO summer conference
  • Place of Presentation: NIH, Bethesda, USA
• [Presentation] CD9 as a therapeutic target of ocular diseases(invited speaker symposium) (2009)
  • Author(s): Samoto T, Kamisasanuki T, Kosai K.
  • Organizer: 8^<th> International symposium of ocular pharmacology and therapeutics
  • Place of Presentation: Rome Cavaliori, Rome, Italy
  • Year and Date: 2009-12-04
• [Presentation] CD9 as a therapeutic target of ocular diseases (invited speaker symposium) (2009)
  • Author(s): Sakamoto T, Kamisasanuki T, Kosai S
  • Organizer: 8th International symposium of ocular pharmacology and therapeutics.
  • Place of Presentation: Rome Cavaliori, Rome, Italy
  • Year and Date: 2009-12-04
• [Presentation] Immediate change after intravitreous triamcinolone for diabetic macular edema. Invited lecture. Symposium of macular disorder (2009)
  • Author(s): Sakamoto T.
  • Organizer: 4^<th> Asia-Pacific Vitreo-Retinal Society
  • Place of Presentation: Grand Hotel, Taipei, Taiwan
  • Year and Date: 2009-11-11
• [Presentation] Immediate change after intravitreous triamcinolone for diabetic macular edema. Invited lecture.Symposium of macular disorder. (2009)
  • Author(s): Sakamoto T.
  • Organizer: 4th Asia-Pacific Vitreo-Retinal Society, The Grand Hotel
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2009-11-11
• [Presentation] Intravitreous staining by triamcinolone during PPV. Symposium (2009)
  • Author(s): Sakamoto T.
  • Organizer: 107^<th> Deutche Ophthalmol
  • Place of Presentation: Gesellshaft. Leipzig Messe, Leipzig, Germany
  • Year and Date: 2009-09-26
• [Presentation] Intravitreous staining by triamcinolone during PPV. (2009)
  • Author(s): Sakamoto T.
  • Organizer: Symposium.107th Deutche Ophthalmol.Gesellshaft
  • Place of Presentation: Leipzig Messe, Leipzig, Germany.
  • Year and Date: 2009-09-26
• [Presentation] Pharmacologic adjuvants in 23G and 20G vitrectomy : intra-and postoperative benefits (2009)
  • Author(s): 坂本泰二
  • Organizer: DOG symposium 2009
  • Place of Presentation: Congress Center Leipzig(Germany)
  • Year and Date: 2009-09-26
• [Presentation] トランスレーショナル研究の観点からの網膜研究 (2009)
  • Author(s): 坂本泰二
  • Organizer: 第15回京滋眼疾患シンポジウム
  • Place of Presentation: ウェスティン都ホテル京都(京都市)
  • Year and Date: 2009-09-19
• [Presentation] 網膜剥離における High-mobility group box 1 protein の関与 (2009)
  • Author(s): 有村昇, 喜井裕哉, 橋口照人, 川原幸一, 中村誠, 園田恭志, 山切啓太, 大久保明子, 丸山征郎, 坂本泰二
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2009-04-17
• [Presentation] 網膜剥離における視細胞死とHigh-mobility group box 1 Protein (2009)
  • Author(s): 有村 昇, 喜井裕哉, 橋口照人, 川原幸一, 中村 誠, 園田恭志, 山切啓太, 大久保明子, 丸山征郎, 坂本泰二
  • Organizer: 厚生労働省難治性疾患克服研究事業 網膜脈絡膜・視神経萎縮症調査研究班 平成20年度班会議
  • Place of Presentation: 名古屋市立大学(名古屋市)
  • Year and Date: 2009-01-17
• [Presentation] 裂孔原性網膜剥離における硝子体中SDF-1とその他のサイトカイン (2009)
  • Author(s): 大塚寛樹, 有村 昇, 山切啓太, 橋口照人, 丸山征郎
  • Organizer: 厚生労働省難治性疾患克服研究事業 網膜脈絡膜・視神経萎縮症調査研究班 平成20年度班会議
  • Place of Presentation: 名古屋市立大学(名古屋市)
  • Year and Date: 2009-01-17
• [Presentation] ポリープ状脈絡膜血管症の長期自然経過 (2009)
  • Author(s): 大久保明子, 〓松徳子, 有村昇, 坂本泰二
  • Organizer: 厚生労働省難治性疾患克服研究事業 網膜脈絡膜・視神経萎縮症調査研究班 平成20年度班会議
  • Place of Presentation: 名古屋市立大学(名古屋市)
  • Year and Date: 2009-01-17
• [Presentation] Postoperative inflammation of ocular surface in eyes after small incision vitrectomy (2009)
  • Author(s): Fujita A, Uchino E, Ohtsuka H, Yamakiri K, Arimura N, Sonoda Y, Sakamoto T
  • Organizer: Association for Research in Vision and Ophthalmology(ARVO)Annual Meeting
  • Place of Presentation: Fort Lauderdale, U.SA
• [Presentation] 黄班円孔のうつ伏せ体位期間の考察 (2008)
  • Author(s): 坂本泰二
  • Organizer: 3^<rd> OWHS Summer School
  • Place of Presentation: ホテルグリーンパーク津(三重県津市)
  • Year and Date: 2008-08-15
• [Presentation] HMGB1 and retinal pigment epithelinal cells. (2008)
  • Author(s): Sakamoto T.
  • Organizer: International symposium of 13^<th> Chineseophthalmology Society Annual Meeting.
  • Place of Presentation: Hong Kong
  • Year and Date: 2008-06-28
• [Presentation] 超音波による眼科領域疾患に対する治療の可能性 (2008)
  • Author(s): 坂本泰二, 山下敏史, 園田祥三, 立花克郎
  • Organizer: 日本超音波医学会 第81回学術集会
  • Place of Presentation: 神戸国際展示場(神戸市)
  • Year and Date: 2008-05-23
• [Presentation] Comparative Therapy Evaluation of Intravitreal Bevacizumab and Triamcinolone Acetonide on Persistent Diffuse Diabetic Macular Edema (2008)
  • Author(s): Shimura M, Nakazawa T, Yasuda K, Shiono T, Iida T, Sakamoto T, Nishida K.
  • Organizer: The Association for Reseach in Vision and ophthalmology.
  • Place of Presentation: Fort Lauderdale, U. S. A
• [Presentation] Macular Hole Closure in GasFilled Eyes at Early Post-Operative Time Proven by Fourier-Domain Optical Coherence Tomography. (2008)
  • Author(s): Masuyama K, Yamakiri K, Sonoda Y, Doi N, Sakamoto T.
  • Organizer: The Association for Reseach in Vision and ophthalmology.
  • Place of Presentation: Fort Lauderdale, U. S. A
• [Presentation] Intraocular Pressure Profile of Children With Acute Lymphoblastic Leukemia on a Systemic Corticosteroid (2008)
  • Author(s): Yamashita T, Kodama Y, Kawano Y, Sakamoto T.
  • Organizer: The Association for Reseach in Vision and ophthalmology.
  • Place of Presentation: Fort Lauderdale, U. S. A
• [Presentation] Concentration of Cytokines After Intravitreous Injection of Bevacizumab or Triamcinolone. (2008)
  • Author(s): Otsuka H, Arimura N, Ki-I Y, Yamakiri K, Doi N, Hashiguchi T, Maruyama I, Sakamoto T.
  • Organizer: The Association for Reseach in Vision and ophthalmology.
  • Place of Presentation: Fort Lauderdale, U. S. A
• [Patent(Industrial Property Rights)] 血管新生抑制剤 (2011)
  • Inventor(s): 小戝健一郎、坂本泰二、上笹貫太郎
  • Industrial Property Rights Holder: 鹿児島大学
  • Industrial Property Number: 2011-510400
  • Filing Date: 2011-10-20
• [Patent(Industrial Property Rights)] 血管新生抑制剤 (2010)
  • Inventor(s): 小戝健一郎,坂本泰二,上笹貫太郎
  • Industrial Property Rights Holder: 鹿児島大学
  • Filing Date: 2010-04-23
  • Overseas
• [Patent(Industrial Property Rights)] 血管新生抑制剤 (2010)
  • Inventor(s): 小戝健一郎、坂本泰二、上笹貫太郎
  • Industrial Property Rights Holder: 鹿児島大学
  • Filing Date: 2010-04-19
  • Overseas
• [Patent(Industrial Property Rights)] 血管新生抑制剤 (2009)
  • Inventor(s): 小戝健一郎、坂本泰二、上笹貫太郎
  • Industrial Property Rights Holder: 鹿児島大学
  • Filing Date: 2009-04-23