• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Creation of new treatment protocol according to the biological prognostic factors for Wilms Tumor

Research Project

Project/Area Number 20390452
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionOsaka University

Principal Investigator

OUE Takaharu  Osaka University, 医学系研究科, 講師 (50314315)

Co-Investigator(Kenkyū-buntansha) FUKUZAWA Masahiro  大阪大学, 医学系研究科, 教授 (60165272)
MUGISHIMA Hideo  日本大学, 医学部, 教授 (80183648)
KANEKO Yasuhiko  埼玉県立がんセンター, 臨床腫瘍研究所, 所長 (50373387)
NOZAKI Miwako  獨協医科大学, 医学部, 准教授 (30197727)
KOSHINAGA Tsugumichi  日本大学, 医学部, 准教授 (70205376)
OKITA Hajime  国立成育医療センター, 小児血液腫瘍研究部・分子病理研究室, 室長 (50317260)
NAKADATE Hisaya  北里大学, 医学部, 講師 (30306633)
HINOTSU Shiro  京都大学, 医学研究科, 准教授 (80323567)
CHIN Motoaki  日本大学, 医学部, 助教 (50277422)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
KeywordsWilms腫瘍 / グループスタディ / 治療プロトコル / 生物学的予後因子 / CCSK / RTK / 両側性腎芽腫 / JWiTS / PTK / 予後因子 / リスク分類 / プロトコール
Research Abstract

The results of the Japan Wilms Tumor Study group JWiTS-1 was that the OS of patients in the JWiTS-1 study were comparable with the results of other multicenter studies in the USA and Europe. The outcome for patients with nephroblastoma and CCSK was fair. In contrast, the cure rate for those with RTK was not satisfactory. In the patients with bilateral tumor, preservation of renal function was not satisfactory. New treatment strategies are needed for patients with RTK and bilateral Wilms tumor.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (54 results)

All 2010 2009 2008 Other

All Journal Article (16 results) (of which Peer Reviewed: 6 results) Presentation (35 results) Remarks (3 results)

  • [Journal Article] Increased expression of the hedgehog signaling pathway in pediatric solid malignancies.2010

    • Author(s)
      Oue T, Yoneda A, Fukuzawa M, et al
    • Journal Title

      Journal of Pediatric Surgery. 45(2)

      Pages: 387-392

    • Related Report
      2010 Final Research Report
  • [Journal Article] Increased expression of the hedgehog signaling pathway in pediatric solid malignancies2010

    • Author(s)
      Oue T, Yoneda A, Uehara S, Yamanaka H, Fukuzawa M
    • Journal Title

      Journal of Pediatric Surgery.

      Volume: 45 Pages: 387-392

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Forskolin, a Hedgehog signal inhibitor, inhibits cell proliferation and induces apoptosis in pediatric tumor cell lines2010

    • Author(s)
      Yamanaka H, Oue T, Uehara S, Fukuzawa M
    • Journal Title

      Moleculaz Medicine Reports

      Volume: 3 Pages: 133-139

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of pediatric renal tumor treated using the Japan Wilms Tumor Study-1 (JWiTS-1) protocol : a report from the JWiTS group.2009

    • Author(s)
      Oue T, Fukuzawa M, Okita H, Mugishima H, Horie H, Hata J, Saito M, Nozaki M, Chin M, Nakadate N, Hinotsu S, Koshinaga T, Kaneko Y, Kitano Y, Tanaka Y
    • Journal Title

      Pediatr Surg Int. 25

      Pages: 923-929

    • NAID

      10029307681

    • Related Report
      2010 Final Research Report
  • [Journal Article] Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a 7p21 homozygous deletion region in a Wilms tumor.2009

    • Author(s)
      Ohshima J, Okita H, Fukuzawa M, Hata J, Horie H, Kaneko Y, et al
    • Journal Title

      Genes Chromosomes Cancer 48(12)

      Pages: 1037-1050

    • Related Report
      2010 Final Research Report
  • [Journal Article] Increased expression of multidrug resistance-associated genes after chemotherapy in pediatric solid malignancies.2009

    • Author(s)
      Oue T, Yoneda A, Fukuzawa M, et al
    • Journal Title

      J Pediatr Surg. 44(2)

      Pages: 377-380

    • Related Report
      2010 Final Research Report
  • [Journal Article] 日本における小児腎腫瘍治療の現況と展望2009

    • Author(s)
      大植孝治, 上原秀一郎, 福澤正洋
    • Journal Title

      日本小児科学会雑誌 113(11)

      Pages: 1619-1625

    • NAID

      10026276367

    • Related Report
      2010 Final Research Report
  • [Journal Article] 日本ウィルムス腫瘍スタディグループ-1登録症例の追跡調査報告2009

    • Author(s)
      大植孝治, 福澤正洋, 大喜多肇, 金子安比古, 北野良博, 越永従道, 齋藤正博, 田中祐吉, 陳基明, 中舘尚也, 野崎美和子, 秦順一, 樋之津史郎, 堀江弘, 麦島秀雄
    • Journal Title

      小児がん 46(3)

      Pages: 349-358

    • Related Report
      2010 Final Research Report
  • [Journal Article] Outcome of pediatric renal tumor treated using the Japan Wilms Tumor Study-1 (JWiTS-1) protocol : a report from the JWiTS group.2009

    • Author(s)
      Oue T, Fukuzawa M, Okita H, et al
    • Journal Title

      Pediatric Surgery International 25

      Pages: 923-929

    • NAID

      10029307681

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本小児科学会雑誌2009

    • Author(s)
      大植孝治, 上原秀一郎, 福澤正洋
    • Journal Title

      日本における小児腎腫瘍治療の現況と展望 113

      Pages: 1619-1625

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 小児がん2009

    • Author(s)
      大植孝治, 福澤正洋, 大喜多肇, 他
    • Journal Title

      日本ワィルムス腫瘍スタディグループ-1(JWiTS-1)登録症例の追跡調査報告 46

      Pages: 349-358

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of multidrug resistance-associated genes afterchemotherapy in pediatric solid malignancies.2009

    • Author(s)
      Oue T, Fukuzawa M, et al
    • Journal Title

      J Pediatr Sure 44 (2)

      Pages: 377-380

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胎児固形腫瘍の治療方針2009

    • Author(s)
      大植孝治, 福澤正洋, 他
    • Journal Title

      日本産婦人科新生児血液学会雑誌 (印刷中)

    • NAID

      10026709761

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Duplication of paternal IGF2 or loss of maternal IGF2 imprinting occurs in half of Wilms tumors with various structural WT1 abnormalities.2008

    • Author(s)
      Haruta M, Nakadate H, Okita H, Hata J, Fukuzawa M, Kaneko Y, et al
    • Journal Title

      Genes Chromosomes Cancer. 47(8)

      Pages: 712-727

    • Related Report
      2010 Final Research Report
  • [Journal Article] Combined BubR1 protein down-regulation and RASSF1A hypermethylation in Wilms tumors with diverse cytogenetic changes.2008

    • Author(s)
      Haruta M, Fukuzawa M, Kaneko Y, et al
    • Journal Title

      Mol Carcinog 47(9)

      Pages: 660-666

    • Related Report
      2010 Final Research Report
  • [Journal Article] Pediatric thyroid cancer arising after treatment forPleuropulmonary blastoma2008

    • Author(s)
      Oue T, Inoue M, et al
    • Journal Title

      Pediatr Blood Cancer 50(4)

      Pages: 901-902

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Outcome of Pediatric Renal Tumor Treated With the JWiTS-1 Protocol : A Report From the Japan Wilms Tumor Study (JWITs) Group.2010

    • Author(s)
      Oue T, Fukuzawa M, Koshinaga T, et al
    • Organizer
      日本小児がん学会
    • Place of Presentation
      大限
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Outcome of Pediatric Renal Tumor Treated With the JWiTS-1 Protocol : A Report From the Japan Wilms Tumor Study(JWITs) Group.2010

    • Author(s)
      Oue T, Fukuzawa M, Koshinaga T, et al
    • Organizer
      日本小児がん学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児悪性固形腫瘍に対する造血幹細胞移植併用大量化学療法後の周術期管理について2010

    • Author(s)
      上原秀一郎, 大植孝治, 米田光宏, 他
    • Organizer
      第26回日本小児がん学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児悪性腫瘍に対するHedgehogシグナル伝達経路阻害剤Forskolinの抗腫瘍効果の可能性に関する検討2010

    • Author(s)
      大植孝治, 山中宏晃, 上原秀一郎, 福澤正洋
    • Organizer
      第23回日本バイオセラピー学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Surgical Management after High-dose Chemotherapy with Hematopoietic Stem Cell Transplantation for Pediatric Malignancies.2010

    • Author(s)
      Oue T, Uehara S, Yoneda A, et al
    • Organizer
      42^<nd> Congress of the International Society of Paediatric Oncology
    • Place of Presentation
      ボストン、アメリカ
    • Year and Date
      2010-10-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児腫瘍領域における胸腔鏡下手術(VATS)の適応と意義2010

    • Author(s)
      大植孝治, 上原秀一郎, 曹英樹, 他
    • Organizer
      第48回日本癌治療学会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Outcome of Pediatric Renal Tumor Treated With the JWiTS-1 Protocol : A Report From the Japan Wilms Tumor Study (JWITs) Group.2010

    • Author(s)
      Oue T, Fukuzawa M, Koshinaga T, et al
    • Organizer
      9^<th> International Conference of the Asian Clinical Oncology Study
    • Place of Presentation
      岐阜
    • Year and Date
      2010-08-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 良性後腹膜腫瘍に対する腹腔鏡補助下摘出術.日本外科学会2010.03第2010

    • Author(s)
      福澤正洋, 大植孝治, 曹英樹, 上原秀一郎
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-04-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児腫瘍におけるHedgehog signal系の発現に関する免疫組織学的検討2010

    • Author(s)
      大植孝治, 山中宏晃, 上原秀郎, 福澤正洋
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大量胸水によりoncologic emergencyを呈したウィルムス腫瘍の1再発例2010

    • Author(s)
      上原秀一郎, 大植孝治, 福澤正洋、他
    • Organizer
      JWiTS研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-01-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Outcome of Pediatric Renal Tumor Treated With the JWiTS-1 Protocol : A Report From the Japan Wilms Tumor Study (JWITs) Group.2010

    • Author(s)
      Oue T, Fukuzawa M, Koshinaga T, Mugishima H, Nozaki M, Chin M, Nakadate H, Hinotsu S, Kaneko Y, Okita H, et al
    • Organizer
      第26回日本小児がん学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2010 Final Research Report
  • [Presentation] Surgical Management after High-dose Chemotherapy with Hematopoietic Stem Cell Transplantation for Pediatric Malignancies.2010

    • Author(s)
      OueT, Uehara S, S,Fukuzawa M, et al
    • Organizer
      42^<nd> Congress of SIOP
    • Place of Presentation
      Boston, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Outcome of Pediatric Renal Tumor Treated With the JWiTS-1 Protocol : A Report From the Japan Wilms Tumor Study (JWITs) Group.2010

    • Author(s)
      Oue T, Fukuzawa M, Koshinaga T, Mugishima H, Nozaki M, Chin M, Hinotsu S, Kaneko Y, Okita H, et al
    • Organizer
      9^<th> International Conference of the Asian Clinical Oncology Study
    • Place of Presentation
      Gifu
    • Related Report
      2010 Final Research Report
  • [Presentation] The Role of WT1 gene in neuroblastoma.2010

    • Author(s)
      OueT, Wang J, Fukuzawa M, et al
    • Organizer
      57^<th> Annual Congress of the British Association of the Paediatric Surgeons
    • Place of Presentation
      Aberdeen, UK
    • Related Report
      2010 Final Research Report
  • [Presentation] Rhabdoid tumor of the kidney(RTK)に対する集学的治療法の提案2009

    • Author(s)
      陳基明、大植孝治、福澤正洋, 他
    • Organizer
      日本小児がん学会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日本ウィルムス腫瘍スタディグループ(JWiTS)-1における晩期障害調査報告2009

    • Author(s)
      中舘尚也、大植孝治、福澤正洋, 他
    • Organizer
      日本小児がん学会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Wilms腫瘍の7p21ホモ欠失領域から同定された候補腫瘍抑制遺伝子MEOX2とSOSTDC12009

    • Author(s)
      大島淳二郎、福澤正洋、金子安比古, 他
    • Organizer
      日本小児がん学会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Wilms腫瘍の7p21ホモ欠失領域から同定された候補腫瘍抑制遺伝子MEOX2とSOSTDCl2009

    • Author(s)
      大島淳二郎、福澤正洋、金子安比古, 他
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] ウイルムス腫瘍で初めて同定されたAPC遺伝子変異2009

    • Author(s)
      春田雅之、福澤正洋、金子安比古, 他
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日本ワイルムス腫瘍スタディグループ(JWiTS)登録症例の追跡調査報告2009

    • Author(s)
      大植孝治、福澤正洋、越永従道, 他
    • Organizer
      日本小児外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-06-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 難治性腎腫瘍に対する治療戦略Rhabdoid tumor of the kidney(RTK)に対する治療戦略2009

    • Author(s)
      陳基明、大植孝治、福澤正洋, 他
    • Organizer
      日本小児外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-06-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rhabdoid tumor of the kidney (RTK)に対する集学的治療法の提案2009

    • Author(s)
      陳基明,大植孝治, 越永従道, 野崎美和子, 桶之津史郎, 大喜多肇, 金子安比古, 麦島秀雄, 福澤正洋、他
    • Organizer
      日本小児がん学会
    • Place of Presentation
      千葉
    • Related Report
      2010 Final Research Report
  • [Presentation] 日本ウィルムス腫瘍シュタディ(JWiTS)-1における晩期障害調査報告2009

    • Author(s)
      中舘尚也, 陳基明, 大植孝治, 越永従道, 野崎美和子, 桶之津史郎, 大喜多肇, 金子安比古, 麦島秀雄, 福澤正洋, 他
    • Organizer
      日本小児がん学会
    • Place of Presentation
      千葉
    • Related Report
      2010 Final Research Report
  • [Presentation] Wilms腫瘍の7p21ホモ欠失領域から同定された候補腫瘍抑制遺伝子MEOX2とSOSTDC12009

    • Author(s)
      大島淳二郎, 大喜多肇, 福澤正洋, 金子安比古、他
    • Organizer
      日本小児がん学会
    • Place of Presentation
      千葉
    • Related Report
      2010 Final Research Report
  • [Presentation] ウィルムス腫瘍で初めて同定されたAPC遺伝子変異2009

    • Author(s)
      春田雅之, 大喜多肇, 秦順一, 福澤正洋, 金子安比古
    • Organizer
      日本がん学会
    • Place of Presentation
      千葉
    • Related Report
      2010 Final Research Report
  • [Presentation] 難治性腎腫瘍に対する治療戦略Rhabdoid tumor of the kidney (RTK)に対する治療戦略2009

    • Author(s)
      陳基明, 大植孝治, 越永従道, 野崎美和子, 桶之津史郎, 大喜多肇, 金子安比古, 麦島秀雄, 福澤正洋、他
    • Organizer
      日本小児外科学会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 難治性腎腫瘍に対する治療戦略日本ウィルムス腫瘍スタディグループにおける両側性腎芽腫の検討2009

    • Author(s)
      越永従道, 大植孝治, 大喜多肇, 金子安比古, 陳基明, 野崎美和子, 樋之津史郎, 麦島秀雄, 福澤正洋、他
    • Organizer
      日本小児外科学会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 日本ウィルムス腫瘍スタディグループ(JWiTS)登録症例の追跡調査報告2009

    • Author(s)
      大植孝治、福澤正洋、越永従道、樋之津史郎、大喜多肇、金子安比古、陳基明、麦島秀雄、野崎美和子、他
    • Organizer
      日本小児外科学会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] ウィルムス腫瘍グループスタディにおける腎横紋筋肉腫様腫瘍(RTK)に対する集学的治療2008

    • Author(s)
      越永従道, 陳基明, 野崎美和子, 麦島秀雄, 大植孝治, 大喜多肇, 金子安比古, 樋之津史郎, 福澤正洋、他
    • Organizer
      日本小児がん学会
    • Place of Presentation
      幕張
    • Related Report
      2010 Final Research Report
  • [Presentation] 日本ウィルムス腫瘍スタディ(JWiTS)-1における晩期障害調査研究JWiTS報告2008

    • Author(s)
      中舘尚也, 陳基明, 越永従道, 樋之津史郎, 大植孝治, 大喜多肇, 金子安比古, 野崎美和子, 麦島秀雄, 福澤正洋、他
    • Organizer
      日本小児がん学会
    • Place of Presentation
      幕張
    • Related Report
      2010 Final Research Report
  • [Presentation] がん抑制遺伝子RASSF1Aのメチル化はウィルムス腫瘍の新しい予後因子である2008

    • Author(s)
      大島淳二郎, 金子安比古, 樋之津史郎, 越永従道, 大喜多肇, 陳基明, 野崎美和子, 大植孝治, 福澤正洋、他
    • Organizer
      日本小児がん学会
    • Place of Presentation
      幕張
    • Related Report
      2010 Final Research Report
  • [Presentation] 日本人Wilms腫瘍においてWTX欠失はWT1異常と合併するがCTNNB1変異とは合併しない2008

    • Author(s)
      春田雅之, 大喜多肇, 福澤正洋, 金子安比古、他
    • Organizer
      日本小児がん学会
    • Place of Presentation
      幕張
    • Related Report
      2010 Final Research Report
  • [Presentation] 日本ウィルムス腫瘍スタディグループ(JWiTS)登録症例の追跡調査報告2008

    • Author(s)
      大植孝治, 福澤正洋, 越永従道, 樋之津史郎, 大喜多肇, 金子安比古, 陳基明, 麦島秀雄, 野崎美和子、他
    • Organizer
      日本小児がん学会
    • Place of Presentation
      幕張
    • Related Report
      2010 Final Research Report
  • [Presentation] Wilms腫瘍における術前化学療法による画像所見及び病理所見の変化2008

    • Author(s)
      大植孝治, 米田光宏, 福澤正洋, 他
    • Organizer
      日本外科学会
    • Place of Presentation
      つくば
    • Related Report
      2010 Final Research Report
  • [Presentation] ncreased expression of multi-drug resist assocoatedgenes after chemo therapy in pesiatric solidmalignacies2008

    • Author(s)
      Oue T, Fukuzawa M, et al
    • Organizer
      55^<th> British Association of PediatricSurgeons
    • Place of Presentation
      Salamanca, Spain
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://jwits.umin.ac.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://jwits.umin.ac.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://jwits.umin.ac.jp/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi