| Project/Area Number |
20390474
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
|
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| Research Institution | Showa University |
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Principal Investigator |
TAKAMI Masamichi Showa University, 歯学部, 講師 (80307058)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIJO Ryutaro 昭和大学, 歯学部, 教授 (70233939)
TAKAYANAGI Hiroshi 東京医科歯科大学, 医歯薬学総合研究科, 教授 (20334229)
|
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| Co-Investigator(Renkei-kenkyūsha) |
TAMURA Tomohiko 横浜市立大学, 医学部, 教授 (50285144)
YAMADA Atsushi 昭和大学, 歯学部, 講師 (50407558)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 骨 / 破骨細胞 / 炎症 / 細胞分化 / IRF-8 / RANKL / 免疫 / 遺伝子 / Toll-like receptor / 歯周病 / 歯 / 骨代謝 / 自然免疫 / 骨芽細胞 / 骨粗鬆症 / 骨破壊 / 転写因子 |
|---|
| Research Abstract |
Identification of osteoclast differentiation regulatory factors will be beneficial for understanding the mechanisms of cellular differentiation and the development of treatment methods for bone diseases. We found that a transcription factor IRF-8 plays a role of suppressing osteoclast differentiation and IRF-8 deficient mice exhibit severe osteoporosis. We also revealed molecular mechanism of the inhibitory action of IRF-8 and published the results in Nature Medicine (15 : 1066-1071, 2009). This finding will contribute to biological research and medicine including bone diseases.
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