| Co-Investigator(Kenkyū-buntansha) |
TSUBOI Akito 東北大学, 病院, 准教授 (00241646)
YAMAGUCHI Satoshi 東北大学, 病院, 助教 (50400263)
KIKUCHI Masahiko 東北大学, 病院, 教授 (60195211)
ITO Shintaro 東北大学, 大学院・歯学研究科, 非常勤講師 (00361105)
FUKUDA Hiroshi 東北大学, 加齢医学研究所, 教授 (30125645)
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| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Research Abstract |
The aim of the present study was to investigate the effects of different mastication on the dopaminergic system in the rat striatum using positron emission tomography (PET)and brain microdialysis (MD). Male F344 rats were fed solid diets (group-S)or powder diets (group-P). These rats were bred reach to 8 and 60 weeks old under the above conditions. As the result of PET study, the accumulation of 11C-RAC at 60 weeks old of group-S was lower than that of group-P. As the result of MD study, dopamine release at 8 and 60 weeks old of group-P was higher than that of group-S. These results suggest that the different mastication influenced on dopaminergic system at the molecular level.
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