| Project/Area Number |
20390514
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyoto University |
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Principal Investigator |
FUJIMURA Kazuma Kyoto University, 大学院・医学研究科, 准教授 (30252399)
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| Co-Investigator(Kenkyū-buntansha) |
OKUBO Yasunori 京都大学, 医学研究科, 講師 (50378618)
別所 和久 京都大学, 医学研究科, 教授 (90229138)
高藤 洋之 京都大学, 医学研究科, 助教 (90378703)
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| Research Collaborator |
BESSHO Kazuhisa 京都大学, 医学研究科, 教授 (90229138)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 滑膜 / 顎関節 / 滑液 / 滑膜細胞 / 顎関節症 / 分化能 |
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| Research Abstract |
Mesenchymal stem cell are fasciating soureces for regenerative medicine. In previous studies, the ability of the proliferation and differentiation was different. Therefore, we investigated that this time clarify the conection between the clinical symptoms and the differentiation potential. Syonovial fluid was obtained from 13 patients with temporomandibular disorder (TMD). We culutured the adherent cells of the 6 in 13 samples that had the detail clinical findings. The subjects were divided into 2 groups. The first group included high differentiation of osteoblast and chondrocyte. The second group included poor differentiation.
The clinic symptoms was measured using the pain score and the mouth-opening distance. The pain score was assessed using a visual analogue scale. There was a significant difference in the osteogenic and chondrogenic potential among the two groups. In the clinical findings, there was a significant correlation in the pain score among the two groups. However, no difference was observed the mouth-opening distance. These results were demonstrated that osteogenic and chondrogenic potential of synovium-derived cells were significantly different in TMD.
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