Evaluation of relationships between root resorption accompanied with orthodontic tooth movement and cell death of cementum-related cells
| Project/Area Number |
20390525
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
MIZOGUCHI Itaru (ITARU Mizoguchi) 北海道医療大学, 歯学部, 教授 (20200032)
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| Co-Investigator(Kenkyū-buntansha) |
TAKUMA Taishin 北海道医療大学, 歯学部, 教授 (40095336)
TORIYA Naoko 北海道医療大学, 歯学部, 助教 (20433435)
上地 潤 北海道医療大学, 歯学部, 講師 (80372879)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Keywords | 歯根吸収 / 歯の移動 / セメント芽細胞 / セメント細胞 / 細胞死 / セメント質 |
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| Research Abstract |
The purpose of this study was to clarify the biological mechanism of root resorption caused by orthodontic tooth movement. 8-week-old Wistar rats were used as an experimental animal model. The unilateral first molar was moved buccaly by a cantilever-type Ni-Ti wire(. 012 inch in diameter). The initial force was adjusted to 20 gf. The results indicate that cell death of cementoblasts of acellular cementum accompanied by orthodontic tooth movement may induce resorptive activities of odontoclasts, which suggest relationship between cell death of cementoblasts and root resorption.
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Report
(6 results)
Research Products
(135 results)
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[Journal Article] High frequency of hypermethylation of p14, p15 and p16 in oral pre-cancerous lesions associated with betel-quid chewing in Sri Lanka2008
Author(s)
Takeshima M, Saitoh M, Kusano K, Nagayasu H, Kurashige Y, Malsantha M, Arakawa T, Takuma T, Chiba I, Kaku T, Shibata T, Abiko Y.
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Journal Title
J Oral Pathol Med
Volume: Vol.37
Pages: 475-479
Related Report
Peer Reviewed
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[Presentation] 歯並びと健康2011
Author(s)
溝口到
Organizer
第31回北海道学校歯科保健研究大会
Place of Presentation
北海道歯科医師会館(北海道)
Year and Date
2011-10-14
Related Report
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[Presentation] 歯並びと健康2011
Author(s)
溝口到
Organizer
北海道歯科医師会
Place of Presentation
北海道歯科医師会館(北海道)(招待講演)
Year and Date
2011-10-14
Related Report
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[Presentation] 矯正歯科治療の変遷2009
Author(s)
溝口到
Organizer
北海道矯正歯科学会(招待講演)
Place of Presentation
札幌歯科医師会館(北海道)
Year and Date
2009-06-21
Related Report
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