Building management systems with highly predictive of periodontal disease

• Project/Area Number: 20390535
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Osaka University
• Principal Investigator: TANAKA Muneo Osaka University, 歯学部附属病院, 講師 (90263300)
• Co-Investigator(Kenkyū-buntansha): OJIMA Miki 大阪大学, 大学院・歯学研究科, 助教 (20263303) ; SHIZUKUISHI Satoshi 大阪大学, 大学院・歯学研究科, 教授 (00028789) ; NISHIDA Nobuko 大阪大学, 歯学部附属病院, 医員 (80456946)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2008: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
• Keywords: メタボリックシンドローム / 歯周病 / 糖尿病 / 動脈硬化性疾患 / 動脈化性疾患 / 咀嚼能力 / 歯数 / 生活習慣 / 全身状態 / 口腔状態 / 血糖値 / QOL

Research Abstract

The purpose of this investigation was to examine the association of periodontal disease and various components of metabolic syndrome. High blood sugar, reduced HDL-Cholesterol and elevated triglycerides were significantly associated with number of teeth as risk indicators. High blood pressure and periodontitis were significantly associated with macrovascular disease(s) as risk indicators. Levels of the inflammatory biomarkers in the subjects with periodontitis increased meaningfully in comparison with the subjects without periodontitis. Periodontal disease was involved in atherosclerotic disease in diabetes. Diabetic patients with periodontitis has significantly higher levels of 8-isopurosutan.

Research Products

• [Journal Article] 最近の歯周病と栄養素・食品に関するエビデンス (2011)
  • Author(s): 雫石聰, 田中宗雄
  • Journal Title: 口腔衛生学会雑誌 61 Pages: 2-12
  • NAID: 110008440556
  • Peer Reviewed
• [Journal Article] 最近の歯周病と栄養素・食品に関するエビデンス (2011)
  • Author(s): 雫石聰, 田中宗雄
  • Journal Title: 口腔衛生学会雑誌 Volume: VOL61 Pages: 2-12
  • NAID: 110008440556
  • Peer Reviewed
• [Journal Article] Fusobacterium nucleatum envelope protein FomA is immunogenic and binds to the salivary statherin-derived peptide. (2010)
  • Author(s): Nakagaki, H. Sekine, S., Terao, Y., Toe, M., Tanaka, M., Ito, H. O., Kawabata, S., Shizukuishi, S., Fujihashi. K., Kataoka, K.
  • Journal Title: Infection and Immunity 78 Pages: 1185-1192
  • Peer Reviewed
• [Journal Article] Association of ALDH2 genotypes with periodontitis progression. (2010)
  • Author(s): Nishida, N., Tanaka, M., Sekine, S., Takeshita, T., Nakayama, K., Morimoto, K., Shizukuishi, S.
  • Journal Title: Journal of Dental Research 89 Pages: 138-142
  • Peer Reviewed
• [Journal Article] Association of ALDH2 genotypes with periodontitis progression. (2010)
  • Author(s): Nishida N, Tanaka M
  • Journal Title: Journal of Dental Research Volume: VOL89 Pages: 138-142
  • Peer Reviewed
• [Journal Article] Fusobaterium nucleatum envelope protein FomA is immunogenic and binds to salivary statherin derived peptide. (2010)
  • Author(s): Nakagaki H, Tanaka M
  • Journal Title: Infection and Immunology Volume: VOL78 Pages: 1185-1192
  • Peer Reviewed
• [Journal Article] Association between involuntary smoking and salivary markers related to periodontitis : a 2-year longitudinal study. (2008)
  • Author(s): Nishida, N., Tanaka, M., Shizukuishi S.
  • Journal Title: Journal of Periodontology 79 Pages: 2233-2240
  • Peer Reviewed
• [Journal Article] 解明されつつあるメタボリックシンドロームと歯周病との関係 (2008)
  • Author(s): 雫石聰, 田中宗雄
  • Journal Title: 医療と検査機器・試薬 31 Pages: 34-40
• [Journal Article] 歯周病と予防食品の開発 (2008)
  • Author(s): 雫石聰, 田中宗雄
  • Journal Title: 食品と開発 43 Pages: 4-6
• [Journal Article] Association between involuntary smoking and salivary markers related to periodontitis : a 2-year longitudinal study. (2008)
  • Author(s): Nishida N
  • Journal Title: Journal of Periodontology 79 Pages: 2233-2240
  • Peer Reviewed
• [Journal Article] 解明されつつあるメタボリックシンドロームと歯周病との関係 (2008)
  • Author(s): 雫石 聰
  • Journal Title: 医療と検査機器・試薬 31 Pages: 34-40
• [Journal Article] 歯周病と予防食品の開発 (2008)
  • Author(s): 雫石 聰
  • Journal Title: 食品と開発 43 Pages: 4-6
• [Presentation] 糖尿病患者において歯周病が動脈硬化性疾患に与える影響の検討 (2010)
  • Author(s): 大月道夫, 田中宗雄, 雫石聰
  • Organizer: 第53回糖尿病学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-29
• [Presentation] Relationship of tooth number and metabolic syndrome in a general urban population : Suita study. (2009)
  • Author(s): 加登聡, 田中宗雄
  • Organizer: 日 補綴歯科学会第118回学術大会
  • Place of Presentation: Kyoto
• [Presentation] Relationship of tooth number and metabolic syndrome in a general urban population : Suita study. (2009)
  • Author(s): Kato S.
  • Organizer: 日本補綴歯科学会 第118回学術大会
  • Place of Presentation: 京都
• [Presentation] 都市部一般住民における歯数とメタボリックシンドロームとの関係:吹田研究 (2008)
  • Author(s): 加登聡, 田中宗雄
  • Organizer: 第19回NPO法人日本咀嚼学会学術大会
  • Place of Presentation: 早稲田
  • Year and Date: 2008-09-27
• [Presentation] 都市部一般住民における歯数とメタボリックシンドロームとの関係 : 吹田研究 (2008)
  • Author(s): 加登 聡
  • Organizer: 第19回NPO法人日本咀嚼学会学術大会
  • Place of Presentation: 早稲田
  • Year and Date: 2008-09-27
• [Presentation] Relationship between the Blood-sugar Level and Daily Tooth Brushing/Tooth Loss in the Urban Living Elderly Japanese : The Suita Study (2008)
  • Author(s): Hori, K, Tanaka M
  • Organizer: European College of Gerodontology Satellite Symposium
  • Place of Presentation: London, UK
  • Year and Date: 2008-09-09
• [Presentation] Relationship between the Blood-sugar Level and Daily ToothBrushing / Tooth Loss in the Urban Living Elderly Japanese : The Suita Study (2008)
  • Author(s): Hori, K
  • Organizer: European College of Gerodontology Satellite Symposium
  • Place of Presentation: London, UK
  • Year and Date: 2008-09-09
• [Presentation] 歯周病進行リスクとしての喫煙と唾液中の歯周病関連バイオマーカーとの関連性に関する縦断的研究 (2008)
  • Author(s): 木林美由紀, 田中宗雄, 雫石聰
  • Organizer: 大阪大学歯学会第106回例会
  • Place of Presentation: 吹田市
  • Year and Date: 2008-07-17
• [Presentation] 歯周病進行リスクとしての喫煙と唾液中の歯周病調連バイオマーカーとの関連性に関する縦断的研究 (2008)
  • Author(s): 木林美由紀
  • Organizer: 大阪大学歯学会第106回例会
  • Place of Presentation: 吹田市
  • Year and Date: 2008-07-17
• [Presentation] Classification of halitosis by malodor intensities measured with an electronic nose. (2008)
  • Author(s): 田中宗雄, 雫石聰
  • Organizer: 86th General session & exhibition of the IADR
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-07-05
• [Presentation] Prediction of halitosis-treatment outcome using malodor intensities measured by an electronic nose. (2008)
  • Author(s): 雫石聰, 田中宗雄
  • Organizer: 86th General session & exhibition of the IADR
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-07-05
• [Presentation] Classification of halitosis by malodor intensities measured with an electronic nose. (2008)
  • Author(s): Tanaka, M
  • Organizer: 86th General session & exhibition of theIADR
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-07-05
• [Presentation] Prediction of halitosis-treatment outcome using malodor intensities measured by an electronic nose. (2008)
  • Author(s): Shizukuishi, S
  • Organizer: 86th General session & exhibition of theIADR
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-07-05
• [Presentation] 電子嗅覚装置による臭気指数を用いた口臭症の分類とその治療予後 (2008)
  • Author(s): 野田倫世, 田中宗雄, 雫石聰
  • Organizer: 第19回日本口腔衛生学会近畿・中国・四国地方会総会
  • Place of Presentation: 徳島市
  • Year and Date: 2008-06-22
• [Presentation] 電子嗅覚装置による臭気指数を用いた口臭症の分類とその治療予後 (2008)
  • Author(s): 野田倫世
  • Organizer: 第19回日本口腔衛生学会 近畿・中国・四国地方会総会
  • Place of Presentation: 徳島市
  • Year and Date: 2008-06-22
• [Presentation] 糖尿病患者における動脈硬化性疾患と歯周病の関連 (2008)
  • Author(s): 笠山宗正, 田中宗雄, 雫石聰
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22
• [Book] 健康寿命を延ばす歯科保健医療(日本歯科総合研究機構編) (2009)
  • Author(s): 田中宗雄
  • Publisher: 医歯薬出版株式会社
• [Book] 健康寿命を延ばす歯科保健医療 (2009)
  • Author(s): 田中宗雄
  • Total Pages: 182
  • Publisher: 医歯薬出所株式会社
• [Book] 歯周病と喫煙との関連性についてのEBM.歯科医学のカッティングエッジ(米田俊行編) (2008)
  • Author(s): 雫石聰, 田中宗雄
  • Publisher: 大阪大学出版会
• [Book] 歯周病と喫煙との関連性についてのEBM. 歯科医学のカッティングエッジ, 米田俊行編 (2008)
  • Author(s): 雫石聰
  • Total Pages: 289
  • Publisher: 大阪大学出版会