| Project/Area Number |
20390537
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Social dentistry
|
|---|
| Research Institution | Kyushu Dental College |
|---|
Principal Investigator |
TAKEHARA Tadamichi Kyushu Dental College, 歯学部, 名誉教授 (00038879)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Akihiro 九州歯科大学, 歯学部, 助教 (20364151)
ANSAI Toshihiro 九州歯科大学, 歯学部, 准教授 (80244789)
AWANO Shuji 九州歯科大学, 歯学部, 講師 (20301442)
SOH Inho 九州歯科大学, 歯学部, 助教 (10285463)
濱嵜 朋子 九州歯科大学, 歯学部, 助教 (60316156)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
|
|---|
| Keywords | 細菌間シグナル / クオラムセンシング / バイオフィルム / 口腔細菌 / 阻害剤 |
|---|
| Research Abstract |
We initially produced several analogues by modifying the chemical structures of autoinducer-2 (AI-2). We examined the inhibitory activities of these analogues by examining the luminescence activities of Vibrio harveyi, a luminescent marine bacterium species. Of the analogues synthesized, we chose those that inhibited the luminescence activities of V.harveyi. Using the selected analogues, we analyzed the inhibitory effects of these analogues on biofilm formation by oral streptococci, including Streptococcus mutans, a human cariogenic species. Some of the analogues inhibited biofilm formation by these bacteria, although some of the analogues that inhibited biofilm formation by S. mutans did not inhibit biofilm formation by other streptococci. We could not find a common inhibitor for all oral streptococci. Now we are analyzing the role of these analogues in the expression of S.mutans glucosyltransferase (GTF) genes and their function in biofilm formation by S.mutans.
|
