| Project/Area Number |
20406014
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Hygiene
|
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
YOSHIDA Takahiko Asahikawa Medical College, 医学部, 教授 (90200998)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUTI Hirosi 北里大学, 医療衛生学部, 教授 (90081661)
角 大悟 筑波大学, 人間総合科学研究科, 講師 (30400683)
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| Co-Investigator(Renkei-kenkyūsha) |
SUMI Daigo 徳島文理大学, 薬学部, 準教授 (30400683)
SAIJYOU Yasuaki 旭川医科大学, 医学部, 教授 (70360906)
ITOU Tosihiro 旭川医科大学, 医学部, 講師 (20271760)
SUGIOKA Yosihiko 旭川医科大学, 医学部, 助教 (30398747)
NAKAGI Yosihiko 旭川医科大学, 医学部, 助教 (90322908)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
|
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| Keywords | 砒素 / 排泄促進 / 解毒 / 無毒化 / 改善予防 |
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| Research Abstract |
Originally manufactured broccoli (B) powder was treated to hamster and healthy volunteer and evaluated metabolism and excretion of arsenic. Secondly, detoxifying process of environmental arsenic was investigated. B powder enhanced methylation and excretion into urine of arsenic. At the same time, there was no obvious effect on the deprivation of essential minerals and the abnormalities of chemical values. Inorganic arsenic was possible to convert to arsenobataine, innoxious arsenic form, under reductive condition with vitamin B12 action. Our results will be helpful for setting up the comprehensive countermeasures, improvement of symptoms and prevention of new victims among the arsenic contaminated area.
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