Subthalamic nucleus stimulation for Parkinson disease : improvement in outcome and assessment of medical economic effect

• Project/Area Number: 20500297
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Fukuoka University
• Principal Investigator: BABA Yasuhiko Fukuoka University, 医学部, 講師 (50352258)
• Co-Investigator(Kenkyū-buntansha): YAMADA Tatsuo 福岡大学, 医学部, 教授 (50142211) ; FUKUSHIMA Takeo 福岡大学, 医学部, 教授 (10078735)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 臨床神経科学 / パーキンソン病 / 深部脳刺激治療 / 術後管理 / 医療経済効果

Research Abstract

The present study evaluated the factor associated with improvement of outcome and the medical economic effect in deep brain stimulation of the subthalamic nucleus (STN-DBS) for Parkinson disease. The results suggested that the preoperative L-dopa response for motor symptoms contributes the postoperative efficacy with STN-DBS. Additionally, excessive reduction of dopaminergic agents after STN-DBS was a factor related to the emergence of neuropsychiatric symptoms. With STN-DBS therapy, the drug cost of dopaminergic agents was reduced by 86% per year after surgery.

Research Products

• [Journal Article] Lack of association of dairy food, calcium, and vitamin D intake with the risk of Parkinson's disease : A case-control study in Japan (2011)
  • Author(s): Miyake Y., Tanaka K., Fukushima W., Sasaki S., Kiyohara C., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's Disease Study Group-Parkinsonism Relat Disord. 17 Pages: 112-6
  • Peer Reviewed
• [Journal Article] テーラーメイド治療のための治療薬の選択と使用法ガイドラインパーキンソン病 (2010)
  • Author(s): 馬場康彦,山田達夫
  • Journal Title: Medical Practice 27 Pages: 180-186
• [Journal Article] ふるえのメカニズム (2010)
  • Author(s): 馬場康彦
  • Journal Title: BRAIN NURSING 26 Pages: 30-32
• [Journal Article] しびれや麻痺のメカニズム (2010)
  • Author(s): 馬場康彦
  • Journal Title: BRAIN NURSING 26 Pages: 25-29
• [Journal Article] Alcohol drinking and risk of Parkinson's disease : a case-control study in Japan (2010)
  • Author(s): Fukushima W., Miyake Y., Tanaka. K., Sasaki S., Kiyohara C., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's Disease Study Group-BMC Neurol. 10 Pages: 111-111
  • Peer Reviewed
• [Journal Article] GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson's disease in a Japanese population (2010)
  • Author(s): Kiyohara C., Miyake Y., Koyanagi M., Fujimoto T., Shirasawa S., Tanaka K., Fukushima W., Sasaki S., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's Disease Study Group-Parkinsonism Relat Disord. 16 Pages: 447-52
  • Peer Reviewed
• [Journal Article] Dietary glycemic index is inversely associated with the risk of Parkinson's disease: a case-control study in Japan (2010)
  • Author(s): Murakami K., Miyake Y., Sasaki S,, Tanaka K., Fukushima W., Kiyohara C., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's Disease Study Group-J Neurol Sci. 288 Pages: 117-122
  • Peer Reviewed
• [Journal Article] Dietary fat intake and risk of Parkinson's disease : a case-control study in Japan (2010)
  • Author(s): Miyake Y., Sasaki S., Tanaka K., Fukushima W., Kiyohara C., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's Disease Study Group-J Neurol Sci. 288 Pages: 117-122
  • Peer Reviewed
• [Journal Article] Active and passive smoking and risk of Parkinson's disease (2010)
  • Author(s): Tanaka K., Miyake Y., Fukushima W., Sasaki S., Kiyohara C., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's disease Study Group-Acta Neurol Scand. 122 Pages: 377-382
  • Peer Reviewed
• [Journal Article] Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease : a case-control study in Japan (2010)
  • Author(s): Murakami K., Miyake Y., Sasaki S., Tanaka K., Fukushima W., Kiyohara C., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's Disease Study Group-Br J Nutr. 104 Pages: 757-764
  • Peer Reviewed
• [Journal Article] Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan (2010)
  • Author(s): Miyake Y., Tanaka K., Fukushima W., Sasaki S., Kiyohara C., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's Disease Study Group-J Neurol Sci. 293 Pages: 82-86
  • Peer Reviewed
• [Journal Article] Dietary glycemic index is inversely associated with the risk of Parkinson's disease : a case-control study in Japan. (2010)
  • Author(s): Murakami, K., Miyake, Y., Sasaki, S., Tanaka, K., Fukushima, W., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura N., Sakae, N., Fukuyama, H., Hirota, Y., Nagai, M.
  • Journal Title: J Neurol Sci Volume: 288 Pages: 117-122
  • Peer Reviewed
• [Journal Article] Dietary fat intake and risk of Parkinson's disease : a case-control study in Japan (2010)
  • Author(s): Miyake, Y., Sasaki, S., Tanaka, K., Fukushima, W., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y., Nagai, M. ; Fukuoka Kinki Parkinson's Disease Study Group
  • Journal Title: J Neurol Sci Volume: 288 Pages: 117-122
  • Peer Reviewed
• [Journal Article] Active and passive smoking and risk of Parkinson's disease (2010)
  • Author(s): Tanaka, K., Miyake, Y., Fukushima, W., Sasaki, S., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y., Nagai, M. ; Fukuoka Kinki Parkinson's disease Study Group
  • Journal Title: Acta Neurol Scand Volume: 122 Pages: 377-382
  • Peer Reviewed
• [Journal Article] Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease : a case-control studyin Japan (2010)
  • Author(s): Murakami, K., Miyake, Y., Sasaki, S., Tanaka, K., Fukushima, W., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N. Sakae, N., Fukuyama, H., Hirota, Y., Nagai, M. ; Fukuoka Kinki Parkinson's Disease Study Group
  • Journal Title: Br J Nutr Volume: 104 Pages: 757-764
  • Peer Reviewed
• [Journal Article] Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan (2010)
  • Author(s): Miyake, Y., Tanaka, K., Fukushima, W., Sasaki, S., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y., Nagai, M. ; Fukuoka Kinki Parkinson's Disease Study Group
  • Journal Title: J Neurol Sci Volume: 293 Pages: 82-86
  • Peer Reviewed
• [Journal Article] GST polymorphisms, interaction with smoking and pesticideuse, and risk for Parkinson's disease in a Japanese population (2010)
  • Author(s): Kiyohara, C., Miyake, Y., Koyanagi, M., Fujimoto, T., Shirasawa, S., Tanaka, K., Fukushima, W., Sasaki, S., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y., Nagai, M. ; Fukuoka Kinki Parkinson's Disease Study Group
  • Journal Title: Parkinsonism Relat Disord Volume: 16 Pages: 447-452
  • Peer Reviewed
• [Journal Article] Alcohol drinking and risk of Parkinson's disease: a case-control study in Japan (2010)
  • Author(s): Fukushima, W., Miyake, Y., Tanaka.K., Sasaki, S., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y., Nagai, M. ; Fukuoka Kinki Parkinson's Disease Study Group
  • Journal Title: BMC Neurol Volume: 10 Pages: 111-111
  • Peer Reviewed
• [Journal Article] 抗aquaporin 4抗体が陽性で妊娠中に脊髄炎が再発したシューグレン症候群の1例 (2010)
  • Author(s): 津川潤、坪井義夫、井上展聡、馬場康彦、山田達夫
  • Journal Title: 臨床神経学 Volume: 50 Pages: 27-30
  • Peer Reviewed
• [Journal Article] しびれや麻痺のメカニズム (2010)
  • Author(s): 馬場康彦
  • Journal Title: BRAIN NURSING Volume: 26 Pages: 25-29
• [Journal Article] ふるえのメカニズム (2010)
  • Author(s): 馬場康彦
  • Journal Title: BRAIN NURSING Volume: 26 Pages: 30-32
• [Journal Article] テーラーメイド治療のための治療薬の選択と使用法ガイドライン パーキンソン病 (2010)
  • Author(s): 馬場康彦, 山田達夫
  • Journal Title: Medical Practice Volume: 27 Pages: 180-186
• [Journal Article] 振戦に対する深部脳刺激の効果 (2010)
  • Author(s): 馬場康彦, 山田達夫
  • Journal Title: 神経内科 Volume: 73 Pages: 478-483
• [Journal Article] パーキンソン病治療の変遷～内科治療と外科治療の融合 (2010)
  • Author(s): 水野美邦, 久保紳一郎, 深谷親, 馬場康彦
  • Journal Title: Pharma Medica Volume: 28 Pages: 79-85
• [Journal Article] Atheroscler Thromb. (2009)
  • Author(s): Furuyama S., Uehara Y., Zhang B., Baba Y., Abe S., Iwamoto T., Miura S., Saku K.
  • Journal Title: Genotypic Effect of ABCG1 gene promoter -257T>G polymorphism on coronary artery disease severity in Japanese men 16 Pages: 194-200
  • Peer Reviewed
• [Journal Article] Restless legs syndromeを伴うパーキンソン病:視床下核刺激術とプラミペキソールの効果 (2009)
  • Author(s): 馬場康彦、樋口正晃、山田達夫
  • Journal Title: Frontiers in Parkinson Disease 2 Pages: 50-51
• [Journal Article] Genotypic Effect of ABCG1 gene promoter -257T>G polymorphism on coronary artery disease severity in Japanese men (2009)
  • Author(s): Furuyama S, Uehara Y, Zhang B, Baba Y, Abe S, Iwamoto T, Miura S, Saku K.
  • Journal Title: Genotypic Effect of ABCG1 gene promoter -257T>G polymorphism on coronary artery disease severity in Japanese men 16 Pages: 194-200
  • NAID: 10025765477
  • Peer Reviewed
• [Journal Article] Restless legs syndrome を伴うパーキンソン病:視床下核刺激術とプラミペキソールの効果 (2009)
  • Author(s): 馬場康彦
  • Journal Title: Frontier in Parkinson Disease 2 Pages: 170-171
• [Journal Article] PD治療におけるドパミンアゴニストへの期待 (2009)
  • Author(s): 野元正弘, 高塚勝哉, 中村雄作, 馬場康彦
  • Journal Title: Pharma Medica 27 Pages: 77-83
• [Journal Article] パーキンソン病治療に関するEBMとその評価 (2009)
  • Author(s): 古和久幸, 武田篤, 馬場康彦
  • Journal Title: Pharma Medica 27 Pages: 141-151
• [Journal Article] テーラーメイド治療を目指した治療薬の選択と使用法ガイドラインUpdate.パーキンソン病 (2008)
  • Author(s): 馬場康彦、山田達夫
  • Journal Title: Medical Practice 25 Pages: 1619-1626
• [Journal Article] 脳深部刺激療法;術後薬物治療の最適化 (2008)
  • Author(s): 馬場康彦、樋口正晃、山田達夫
  • Journal Title: Pharma Medica Pages: 2646-51
• [Journal Article] ATP-binding cassette transporter G4 is highly expressed in microglia in Alzheimer's brain (2008)
  • Author(s): Uehara Y., Yamada T., Baba Y., Miura S., Abe S., Kitajima K., Higuchi MA., Iwamoto T., Saku K.
  • Journal Title: Brain Res. 1217 Pages: 239-246
  • Peer Reviewed
• [Journal Article] テーラーメイド治療を目指した治療薬の選択と使用法ガイドラインupdate : パーキンソン病. (2008)
  • Author(s): 馬場康彦, 山田達夫
  • Journal Title: Medical Practice 25 Pages: 1919-1926
• [Journal Article] パーキンソン病に対する脳深部刺激療法 : 術後薬物治療の最適化. (2008)
  • Author(s): 馬場康彦, 樋口正晃, 山田達夫
  • Journal Title: Pharma Medica 26
• [Journal Article] ATP-binding cassette transporter G4 is highly expressed in microglia in Alzheimer's brain (2008)
  • Author(s): Uehara Y. Yamada T, Baba Y, Miura S. Abe S, Kitajima K, Higuchi MA, Iwamoto T, Saku K.
  • Journal Title: Brain Res. 1217 Pages: 239-246
  • Peer Reviewed
• [Journal Article] Eur Effect of chronic kidney disease on excessive daytime sleepiness in Parkinson disease
  • Author(s): Baba Y., Higuchi M., Fukuyama K., Abe H., Uehara U., Inoue T., Yamada T.
  • Journal Title: J Neurol (in press)
  • Peer Reviewed
• [Presentation] DBSの適応の判断に苦慮した一例 (2010)
  • Author(s): 馬場康彦
  • Organizer: 第51回日本神経学会総会イブニングセミナー9
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-05-22
• [Presentation] DBSのインフォームドコンセントについて (2010)
  • Author(s): 馬場康彦
  • Organizer: 第51回日本神経学会総会ランチョンセミナー26
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-05-21
• [Presentation] STN-DBS後に出現するapathy:術前予測因子の検討 (2010)
  • Author(s): 樋口正晃、馬場康彦、他
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-05-21
• [Presentation] The effect of subthalamic nucleus stimulation on nonmotor symptoms in Parkinson's disease. (2009)
  • Author(s): Higuchi M, Baba Y, et al.
  • Organizer: WFN XVIII World Congress on Parkinson's Disease and Related Disorders
  • Place of Presentation: Miami, Florida, USA
  • Year and Date: 2009-12-15
• [Presentation] Anticholinergic therapy for management of axial symptoms in Parkinson's disease with deep brain stimulation of the subthalamic nucleus. (2009)
  • Author(s): Baba Y, Higuchi M, et al.
  • Organizer: XVIII WFN World Congress on Parkinson's Disease and Related Disorders
  • Place of Presentation: Miami, Florida, USA
  • Year and Date: 2009-12-15
• [Presentation] Switching to ropinirole reduces the severity of daytime sleepiness associated with pramipexole therapy in Parkinson's disease with renal dysfunction (2009)
  • Author(s): Baba Y, Higuchi M, Onozawa R, Fukuyama K, Abe H, Inoue T, Yamada T
  • Organizer: XVIII WFN World Congress on Parkinson's Disease and Related Disorders
  • Place of Presentation: Miami, USA
  • Year and Date: 2009-12-14
• [Presentation] Anticholinergics for axial symptoms in Parkinson's disease with subthalamic nucleus stimulation (2009)
  • Author(s): Onozawa R, Baba Y, Higuchi M, Fukuyama K, Abe H, Inoue T, Yamada T
  • Organizer: XVIII WFN World Congress on Parkinson's Disease and Related Disorders
  • Place of Presentation: Miami, USA
  • Year and Date: 2009-12-14
• [Presentation] The effect of subthalamic nucleus stimulation on nonmotor symptoms in Parkinson's disease (2009)
  • Author(s): Higuchi M, Onozawa R, Baba Y, Fukuyama K, Abe H, Inoue T, Yamada T
  • Organizer: XVIII WFN World Congress on Parkinson's Disease and Related Disorders
  • Place of Presentation: Miami, USA
  • Year and Date: 2009-12-14
• [Presentation] パーキンソン病に対するSTN-DBSと非運動症状に対する影響 (2009)
  • Author(s): 馬場康彦, 樋口正晃, 小野澤里衣子, 山田達夫
  • Organizer: 第3回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 東京品川プリンスホテル
  • Year and Date: 2009-10-10
• [Presentation] STN-DBS後に悪化するパーキンソン病の体軸症状:抗コリン薬の効果検討 (2009)
  • Author(s): 小野澤里衣子, 馬場康彦, 樋口正晃, 山田達夫
  • Organizer: 第3回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 東京品川プリンスホテル
  • Year and Date: 2009-10-09
• [Presentation] パーキンソン病における日中の傾眠:非麦角系ドパミンアゴニストの切り替えと眠気に対する影響 (2009)
  • Author(s): 樋口正晃, 馬場康彦, 小野澤里衣子, 山田達夫
  • Organizer: 第3回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 東京品川プリンスホテル
  • Year and Date: 2009-10-09
• [Presentation] Increased expression of a T-helper-cell transcriptional factor t-bet in Parkinson disease (2009)
  • Author(s): Baba Y, Higuchi M, Onozawa R, Uehara Y, Kuroiwa A, Yamada T
  • Organizer: The Movement Disorder Society 13^<th> International congress
  • Place of Presentation: Paris, France
  • Year and Date: 2009-06-10
• [Presentation] The relationship between daytime sleepiness associated with non-ergot dopamine agonist therapy and renal function in Parkinson disease (2009)
  • Author(s): Higuchi M, Baba Y, Onozawa R, Fukuyama K, Yamada T
  • Organizer: The Movement Disorder Society 13^<th> International congress
  • Place of Presentation: Paris, France
  • Year and Date: 2009-06-09
• [Presentation] Effect of spinal cord stimulation on pain and axial symptoms in progressive supranuclear palsy with intractable low back pain (2009)
  • Author(s): Onozawa R, Baba Y, Higuchi M, Fukuyama K, Yamada T
  • Organizer: The Movement Disorder Society 13^<th> International congress
  • Place of Presentation: Paris, France
  • Year and Date: 2009-06-09
• [Presentation] Parkinson 病における helper T細胞転写因子と免疫動態の検討 (2009)
  • Author(s): 馬場康彦, 樋口正晃, 山田達夫
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台宮城仙台国際センター
  • Year and Date: 2009-05-20
• [Presentation] パーキンソン病に対する深部脳刺激術;ドパミン調節異常症候群に対する影響 (2009)
  • Author(s): 樋口正晃、馬場康彦、他
  • Organizer: 第11回福岡神経内科疾患研究会
  • Place of Presentation: ANAクラウンプラザホテル福岡
  • Year and Date: 2009-04-24
• [Presentation] Parkinson病に対する視床下核刺激に伴う精神症状の検討 (2008)
  • Author(s): 大村忠寛, 安部洋, 馬場康彦, 坪井義夫, 山田達夫, 井上亨
  • Organizer: 第67回日本脳神経外科学会総会
  • Place of Presentation: 盛岡, 岩手
  • Year and Date: 2008-10-02
• [Presentation] パーキンソン病とrestless legs syndromeに対する視床下核刺激術 (2008)
  • Author(s): 馬場康彦,他
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] Parkinson病におけるSTN-DBS : Restless legs syndromeに対する効果の検討 (2008)
  • Author(s): 馬場康彦, 樋口正晃, 福原康介, 合馬慎二, 井上展聡, 坪井義夫, 山田達夫
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜, 神奈川
  • Year and Date: 2008-05-16
• [Presentation] パーキンソン病のNon-motor Symptoms : STN-DBS前後の変化について (2008)
  • Author(s): 馬場康彦,他
  • Organizer: 第10回福岡神経内科疾患研究会
  • Place of Presentation: ホテル日航福岡
  • Year and Date: 2008-04-18