Real-time imaging of synapse underlying pheromonal memory
| Project/Area Number |
20500319
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
ICHIKAWA Masumi Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 副参事研究員 (20124414)
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| Co-Investigator(Renkei-kenkyūsha) |
MORIYA Keiko 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (70392371)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経再生 / 神経可塑性 / 棘突起 / 副嗅球ニューロン / 鋤鼻器 / ノルアドレリン / フェロモン / 共焦点レーザー顕微鏡 / リアルタイムイメージング / 記憶 / シナプス可塑性 / ノルアドレナリン / カルシウム / GFP / 共培養 |
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| Research Abstract |
To determine the neuronal mechanism underlying pheromonal memory, we applied real-time imaging of cultured accessory olfactory bulb neurons. The effect of plastic change of spines on the dendrites following noradrenalin stimulation is examined. It is revealed that two types of spines are identified. One is enlargement of the spine size and the other is increment of the spine number. This result is important for study of synapse mechanism underlying memory.
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Report
(4 results)
Research Products
(23 results)
