Elucidating the mechanism of CNS remyelination and development of an effective therapeutic approach in age-induced demyelination

• Project/Area Number: 20500348
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Tokyo Metropolitan Institute of Gerontology
• Principal Investigator: ASOU Hiroaki Tokyo Metropolitan Institute of Gerontology, 医学部, 教授 (30104160)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 神経科学 / 脳神経疾患 / 再生医学

Research Abstract

We report that chinpi, upregulates the FcR-Fyn-MBP signaling casdade resulting in a potentially therapeutic effect against age-induced demyelinaion. In addition we observed that phosphorylated (activated) FcR/Fyn upregulated the expression of the 21.5kDa isoform of myelin basic protein, inducing rapid morphologycal differentiation, when oligodendrocyte precursor cells (OPCs) were cultured in the presence of hesperidin and narirutin which participate in the FcR-Fyn-MBP signaling pathway in OPCs caursing these cells to differentiate into myelinating oligodendrocytes.

Research Products

• [Journal Article] Hypothermia-induced increase of oligodendrocyte precursor cells : Possible involvment of plasmalemmal voltage- dependen anion channel 1. (2010)
  • Author(s): Imada S, Yamamoto M, Seiwa C, Watanabe K, Kamei Y, Kozuma S, Taketani Y, Asou H.
  • Journal Title: J Neurosci Res. 88(16) Pages: 3457-66
  • Peer Reviewed
• [Journal Article] Hypothermia-induced increase of oligodendrocyte precursor cells. (2010)
  • Author(s): Imada S, et al.
  • Journal Title: J Neurosci Res Volume: Vol.88 Pages: 3457-3466
  • Peer Reviewed
• [Journal Article] Administration of chinpi, a component of the herbal medicine Ninjin-Youei-To, reverses age-induced demyelination. (2010)
  • Author(s): N.Sato, et al.
  • Journal Title: eCAM Doi : 10.1093 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Caspase-9 activation revealed by semaphoring 7A cleavage is independent of apoptosis in the aged olfactory bulb. (2009)
  • Author(s): Ohsawa S, Hamada S, Asou H, Kuida K, Uchiyama Y, Yoshida H, Miura M.
  • Journal Title: J Neurosci. 29(36) Pages: 11385-92
  • Peer Reviewed
• [Journal Article] Yamoto M, Yoshimura K, Kitada K, Nakahara J, Seiwa C, Ueki T, Shimoda Y, Ishige A, Watanabe K, Asou H. (2009)
  • Author(s): A new monoclonal antibody A3B10, specific for astrocyte-lineage cells recognizes calmodulin-regulated spectrin-associated protein 1 (Camsap 1).
  • Journal Title: J Neuro Sci Res. 87(2) Pages: 502-1
  • Peer Reviewed
• [Journal Article] A new monoclonal antibody, A3B10, specific for astrocyte-lineage cells recognizes calmodulin-regulated spectrin-associated protein (2009)
  • Author(s): Masahiro Yamamoto, et al.
  • Journal Title: J. Neurosci. Res 87 Pages: 503-513
  • Peer Reviewed
• [Presentation] 陳皮の有効成分による老齢脳での脱髄回復効果について (2010)
  • Author(s): Rui Zhan、清和千佳、渡辺賢治、阿相皓晃
  • Organizer: 第53回日本神経化学会大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-09-03
• [Presentation] カプリゾン脱髄モデルマウスにおける陳皮の脱髄回復効果に関する研究 (2010)
  • Author(s): 味澤佑美、渡辺賢治、阿相皓晃
  • Organizer: 第53回日本神経化学会大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-09-03
• [Presentation] 陳皮の薬効成分による老齢脳での脱髄回復効果について (2010)
  • Author(s): Rui Zhan, ほか
  • Organizer: 第53回日本神経化学学会大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-09-03
• [Presentation] 発達段階によるMBP isoformの分布や特性の違い (2008)
  • Author(s): 漆瀬道洋、築地謙治、佐藤菜名子、佐藤友里恵、石毛敦、阿相皓晃、深井文雄、渡辺賢治
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2008-09-12
• [Presentation] オリゴデンドロサイトの成熟に伴うMBPの局在の変化 (2008)
  • Author(s): 佐藤菜名子、清和千佳、築地謙治、漆瀬道洋、佐藤友里恵、品川理佳、下田泰治、阿相皓晃、渡辺賢治
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2008-09-12
• [Presentation] オリゴデンドロサイトの成熟に伴うMBP局在の変化 (2008)
  • Author(s): 佐藤菜名子, 他
  • Organizer: 第51回 日本神経化学会大会
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2008-09-12
• [Remarks] ホームページ等