Elucidating the mechanism of CNS remyelination and development of an effective therapeutic approach in age-induced demyelination
| Project/Area Number |
20500348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tokyo Metropolitan Institute of Gerontology |
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Principal Investigator |
ASOU Hiroaki Tokyo Metropolitan Institute of Gerontology, 医学部, 教授 (30104160)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 神経科学 / 脳神経疾患 / 再生医学 |
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| Research Abstract |
We report that chinpi, upregulates the FcR-Fyn-MBP signaling casdade resulting in a potentially therapeutic effect against age-induced demyelinaion. In addition we observed that phosphorylated (activated) FcR/Fyn upregulated the expression of the 21.5kDa isoform of myelin basic protein, inducing rapid morphologycal differentiation, when oligodendrocyte precursor cells (OPCs) were cultured in the presence of hesperidin and narirutin which participate in the FcR-Fyn-MBP signaling pathway in OPCs caursing these cells to differentiate into myelinating oligodendrocytes.
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Report
(4 results)
Research Products
(13 results)
