Stress tolerance of the cell induced by a sonochemical preconditioning using ultrasound
| Project/Area Number |
20500416
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Akita University |
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Principal Investigator |
KUME Makoto Akita University, 歯学部, 准教授 (00372326)
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| Co-Investigator(Kenkyū-buntansha) |
UCHINAMI Hiroshi 秋田大学, 大学院・医学研究科消化器外科, 助教 (40400486)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 超音波 / 音響化学 / 臓器保護 / ストレス応答 / 熱ショックタンパク質 / 酸化ストレス / 環境制御 / 強力超音波 / 肝虚血再灌流障害 / 肝虚血再還流障害 |
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| Research Abstract |
This study suggested that sonochemical effect of ultrasound could generate reactive oxygen species in biological milieu and this chain of potential stimuli would induce stress response of the cells to generate stress protein, hemeoxygenase-1. As a result, this artificial treatment, named sonochemical preconditioning, provided the target cells with significant tolerance against a critical state of oxidative stress.
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Report
(4 results)
Research Products
(8 results)
