Development of ultrasound index to evaluate the effect of stress on cardiac function in small animals

• Project/Area Number: 20500419
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Osaka University
• Principal Investigator: ISHIKURA Fuminobu Osaka University, 大学院・医学系研究科, 准教授 (50303970)
• Co-Investigator(Kenkyū-buntansha): ASANUMA Toshihiko 大阪大学, 大学院・医学系研究科, 特任研究員 (80379271)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ストレス / 心機能 / 超音波法 / 小動物 / 性差

Research Abstract

We measured the fractional area change (FAC) using SONOS5500 with s12 probe (frequency : 5-12MHz, frame rate : ≧120Hz) at the end of immobilization stress (IMO) and every 10min for 60 minutes in rats. FAC at 20 minutes after IMO significantly deceased and gradually recovered to 60 minutes after IMO. Acute administration of α β blocker or calcium antagonist could prevent a sudden drop of cardiac function and heart rate after acute stress like IMO. A α β blocker or calcium antagonist might have a very important role to prevent stress induced cardiac dysfunction.

Research Products

• [Journal Article] 誌上ディベート テストステロンを使う?使わない? (2010)
  • Author(s): 石蔵文信
  • Journal Title: アンチ・エイジング医学 Volume: 6 Pages: 66-69
• [Journal Article] Assessment of myocardial ischemic memory using persistence of post-systolic thickening after recovery from ischemia. (2009)
  • Author(s): Asanuma T, Uranishi A, Masuda K, Ishikura F, Beppu S, Nakatani S.
  • Journal Title: JACC Cardiovasc Imaging. 2 Pages: 1253-1261
  • Peer Reviewed
• [Journal Article] Assessment of myocardial ischemic memory using persistence of post-systolic thickening after recovery from ischemia (2009)
  • Author(s): Asanuma T, らほか5名
  • Journal Title: JACC Cardiovasc Imaging 2 Pages: 1253-61
  • Peer Reviewed
• [Presentation] 心拍数増加をもたらさないCa拮抗剤:アゼルニジピンのストレス誘発型心機能低下に対する予防効果 (2010)
  • Author(s): 高野友里, 西川理沙, 江川舞, 猪原萌, 石蔵文信
  • Organizer: 第58回日本心臓病学会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-17
• [Presentation] Azelnidipine, Unique Calcium Channel Antagonist Could Prevent Stress Induced Cardiac Dysfunction Like α・β Blocker. (2010)
  • Author(s): Ishikura F, Ihara M, Takano T, Egawa M
  • Organizer: 第20回欧州高血圧学会
  • Place of Presentation: オスロ
  • Year and Date: 2010-06-19
• [Presentation] ACUTE EFFECTS OF BETA-BLOCKER WITH INTRINSIC SYMPATHOMIMETIC ACTIVITY ON STRESS INDUCED CARDIAC DYSFUNCTION IN A RAT : ECHOCARDIOGRAPHIC OBSERVATION. (2010)
  • Author(s): Takano T, Nishikawa R, Egawa M, Ihara M, Egawa M, Ishikura F.
  • Organizer: 第20回欧州高血圧学会
  • Place of Presentation: オスロ
  • Year and Date: 2010-06-19
• [Presentation] Acute effects of beta-blocker with intrinsic sympathomimetic activity on stress induced cardiac dysfunction in a rat : Echocardiographic observation. (2010)
  • Author(s): Takano Y, Ishikura F, 他3名
  • Organizer: 第20回欧州高血圧学会
  • Place of Presentation: オスロ
  • Year and Date: 2010-06-19
• [Presentation] Azelnidipine, unique calcium channel antagonist could prevent stress induced cardiac dysfunction like alfa and beta blocker. (2010)
  • Author(s): Ishikura F, 他4名
  • Organizer: 第20回欧州高血圧学会
  • Place of Presentation: オスロ
  • Year and Date: 2010-06-19
• [Presentation] 心エコー図法によるストレス誘発型心機能低下に対するβブロッカーの予防効果の検討:内因性交感神経刺激作用に関して (2010)
  • Author(s): 高野友里, 西川理沙, 江川舞, 猪原萌, 石蔵文信
  • Organizer: 第21回日本心エコー図学会
  • Place of Presentation: 札幌
  • Year and Date: 2010-05-13
• [Presentation] 心エコー図法によるストレス誘発型心機能低下に対するβブロッカーの予防効果検討:内因性交感神経刺激作用に関して (2010)
  • Author(s): 高野友里, 石蔵文信, 他3名
  • Organizer: 第21回日本心エコー図学会
  • Place of Presentation: 札幌
  • Year and Date: 2010-05-13
• [Presentation] From arteriole to microcirculation imaging using real-time contrast echocardiography. (2009)
  • Author(s): Ishikura F.
  • Organizer: 第11回国際造影超音波シンポジウム
  • Place of Presentation: 昆明中国
  • Year and Date: 2009-12-19
• [Presentation] From Arteriole to Microcirculation Imaging Using Real-time Contrast Echocardiography (2009)
  • Author(s): 石蔵文信, ほか2名
  • Organizer: 11^<th> International Symposium on Ultrasound Contrast Imaging
  • Place of Presentation: 昆明 (中国)
  • Year and Date: 2009-12-19
• [Presentation] Acute Preventive Effects of α-and β-Adrenoceptor Blocker : Labetalol Hydrochloride on Stress-Induced Cardiac Dysfunction in Rats : Echocardiographic Observation. (2009)
  • Author(s): Ishikura F, Nakajima A, Uchida M,Nishikawa R, Yamaguchi S, Egawa M.
  • Organizer: 第19回欧州高血圧学会
  • Place of Presentation: ミラノ
  • Year and Date: 2009-06-14
• [Presentation] Acute Preventive Effects of α- and β-Adrenoceptor Blocker : Labetalol Hydrochloride on Stress-Induced Cardiac Dysfunction in Rats : Echocardio graphic Observation (2009)
  • Author(s): 石蔵文信, らほか4名
  • Organizer: 19^<th> European Meeting on Hypertension
  • Place of Presentation: ミラノ (イタリア)
  • Year and Date: 2009-06-14
• [Presentation] Protective effects on emotional stress-induced cardiac dysfunction depend on α/β ratio of adrenoceptor blocker (2009)
  • Author(s): 内田雅宏、石蔵文信
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Preventive effects of estrogen and β blocker on stress-induced cardiac dysfunction in a experimental rat model (2009)
  • Author(s): 石蔵文信
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Protective Effects of Emotional Stress-Induced Cardiac Dysfunction depend on α/βRatio of Adrenoceptor Blocker (2009)
  • Author(s): 内田 雅宏, 石蔵 文信
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Preventive Effects of Estrogen and B Blocher on Stress-Induced Cardiac Dysfunction in a Experimental Rat Model (2009)
  • Author(s): 石蔵 文信
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Book] 下痢・ストレスは腸にくる (2011)
  • Author(s): 石蔵文信
  • Publisher: 大阪大学出版会
• [Book] 最新循環器診療マニュアル(分担) (2009)
  • Author(s): 石蔵文信
  • Publisher: 中山書店
• [Book] 最新循環器診療マニュアル (2009)
  • Author(s): 石蔵文信 (分担)
  • Total Pages: 822
  • Publisher: 中山書店