Development of multi-probe sono-irradiation system on microscopy

• Project/Area Number: 20500428
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Meiji University
• Principal Investigator: HIRAOKA Wakako Meiji University, 理工学部, 教授 (00212168)
• Co-Investigator(Kenkyū-buntansha): SAI Hiroshi 明治大学, 理工学部, 教授 (30143530)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 超音波 / マルチプローブ / ドラッグデリバリーシステム / ケージド化合物 / ソノケミカル反応 / ソノダイナミック反応 / 安全性 / MHz超音波 / 生物物理 / 生物・生体工学 / 薬剤反応性 / 音響化学 / 照射システム / 培養細胞 / 音響化学効果

Research Abstract

Development of multi-probe sono-irradiation system on microscopy is a part of the research that aims at the development of new treatment and the diagnosis technique in sonomedicine. It is a diagnosis and treatment method development device that has both detection and the diagnostic system of biological function by sono-irradiation in providing with the multi probe. It succeeded in developing of a new drug delivery system and developing of a micro-scaling diagnostic system in tissues with this device.

Research Products

• [Journal Article] Sonoluminescence of Alkali-Metal Atoms in Sulfuric Acid : Comparison with That in Water (2010)
  • Author(s): S.Hatanaka, S.Hayashi, P.-K.Choi
  • Journal Title: Jpn.J.Appl.Phys 49/7
  • Peer Reviewed
• [Journal Article] Multibubble sonoluminescence pulse from Na atom in viscous liquid (2010)
  • Author(s): Y.Sawada, Y.Takeuchi, P-K.Choi
  • Journal Title: Proc.20th Inter.Congress on Acoustics,(Sydney, 2010/08) Pages: 540-543
  • Peer Reviewed
• [Journal Article] Effects of rare gases on MBSL spectrum of K atom emission (2010)
  • Author(s): Y.Hayashi, P.-K.Choi
  • Journal Title: Proc.20th Inter.Congress on Acoustics,(Sydney, 2010/08) Pages: 248-251
  • Peer Reviewed
• [Journal Article] Frequency Effects on Sonoluminescence of Alkali-Metal Atoms in Sulfuric Acid. (2010)
  • Author(s): S.Hatanaka, S.Hayashi, P.-K.Choi
  • Journal Title: Proc.20th Inter.Congress on Acoustics,(Sydney, 2010/08) Pages: 816-820
  • Peer Reviewed
• [Journal Article] A novel copper(II) coordination at His186 in full-length murine prion protein (2010)
  • Author(s): Y.Watanabe, W.Hiraoka, M.Igarashi, K.Ito, Y.Shimoyama, M.Horiuchi, T.Yamamori, H.Yasui, M.Kuwabara, O.Inanami
  • Journal Title: Biochem Biophys Res Commun 394 Pages: 522-528
  • NAID: 120002148672
  • Peer Reviewed
• [Journal Article] A novel copper(II) coordination at His186 in full-length murine prion protein (2010)
  • Author(s): Y.Watanabe, W.Hiraoka, et al.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 394 Pages: 522-528
  • NAID: 120002148672
  • Peer Reviewed
• [Journal Article] Frequency Effects on Sonoluminescence of Alkali-Metal Atoms in Sulfuric Acid (2010)
  • Author(s): S.Hatanaka, S.Hayashi, P.-K.Choi
  • Journal Title: Proc.20th Inter.Congress on Acoustics, (Sydney, 2010/08) Pages: 816-820
  • Peer Reviewed
• [Journal Article] Effects of rare gases on MBSL spectrum of K atom emission (2010)
  • Author(s): Y.Hayashi, P.-K.Choi
  • Journal Title: Proc.20th Inter.Congress on Acoustics, (Sydney, 2010/08) Pages: 248-251
  • Peer Reviewed
• [Journal Article] Multibubble sonoluminescence pulse from Na atom in viscous liquid (2010)
  • Author(s): Y.Sawada, Y.Takeuchi, P-K.Choi
  • Journal Title: Proc.20th Inter.Congress on Acoustics, (Sydney, 2010/08) Pages: 540-543
  • Peer Reviewed
• [Journal Article] Sonoluminescence of Alkali-Metal Atoms in Sulfuric Acid : Comparison with That in Water (2010)
  • Author(s): S.Hatanaka, S.Hayashi, P.-K.Choi
  • Journal Title: Jpn.J.Appl.Phys. Volume: 49/7
  • Peer Reviewed
• [Journal Article] A novel copper (II) coordination at His186 in full-length murine prion protein (2010)
  • Author(s): Yasuko Watanabe, Wakako Hiraoka, Manabu Igarashi, Kimihito Ito, Yuhei Shimoyama, Motohiro Horiuchi, Tohru Yamamori, Hironobu Yasui, Mikinori
  • Journal Title: Biochem Biophys Res Commun. 394(3) Pages: 522-528
  • NAID: 120002148672
  • Peer Reviewed
• [Journal Article] Effects of phytic acid on cell proliferation and apoptosis Free Radicals, Health and Lifestyle (2009)
  • Author(s): W.Hiraoka, A.Kato
  • Journal Title: International Proceedings from The Europe Meeting of the Society for Free Radical Research Pages: 65-67
  • Peer Reviewed
• [Journal Article] Effects of phytic acid on cell proliferation and apoptosis (2009)
  • Author(s): Wakako Hiraoka, Asuka Kato
  • Journal Title: Free Radicals, Health and Lifestyle, International Proceedings from The Europe Meetinf of the Society for Free Radical Research, 2009. Pages: 65-67
  • Peer Reviewed
• [Presentation] 酸化ストレス応答に及ぼすO-結合型N-アセチルグルコサミン修飾の影響 (2010)
  • Author(s): 佐藤貴俊、三浦ゆり、櫻井洋子、平岡和佳子、遠藤玉夫
  • Organizer: 第63回日本酸化ストレス学会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-06-24
• [Presentation] フィチン酸を用いたアパタイトセメントによる活性酸素への影響 (2010)
  • Author(s): 加藤あす香、平川裕樹、猪股義彦、相澤守、平岡和佳子
  • Organizer: 第63回日本酸化ストレス学会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-06-24
• [Presentation] Effect of inositol hexaphosphate and its apatite cements on ROS and its biological implication on PLB-985 cells (2010)
  • Author(s): W.Hiraoka, A.Kato, Y.Hirakawa, Y.Inomata, M.Aizawa
  • Organizer: Asia-Pacific EPR/ESR Symposium 2010
  • Place of Presentation: Jeju, Republic of Korea
• [Presentation] Identification of a novel Cu(II) binding site in full-length murine (2010)
  • Author(s): O.Inanami, Y.Watanabe, M.Igarashi,K.Ito, T.Yamamori, H.Yasui, W.Hiraoka
  • Organizer: prionprotein by using ESR/SDSL technique Asia-Pacific EPR/ESR Symposium 2010
  • Place of Presentation: Jeju, Republic of Korea
• [Presentation] Inositol hexaphosphate and its apatite cements-induced ROS generation and their biological effects on human cells (2010)
  • Author(s): A.Kato, Y.Hirakawa, Y.Inomata, M.Aizawa, W. Hiraoka
  • Organizer: 第48回日本生物物理学会年会
  • Place of Presentation: 仙台市
• [Presentation] Effect of O-linked N-acetylglucosamine (O-GlcNAc) modification on oxidative stress-induced apoptosis (2010)
  • Author(s): T.Sato, Y.Miura, Y.Sakuai, W.Hiraoka, T.Endo
  • Organizer: 第48回日本生物物理学会年会
  • Place of Presentation: 仙台市
• [Presentation] Cu^<2+> binding ability of His96 and His111 in human prion protein (2010)
  • Author(s): K.Kubota, T.Imaki, W.Hiraoka
  • Organizer: 第48回日本生物物理学会年会
  • Place of Presentation: 仙台市
• [Presentation] Identification of a novel Cu(II) binding site in full-length murine prionprotein by using ESR/SDSL technique (2010)
  • Author(s): O.Inanami, Y.Watanabe, M.Igarashi, K.Ito, T.Yamamori, H.Yasui, W.Hiraoka
  • Organizer: Asia-Pacific EPR/ESR Symposium 2010
  • Place of Presentation: Jeju, Republic of Korea
• [Presentation] Effects of phytic acid on cell proliferation and apoptosis. (2009)
  • Author(s): W.Hiraoka, A.Kato
  • Organizer: SFRR-Europemeeting 2009
  • Place of Presentation: Roma
  • Year and Date: 2009-08-26
• [Presentation] Effects of phytic acid on cell proliferation and apoptosis (2009)
  • Author(s): Wakako Hiraoka, Asuka Kato
  • Organizer: SFRR-Europe meeting 2009
  • Place of Presentation: Roma
  • Year and Date: 2009-08-26
• [Presentation] フィチン酸(IP6)の活性酸素阻害作用と生物学的効果 (2009)
  • Author(s): A.Kato, Y.Hirakawa, Y.Inomata, M.Aizawa, W.Hiraoka
  • Organizer: 日本生物物理学会第47回年会
  • Place of Presentation: 徳島市
• [Presentation] マウスプリオンタンパク質ミュータントの線維形成 (2009)
  • Author(s): M.Shibuya, Y.Watanabe, K.Kubota, K.Takahashi, Hi.Nakagawa, N.Miyata, O.Inanami, W.Hiraoka
  • Organizer: 日本生物物理学会第47回年会
  • Place of Presentation: 徳島市
• [Presentation] MHz超音波によるU937細胞における遺伝子発現の誘導 (2009)
  • Author(s): Y.Odate, P.-K.Choi, W.Hiraoka
  • Organizer: 日本生物物理学会第47回年会
  • Place of Presentation: 徳島市
• [Presentation] A preliminary study on anti-tumorigenesis of chelate-setting hydroxyapatite cements using inositol phosphate (2009)
  • Author(s): Y.Inomata, W.Hiraoka, M.Aizawa
  • Organizer: Bioceramics(22)
  • Place of Presentation: Daegu
• [Presentation] MHz超音波によるU937細胞におけるシグナルトランスダクションの発現 (2009)
  • Author(s): 大館祐介,崔博坤,平岡和佳子
  • Organizer: 第18回ソノケミストリー討論会
  • Place of Presentation: 長岡市
• [Presentation] ケージドカルシウムキレーターの超音波による活性化 (2009)
  • Author(s): 平岡和佳子,金森茜
  • Organizer: 第18回ソノケミストリー討論会
  • Place of Presentation: 長岡市
• [Presentation] イノシトールリン酸を用いたキレート硬化型アパタイトセメントの抗腫瘍効果に関する研究 (2009)
  • Author(s): 猪股義彦・平岡和佳子・相澤守
  • Organizer: 日本セラミックス22シンポジウム
  • Place of Presentation: 松山市
• [Presentation] Redox regulation in radiation-induced apoptosis-related cytochrome c release from mitochondria. (2009)
  • Author(s): O.Inanami, Y.Watanabe, W.Hiraoka
  • Organizer: SFRR-Europe meeting2009
  • Place of Presentation: Roma
• [Presentation] REDOX REGULATION IN RADIATION-INDUCED APOPTOSIS-RELATED CYTOCHROME C RELEASE FROM MITOCHONDRIA (2009)
  • Author(s): Osamu Inanami, Yasuko Watanabe, Wakako Hiraoka
  • Organizer: SFRR-Europe meeting 2009
  • Place of Presentation: Roma
• [Presentation] A preliminary study on anti-tumorigenesis of chelate-setting hydroxyapatite cements using inositol phosphate (2009)
  • Author(s): Yoshihik. Inomata, Wakako Hiraoka, Mamoru Aizawa
  • Organizer: Bioceramics 22
  • Place of Presentation: Daegu
• [Presentation] 高強度ソノルミネッセンス気泡によるカーボンナノ材料の合成 (2008)
  • Author(s): 畑中信一, 林茂雄, 崔博坤
  • Organizer: 日本ソノケミストリー学会
  • Place of Presentation: 電気通信大学
  • Year and Date: 2008-12-06
• [Presentation] 非水溶媒中アルカリ金属原子のソノルミネセンス (2008)
  • Author(s): 和久井奈々,畑中信一,林茂雄,崔博坤
  • Organizer: 日本ソノケミストリー学会
  • Place of Presentation: 電気通信大学
  • Year and Date: 2008-12-06
• [Presentation] アルカリ金属原子からのソノルミネセンス (2008)
  • Author(s): 崔博坤
  • Organizer: 日本ソノケミストリー学会
  • Place of Presentation: 電気通信大学
  • Year and Date: 2008-12-06
• [Presentation] 高強度ソノルミネツセンス気泡によるカーボンナノ材料の合成 (2008)
  • Author(s): 畑中信一, 林茂雄, 崔博坤
  • Organizer: 日本ソノケミストリー学会
  • Place of Presentation: 電気通信大学
  • Year and Date: 2008-12-06
• [Presentation] PLB-985細胞内における光分解性ケージド化合物の超音波による活性化 (2008)
  • Author(s): 金森茜,近藤隆,平岡和佳子
  • Organizer: 日本ソノケミストリー学会
  • Place of Presentation: 日電気通信大学
  • Year and Date: 2008-12-05
• [Presentation] 低MHz超音波によるU937細胞への生物学的効果 (2008)
  • Author(s): 大館祐介,崔博坤, 平岡和佳子
  • Organizer: 日本ソノケミストリー学会
  • Place of Presentation: 電気通信大学
  • Year and Date: 2008-12-05
• [Presentation] 硫酸中マルチバブルソノルミネッセンスにおける高強度Na* 発光気泡のダイナミクス (2008)
  • Author(s): 畑中信一,林茂雄,崔博坤
  • Organizer: 日本ソノケミストリー学会
  • Place of Presentation: 電気通信大学
  • Year and Date: 2008-12-05
• [Presentation] PLB-985 細胞内における光分解性ケージド化合物の超音波による活性化 (2008)
  • Author(s): 金森茜, 近藤隆, 平岡和佳子
  • Organizer: 日本ソノケミストリー学会
  • Place of Presentation: 電気通信大学
  • Year and Date: 2008-12-05
• [Presentation] 超音波照射による光分解性ケージド化合物の活性化 (2008)
  • Author(s): 金森茜,近藤隆,平岡和佳子
  • Organizer: 第46回日本生物物理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2008-12-03
• [Presentation] 低MHZ超音波によるU937細胞への生体影響 (2008)
  • Author(s): 大館祐介,崔博坤,平岡和佳子
  • Organizer: 第46回日本生物物理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2008-12-03
• [Presentation] 低MHZ超音波によるU 9 3 7細胞への生体影響 (2008)
  • Author(s): 大館祐介, 崔博坤, 平岡和佳子
  • Organizer: 第46回日本生物物理学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2008-12-03