Elucidation of cartilage degeneration mechanism and rehabilitaton
Project/Area Number |
20500449
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Rehabilitation science/Welfare engineering
|
Research Institution | Nagasaki University |
Principal Investigator |
ORIGUCHI Tomoki Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (90295105)
|
Co-Investigator(Kenkyū-buntansha) |
OKITA MINORU 長崎大学, 大学院・医歯薬学総合研究科, 教授 (50244091)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | リハビリテーション医学 / 関節 / 軟骨 / 拘縮 / アポトーシス / 細胞内シグナル伝達 / マトリックスメタロプロテアーゼ / NF-kB / 持続的他動運動(CPM) / 免疫組織化学 / 細胞外マトリックス / 血管新生 |
Research Abstract |
We showed that immobilization induced thinning of the articular cartilage and cartilage degeneration. There were increased TUNNEL-posiyive chondrocytes and MMP expression. Vascular channels were appeared in the area between the calcified cartilage zone, in area with balanced expression of HIF-1alpha/VEGF and ChM-1. In addition, these changes were inhibited by continuous passive motion.
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Report
(4 results)
Research Products
(63 results)