Role of fibroblast growth factors on regenerating skeletal muscle
| Project/Area Number |
20500583
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
YAMAGUCHI Akihiko Health Sciences University of Hokkaido, 歯学部, 准教授 (50244869)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | スポーツ生理学 / 線維芽細胞増殖因子 / 筋成長 / 骨格筋 / 筋分化制御因子 |
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| Research Abstract |
To examine the relations between specific fibroblast growth factors (FGFs) and satellite cell activation during muscle regeneration in vivo, we measured mRNA expression of FGFs and myogenic markers in rat plantaris muscle after bupivacaine administration. FGF-1, FGF-5 and FGF-7 mRNAs after the treatment started to increase at the same time as MyoD and PCNA mRNAs. FGF-7 protein was expressed in immature muscle fiber nuclei and the extracellular matrix. These results indicate that FGF-7 is associated with specific myogenic marker expression during muscle regeneration. However, suppression of FGF-7 mRNA expression following short hairpin RNA administration did not change the expression of myogenic markers. Consequently, the role of FGF-7 during muscle regeneration in vivo remains unclear.
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Report
(4 results)
Research Products
(13 results)
