Development of the new method for evaluation of vascular function after exercise as a risk assessment for early phase atherosclerosis

• Project/Area Number: 20500622
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: TAKANAMI Yoshikazu Kyoto Prefectural University of Medicine, 家政学部, 教授 (40206777)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 生活習慣病 / 運動負荷 / 血管機能検査 / 動脈硬化 / 血管トーヌス / 血管スティフネス / 動脈スティフネス / 血管内皮機能

Research Abstract

The purpose of this study was to establish the method to evaluate an insufficiency of vasodilation after exercise which is considered to be a symptom of an early phase atherosclerosis. Arterial stiffness was used as a marker of vascular function. A transient decrease in arterial stiffness was observed after a medium intensity step exercise. There was an individual difference in this change and this decrease in arterial stiffness was not observed after high fat meal which is considered to impair vascular function. In conclusion, the measurement of arterial stiffness after ten minutes step exercise at medium intensity may be useful to evaluate a symptom of early phase atherosclerosis

Research Products

• [Journal Article] 動脈硬化と運動 (2011)
  • Author(s): 高波嘉一、川合ゆかり、下光輝一
  • Journal Title: 成人病と生活習慣病 41(3) Pages: 296-303
• [Journal Article] メタボリックシンドロームと運動療法 (2009)
  • Author(s): 高波嘉一
  • Journal Title: Angiology Frontier 8 Pages: 274-282
• [Journal Article] Arterial stiffness acutely decreases after whole-body vibration in humans (2008)
  • Author(s): Otsuki T, Takanami Y, et al
  • Journal Title: Acta Physiol 194 Pages: 189-194
  • Peer Reviewed