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Elucidation of mechanism of thrombus formation in older people during sporting activity and preventive measure thereof

Research Project

Project/Area Number 20500623
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionNara Medical University

Principal Investigator

ISHIZASHI Hiromichi  Nara Medical University, 医学部, 准教授 (50260807)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Masanori  奈良県立医科大学, 医学部, 准教授 (60316081)
FUJIMURA Yoshihiro  奈良県立医科大学, 医学部, 教授 (80118033)
INOUE Yoshimitsu  大阪国際大学, 人間科学部, 教授 (70144566)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsスポーツ活動 / VWF / ADAMTS13 / 老化 / 脱水 / 血栓形成 / 水分摂取量 / ヘマトクリット(HCT)
Research Abstract

Since there is a possibility of occurrence of imbalance between the thrombophilic action of VWF and the antithrombogenic action of ADAMTS13 due to aging, production of VWF in resting state and before and after sporting activity was investigated and compared between older peoples and young adults. The results indicated that older peoples had higher VWF antigen level in resting state as compared with young adults. In contrast, enzyme activity for decomposing ADAMTS13 activity was recognized as significantly lower in older peoples as compared with young adults. Based on this, lowering of the ADAMTS13 production amount itself due to aging was also presumed, though there is a possibility of lowering of the activity for decomposing VWF showing high level in resting state.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (40 results)

All 2011 2010 2009 2008 Other

All Journal Article (22 results) (of which Peer Reviewed: 19 results) Presentation (17 results) Remarks (1 results)

  • [Journal Article] 老若男女の発汗機能2011

    • Author(s)
      井上芳光
    • Journal Title

      大阪市立大学生活科学研究誌

      Volume: 8(印刷中)

    • NAID

      110008507601

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Potential role of enhanced cytokinemia and plasma inhibitor on the decreased activity of plasma ADAMTS13 in patients with alcoholic hepatitis : relationship to endotoxemia.2010

    • Author(s)
      Ishikawa M, Uemura M, Matsuyama T, Matsumoto M, Ishizashi H, et al
    • Journal Title

      Alcohol Clin Exp Res. 34

      Pages: 25-33

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pivotal role of ADAMTS13 function in liver diseases.2010

    • Author(s)
      Uemura M, Fujimura Y, Ko S, Matsumoto M, et al
    • Journal Title

      Int J Hematol. 91(1)(Review)

      Pages: 20-29

    • NAID

      10026110380

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sex differences in the effects of physical training on sweat gland responses during a graded exercise.2010

    • Author(s)
      Ichinose-Kuwahara T, Inoue Y, et al.
    • Journal Title

      Exp Physiol. 95

      Pages: 1026-1032

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential role of enhanced cytokinemia and plasma inhibitor on the decreased activity of plasma ADAMTS13 in patients with alcoholic hepatitis : relationship to endotoxemia.2010

    • Author(s)
      Ishikawa M, Uemura M, Ishizashi H, et al.
    • Journal Title

      Alcohol Clin Exp Res.

      Volume: 34

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sex differences in the effects of physical training on sweat gland responses during a graded exercise.2010

    • Author(s)
      Ichinose-Kuwahara T, Inoue Y, Iseki Y, et al.
    • Journal Title

      Exp Physiol

      Volume: 95 Pages: 1026-1032

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-thermal modification of heat-loss responses during exercise in humans.2010

    • Author(s)
      Kondo N, Nishiyasu T, Inoue Y, Koga S
    • Journal Title

      Eur J Appl Physiol

      Volume: 110 Pages: 447-458

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential role of enhanced cytokinemia and plasma inhibitor on the decreased activity of plasma ADAMTS13 in patients with alcoholic hepatitis : relationship to endotoxemia2010

    • Author(s)
      石川昌利, 植村正人, 石指宏通, et al.
    • Journal Title

      Alcohol Clin Exp Res. 34

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased ADAMTS13 levels in patients after living donor liver transplantation.2009

    • Author(s)
      Kobayashi T, Wada H, Usui M, Sakurai H, Matsumoto T, Nobori T, Katayama N, Uemoto S, Ishizashi H, et al
    • Journal Title

      Thromb Res. 124(5)

      Pages: 541-545

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sweat gland function Thai and Japanese Males in relation to physic training.2009

    • Author(s)
      Inoue Y, Ueda H, et al.
    • Journal Title

      Environmental Ergonomic. 13

      Pages: 276-279

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased ADAMTS13 levels in patients after living donor liver trasplantation2009

    • Author(s)
      Kobayashi T, Matsumoto M, Ishizashi H, et al.
    • Journal Title

      Thrombosis Research 124

      Pages: 541-545

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sweat gland function Thai and Japanese Males in relation to physic training2009

    • Author(s)
      Inoue Y, Ueda H, et al.
    • Journal Title

      Environmental Ergonomic 13

      Pages: 276-279

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アルコール性肝炎における血漿エンドトキシン濃度とADAMTS13活性の動態―重症度と多臓器不全合併との関連において2009

    • Author(s)
      石川昌利, 植村正人, 石指宏通, 他
    • Journal Title

      アルコールと医学生物学 28

      Pages: 77-85

    • NAID

      10021950637

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 動脈血栓症の制圧:VWF-GPIb軸依存性血小板血栓形成を調節するADAMTS13の基礎・臨床的解析2009

    • Author(s)
      藤村吉博, 松本雅則, 植村正人, 他
    • Journal Title

      日本医師会雑誌 137

      Pages: 2519-2521

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Potential role of ADAMTS13 in the progression of alcoholic hepatitis2008

    • Author(s)
      Uemura M, Fujimura Y, Matsuyama T, Matsumoto M, Ishikawa M, Ishizashi H, et al
    • Journal Title

      Curr Drug Abuse Rev. 1(2)(Review)

      Pages: 188-196

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation.2008

    • Author(s)
      Horii M, Uemura S, Uemura M, Matsumoto M, Ishizashi H, et al
    • Journal Title

      Heart Vessels. 23(5)

      Pages: 301-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma ADAMTS13 activity parallels the APACHE II score, reflecting an early prognostic indicator for patients with severe acute pancreatitis.2008

    • Author(s)
      Morioka C, Uemura M, Matsuyama T, Matsumoto M, Kato S, Ishikawa M, Ishizashi H, et al
    • Journal Title

      Scand J Gastroenterol. 43(11)

      Pages: 1387-1396

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive analysis of ADAMTS13 in patients with liver cirrhosis.2008

    • Author(s)
      Uemura M, Fujimura Y, Matsumoto M, Ishizashi H, et al
    • Journal Title

      Thromb Haemost. 99(6)

      Pages: 1019-1029

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential Role of Enhanced Cytokinemia and Plasma Inhibitor on the Decreased Activity of Plasma ADAMTS13 in Patients With Alcoholic Hepatitis : Relationship to Endotoxemia.2008

    • Author(s)
      Ishikawa M, Uemura M, Ishizashi H, (他11名)
    • Journal Title

      Alcohol Clin Exp Res. 33

      Pages: 1-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation.2008

    • Author(s)
      Horii M, Uemura S Ishizashi H, (他9 名)
    • Journal Title

      Heart Vessels. 23(5)

      Pages: 301-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma ADAMTS 1 3 activity parallels the APACHE II score. reflecting an early prognostic indicator for patients with severe acute pancreatitis.2008

    • Author(s)
      Morioka C, Uemura M Ishizashi H, (他17名)
    • Journal Title

      Scand J Gastroenterol. 43(11)

      Pages: 1387-96

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive analysis of ADAMTS13 in patients with liver cirrhosis.2008

    • Author(s)
      Uemura M, Fujimura Y Ishizashi H, (他11名)
    • Journal Title

      Thromb Haemost. 99(6)

      Pages: 1019-29

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 後天性・特発性TTPでADAMTS13活性著減を示す195例と古典的pentadで診断された89例の比較検討2010

    • Author(s)
      松本政則、藤村吉博, 石指宏通
    • Organizer
      第33回日本血栓止血学会
    • Place of Presentation
      鹿児島
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Required clothing ventilation in disposable diapers for Adult.2010

    • Author(s)
      Ueda H, Inoue Y, Matsudaira
    • Organizer
      The 36^<th> Textile Research Symposium at India
    • Place of Presentation
      Delhi, India
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高齢者の発汗機能 (シンポジウム)2010

    • Author(s)
      井上芳光
    • Organizer
      第10回日本抗加齢医学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高温高湿下運動時の有効発汗量と無効発汗量の性差2010

    • Author(s)
      井上芳光, 石指宏通, 他
    • Organizer
      日本生理人類学会第63回大会
    • Place of Presentation
      千葉
    • Related Report
      2010 Annual Research Report
  • [Presentation] Two Patient Groups with Acquired Idiopathic Thrombotic Thrombocytopenic Purpura, Defined by ADAMTS13(n=195)and/or Classic Pentad(n=89)2009

    • Author(s)
      松本雅則, 石指宏通, 他3名
    • Organizer
      51th ASH Annual Meeting
    • Place of Presentation
      New Orleans(USA)
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 進行した肝硬変のADAMTS13著減例は血栓性血小板減少性紫斑病と類似している2009

    • Author(s)
      植村正人, 松本雅則, 石指宏通, 他
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 急性肝不全における血漿Et活性とADAMT13活性の動態2009

    • Author(s)
      藤本正男, 植村正人, 石指宏通, 他
    • Organizer
      第35回日本急性肝不全研究会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] アルコール性肝炎における血漿エンドトキシン濃度とADAMTS13活性の動態―重症度との関連において2009

    • Author(s)
      石川昌利, 植村正人, 石指宏通, 他
    • Organizer
      第95回日本消化器病学会
    • Place of Presentation
      北海道
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Two Patient Groups with Acquired Idiopathic Thrombotic Thrombocytopenic Purpura, Defined by ADAMTS13 (n=195) and/or Classic Pentad (n=89).2009

    • Author(s)
      石川昌利, 石指宏通
    • Organizer
      51th ASH Annual Meeting.
    • Place of Presentation
      New Orleans (USA)
    • Related Report
      2010 Final Research Report
  • [Presentation] アルコール性肝炎における血漿エンドトキシン濃度とADAMTS13活性の動態-重症度との関連において2009

    • Author(s)
      石川昌利、植村正人、石指宏通
    • Organizer
      第95回日本消化器病学会
    • Place of Presentation
      北海道.
    • Related Report
      2010 Final Research Report
  • [Presentation] 行した肝硬変のADAMTS13著減例は血栓性血小板減少性紫斑病と類似してい2009

    • Author(s)
      植村正人、松本雅則、石指宏通
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 汗腺機能の加齢的変化とその性差2009

    • Author(s)
      井上芳光, 他
    • Organizer
      第45回日本体力医学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Annual Research Report
  • [Presentation] Potential role of enhanced cytokinemia and endotoxemia on the decreased activity of plasma ADAMTS13 in patients with alcoholic hepatitis.2008

    • Author(s)
      Ishikawa M, Ishizashi H, (他9名)
    • Organizer
      50^<th> ASH annual meeting
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2008-12-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肝硬変における血漿von Willebrand factor multimerと病態解析2008

    • Author(s)
      石川昌利, 植村正人, 石指宏通, (他11名)
    • Organizer
      第12回日本肝臓学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] アルコール性肝炎における血漿エンドトキシン濃度とADAMTS13活性の動態-重症度と多臓器不全との関連において2008

    • Author(s)
      石川昌利, 植村正人, 石指宏通, (他11名)
    • Organizer
      第28回アルコールと医学生物学研究会
    • Place of Presentation
      横浜
    • Year and Date
      2008-09-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Potential role of enhanced cytokinemia and endotoxemia on the decreased activity of plasma ADAMTS13 in patients with alcoholic hepatitis.2008

    • Author(s)
      石川昌利, 石指宏通
    • Organizer
      50^<th> ASH annual meeting.
    • Place of Presentation
      San Francisco(USA)
    • Related Report
      2010 Final Research Report
  • [Presentation] 重症急性膵炎における血漿ADAMTS13活性と超高分子VWFマルチマーの動態2008

    • Author(s)
      森岡千恵、植村正人、石指宏通
    • Organizer
      第44回日本肝臓学会
    • Place of Presentation
      愛媛
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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