Induction Mechanism of carcinogenesis in diabetic status and inhibitory effect of food components on the cancer.
| Project/Area Number |
20500711
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
MASUDA Shuichi (2009-2010) University of Shizuoka, 食品栄養科学部, 准教授 (40336657)
木苗 直秀 (2008) University of Shizuoka, 食品栄養科学部, 教授 (00046286)
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| Co-Investigator(Kenkyū-buntansha) |
増田 修一 静岡県立大学, 食品栄養科学部, 助教 (40336657)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アクリルアミド / 糖尿病 / グリシダミド / 変異原性 / CYP2E1 / 緑茶 / ワサビ / 発がん / 機能性食品 / 変異原物質 / ニトロソアミン / ヘテロサイクリックアミン |
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| Research Abstract |
Genotocicities of acrylamide, which is a mutagen/carcinogen contained in foodstuffs, was increased in diabetic rats compared with those in normal rats. The activity of CYP2E1, known as a drug-metabolizing enzyme, in diabetic rats was stronger than that in normal rats. Therefore, AA was metabolic-activated to glycidamide by CYP2E1 in diabetic status. And green tea and Wasabi extracts showed the inhibitory effects against the genotocities of AA.
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Report
(4 results)
Research Products
(39 results)
