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Induction Mechanism of carcinogenesis in diabetic status and inhibitory effect of food components on the cancer.

Research Project

Project/Area Number 20500711
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionUniversity of Shizuoka

Principal Investigator

MASUDA Shuichi (2009-2010)  University of Shizuoka, 食品栄養科学部, 准教授 (40336657)

木苗 直秀 (2008)  University of Shizuoka, 食品栄養科学部, 教授 (00046286)

Co-Investigator(Kenkyū-buntansha) 増田 修一  静岡県立大学, 食品栄養科学部, 助教 (40336657)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsアクリルアミド / 糖尿病 / グリシダミド / 変異原性 / CYP2E1 / 緑茶 / ワサビ / 発がん / 機能性食品 / 変異原物質 / ニトロソアミン / ヘテロサイクリックアミン
Research Abstract

Genotocicities of acrylamide, which is a mutagen/carcinogen contained in foodstuffs, was increased in diabetic rats compared with those in normal rats. The activity of CYP2E1, known as a drug-metabolizing enzyme, in diabetic rats was stronger than that in normal rats. Therefore, AA was metabolic-activated to glycidamide by CYP2E1 in diabetic status. And green tea and Wasabi extracts showed the inhibitory effects against the genotocities of AA.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (39 results)

All 2011 2010 2009 2008 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (19 results) Book (6 results) Remarks (2 results)

  • [Journal Article] Genotoxicity of acrylamide in vitro : Acrylamide is not metabolically activated in standard in vitro systems.2011

    • Author(s)
      Koyama N, Masuda S
    • Journal Title

      Environ.Mol.Mutagen

      Volume: 52(1) Pages: 545-549

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotoxicity of acrylamide in vitro : Acrylamide is not metabolicallyactivated in standard in vitro systems.2010

    • Author(s)
      Koyama N, Masuda S (10名中8番目)
    • Journal Title

      Environ. Mol. Mutagen Epub ahead of print

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Benzo[a]pyrene exposed to solar-simulated light inhibits apoptosis and augments carcinogenicity2010

    • Author(s)
      Teranishi M, Masuda S, et al.
    • Journal Title

      Chem Biol Interact. 185(1)

      Pages: 4-11

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems2009

    • Author(s)
      Totsuka Y, Masuda S, et al.
    • Journal Title

      Part Fibre Toxicol. 3

      Pages: 3-23

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of a newbioassay technique using goldfish forassessment of water toxicity2008

    • Author(s)
      Deguchi, Y., T., Masuda, S., Kinae, N.(9名中4番目)
    • Journal Title

      Environ.Toxicol 23(6)

      Pages: 720-727

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional analyses ofneutrophil-like differentiated cell linesunder a hyperglycemic condition2008

    • Author(s)
      Oya-Ito, T., Masuda, S., Ohashi, N.(5名中3番目)
    • Journal Title

      Molecular Nutrition and FoodResearch 52(3)

      Pages: 360-369

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of tea extracts ongastric mucosal erosion andhemorrhage in Helicobacter pyloriinfected Mongolian Gerbils2008

    • Author(s)
      Kinae, N., Oguni, I., Takabayashi, F.,Masuda, S.
    • Journal Title

      J. Clin.Biochem. Nutri 43

      Pages: 22-23

    • Related Report
      2010 Final Research Report
  • [Journal Article] Application of a new bioassay technique using goldfish for assessment of water toxicity.2008

    • Author(s)
      Deguchi, Y., et al.
    • Journal Title

      Environ. Toxicol. 23(6)

      Pages: 720-727

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of neutrophil-like differentiated cell lines under hyperglycemic condition.2008

    • Author(s)
      Oya-Ito, T., et al.
    • Journal Title

      Molecular Nutrition and Food Research 52(3)

      Pages: 360-369

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotoxicity and estrogenic activity of 3, 3'-dinitrobis phenol A in goldfish.2008

    • Author(s)
      Toyoizumi, T., et. al
    • Journal Title

      Biosci. Biotechnol. Biochem. 72(8)

      Pages: 2118-2123

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of green tea extracts on gastric mucosal erosion and hemorrhage in Helicobacter pylori infected Mongolian Gerbils2008

    • Author(s)
      Kinae, N., et. al
    • Journal Title

      J. Clin. Biochem. Nutri. 43

      Pages: 22-23

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Steptoe A. Responses of ultra-weak chemiluminescence and secretory IgA in saliva to the induction of angry and depressive moods.2008

    • Author(s)
      Tsuboi, H., et. al
    • Journal Title

      Brain Behav. Immun. 22(2)

      Pages: 17-23

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肥満モデルマウスにおける酸化損傷に関するDNA 付加体生成の増加2010

    • Author(s)
      加藤竜也, 増田修一
    • Organizer
      日本環境変異原学会 第39回大会
    • Place of Presentation
      つくば
    • Related Report
      2010 Final Research Report
  • [Presentation] メイラード反応生成物および日常食品の亜硝酸処理による変異原性の発現に関する研究2010

    • Author(s)
      森上三穂, 増田修一
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 肥満モデルマウスにおける酸化損傷に関するDNA付加体生成の増加2010

    • Author(s)
      加藤竜也, 増田修一
    • Organizer
      日本環境変異原学会 第39回大会
    • Place of Presentation
      つくば
    • Related Report
      2010 Annual Research Report
  • [Presentation] アスピリンによる胃粘膜細胞損傷に対する陳皮抽出物の抑制効果2010

    • Author(s)
      清俊介, 増田修一, 他
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター他(岡山)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖尿病状態及びアルコール摂取時におけるアクリルアミドの遺伝毒性の変動2009

    • Author(s)
      平野元美, 増田修一
    • Organizer
      第19回日本メイラード学会
    • Place of Presentation
      金沢
    • Year and Date
      2009-11-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖尿病状態及びアルコール摂取時におけるアクリルアミドの遺伝毒性の変動2009

    • Author(s)
      平野元美, 増田修一, 他
    • Organizer
      第19回日本メイラード学会
    • Place of Presentation
      金沢エクセルホテル(金沢)
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] ライフステージ(週齢)を考慮したアクリルアミドの多臓器遺伝毒性評価2009

    • Author(s)
      小山直己, 増田修一
    • Organizer
      日本環境変異原学会 第38回大会
    • Place of Presentation
      静岡
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖尿病発症時における変異・発がん物質の遺伝毒性の変動2009

    • Author(s)
      増田修一, 平野元美
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖尿病マウスにおける各臓器中の酸化的DNA 損傷性の比較とそのメカニズム2009

    • Author(s)
      横地俊輔, 増田修一
    • Organizer
      日本薬学会129年会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖尿病発症時における変異・発がん物質の遺伝毒性の変動2009

    • Author(s)
      増田修一, 平野元美, 他
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ライフステージ(週齢)を考慮したアクリルアミドの多臓器遺伝毒性評価2009

    • Author(s)
      小山直己, 増田修一, 他
    • Organizer
      日本環境変異原学会 第38回大会
    • Place of Presentation
      清水テルサ(静岡)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ナノ粒子により誘発される in vivo 遺伝毒性2009

    • Author(s)
      松本陽子, 増田修一, 他
    • Organizer
      日本環境変異原学会 第38回大会
    • Place of Presentation
      清水テルサ(静岡)
    • Related Report
      2009 Annual Research Report
  • [Presentation] In vivo における3,6-dinitrobenzo[e]pyrene の遺伝毒性2009

    • Author(s)
      加藤竜也, 増田修一, 他
    • Organizer
      日本環境変異原学会 第38回大会
    • Place of Presentation
      清水テルサ(静岡)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genotoxic activities of Maillard reaction products and their relationship to diabetic disease2008

    • Author(s)
      木苗直秀
    • Organizer
      第1回国際健康長寿コンファレンス
    • Place of Presentation
      静岡県
    • Year and Date
      2008-12-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] ライフステージを考慮したアクリルアミドの多臓器遺伝毒性評価2008

    • Author(s)
      小山直己、増田修一
    • Organizer
      日本環境変異原学会第37回大会
    • Place of Presentation
      沖縄県
    • Year and Date
      2008-12-05
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 糖尿病発症時におけるアクリルアミドの遺伝毒性の変動2008

    • Author(s)
      平野元美、増田修一
    • Organizer
      日本環境変異原学会第37回大会
    • Place of Presentation
      沖縄県
    • Year and Date
      2008-12-05
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 糖尿病誘発ラットにおけるニトロソアミンの生成と毒性変動に関する基礎的研究2008

    • Author(s)
      田里李奈、増田修一
    • Organizer
      日本環境変異原学会第37回大会
    • Place of Presentation
      沖縄県
    • Year and Date
      2008-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Formation ofGenotoxic Compounds underPhysiological Conditions and theirRelationship to Diabetic mellitus2008

    • Author(s)
      木苗直秀, 増田修一
    • Organizer
      The Eighth China-Japan International Symposium on Health Sciences
    • Place of Presentation
      Zhejiang, China
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖尿病発症時における変異・発がん物質の生成及び遺伝毒性の変動2008

    • Author(s)
      増田修一, 木苗直秀
    • Organizer
      2007 US フォーラム
    • Place of Presentation
      静岡
    • Related Report
      2010 Final Research Report
  • [Book] 2.2.3 多環式芳香族炭化水素(PAH)、食品安全の事典2009

    • Author(s)
      木苗直秀, 増田修一
    • Publisher
      朝倉書店
    • Related Report
      2010 Final Research Report
  • [Book] 6. 加工食品に含まれる化学物質の安全性、食品の安全性と対策2009

    • Author(s)
      木苗直秀, 増田修一
    • Publisher
      社団法人 日本食品衛生協会
    • Related Report
      2010 Final Research Report
  • [Book] 多環式芳香族炭化水素(PAH)(食品安全の事典)2009

    • Author(s)
      木苗直秀, 増田修一
    • Total Pages
      2
    • Publisher
      朝倉書店
    • Related Report
      2009 Annual Research Report
  • [Book] 加工食品に含まれる化学物質の安全性(食品の安全性と対策)2009

    • Author(s)
      木苗直秀, 増田修一
    • Total Pages
      9
    • Publisher
      社団法人日本食品衛生協会
    • Related Report
      2009 Annual Research Report
  • [Book] Functional Food -機能性食品の基礎から臨床へ- 2.糖尿病と機能性食品2008

    • Author(s)
      増田修一、木苗直秀
    • Publisher
      フジメディカル出版
    • Related Report
      2010 Final Research Report
  • [Book] 食品機能性の科学、アブラナ科野菜(イソチオシアネートの生理活性)、「ワサビの生理的効果」、「アブラナ科野菜の安全性」「栄養への影響」2008

    • Author(s)
      木苗直秀、増田修一
    • Publisher
      産業技術サービスセンター
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://sfns.u-shizuoka-ken.ac.jp/foodhygn/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://sfns.u-shizuoka-ken.ac.jp/foodhygn/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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